Retinol acetate: instructions for use and what it is for, price, reviews, analogues. Retinol acetate - instructions for use Retinol oil solution instructions for use

Or Retinol acetate is a source of vitamin A, an analogue of natural vitamin A, necessary for the normal functioning of the body. Retinol is prescribed to patients suffering from eye diseases, beriberi, skin and gastrointestinal tract diseases.

Let's present the most important information about the use of the drug, the main indications and contraindications of Retinol.

Retinol: formula and description of the drug

Gross formula of Retinol acetate: C 20 H 30 O

Description of the drug: Retinol is an odorless oily liquid. The color of the drug varies from light yellow to dark yellow.

Pharmacological action and pharmacokinetics

Vitamin A is a fat-soluble vitamin that ensures the functioning of the retina, endocrine glands, participates in the process of bone growth, supports the embryonic development of the fetus, helps protect the body from infectious and other diseases, the rapid reproduction of epithelial cells, maintains skin elasticity, rejuvenates cells, accelerates healing processes, is a participant in many biochemical processes in the body.

Vitamin A has the properties of an excellent antioxidant, it is able to have an antitumor effect.

Retinol is well and quickly absorbed into the blood from the organs of the gastrointestinal tract, mainly in the sections small intestine. The maximum level of the drug is observed in the blood serum 3 hours after administration. Vitamin A accumulates in the epithelial cells of the liver and in the epithelium of the skin. It is excreted quite slowly, by the kidneys and partially with bile.

Indications for use Retinol acetate

Retinol is taken as prescribed by a doctor. As a rule, the drug is prescribed for the following diseases:

• beriberi and severe beriberi;
• retinitis pigmentosa;
• eczematous lesions of the eyelids;
• treatment of hemeralopia;
• xerophthalmia;
• superficial keratitis;
• damage to the cornea of ​​​​the eyes;
• conjunctivitis of various nature;
• pyoderma.

AT complex therapy Retinol is used for various skin diseases, colds and infectious diseases:

• eczema in subacute and acute stages;
• lupus;
• psoriasis;
• neurodermatitis;
• seborrheic dermatitis;
• skin ulcers;
• ichthyosis;
• burns, frostbite, cracks in the skin;
• when there are wounds on the skin;
• follicular dyskeratosis;
• stomach ulcer;
• cirrhosis of the liver;
• problems with the bronchi;
• respiratory diseases;
• in the treatment of collagenoses;
• rickets treatment.

Retinol is prescribed for children to maintain normal growth and development of the body. The dosage of the drug is determined by the doctor after diagnosing the disease, depending on the severity of the patient's condition and individual features organism.

Uncontrolled and self-administration of Retinol can cause serious harm to the body, so before you start taking the drug, you should consult with specialists.

The main contraindications to the use of the drug

The benefits of Retinol are unconditional, however, taking the drug in a number of people can cause contraindications and adversely affect the state of the patient's body. Here is a list of diseases in which Retinol acetate is prohibited for use:

• allergy to the drug;
• chronic nephritis;
• diseases of the biliary tract, cholelithiasis;
• heart failure;
• chronic pancreatitis;
• with hypervitaminosis caused by an excess of vitamin A;
• with an overdose of carotenoids;
• hyperlipidemia and lipid metabolism disorders;
• chronic alcoholism;
• the presence of significant overweight in the patient;
• sarcoidosis.

Taking Retinol with the above diseases can provoke dangerous side effects significantly worsen the patient's condition.

Method of application and dosage of Retinol

Retinol is used for oral administration in the form of capsules. The drug is also used for local application in the form of a solution, it is produced in ampoules. The type and method of application of the drug is determined by the doctor depending on the disease. Also, information about the drug can be found in the instructions for use.

Retinol is taken 10-15 minutes after a meal.

1 ml Retinol acetate contains 100,000 IU Vitamin A. For adult patients, a single dose of vitamin A is not more than 50,000 IU, and the daily intake is not more than 100,000 IU. Children are prescribed 5,000 of the drug at a time, and the daily proportion of Retinol when taken by children should not exceed 20,000 IU.

With beriberi, patients are prescribed 8 drops of the drug per day. If the patient has skin diseases, 10-20 drops of Retinol per day are prescribed. The affected areas of the skin are lubricated with Retinol (gel or ointment) and covered with a gauze bandage. Such applications are done 5-6 times a day, and as the skin lesions begin to pass, reduce the number of applications. These gauze dressings with Retinol work well for burns or frostbite.

Sometimes doctors prescribe Retinol injections.

