How many days pyrogenal is excreted in alcoholics. Pyrogenal, solution for intramuscular injection

Pyrogenal is a drug in demand in modern pharmaceutical practice, the main action of which is aimed at providing a high-quality immunomodulatory effect. If we talk about why Pyrogenal is prescribed for children and adults, then the following indications for use can be distinguished:

• Hepatic pathologies of a chronic nature.
• Severe burns localized in different parts of the body.
• Prostatitis, urethritis (chronic form).
• All kinds of pathologies of a venereal nature.
• Inflammatory lesions of the uterine appendages.
• Adhesive disease of the peritoneum.
• Strictures of the urethra and ureters.

be careful

The presence of papillomas, warts, warts, moles and spines on the body is the first sign of malignant melanoma!

We hasten to warn you, most medicines "treat" warts, papillomas, moles, etc. - this is a complete deception of marketers who wind up hundreds of percent on drugs whose effectiveness is zero. They do not cure the disease, but only mask the symptoms.

The pharmacy mafia earns a lot of money by deceiving sick people.

But what to do? How to be treated if there is deceit everywhere? Doctor of Medical Sciences Anatoly Makhson conducted own investigation and found a way out of this situation. AT this article The doctor also told how to 100% protect yourself from melanoma, for only 149 rubles!
Read the article in official source on link.

At the same time, Pyrogenal is also sold in the form of suppositories and injections. Most often, suppositories of the drug are prescribed if there is a patient in the body, as well as in a state of incomplete recovery (against the background of past pathologies of a viral-bacterial nature).

Pyrogenal solution can be prescribed in the presence of mechanical disturbances in the work of the central nervous system and peripheral system, with herpetic infection of the eyes, with tuberculosis disease ( different forms), uveitis and other diseases.

Judging by the reviews on the forums on the Internet, at the moment there are no direct (more expensive or cheaper) analogues of Pyrogenal, according to active substance and impact on the human body, pathogenic microorganisms.

Important! The most similar are the following drugs: Transfer Factor, Prodiogysan. But the use of these drugs as a replacement for Pyrogenal is not allowed.

Pyrogenal: instructions for use

The active ingredient is bacterial lipopolysaccharide. Also included are: lanolin, cocoa butter, water. The mechanism of action of Pyrogenal is aimed at helping the human immune system, which is to provide a powerful immunomodulatory effect. The drug allows you to activate the "hypothalamus-pituitary-adrenal cortex" chain, as well as positively affect other systems associated with work immune system person. In many ways positive impact medication is to increase the content in the human body of corticosteroids - hormones that suppress inflammation.

Pyrogenal after application also has a good anti-inflammatory and healing effect, increasing the resistance of the human body.

AT last years the drug is actively used as a complex tool in the treatment of viral and bacterial pathologies of the gynecological sphere, for example. Pyrogenal in gynecology is used for chlamydia, trichomoniasis, neuroinfections, in the treatment of infertility. Also, the medicine shows good results in the elimination of adhesive disease. abdominal cavity and herniated intervertebral discs.

The release of Pyrogenal is now carried out in two dosage forms: suppositories and ampoules with a solution for intramuscular injections. The dose in each case is determined individually. The dosage should be prescribed by a doctor who takes into account many factors:

• Patient's age.
• Presence of comorbidities.
• Type of developing infection, virus, disease.
• Individual indicators of the patient, anamnesis, etc.

On the forums you can find a message that Pyrogenal helped many people get pregnant. However, this is only part of the truth, because Pyrogenal does not help in any way in the processes of pregnancy, however, it improves the functioning of the human immune system, qualitatively eliminates adhesions, accelerates recovery from infectious diseases (including sexually transmitted diseases), which has a positive effect on increasing the chances of getting pregnant for every woman.

In the case when a woman was found to have an infection after pregnancy, Pyrogenal should be used late, unless the doctor orders otherwise. This drug causes a short-term increase in temperature, which is unsafe for the fetus. .

The main contraindications for taking the medicine include:

• Hypersensitivity to the components of the drug.
• Heart, kidney, liver failure.
• The period of pregnancy and breastfeeding.
• The presence of chronic autoimmune pathologies.

Important! Pyrogenal has good compatibility with alcohol, so the drug is often used to stop drinking binges and relieve withdrawal symptoms. Reception this medicine can significantly reduce cravings for alcoholic beverages. The course of treatment in this case is created individually - the dosage of the medication taken is increased daily.

Therefore, the drug is often used in the treatment of alcohol dependence (and the stage of the disease does not matter). At the same time, Pyrogenal cannot be used to eliminate the withdrawal syndrome and in order to get out of hard drinking on your own - many factors must be taken into account in order to choose the correct dosage of the drug. This can only be done by an experienced and qualified specialist.

The opinion of doctors about the most effective methods of treating warts and papillomas

Anatoly Nakhimovich Makhson, the chief physician of the Moscow City Hospital No. 62, describes his vision on this matter.
Medical practice: more than 40 years.

“I have been treating papillomas and warts in people for many years. I tell you as a doctor, papillomas along with HPV and warts can lead to really serious consequences if they are not dealt with.