It is very important to strictly observe the dosage of the drug. It is determined by the doctor and individually for each patient.

drug overdose

In the event that the patient exceeds the allowable intake of Retinol, taking a much larger number of capsules than expected, symptoms of an overdose of the drug are possible:

• severe dizziness;
• abdominal pain and diarrhea;
• dehydration of the body;
• peeling of the skin and flaking of small parts of the skin;
• bleeding gums;
• feeling of dryness in the mouth;
• peeling lips, cracked lips.

In the event that the permissible dose of Retinol is exceeded several times or more, the patient has symptoms of hypervitaminosis. The body reacts to an excess amount of vitamin A with the following symptoms:

• headache attacks;
• temperature rise;
• drowsiness and feeling of weakness in the whole body;
• nausea and vomiting;
• blurred vision;
• double vision effect
• dry skin;
• the appearance of small spots on the body;
• pain in muscles, bones;
• jaundice;
• an increase in the size of the liver;
• convulsions;
• malfunctions of the heart.

In case of an overdose of Retinol, it is necessary to stop taking the drug and consult a doctor. The patient's condition in this case must be monitored, he will be prescribed special therapy. If appropriate measures are not taken, irreversible consequences are possible.

Side effects of Retinol

Long-term and constant use of the drug Retinol acetate, as well as the present intolerance to the drug, may contribute to the manifestation of the following side effects:

From the side nervous system:

• fast fatiguability;
• drowsiness during the daytime;
• headache;
• nervousness and irritability;
• malaise and complaints of lack of strength;
• decreased clarity of vision;
• convulsions;
• intraocular hypertension;

From the side digestive system:

• bouts of nausea and vomiting;
• weight loss;
• loss of appetite.

Allergic reactions and manifestations on the skin:

• cracked lips;
• the appearance of orange spots on the cheeks;
• subcutaneous edema;
• rash behind the body, accompanied by severe itching;
• increased dryness of the skin and dryness of the mucous membranes;
• increase in body temperature;
• hyperemia on the face;
• increased fragility of nails;

Other side effects:

• severe hair loss;
• stomach ache;
• menstrual irregularities;
• the appearance of photophobia;

As soon as the patient stops taking Retinol, all side effects disappear. Sometimes a number of patients have minor allergic skin rashes at the start of taking the drug. These rashes pass quickly.

It is necessary to carefully monitor the patient's condition: if, when taking Retinol, side effects appear that do not go away, begin to worsen, you should immediately consult a doctor. In this case, the doctor may adjust the dosage of the drug or cancel it altogether.

Use of the drug during pregnancy and breastfeeding

Retinol is contraindicated during pregnancy (at any time) and during breastfeeding child, as the drug can adversely affect the condition of the fetus, and in a small child cause severe allergies. The drug is allowed to be given to children only from 7 years.

Conditions and rules for storing Retinol

Retinol acetate (capsules, ointment, or tablets) must be stored in the refrigerator in its original packaging. Storage temperature of the drug: from +2 to +8 degrees. The drug is stored out of the reach of children.

The shelf life of Retinol is two years from the date of manufacture. After the expiration date, the drug is disposed of.

The price of the drug in pharmacies and analogues of Retinol

Retinol can be purchased at every pharmacy without a prescription. The cost of 10 capsules of the drug is about 10–15 rubles, an oil solution of Retinol acetate costs 35–40 rubles (10 ml.) And 85–90 rubles (30 ml.)

Retinol has a number of analogues similar in composition, among which the following are the most popular:

• Aevit (available in the form of transparent capsules) - from 40 rubles;
• Videstim (ointment 0.5%) - from 100 rubles;
• Xerofrol (powder) - from 130 rubles.
• Retsedil (ointment) - from 210 rubles;

Vitamin A is vital for the body, but it is unstable in its pure form, so it is replaced by Retinol, an analogue of vitamin A, from which vitamin A is already secreted in the body - the vitamin of youth and beauty, which in normal doses has a beneficial effect on the skin and eyesight.

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The composition of the medicinal product

Active substance: retinol acetate (vitamin A-acetate)

1 ml of the drug contains retinol acetate (vitamin A-acetate) in terms of 100% retinol acetate - 34.4 mg (100,000 IU)

Excipients: sunflower oil.

Dosage form

Oily oral solution.

Clear oily liquid from light yellow to dark yellow without rancid smell and taste.

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Pharmacological group

Simple drugs vitamin A. Retinol (vitamin A). ATC code A11C A01.

Vitamin A (retinol) belongs to the group of fat-soluble vitamins.

Retinol acetate is an analogue of natural vitamin A and is necessary to restore the normal concentration of retinol in the body. Vitamin A plays an important role in the synthesis of proteins, lipids, mucopolysaccharides, regulates the balance of minerals.

A specific function of vitamin A is to provide vision processes (photoreception). Retinol is involved in the synthesis of visual purple - rhodopsin, located in the rods of the retina.