Everyone has human papillomavirus on whose body there are papillomas, moles, warts and other pigmented formations. According to rough estimates, 80-85% of the world's population has it. By themselves, they are not dangerous. The problem is that an ordinary papilloma can become melanoma at any time.

It's incurable malignant tumors, which kill a person in just a few months and from which there is no salvation.

Unfortunately, in Russia and the CIS countries, pharmacy corporations sell expensive drugs that only relieve symptoms, thereby putting people on one drug or another. That is why in these countries such a high percentage cancer and so many people suffer from "non-working" drugs.

The only one medicinal product, which I want to advise, and it is also officially recommended by WHO for the treatment of papillomas and warts, this is Papinol. This drug is the only remedy that has an effect not only on external factors(that is, it removes papillomas), and also acts on the virus itself. At the moment, the manufacturer has managed not only to create a highly effective tool, but also to make it available to everyone. Moreover, within the framework federal program every resident of the Russian Federation and the CIS can get it for 149 rubles.

Pyrogenal provocation

Often, various sexually transmitted pathologies develop in the human body without pronounced and noticeable symptoms (for example, the same gonorrhea). Therefore, a person who is a carrier of diseases of this type, without realizing it, infects his sexual partner (or several).

With the help of Pyrogenal, a provocation is carried out, i.e. the transfer of the disease from a latent form to an explicit one, which makes it possible to detect developing, but imperceptible venereal infections in men and women. This approach allows for a qualitative diagnosis of the disease, as well as for rational control of the effectiveness of the prescribed therapeutic effect.

The drug is administered intramuscularly during provocation (together with other vaccines against venereal disease). The dosage in each case is determined individually (usually it is 20 mcg for men and women). Two injections may also be given before STI testing. If you believe the reviews, then the use of Pyrogenal is one of the most effective ways provocations of hidden venereal pathologies.

You can clarify how many injections of Pyrogenal need to be done to provoke and trigger an exacerbation of sexually transmitted pathology with a doctor who will first study all the available facts. With the help of the drug, the work of the human immune system is artificially restarted, and there is also an increase in the active life of the causative agents of venereal disease.

Side effects of Pyrogenal

When using Pyrogenal, various side effects may occur. The most common side effect is fever, which often lasts a month after a course of treatment with this drug.

Important! During treatment with this medicine, patients may experience an increase in body temperature up to 37.5 degrees. Along with this, another characteristic symptomatology arises: a slight chill, increased fatigue, a feeling of weakness. Such an unpleasant and uncomfortable state can last for several hours, and in some cases all day.

In this case, the doctor can also administer the same dose of Pyrogenal the next day, following the reaction of the patient's body. If the temperature rises again and the corresponding symptoms are observed, then this, oddly enough, is a good sign. The dosage is not reduced until the moment when the body stops giving such a reaction. Once this happens, the doctor may decide to increase the dosage.

In exceptional cases, after the administration of Pyrogenal, some patients experience severe chills, an increase in body temperature up to 39 degrees, pain in the head and lumbar region. A similar reaction to the use of the drug can last for several hours. Then there is a gradual decrease in temperature, weakening pain, which after a day completely disappear. If there is such a strong reaction to the drug the next day, doctors will definitely reduce the dosage.

If the injection site is inflamed, then a doctor should examine it. Pyrogenal cannot cause such a reaction.

Pyrogenal candles

Pyrogenal suppositories are popular in the field of gynecology, proctology, urology and other medical fields. You can buy rectal suppositories 50, 100, 150, 200 mcg. Candles are prescribed for various diseases (listed in the part of the article "Indications for use").

It is forbidden to use rectal suppositories if available acute form fever ( different type), various diseases of a chronic nature during an exacerbation (as an exception, those pathologies are those from which Pyrogenal is prescribed). Also, judging by the reviews, it is not recommended to use pills and suppositories of medicine in the presence of various blood diseases ( various types anemia and hemoglobinopathies).

It is very difficult to find analogues for Pyrogenal suppositories, because there are simply no direct structural analogues of this drug (which would have a similar active substance and mechanisms of action). Therefore, if for some reason the use of Pyrogenal is not possible, then you should contact your doctor who can find a suitable treatment option. It is quite possible that this will be a complex therapy, including suppositories, intramuscular injections, tablets and drugs of other forms that can give the same effect as Pyrogenal. Of the indirect analogues, there are other candles that affect the immune system, for example.

Pyrogenal: injections

The most common form of Pyrogenal is injection. It is they who are prescribed by many doctors, preferring suppositories. Usually the drug is prescribed at the rate of 1 injection once a day every other day. Often, if necessary, before the introduction of the drug is mixed with sodium chloride 0.9%. It is forbidden to store an open ampoule with medicine. You can clarify why Pyrogenal injections are prescribed from your doctor.

At the very beginning of treatment, according to the reviews, the lowest possible dosage of the drug is chosen (about 2.5 mcg). During the course of treatment, the dose is gradually increased from 2.5 to 100 mcg. The duration of this type of therapy can vary from 5-8 injections to several dozen (depending on the patient's condition, the type of his disease and the stage of development of the pathology). It is possible to repeat the course of treatment with Pyrogenal approximately 3-4 months after the completion of the previous one.