Vitamin A modulates differentiation processes epithelial cells, participates in the development of secretory glands, keratinization processes, regeneration of mucous membranes and skin.

Vitamin A is necessary for the normal functioning of the endocrine glands and the growth of the body, because there are somatomedin synergists.

Vitamin A affects the division of immunocompetent cells, the synthesis of factors of specific (immunoglobulin) and non-specific (interferon, lysozyme) protection of the body against infectious and other diseases, stimulates myelopoiesis.

Retinol increases the level of glycogen in the liver, stimulates the production of trypsin and lipase in the digestive system; inhibits photochemical free radical reactions and cysteine ​​oxidation; activates the inclusion of sulfates in the components of connective tissue, cartilage, bones; satisfies the need for sulfocerebrosides and myelin, providing the conduction and transmission of nerve impulses.

With a lack of vitamin A, impaired twilight vision (night blindness) and atrophy of the epithelium of the conjunctiva, cornea, and lacrimal glands develop. Degenerative-dystrophic processes are observed in respiratory tract(mucous membranes of the nasopharynx, paranasal sinuses, trachea, bronchi), in the genitourinary system (epithelium of the renal pelvis, ureters, Bladder, urethra, vagina, ovaries, fallopian tubes and endometrium, seminal vesicles and cords, prostate), in the digestive system (mucous membrane of the digestive tract, salivary glands, pancreas). Vitamin A deficiency leads to a violation of skin trophism (hyperkeratosis), deterioration in the growth and quality of hair and nails, as well as the function of the sebaceous and sweat glands. In addition, there is a decrease in body weight and a slowdown in bone growth, a decrease in the synthesis of glucocorticoids and steroid hormones, and a violation of the body's resistance to infectious and other diseases. There is a tendency to cholera and nephrolithiasis.

A lack or excess of vitamin A in a woman's body can cause abnormalities in the intrauterine development of the fetus.

Retinol has an antitumor effect, does not apply to non-epithelial tumors.

Ingested retinol acetate is well absorbed in the upper small intestine. Then, as part of chylomicrons, it is transported from the intestinal wall to lymphatic system and enters the bloodstream through the thoracic duct. Transport Retinol ether in the blood is carried out by β-lipoproteins. The maximum level of vitamin A esters in the blood serum is reached 3:00 after ingestion. The place of deposition of vitamin A is the liver parenchyma, where it accumulates in stable ether forms. In addition, a high content of vitamin A is determined in the pigment epithelium of the retina. This depot is necessary for the regular supply of vitamin A to the outer segments of the rods and cones.

The metabolism of retinol takes place in the liver, then in the form of inactive metabolites, it is excreted by the kidneys. Retinol can be partially excreted in the bile and participate in the enterohepatic circulation. The excretion of retinol occurs slowly - 34% of the dose of the drug is excreted from the body in 3 weeks.

Indications

A-avitaminosis and A-hypovitaminosis, eye diseases (retinitis pigmentosa, xerophthalmia, hemeralopia, superficial keratitis, corneal lesions, conjunctivitis, pyoderma and eczematous eyelid lesions), as part of complex therapy:

• rickets;
• acute respiratory diseases that pass against the background of exudative diathesis;
• acute and chronic bronchopulmonary diseases;
• malnutrition;
• collagenosis;
• with pathological processes of the skin (frostbite, burns, wounds, ichthyosis, follicular dyskeratosis, senile keratosis, tuberculosis of the skin, some forms of eczema, psoriasis), with inflammatory and ulcerative-erosive lesions of the intestine, cirrhosis of the liver.

Contraindications

Hypersensitivity to the components of the drug, acute and chronic nephritis, heart failure in the stage of decompensation, cholelithiasis, chronic pancreatitis, hypervitaminosis A, retinoid overdose, hyperlipidemia, obesity, chronic alcoholism, sarcoidosis (including history).

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Appropriate safety precautions for use

The drug should be taken under medical supervision. With prolonged use of retinol acetate, it is necessary to control biochemical parameters and clotting time.

In the treatment of impaired twilight vision (night blindness), Retinol acetate should be used in complex treatment.

Use with caution in case of severe damage to the digestive system, diseases accompanied by impaired blood clotting.

Retinol should be taken 1 hour before or 4-6 hours after taking cholestyramine.

The drug tends to accumulate for a long time to be in the body. Women who have taken high doses of retinol can plan pregnancy no earlier than 6-12 months later. This is due to the fact that during this time there is a risk of improper development of the fetus under the influence of a high content of vitamin A in the body.

For normal absorption of vitamin A necessary condition is the presence of fat in food.

Abuse of alcohol and tobacco disrupts the absorption of the drug in the gastrointestinal tract.

Use during pregnancy or lactation

Given the large dose of vitamin A in this dosage form the drug is contraindicated for oral administration during pregnancy or lactation.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms

There are no data on the effect of the drug on the ability to drive a car or work with mechanisms.

Children

The drug is prescribed to children aged 7 years.

Dosage and administration

Retinol acetate is administered orally 10-15 minutes after meals and externally.

1 ml of the drug contains 100,000 IU (25 drops) of vitamin A.

1 drop from a dropper cap contains about 4,000 IU of vitamin A.

When determining the doses of the drug, proceed from the fact that the highest single dose of vitamin A is:

• for adults - 50,000 IU (12 drops (48,000 IU)
• for children from 7 years old - 5000 IU (1 drop of the drug (4000 IU).

The highest daily dose of vitamin A is:

• for adults - 100,000 IU (25 drops)
• for children from 7 years old - 20,000 IU (5 drops).

Therapeutic doses of vitamin A for mild and medium degree severity for adults is up to 33,000 IU (8 drops (32,000 IU) per day.

For skin diseases, as well as for retinitis pigmentosa, xerophthalmia, hemeralopia, the daily dose of vitamin A is 50,000-100,000 IU (12-25 drops (48,000-100,000 IU).

For the treatment of children over the age of 7 years, prescribe 3000-6000 IU (1 drop of the drug (4000 IU) per day, depending on the nature and course of the disease.

In case of skin lesions (ulcers, burns, frostbite), after hygienic cleaning, lubricate the affected areas with a solution and cover with a gauze bandage (5-6 times a day, with a decrease in the number of applications to one, depending on epithelization).

Overdose

Symptoms of an overdose: dizziness, confusion, diarrhea, severe dehydration, irritability, generalized rash, followed by coarse peeling, which begins with the face; bleeding gums, dryness and ulceration of the oral mucosa, peeling of the lips, sharply painful palpation of long tubular bones due to pelvic hemorrhage.

Acute and chronic hypervitaminosis A is accompanied by severe headache, fever, drowsiness, vomiting, blurred vision (double vision), dry skin, pain in the joints and muscles, the appearance of age spots, an increase in the size of the liver and spleen, jaundice, changes in the blood picture, loss of energy and appetite. In severe cases, seizures, cardiac weakness and hydrocephalus develop.

Treatment. Treatment is symptomatic.

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Side effects

Long-term intake of large doses of vitamin A can cause the development of hypervitaminosis A.

From the nervous system and sensory organs: fatigue, drowsiness, lethargy, irritability, headache, sleep loss, convulsions, discomfort, intraocular hypertension, visual disturbances.

From the digestive tract: loss of appetite, weight loss, nausea, rarely - vomiting.

Possible exacerbation of liver disease, increased activity of transaminases and alkaline phosphatase.

The instructions for use of retinol acetate indicate that it is a fat-soluble vitamin A, which belongs to the group of retinoids. It is necessary as part of a balanced diet to maintain health, especially during periods of increased stress and stress. Affordable and effective remedy for those who are worried about the condition of the skin, hair and nails, it is used for internal and external use.

Retinol acetate - instructions for use, effects on the body

Vitamin A has vital properties:

• participates in cell division and the formation of cell membranes;
• regulates antioxidant processes and restoration of organic tissues;
• contributes to the full absorption of minerals and the formation of cholesterol;
• helps to improve digestion, strengthen the immune system, as well as get rid of skin diseases(dermatitis, acne).

The main indications that are contained in the instructions for use of retinol acetate (vitamin A):

• avitaminosis A is a disease resulting from a prolonged deficiency of vitamin A, in which vision adaptation worsens (especially at night), conjunctivitis (inflammation of the conjunctiva), xerophthalmia (drying of the conjunctiva and cornea), skin hyperkeratosis (formation of dense growths and spikes);
• hypovitaminosis - a condition in which there is not enough vitamins in the body in relation to required level, characteristic of most modern residents, is compensated by a balanced diet or the use of multivitamin complexes;
• eye diseases - retinitis pigmentosa (damage to the retinal pigment epithelium leading to blindness), hemeralopia (night blindness, reduced vision in the dark), conjunctivitis, xerophthalmia, eczema on the eyelids or inflammation of the skin in the eye area;
• diseases and skin lesions - psoriasis, eczema, after burns, frostbite, injury;
• malnutrition therapy (protein deficiency, chronic indigestion in children, in which there is an exhaustion of the body and a decrease in body weight), treatment of rickets (impaired bone structure formation, insufficient bone mineralization);
• treatment of acute respiratory infections, chronic diseases bronchopulmonary system, inflammatory and ulcerative symptoms in the gastrointestinal tract;
• complex treatment of leukemia and epithelial tumors (to strengthen hematopoietic cells during chemotherapy).