In some cases, it is possible to prescribe a combined treatment with Pyrogenal. In this case, injections of the drug and the use of suppositories alternate. Often this approach allows you to give the most effective result of treatment.

Due to the fact that Pyrogenal is forbidden to use on its own, learn how to inject the drug and where you can go to a doctor or nurse - all procedures with this medicine should be performed by specialists, because the wrong dosage can lead to quite serious consequences.

This video provides information on the reaction of provoking latent STDs using Pyrogenal injections:

Thanks

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

The drug Pyrogenal

Pyrogenal has many properties:

• desensitizing (anti-allergic);
• anti-inflammatory;
• regenerating;
• regulated pyrogenic (increases body temperature by 1-2 o within 2-4 hours, affecting the thermoregulatory center in the hypothalamus);
• specific and general immunostimulating (increases the overall resistance of the body to infections);
• stimulates the activity of the adrenal glands, as a result of which the concentration of corticosteroid hormones in the blood increases;
• increases the permeability of tissues, capillary walls and the blood-brain barrier, resulting in improved metabolic processes;
• accelerates the processes of regeneration (recovery) of the nervous tissue;
• facilitates the penetration of antibiotics and other chemotherapeutic drugs into the focus of inflammation;
• restores blood circulation in the affected areas of tissues and organs;
• prevents the formation of adhesions and scars, and also smoothes existing post-traumatic skin defects;
• improves fibrinolytic (anticoagulant) properties of blood;
• helps to restore the lost functions of organs.

After introduction into the body, the main part (up to 90%) of Pyrogenal settles on the surface of leukocytes, and only 10% circulates freely in the blood.

The drug is excreted only by the kidneys.

Release forms

• rectal suppositories yellowish-white, cylindrical, pointed at one end, 50, 100, 150 and 200 micrograms of the active substance, packaged in packs of 10 pieces;
• ampoules 1 ml with a colorless transparent solution for intramuscular injections, 10 ampoules per box; the ampoule contains 10, 25, 50 or 100 mcg of the main active ingredient.

Instructions for use Pyrogenal

Indications for use

• chronic liver diseases;
• strictures (narrowing) of the ureters and urethra;
• chronic prostatitis (inflammation of the prostate gland) and urethritis (inflammation of the urethra);
• adnexitis (inflammation of the uterine appendages);
• secondary infertility (inability to conceive a child after an ectopic pregnancy, the birth of a second child, abortion or miscarriage);
• adhesive disease of the abdominal cavity;
• burn disease.

Rectal suppositories Pyrogenal are used in the following cases:

• papillomavirus infection;
• immunorehabilitation and immunoprophylaxis for prolonged acute viral or bacterial diseases, as well as frequent relapses ORZ.

• sluggish forms of tuberculosis in the resorption phase;
• some allergic diseases eg bronchial asthma;
• iridocyclitis (inflammation of the iris and ciliary body);
• uveitis (inflammation of the choroid of the eye);
• clouding of the cornea;
• severe eye burns;
• herpesvirus eye infection;
• neuritis optic nerve;
• viral conjunctivitis and keratitis;
• psoriasis and other chronic skin diseases;
• chronic diffuse streptoderma (pustular skin disease);
• sclerotic processes in the bronchi;
• epididymitis (inflammation of the epididymis);
• traumatic injuries of the peripheral and central nervous system;
• spinal hernias;
• diseases of the central and peripheral nervous system;
• cerebral arachnoiditis (inflammation of the arachnoid membrane of the brain);
• the need for pyrotherapy (a method of treating many diseases, which consists in artificially raising body temperature);
• prevention of the formation of post-traumatic scars with extensive skin lesions;
• provocation of latent infectious diseases.

Contraindications

• Hypersensitivity to the main active substance or auxiliary components of the drug;
• cardiovascular insufficiency;
• renal and hepatic insufficiency;
• autoimmune diseases in history;
• acute diseases with a large rise in temperature;
• blood diseases;
• chronic diseases during an exacerbation or in the stage of decompensation (with the exception of diseases that are indications for prescribing a medicine).

Side effects

• an increase in body temperature to 37-37.5 o C;
• flu-like syndrome - headache, fever, severe fatigue, muscle pain, joint pain, anorexia (lack of appetite), chills, nausea and vomiting.

• An increase in temperature up to 37.5 o C, which may be accompanied by a slight chill and malaise, and last for several hours (average 3-8 hours). If there is such a reaction to the administration of Pyrogenal, the current dose of the drug should be repeated until the side effects disappear. And only after that the dose can be increased.
• Less common side effects are severe chills and high temperature(up to 39.5 o C), headache and nagging pain in the lower back. Such reactions are transient and last no more than 8 hours. Then the temperature drops and the symptoms disappear. If such side effects occur, the dose of the drug should be reduced.

During pyrotherapy, all of the above reactions are considered acceptable.

Overdose manifests itself in pronounced side effects. In this case, an immediate dose reduction is required.

Treatment with Pyrogenal

The doctor individually selects for each patient the minimum dose of Pyrogenal, which causes an increase in temperature. This dose is administered until the temperature stops rising after an injection or suppository. As soon as this happens, the dose begins to increase.

When treating with Pyrogenal, due to the high likelihood of side effects, one should refrain from driving transport, complex mechanisms and other dangerous species activities requiring heightened attention and speed of reaction.

Pirogenal is prescribed to children rarely and with caution due to the lack of reliable data on the results of treatment.

For patients prone to febrile convulsions or with convulsive readiness, Pyrogenal is prescribed under the guise of anticonvulsant therapy and only in stationary conditions.

Dosage of Pyrogenal
suppositories
Candles are administered rectally once a day, daily or every other day, depending on the doctor's prescription. The minimum single dose is 50 mcg, the maximum is 200 mcg.

Treatment with suppositories most often takes place according to such a scheme, in which 12 suppositories are required per course - 3 x 50 mcg, 3 x 100 mcg, 3 x 150 mcg and 3 x 200 mcg.

But sometimes the scheme and course of treatment can be individual and differ from the generally accepted ones.

With prolonged acute processes of bacterial or viral etiology or frequent relapses of acute respiratory infections, Pyrogenal is prescribed as an immunomodulator in the form of rectal suppositories of 50 mcg or 100 mcg. The course of therapy in this case is from 5 to 10 suppositories.

Solution for intramuscular injection
Injections are made once a day every other day. Sometimes Pyrogenal is diluted with 0.9% sodium chloride solution before administration. An open ampoule with a solution can not be stored.

The dose of the drug at the first injection is minimal - 2.5 mcg. But in the process of therapy, it is gradually increased by 2.5 - 5 mcg and brought to a maximum of 100 mcg. The course of treatment is from 10 to 30 injections. If necessary, it can be repeated, but not earlier than after 2-3 months.

In pyrotherapy, Pyrogenal is prescribed in a dose of 5-10 mcg and administered intramuscularly 1 time per day. This dose is gradually increased to 100-150 mcg. The interval between injections is 1 - 2 days.

Physicians sometimes practice combined treatment in which injections alternate with the introduction of suppositories.

Pyrogenal and alcohol

In this case, the drug is administered for five days according to a special scheme with a gradual increase in dosage: 50 mcg - 75 mcg - 100 mg - 125 mcg - 150 mcg per day. Within two to three hours, the body temperature rises to 38-39 o C and returns to normal within a day.

If the treatment of alcoholism is carried out on an outpatient basis, then the maximum dose of Pyrogenal should not exceed 100 mcg per day.

Pyrogenal in gynecology

• secondary infertility;
• sexually transmitted diseases - syphilis, trichomoniasis, gonorrhea, etc.;
• inflammation of the uterine appendages;
• papillomavirus infection.

Pyrogenal suppresses trichomonas (pathogens of trichomoniasis) and giardia at the cellular level, and promotes recovery processes in tissues affected by pathogens.

In the treatment of sexually transmitted diseases, Pyrogenal consistently fights each new wave of the pathogen, and also helps chemotherapy drugs to penetrate into the focus of inflammation and completely destroy microorganisms.

The drug is effective in the fight against gonococci, chlamydia, Trichomonas and Giardia.

Pyrogenal provocation

Pyrogenal provocation is used to detect hidden sexual infections in the human body that are asymptomatic; to clarify the diagnosis and monitor the effectiveness of the treatment.

In case of provocation, Pyrogenal is administered intramuscularly, in parallel with gonovaccine.

The purpose of the provocation is to cause an exacerbation of the disease by artificially induced decrease in immunity and a simultaneous increase in the viability of the pathogens.

Pyrogenal drug interaction

At complex therapy Pyrogenal improves the penetration of antibiotics and other chemotherapeutic drugs into the lesions.

Do not mix Pyrogenal in the same syringe with other drugs.

Pyrogenal's analogs

Pirogenal's analogues for pharmacological action- the drug "Prodiogizan", as well as "Transfer-Factor", which is considered a better and more effective remedy.

Instructions for medical use

medicinal product

Pyrogenal

Tradename

Pyrogenal

International non-proprietary name

Dosage form

Solution for intramuscular injection 10, 25, 50, 100 mcg/ml

Compound

1 ml of solution contains

activesubstance - bacterial lipopolysaccharide 10 mcg, 25 mcg,

50 mcg, 100 mcg,

Excipients: sodium hydrogen phosphate, dodecahydrate (sodium

phosphate disubstituted 12-aqueous), sodium dihydrogen phosphate dihydrate (sodium phosphate monosubstituted 2-aqueous), sodium chloride, purified water.

Description

Colorless transparent liquid.

Pharmacotherapeutic group

Immunomodulators. Immunostimulants. Other immunostimulants.

ATX code L03AX

Pharmacological properties

Pyrogenal is a lipopolysaccharide (LPS) isolated from Salmonella typhi Ty 2 cells by enzymatic hydrolysis followed by hot phenol extraction, alcohol precipitation, drying of the precipitate in a vacuum desiccator and dissolution in phosphate-buffered saline. The preparation does not contain preservatives.

The main pharmacological action is an agent intended for non-specific therapy. Pyrogenal is a highly active non-specific broad-spectrum immunomodulator.