In combination with vitamin A, vitamin E is often prescribed (type preparations), since in this form vitamins are stored longer in active form and have an anabolic effect. Vitamin A is also recommended to be taken together with vitamin D (calciferol), B2 (riboflavin), B3 (nicotinic acid).

Side effects and contraindications

Possible manifestation of hypervitaminosis A:

• depressed state, tendency to drowsiness;
• headaches, dizziness;
• overflow of blood vessels on the face;
• discoordination of movements;
• fever, sweating;
• skin rashes.

Contraindications depend on general condition and history: liver and kidney disease (stones in gallbladder and ducts chronic inflammation pancreas, acute or chronic nephritis).

Use with caution during pregnancy if the expected benefit to the mother outweighs the possible Negative consequences for the fetus.

Joint use with drugs

Use with antibiotics for external use (Neomycin, Nefluan, Triasept, Polygynax, Polydex, Pimafucort, Flucort N, Flucinar N, Elzhina and others) leads to reduced absorption of retinol.

With the simultaneous use of retinol with glucocorticoids, the anti-inflammatory effect becomes weaker. Oral use of the drug together with anticoagulants can lead to bleeding.

It is contraindicated to prescribe cholestyramine together with retinol, Activated carbon that interfere with its absorption in the gastrointestinal tract.

The most popular form of the retinol acetate preparation is an oil solution in capsules with instructions for use in a cardboard box, capsules are placed in 10 pieces in a blister pack.

The drug is taken orally after eating in 15-20 minutes. According to the instructions for use of retinol acetate in capsules, the following dosage is prescribed:

• with a lack of vitamin A in adults - up to 33,000 IU / day;
• with hemeralopia, xerophthalmia, retinitis pigmentosa - up to 50,000-100,000 IU / day;
• for skin diseases in adults - up to 50,000-100,000 IU / day;
• during pregnancy and lactation - up to 10,000 IU / day;
• separately specified in the instructions for use, the dosage of retinol acetate for children is 1000-5000 IU / day, depending on age and indications, in special cases under the strict supervision of a doctor - up to 5000-20,000 IU / day.

Oil-based retinol is produced in the form of a clear yellowish liquid without a pronounced taste and smell. The oil solution is in glass bottles of 10 ml, 15 ml, 30 ml, 50 ml. The instructions for use of oil with retinol acetate describe the following composition:

• active substance - retinol acetate in the amount of 34.4 mg (which corresponds to 100,000 IU) or 86.0 mg (250,000);
• auxiliary components - vegetable oil (sunflower, peanut), deodorized, refined.

The prescribed dose of the drug for adults 33,000 IU is determined approximately as follows: 10-12 drops of a solution with retinol in the amount of 34.4 mg or 4-5 drops with 86 mg are collected.

Retinol oil solution is used for intramuscular injection injections can be combined with oral administration drug. Ampoules contain 1 ml of solution, after an injection, patients sometimes notice pain. The contents of the ampoules can also be used for external use, applied to the skin.

Retinol acetate oil solution can be in bottles with a dropper cap, which allows you to more accurately and conveniently get the required dosage. In this form, retinol is used for both oral and external use, especially in the treatment of eye diseases. We remind you that the recommended daily dose of retinol 33,000 IU is defined in drops as follows:

• 10-12 drops at a drug concentration of 3.44%,
• 4-5 drops of 8.6% solution.

Other forms of the drug:

• retinol acetate tablets with instructions for use in a cardboard box, packaged in 10 pieces in a contour package or 20, 30, 40, 50 pieces in a polymer bottle, coated with a yellow shell;
• ointment containing retinol acetate, with instructions for use in a cardboard box, is prescribed for the treatment of skin diseases (dermatitis, seborrhea, eczema of various etiologies, acne).

Retinol must be used to maintain the normal condition of the skin and mucous membranes, to ensure the regeneration and renewal of epithelial tissue. The local effect of the drug is due to the fact that there are retinol-binding receptors on the skin, which contribute to the division and reproduction of epidermal cells.

With age, the processes of natural production of collagen and elastin slow down, so the skin loses its ability to maintain elasticity and extensibility, becomes dry and lethargic. Retinol promotes the synthesis of collagen, elastin and hyaluronic acid in the body. With regular use, capillary vessels are strengthened, blood microcirculation and skin oxygenation are improved.

For acne and acne retinol has the following effect: it eliminates excess sebum and cleanses pores, helps to exfoliate old cells faster, accelerates healing and reduces scar marks.

Topical application of retinol helps:

• regenerate damaged, overdried skin areas;
• improve subcutaneous circulation, accelerate the healing of inflammation;
• maintain the elastic and elastic state of the skin, taut oval of the face;
• eliminate signs of fatigue and age-related changes.

Ways to use retinol at home help maintain young and healthy skin, prevent premature signs of aging:

• base agent - the oil solution is applied to the cleansed (steamed) skin of the face, neck and décolleté, remains until completely absorbed, without rinsing, decorative cosmetics can be used no earlier than after 20-30 minutes;
• as an additional component in the composition of a purchased cream - add 2-3 drops of the solution when applying the cream on the face, after mixing in the palm of your hand;
• as a cosmetic mask with the addition of pharmacy and home components (tocopherol - vitamin E, glycerin, vegetable and essential oils, spices, vegetable and fruit mixtures, dairy and dairy products, bee products).

To prepare the mask, use 2-3 components: for example, one milk, one fruit in the same proportion and 1/4 spoon of retinol. The total volume of the mixture should not exceed the amount sufficient for one application to the face and neck. You should immediately use the prepared composition, which is not subject to long-term storage.

Subject to certain rules for the use of retinol in cosmetology, a noticeable effect is observed within a month:

• it is necessary to pre-test the drug - apply 2-3 drops on the wrist or elbow and leave for half an hour, if there is no redness or irritation, you can use retinol to apply to the face, including the area around the eyes;
• use the drug daily for two weeks, then take a break for two weeks;
• follow the expiration date and storage conditions (in a dark, cool place), if an unusual smell or sediment appears, you need to get rid of this product;
• do not use in bright sun or tanning beds as the skin is particularly susceptible to UV radiation at this point.

An analogue of retinol acetate can be called retinol palmitate, the differences are in production costs. Retinol acetate is based on an inexpensive salt acetic acid, which is sufficient, but it is absent in the body and does not have physiological properties, therefore it is not fully absorbed. And in the basis of retinol, palmitate is a physiological salt of palmitic acid, which is better absorbed by the body.

For oil solution price comparison:

• retinol acetate, 50 ml - from 80 rubles;
• retinol palmitate, 50 ml - from 240 rubles.

Retinol acetate, capsules 33,000 IU, 10 pieces - from 10 rubles. (manufactured by OJSC Marbiopharm, CJSC FP Meligen, LLC Lumi).

Combined preparations for face care: with wheat germ oil, with collagen, with snail mucin, with fruit acids, with extracts medicinal plants, 50 ml - from 200 rubles. (manufactured by CJSC Twins Tek, Dr. Retter EC, Teana, Klapp, Aravia Professional).

Vitamin A, or retinol acetate, is able to cleanse the skin of rashes, smooth out wrinkles and even tighten the oval. This is an effective tool in the fight against the aging process. It is impossible to overestimate the benefits of retinol acetate for facial skin. This unique substance is often used in the production of anti-aging cosmetics, as well as in preparations for the treatment of acne.

The benefits of retinol for the skin

Vitamin A was one of the first to be discovered. Therefore, it received such a name. At first it was used to treat such a pathology as "night blindness". Much later, doctors noticed that this substance strengthens the immune system and has a beneficial effect on the epidermis.

Retinol acetate for the skin is a powerful biogenic stimulant. Its small molecular weight allows the vitamin to penetrate deep into the epidermis. It has the following positive effects there:

In some cases, retinol acetate can be dangerous for the skin. Sometimes it provokes the development of allergic reactions. For example: redness, severe peeling and itching. Therefore, before using it, it is recommended to conduct a sensitivity test. Vitamin or cosmetics containing it are applied to the skin of the wrist and observe its reaction.

Forms of release of the drug

Retinol acetate for the skin can be used in its pure form. And also prepare face masks, lotions, creams and scrubs on its basis. Vitamin can be purchased at a pharmacy, it has the following forms of release:

1. Oil capsules. The gelatin shell is easily pierced with a needle. The contents of the capsule can be used in pure form or added to masks and creams.
2. Ampoules with solution for injections. Contain the highest concentration of retinol. The solution leaves no oily residue. It is most often used to make lotions.
3. Retinol acetate oil solution. For the skin, it is used in the preparation of homemade scrubs. Packed in dark glass bottles.
4. Tablets. Used exclusively for oral administration.

Application features

Before applying retinol acetate to the skin of the face, you need to make sure that even a small dose will not provoke allergic reaction. It must be remembered that the vitamin penetrates well deep into the epidermis. In some cases, even external use can lead to an overabundance of this substance in the body. Therefore, cosmetics with retinol will need to be abandoned in such cases:

1. Pregnancy and lactation.
2. Pathology of the kidneys and biliary tract.
3. With active sun.
4. In case there are wounds and extensive purulent rashes on the skin.