The drug has adjuvant, desensitizing and anti-inflammatory properties, increases the general and specific resistance of the body.

Pharmacokinetics

Pyrogenal is metabolized in the liver to form pharmacologically active metabolites (pyridoxal phosphate and pyridoxamino phosphate). Distribution is predominantly in the muscles, liver and central nervous system. Penetrates through the placenta and into mother's milk. It is excreted by the kidneys (when administered intravenously with bile - 2%).

Pharmacodynamics

With the introduction of pyrogenal into the body, 85-90% of bacterial lipopolysaccharide is fixed on the surface of circulating blood leukocytes, about 10% remains in the circulating plasma, and about 5% is absorbed on the membranes of erythrocytes.

When introduced into the body, pyrogenal causes a whole complex of complex immunological and physiological reactions in the body. By connecting with Toll receptors located on the cell membranes of the macrophage-monocyte system, pyrogenal triggers a cascade of anti-inflammatory reactions of the body: it stimulates the activation of biochemical processes leading to the activation of NF-kB transcription factors that cause the expression of genes responsible for the production of cytokines, chemokines, antimicrobial peptides , interferons and other factors that provide antiviral, antiprotozoal and antibacterial immune response. Pyrogenal accelerates the reproduction of cells of the reticuloendothelial system (RES), activates the functions of cells of the phagocytic system, accelerates the formation of antibodies, interferon, activates the enzyme and hormonal systems, increases the general and specific resistance of the body.

After the introduction of the drug in the latent period of the disease (45-90 minutes), leukopenia develops, which is replaced by leukocytosis, which persists for 24-48 hours.

Leukocytosis, as well as an increase in the phagocytic activity of the leukocytes themselves, does not depend on an increase in body temperature. These changes are caused by the direct effect of pyrogenal on macrophages, which, under its influence, change their surface potential.

The targets for pyrogenal are the system of phagocytic cells: monocytes (Mo), macrophages (Mf), neutrophils (Nf). Pyrogenal stimulates the production of active oxygen radicals, which are antimicrobial protection factors.

The immunomodulatory and pyrogenic properties of pyrogenal are associated with its ability to stimulate the production of interleukin-1 (IL-1), which is highly active against pathogens.

Depending on individual sensitivity and dose, an increase in body temperature up to 37.5-38ºС is possible. When prescribing a drug for pyrotherapy, the temperature rises to 39.5-40ºС. Temperature reaction usually lasts from 6 to 8 hours.

IL 1 causes the activation of phagocytosis, an increase in body temperature (pyrogenic effect), the proliferation of fibroblasts, endothelial cells, hematopoietic cells and others, the production of IL 2, which is necessary to maintain the growth of lymphocytes (primarily T cells). Thus, due to the activation of cells of the macrophage-monocytic series and the cytokines secreted by them, the functional activity of both the cellular and humoral immune responses is enhanced.

In the connective tissue, under the influence of pyrogenal, the development of fibroblasts and the formation of collagen fibers are suppressed, which leads to rejuvenation. cellular composition loose connective tissue and resorption of keloid scars, and in the nervous tissue to inhibition of the formation of glial scarring.

Pyrogenal stimulates the activity of hyaluronizade, thereby inhibiting the formation of collagen fibers from fibroblasts. Under the influence of liposomal enzymes, the fibrinolytic and kinin systems of the blood are activated, resulting in increased vascular permeability, improved blood supply and tissue regeneration.

The increase in the permeability of blood vessels and tissues that occurs with the introduction of pyrogenal facilitates the penetration of chemotherapeutic drugs into the lesion, which leads to its use in combination with specific agents.

The pronounced anti-inflammatory effect of pyrogenal is associated with the activation of the function of the adrenal cortex and the release of corticosteroids, the concentration of which depends on the stimulating effect of pyrogenal on the hypothalamus and anterior pituitary gland.

The peculiarity of the action of pyrogenal is the lack of specificity, therefore it can be used in various diseases to accelerate recovery processes, when inflammatory infiltrates and adhesions are the source functional disorders and pain sensations.

Indications for use

Non-specific agent in the treatment of various diseases in surgical, neurosurgical, urological, gynecological, dermatovenerological, therapeutic, psychiatric practice, ophthalmology, narcology, etc.

In surgical practice: adhesive disease, post-burn keloid scars and contractures, injuries, vascular diseases, prevention of vascular obliteration, prevention of the formation of postoperative and post-traumatic connective tissue scars

Traumatic injuries of the central and peripheral nervous system, spinal hernias, cerebral arachnoiditis,

Torpid-current forms of tuberculosis in the phase of resorption,

chronic liver disease,

Strictures of the urethra and ureters,

Chronic prostatitis and urethritis,

Severe eye burns, uveitis, iridocyclitis, herpes virus eye infection, corneal clouding, optic and auditory nerve, viral keratitis and conjunctivitis,

Inflammatory processes of the uterine appendages, infertility,

Adhesive disease of the abdominal cavity,

Venereal diseases,

Psoriasis and other chronic skin diseases,

Increased resistance of microorganisms to chemical and antibiotic therapy,

Pyrotherapy (narcology, psychiatry, dermatovenereology).

Dosage and administration

Pyrogenal is used intramuscularly once a day, regardless of the time of day. Injections are carried out every other day. Doses must be selected individually. A dose is set that causes an increase in body temperature to 37.5-38.0 ° C and is administered until the temperature rise stops, after which the dose is gradually increased by 2.5-5.0 mcg. To obtain the required dose, the drug is diluted with a sterile 0.9% sodium chloride solution for injection. The drug in the opened ampoule is not subject to storage.

The initial single and daily dose for adults is 2.5 mcg. On subsequent days of injection, the dose is gradually increased by 2.5-5.0 mcg. The maximum single and daily dose is 100 mcg. The course of treatment is from 10 to 30 injections, depending on the disease.

If the next injection is missed, the course of treatment is continued according to the scheme, without doubling the dose.

If necessary, injection courses are repeated after 2-3 months.

When prescribing pyrogenal for the purpose of pyrotherapy, the drug is administered intramuscularly once a day, starting from 5-10 mcg, with a gradual increase in dose to 100-150 mcg. Injections are carried out in one or two days as prescribed by the doctor.

Example: For a 2.5 mcg or 5.0 mcg dose

In an ampoule containing 10 µg in 1 ml, add 1 ml of sterile 0.9% sodium chloride solution with a syringe, mix gently. 2.0 ml of a solution with a concentration of 5 μg / ml will be obtained, 0.5 ml of the resulting solution will contain a dose of 2.5 μg, 1 ml of the resulting solution will contain a dose of 5 μg, 1.5 ml - a dose of 7.5 μg.

The indicated volumes will be a single dose.

Reaction to the introduction:

When the drug is administered, usually no reactions occur. In some patients, the temperature may rise to 37.5 degrees. C, accompanied by mild chills and slight malaise. This condition can last from 3 to 8 hours. Treatment with antipyretics in this case is not required. The dose that caused such a reaction is repeated in the following days until the reaction to its administration stops (usually 1-3 injections), after which the dose is sequentially increased.

In rare cases, individuals may experience severe chills, fever up to 39.5 degrees C, headache, back pain. These reactions usually last from 6 to 8 hours, after which the temperature decreases and the side effects disappear. In these cases, it is possible to use antipyretics (paracetamol). It is not recommended to use antipyretics with non-specific anti-inflammatory action (diclofenac, ibuprofen), as they reduce the effectiveness of pyrogenal.

When using the drug for pyrotherapy, the above reactions are acceptable.

Side effects

Temperature increase up to 37-37.6 °C

Rarely:

Flu-like syndrome (fever, headache, fatigue, myalgia, chills, arthralgia, anorexia, nausea).

Contraindications

• hypersensitivity to the drug or its components
• acute febrile illness, accompanied by a sharp rise in body temperature
• hemorrhage in the brain
• pulmonary edema
• hepatic and/or kidney failure
• sharp viral hepatitis
• blood diseases, autoimmune diseases (history)
• chronic infectious diseases in the acute stage
• pregnancy and lactation

Drug Interactions

The drug is compatible and well combined with all drugs used in the treatment of these diseases. Enhances the effectiveness of specific chemotherapeutic drugs in complex therapy.

special instructions

People suffering chronic diseases of cardio-vascular system, kidney and diabetes, as well as people over 60 years of age, for any disease, pyrogenal should be prescribed with caution, under the supervision of a physician: start with a dose of 1.5-2.0 mcg and increase only if well tolerated.

In the presence of convulsive readiness or febrile seizures in history, the drug is not prescribed, or prescribed under the guise of anticonvulsant therapy.

Application in pediatrics

There are no clinical data on the use of pyrogenal intramuscularly in children.

The danger of the effect of the drug on the ability to drive a vehicle or a potentially dangerous mechanism.

Considering side effects, during the period of treatment, one should refrain from engaging in hazardous activities that require increased concentration of attention and speed of psychomotor reactions (management vehicles, as well as mechanisms).

How effective is Pyrogenal? Reviews about this tool are discussed at the very end of the article. In addition, the properties of this medication, its form of release and methods of application will be presented to your attention.

Form, description of the drug, composition

The drug in question goes on sale in the following forms:

• "Pyrogenal" - injections. Reviews of experts report that such a remedy is available in the form of a colorless and transparent intramuscular solution in ampoules of one milliliter. Its main substance is lipopolysaccharide, which was isolated from Salmonella typhi bacteria. Also, the composition of this medicinal liquid includes a buffered phosphate-saline solution with a pH of 6.7-7.3.
• "Pyrogenal" - rectal suppositories. Reviews of pharmacists indicate that such suppositories are yellowish-white in color, as well as a cylindrical shape, pointed at one end. The active component of this product is bacterial-type lipopolysaccharide and auxiliary elements such as lanolin, purified water and cocoa butter.

Pharmacology of the drug

What is the drug "Pyrogenal"? Reviews of experts claim that this is a non-specific highly active immunomodulator that can cause a whole range of complex physiological and immunological changes in the patient's body, as well as activate the fibrinolytic, hypothalamic-pituitary and reticuloendothelial systems.