Retinol acetate breaks down quite quickly when exposed to heat, light, and some other factors. Therefore, masks and scrubs with vitamin A should be used immediately after they are prepared.

Pharmacy preparations

Retinol acetate for facial skin can be found in some pharmaceutical ointments. Medical preparations contain a higher concentration of the vitamin compared to cosmetic products. Therefore, many women believe that it is more effective to use ointments that are sold in pharmacies for skin rejuvenation. Despite the fact that they are intended for the treatment of certain pathologies.

Preparations containing vitamin A:

1. Retinoic ointment. Used for prevention age-related changes. The ointment is applied at bedtime. The drug should not be used more than twice a week. It is not recommended to apply ointment to the periorbital region.
2. "Radevit". In addition to retinol, the ointment contains vitamin E and D. The drug is used to combat the signs of skin aging. The use of the ointment allows you to reduce the depth of wrinkles and increase skin turgor. In addition, collagen production is stimulated. It is recommended to use "Radevit" in a course of 45 days, at night. After that, you should take a break for a month.
3. "Relief". Ointment for hemorrhoids. It contains oil derived from shark liver. It is known that fish fat- this is one of the richest sources of vitamin A. The use of "Relief" allows you to smooth wrinkles and eliminate dry skin. And also the ointment stimulates cell regeneration and eliminates puffiness.
4. "Regecin". In addition to retinol, it contains zinc. This remedy is most often used to combat acne. However, it is also capable of rejuvenating the skin.

The best cosmetics with retinol

Anti-aging cosmetics with vitamin A effectively eliminate wrinkles, dark spots and other signs of aging. This is confirmed by numerous positive reviews. Retinol acetate for facial skin works well in the following beauty products:

Anti-aging homemade masks

Retinol acetate for facial skin at home can be used to prepare anti-aging masks. For these purposes, it is better to purchase an oil solution in gelatin capsules. You can eliminate the signs of aging with the help of the following recipes:

Vitamin A for acne treatment

Retinol acetate for the skin is also useful if it is problematic. Regular use of masks with vitamin A will normalize the work sebaceous glands, cleanses and narrows pores, relieves inflammation. The most useful will be the following masks:

Scrubs and lotions

Cleansing the skin with scrubs allows you to cleanse the pores, eliminate dead cells and improve the microrelief of the skin. In addition, the respiration of the dermis and blood circulation in its tissues improves. A retinol scrub will be beneficial for all skin types. To prepare it, you will need the following ingredients:

1. Oatmeal - 25 g.
2. Milk (fatty for dry skin and vice versa) - 25 ml.
3. Retinol oil solution - 5 ml.

Flakes must be ground in a coffee grinder. Oatmeal powder is poured into hot milk. When it has cooled to room temperature, add retinol and mix. The mixture can be used as a scrub.

An oil solution of retinol or a vitamin from injection ampoules can be added to ready-made tonics or lotions. In addition, it is easy to prepare such care products yourself from cucumber juice or the pulp of aloe leaves.

In this article, you will learn about the effect of vitamin A on the skin, in what form this substance is sold and how it is used as an ingredient in face masks.

Feature of Retinol Acetate

• Participates in metabolic processes.
• Promotes normal growth and development of the body.
• Affects vision.
• Increases immunity.
• It is cancer prevention.
• Relieves premenstrual syndrome.
• Supports optimal blood sugar levels.
• Favorably affects the skin.
• Fights infections.
• Increases attention.
• Participates in the growth of nails, bones and hair.

The effect of retinol acetate on the skin

To improve vision and better growth body, many ophthalmologists recommend that children eat more carrots, and all because they contain a lot of vitamin A. Retinol can be very necessary for their mothers, not only to maintain an optimal level of health, but also to improve the condition of the skin of the face.

Vitamin A can be called the elixir of youth. It is often used by manufacturers cosmetics for the manufacture of active anti-aging creams.

Initially, retinol acetate was used in cosmetology to eliminate acne. This substance helped fight excessive secretion of sebum, reduced the size of the sebaceous glands and the number of skin microbes. In the process given treatment a gradual decrease in fine wrinkles was noticed, after which vitamin A began to be used as a component in a skin rejuvenation agent. It promotes the renewal of epithelial tissues, the production of collagen and elastin, which play a significant role in skin elasticity.

If you are tired of constantly looking for products that would effectively cope with dry and flaky skin, with wrinkles and a dull complexion, try changing your diet, eliminating “bad” foods, replacing them with more useful ones with a content a large number vitamin A (carrots, sea buckthorn, viburnum, parsley, tomatoes, persimmon, butter, peaches, egg yolk, dairy products, liver, fish oil, etc.).