The drug in question exhibits desensitizing, anti-inflammatory and adjuvant properties, and also increases the specific and general resistance of the human body and affects the thermoregulation centers of the hypothalamus.

Features of the drug

What is remarkable about such a tool as Pyrogenal? Reviews of doctors report that this medicine is able to activate macrophages, enhance phagocytosis, stimulate the production of interleukin-1, which causes the proliferation of body cells, interleukin-2, necessary to support the growth of lymphocytes, induction of interferon (endogenous), and active forms O2. It should also be noted that an increase in the activity of phagocytes accelerates the formation of antibodies and contributes to the growth of antimicrobial resistance of the human body.

Thus, due to the activation of cells of the monocyte-macrophage series and the cytokines secreted by them, the working activity of the humoral and cellular immune response is noticeably enhanced.

Under the influence of the drug "Pyrogenal" in the connective tissue, the development of fibroblasts, as well as the formation of collagen fibers, are suppressed, which ultimately leads to rejuvenation of the cell composition and slowing down of glial scarring.

It should also be noted that taking the agent in question can prevent the formation of new and resorption of previously formed dense scars and adhesions at the sites of injury, as well as prevent vascular obliteration and stimulate epithelialization and tissue regeneration.

Properties of the drug

What features are characteristic of such a medication as "Pyrogenal"? The reviews indicate that this remedy not only stimulates the activity of hyaluronidase and the kinin system well, but also improves the fibrinolytic properties of the blood, and also increases the activity of lysosomal enzymes and tissue permeability, accelerates the penetration of medicinal elements into the lesion, eliminates inflammatory process and restores circulation.

It should also be said that the use of "Pirogenal" helps to activate the pituitary system, increase the concentration of hormones in the blood, anti-inflammatory and analgesic effects.

Indications for use

What is the drug "Pyrogenal" prescribed for? The use (reviews about this remedy are presented below) of the drug in question is indicated for non-specific therapy:

• with traumatic injuries of the peripheral and central nervous system, and spinal hernias;
• in surgery for post-burn keloid scars and contractures, injuries, vascular diseases, as well as to prevent vascular obliteration;
• with infertility and inflammation of the uterine appendages;
• at chronic diseases liver;
• with adhesive diseases of the abdominal cavity;
• with a torpid current form of tuberculosis at the stage of resorption;
• for severe burns visual organs, iridocyclitis, uveitis, clouding of the cornea, eyes, neuralgia of the auditory and optic nerve, conjunctivitis and viral keratitis;
• with and urethra, as well as chronic urethritis and prostatitis;
• with venereal diseases, psoriasis and other chronic skin ailments;
• with resistance of microorganisms to antibiotic and chemotherapy.

It should also be noted that as a pyrogenic drug, the drug in question is actively used for indications for pyrotherapy, including in dermatovenereology, narcology and psychiatry.

Prohibitions for use

In what cases it is impossible to use the drug "Pyrogenal"? Reviews speak of the following contraindications to the use of the drug:

• chronic diseases in the stage of decompensation and exacerbation, except for those that are indications for prescribing a medication;
• blood diseases;
• febrile diseases (acute);
• lactation period and pregnancy.

Patients suffering from kidney disease, chronic diseases of the cardiovascular system and diabetes, Pyrogenal therapy should be carried out only under the supervision of a doctor.

In the presence of febrile convulsions and convulsive readiness, the medication in question is either not used or administered in conjunction with anticonvulsant therapy.

The drug "Pirogenal": instructions for use

Reviews of doctors report that intramuscular injections of this medication should be carried out every other day, 1 injection per day.

To prepare medicinal solution, the contents of the ampoule must be mixed with sodium chloride.

The course of treatment with this agent begins with a dosage of 2.5 mgk, after which it is gradually increased (every day) by 5 mgk. The maximum allowable single dose of "Pyrogenal" is 100 mgk.

The course of treatment with the drug in question is usually limited to 15-30 injections. Repeated injections can be carried out only after two months.

How should I use the drug in the form of suppositories? According to the instructions, use one piece per day (50 mgk). The highest dosage of this remedy per day is 200 mgk.

Patients using this form of medication should adhere to the following treatment regimen - rectal suppositories are administered three times a day at a dosage of 50, 150, 100 or 120 mgc.

Usually, about twelve suppositories are consumed per course of therapy. Most often, such suppositories are used for the purpose of immunorehabilitation and for immunoprophylactic treatment in the process of recovering a patient after acute bacterial and viral diseases at a dose of 100 or 50 mg. As a rule, the course of such therapy is limited to 10 suppositories.

Combining injections and candles "Pyrogenal" is not prohibited.

Negative Effects

What side effects does the drug "Pyrogenal" cause? Reviews of men and women say that when using suppositories, their body temperature often rises to 37.6-37.8 degrees, and such primary symptoms flu like chills, fatigue, fever, nausea, headaches, arthralgia and myalgia.

As for the solution for injection, when it is administered, the same side reactions are observed in patients, there are pains in the lower back.

Interaction

"Pyrogenal" can be combined with drugs used to treat the above indications. At the same time, it should be remembered that as part of complex therapy this remedy may enhance the effect of chemotherapy drugs.

Similar funds

Analogues of the drug "Pirogenal" in the main active substance no. As for similar drugs in terms of pharmacological action, they include the following: "Prodiogysan" and "Transfer Factor". By the way, last drug considered the most effective and high quality.

Pyrogenal is an immunostimulating drug of bacterial origin that activates the reticuloendothelial, hypothalamic-pituitary and fibrinolytic systems.

The active ingredient is Lipopolysaccharide (LPS) of a bacterial type, isolated from Salmonella typhi (typhoid bacterium).

It has an anti-inflammatory, adjuvant, desensitizing effect, and also increases the general and specific resistance of the body and affects the thermoregulatory centers of the hypothalamus.

The drug promotes the process of resorption of foci of inflammation and restoration of blood circulation. It activates the function of the pituitary gland system, increases the concentration of hormones in the blood, has an anti-inflammatory and analgesic effect.

The composition of 1 candle Pyrogenal includes:

• Active ingredient: bacterial (from Salmonella typhi cells) lipopolysaccharide - 50, 100, 150 or 200 mcg;
• Additional components: lanolin, cocoa butter, purified water.

The composition of 1 ml of injection solution includes:

• Active ingredient: bacterial (from Salmonella typhi cells) lipopolysaccharide - 10, 25, 50 or 100 mcg;
• Additional components: buffered phosphate-saline solution (pH 6.7-7.3).

The use of Pyrogenal promotes the resorption of previously formed dense scars and adhesions at the sites of injury, prevents the formation of new ones, which stimulates epithelialization and tissue regeneration, and prevents vascular obliteration.

Indications for use

What helps Pyrogenal? According to the instructions, the drug is prescribed in the following cases:

• Liver diseases in a chronic course;
• burn disease;
• Strictures of the ureters and urethra;
• Adhesive disease of the abdominal cavity;
• Prostatitis and urethritis in chronic course;
• Venereal diseases;
• Secondary infertility;
• Diseases of the uterine appendages of inflammatory etiology.

Suppositories (optional):

• papillomavirus infection;
• Incomplete recovery after acute viral and bacterial diseases (immunorehabilitation and immunoprophylaxis).

Pyrogenal injections (optional):

• Traumatic injuries of the peripheral and central nervous system;
• herpes virus eye infection;
• Tuberculosis in a sluggish form in the resorption phase;
• Chronic skin diseases, including psoriasis;
• iridocyclitis;
• clouding of the cornea;
• Uveitis;
• The need for pyrotherapy (as a pyrogenic drug).

Instructions for use Pyrogenal, dosage

Intramuscularly 1 time per day every other day, if necessary, the drug is diluted with 0.9% sodium chloride solution.

The initial single dose is 0.2 mcg, in the following days the dose is gradually increased by 2.5-5 mcg.

• The maximum single dose is 100 mcg.
• Full course - 10-30 injections, if necessary, it is possible to repeat the course - in 2-3 months.

Candles Pyrogenal

According to the instructions, the suppositories are administered rectally, 1 suppository per day. The drug is used daily or every other day.

• The initial dose is 50 mcg,
• The maximum allowable is 200 mcg.
• The duration of therapy is 12-15 suppositories.

The following scheme is used for treatment: the initial dose is 50 mcg, and then every 3 days an increase of 50 mcg is performed.

If suppositories are used as monotherapy, suppositories of 50 or 100 mcg are prescribed. The course of therapy is 5-10 suppositories.

The simultaneous use of Pyrogenal suppositories and intramuscular injections is permissible.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Pyrogenal:

• Increase in body temperature up to 37.5 ° C), chills, malaise;
• Rarely - hyperthermia (up to 39.5 ° C), severe chills, headache, back pain.

The described reactions when used for pyrotherapy are allowed.

Contraindications

Pyrogenal is contraindicated in the following cases:

• acute febrile illnesses;
• chronic diseases in the stage of exacerbation and decompensation, with the exception of diseases that are an indication for the appointment of pyrogenal;
• blood diseases;
• pregnancy and lactation.

People suffering from chronic diseases of the cardiovascular system, kidneys and diabetes should be treated under medical supervision.

In the presence of convulsive readiness or febrile convulsions in history, the drug is either not prescribed, or administered against the background of anticonvulsant therapy.

For children under 5 years of age and patients over 60 years of age, Pyrogenal injection solution should be administered at a reduced dose. Its increase is possible only under the supervision of a specialist and with good tolerability of the drug.

Overdose

There are no data on overdose. Possible increased side effects.

Pyrogenal analogues, price in pharmacies

If necessary, you can replace Pyrogenal with an analogue in terms of therapeutic effect - these are drugs:

Store in a dark place at a temperature of 2 ... 10 ° C. Keep away from children. Shelf life - 2 years. The drug in the opened ampoule is not subject to storage.

Conditions for dispensing from pharmacies - by prescription.

What do the reviews say?

Most reviews of Pirogenal testify to the high effectiveness of the drug. At the same time, many people point to the development adverse reactions to the introduction of the drug in the form of an increase in temperature.