To enhance the effect, it is recommended to use retinol externally. The fact is that if a woman is over 35 years old, some foods containing vitamin A will not be enough. Look for creams that contain retinol acetate, retinol, or retinol palmitate.

To prove the effect of retinol on the skin, a number of studies were conducted, in one of which women smeared an ointment with 0.4% vitamin A on their skin for 24 weeks. As a result, it turned out that the skin area that was exposed to retinol acetate became significantly smooth and elastic.

• Wrinkles have become less noticeable.
• The vascular network on the face brightens.
• Pigmented spots have become less pronounced.
• The tone and relief of the skin was evened out.
• The skin became softer, less dry.
• Significantly improved the situation with black dots, pimples and acne.
• The complexion has become fresher.

Where can you buy vitamin A

• In capsules with oil content. If you intend to do creaming or make a mask at home, this option will not be very successful for you, since you will have to pierce the capsule each time with a clean needle or the tip of a knife to extract the liquid.
• Oil solution. He is great solution to create effective anti-aging masks and creams.
• Vitamin A in ampoules. This option is intended for intramuscular injection, but may also be needed for the preparation of home cosmetics for the skin.

• Retinol capsules, Altaivitamins- substance for internal and external use. Quantity - 10 capsules, price - 658.6 rubles.
• Retinol acetate in oil 3.44%, Marbiopharm- solution for oral and external use. The manufacturer recommends that in the case of taking this drug, do not take other multivitamin complexes containing vitamin A orally in order to protect the body from overdose. Volume - 50 ml, cost - 79 rubles.
• Ampoules Vitamin A + Retinol KLAPP- an anti-aging agent for the skin. Before using the concentrate on the skin, be sure to carry out the procedure for removing makeup and cleansing the face. Open the ampoule and apply the product on the skin with patting movements until completely absorbed, then use a nourishing cream. Size - 6 ampoules of 2 ml, price - 1890 rubles.

What retinol creams are on sale

• Life Flo Health Retinol A 1% Advanced Revitalization Cream- face cream with vitamin A, smoothing the skin texture and preventing the appearance of wrinkles. If the skin is sensitive, the manufacturer recommends using the product no more than twice a week. When applying the cream, do not touch the skin around the eyes, mouth and on the wings of the nose. Volume - 50 ml, cost - 1135 rubles.
• Avene Eluage Repair Cream- a tool that perfectly copes with aging and dry skin, loss of elasticity. The night cream contains hyaluronic acid, which helps smooth wrinkles. Volume - 30 ml, price - 2130 rubles.
• Skincare Cosmetics Retinol Day Cream With SPF 20- a cosmetic product with retinol that evens out the relief of the face and protects the skin from the harmful effects of sunlight. Weight - 48 g, price - $17.75.

By the way, the first company to produce cosmetic products with vitamin A was Ortho Pharmaceutical. In 1971, the world saw an acne drug called Retin-A. In 1996, the same company put up for sale the product "Renova", which was intended for pigmentation and to prevent the appearance of wrinkles. Looking at the increasing popularity of retinol cosmetics, other companies have also begun to include vitamin A in their products.

Vitamin A Recipes at Home

• Remove the contents of a retinol capsule, ampoule or vial a little and apply it on your wrist to see how the skin reacts to the substance. If itching and redness do not appear, you can use vitamin A to prepare a cream, ointment or mask without much doubt.
• If you decide to make a mask or cream, keep in mind that some ingredients cannot be heated to temperatures above 40 ° C, including retinol.
• Before using the vitamin for the skin, you can take a steam bath or just take a shower to expand the pores (be careful if you have vascular problems), then clean the stratum corneum with a light scrub or other cleanser.
• The prepared mask with retinol is best applied along massage lines. After 15-30 minutes, wash it off with warm water, milk or herbal decoction, and apply a regular cream.
• The above procedures can be performed once a week. Don't forget to take breaks for a couple of months.

1. Anti-inflammatory mask with aloe juice. Take as a basis for the mask literally 1 tbsp. spoon of regular face cream, add to it 1 teaspoon of fresh aloe juice, as well as 10 drops of retinol.
2. Vitamin oil mask. If you have unrefined olive oil, wheat germ oil, jojoba, grape seed or any other base oil, take it in the amount of 1 tbsp. spoon and add just one capsule of vitamin A, stir well. Apply to face and do not rinse. Liquid that has not been absorbed into the skin can be wiped off with a napkin.
3. Rejuvenating honey-oil mask. Mix 1 teaspoon burdock oil, sweet almond and honey oils. Add there a solution of vitamin A in oil in the amount of half a teaspoon. This mask should be applied with patting movements and washed off after half an hour.

Video about the features of retinol for the skin: