Sulfamonomethoxine (Sulfamonomethoxine) - instructions for use, description, pharmacological action, indications for use, dosage and method of application, contraindications, side effects. Sulfamonomethoxine (Sulfamonomethoxine) - instructions for use

Actovegin activates cellular metabolism (metabolism) by increasing the transport and accumulation of glucose and oxygen, enhancing their intracellular utilization. These processes lead to an acceleration of ATP (adenosine triphosphoric acid) metabolism and an increase in cell energy resources.

Under conditions that limit the normal functions of energy metabolism (hypoxia / insufficient supply of oxygen to the tissue or impaired absorption /, lack of substrate) and with increased energy consumption (healing, regeneration / tissue repair /), Actovegin stimulates the energy processes of functional metabolism (the process of metabolism in body) and anabolism (the process of assimilation of substances by the body). The secondary effect is increased blood supply.

They produce the following types:

• Solution for injection 2 ml, 5.0 No. 5, 10 ml No. 10. Actovegin injections fit in colorless glass ampoules that have a break point. Packed in a blister pack of 5 pieces.
• The solution for infusion (Actovegin intravenously) is placed in 250 ml bottles, which are corked and placed in a cardboard box.
• Actovegin tablets have a round biconvex shape, covered with a yellow-green shell. Packed in dark glass bottles of 50 pieces.
• The cream is packaged in tubes of 20 g.
• Gel 20% is packaged in tubes of 5 g.
• Actovegin eye gel 20% is packaged in tubes of 5 g.
• Ointment 5% is packaged in tubes of 20 g.

The composition of the drug Actovegin, from which it helps with insufficient blood flow, is included as active substance deproteinized hemoderivative from calf blood. The injection also contains sodium chloride and water as additional substances.

By pharmacological properties Actovegin belongs to the group of tissue regeneration stimulants. It improves the flow of oxygen and glucose into cells, accelerates metabolism and healing processes, and increases the energy resources of the body. It is used in neurology, ophthalmology, transplantology, dermatology and therapy. In the sports world, it is known as one of the doping drugs.

Active ingredient: deproteinized standardized hemodialysate (otherwise hemoderivat) from the blood of dairy calves.

The use of Actovegin has the following effect:

• The drug improves the absorption of oxygen by brain cells.
• It promotes the formation of acetylcholine and ATP in the brain cells.
• The drug helps glucose to better penetrate into neurons, which has a positive effect on the nutrition of brain cells.
• The tool acts as a strong antioxidant.
• The medicine also has a beneficial effect on liver cells and myocardial tissues.

Indications for use

Why is Actovegin prescribed? Indications differ depending on the form of release of the drug.

Indications for the appointment of Actovegin tablets:

• violations of blood circulation in the brain after diseases, injuries at the stage of recovery;
• circulatory disorders in peripheral arteries in the initial stages or after injections; obliterating atherosclerosis, obliterating endarteritis (inflammation of the walls of the arteries) of the extremities are subject to treatment;
• disorders of blood circulation in the veins - varicose veins, trophic ulcers lower extremities, thrombophlebitis at the recovery stage;
• diabetes mellitus, complicated by damage to blood vessels and nerves (diabetic angioneuropathy), in the initial stages or at the stage of recovery.

Indications for Actovegin injections and droppers:

• acute period of illness, injury;
• violations of blood circulation in the brain with cervical osteochondrosis;
• decreased intelligence against the background of age-related or post-traumatic disorders;
• severe course of obliterating endarteritis, obliterating atherosclerosis, Raynaud's disease;
• severe venous insufficiency, recurrent thrombophlebitis, leg ulcers;
• extensive bedsores in bedridden patients, long-term non-healing wounds;
• extensive burn lesions;
• diabetic foot;
• radiation injury;
• skin transplant.

Actovegin is prescribed externally for:

• fresh wounds, small burns, frostbite;
• inflammatory skin diseases at the healing stage;
• extensive burns at the stage of recovery;
• bedsores, trophic ulcerative processes;
• radiation burns;
• skin graft.

20% eye gel for:

• corneal burns;
• corneal erosions;
• acute and chronic keratitis;
• processing of the cornea before its transplantation;
• radiation burns of the cornea;
• corneal microtrauma in contact lens wearers.

Instructions for use Actovegin, dosage

Intra-arterially, intravenously (including in the form of infusion) and intramuscularly. In connection with the potential for the development of anaphylactic reactions, it is recommended to test for the presence of hypersensitivity to the drug before infusion.

Depending on the severity clinical picture, the initial dose is 10-20 ml / day intravenously or intra-arterially; then 5 ml intravenously or 5 ml intramuscularly.

When administered in the form of an infusion, 10-20 ml of ACTOVEGIN© is added to 200-300 ml of the stock solution (0.9% sodium chloride solution or 5% dextrose solution). Injection rate: about 2 ml/min.

Metabolic and vascular disorders of the brain: at the beginning of treatment, 10 ml intravenously daily for two weeks, then 5-10 ml intravenously 3-4 times a week for at least 2 weeks.

Ischemic stroke: 20-50 ml in 200-300 ml of stock solution intravenously drip daily for 1 week, then 10-20 ml intravenously drip - 2 weeks.

Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml of the drug in 200 ml of the stock solution intra-arterially or intravenously daily; the duration of treatment is about 4 weeks.

Wound healing: 10 ml intravenously or 5 ml intramuscularly daily or 3-4 times a week depending on the healing process (in addition to the local treatment of Actovegin in dosage forms ah for local application).

Prevention and treatment of radiation injuries of the skin and mucous membranes in radiotherapy: the average dose is 5 ml intravenously daily during breaks in radiation exposure.

Radiation cystitis: daily 10 ml transurethral in combination with antibiotic therapy.

Tablets

It is necessary to take the tablets before meals, they do not need to be chewed, they should be washed down with a small amount of water. In most cases, 1-2 tablets are prescribed three times a day. Therapy usually lasts 4 to 6 weeks.

For people suffering from diabetic polyneuropathy, the drug is initially administered intravenously at 2 g per day for three weeks, after which tablets are prescribed - 2-3 pcs. per day for 4-5 months.

Gel and ointment Actovegin

The gel is applied topically to cleanse wounds and ulcers, as well as their subsequent treatment. If there is a burn or radiation injury on the skin, the product should be applied in a thin layer. In the presence of an ulcer, the gel is applied in a thick layer and covered with a compress on top, which is saturated with Actovegin ointment.

The bandage should be changed once a day, but if the ulcer gets very wet, then this should be done more often. For patients with radiation injuries, the gel is applied in the form of applications. For the purpose of treatment and prevention of bedsores, dressings should be changed 3-4 times a day.

The ointment is applied in a thin layer to the skin. It is used for long-term treatment of wounds and ulcers in order to accelerate their epithelialization (healing) after gel or cream therapy. For the prevention of bedsores, the ointment must be applied to the appropriate areas of the skin. To prevent radiation damage to the skin, the ointment should be applied after irradiation or in between sessions.

eye gel

Squeeze 1 drop of gel directly from the tube into the affected eye. Apply 2-3 times a day. After opening the package, the eye gel can be used for no more than 4 weeks.

Side effects

Most often, the drug is well tolerated. However, sometimes a side process may occur - allergies, anaphylactic shock or other reactions:

• hypersensitivity occurs;
• increase in temperature;
• trembling, angioedema;
• skin plethora;
• rash, irritation;
• increased sweat separation;
• swelling skin or mucous;
• transformation in the injection zone;
• dyspeptic phenomena;
• pain in the epigastric zone;
• vomiting, diarrhea;
• feeling of pain in the region of the heart, rapid pulse;
• shortness of breath, pale skin;
• jumps in blood pressure, frequent breathing, a feeling of squeezing in the chest;
• soreness in the throat;
• pain in the head, dizziness;
• agitation, trembling;
• soreness of muscles, joints;
• discomfort in the lumbar region.

When the use of Actovegin leads to the listed side effects, its use should be terminated, if necessary, symptomatic therapy is prescribed.

Use during pregnancy and lactation

Use Actovegin during pregnancy and lactation only when the expected benefit to the mother outweighs the possible risk to the fetus or child. During the use of the drug in placental insufficiency, although rarely, fatal cases were observed, which could be a consequence of the underlying disease. The use during lactation was not accompanied by negative effects either for the mother or for the child.

Contraindications

Actovegin is not used in the following conditions:

• individual intolerance to the drug or its components;
• during pregnancy is prescribed with caution;
• its use during lactation is undesirable;
• heart diseases;
• pulmonary edema;
• with oliguria and anuria.

Analogues and price Actovegin, list of drugs

The only analogue of Actovegin is Solcoseryl. It is produced by the German pharmaceutical concern Valeant.

An analogue of an external agent is produced by the Belarusian pharmaceutical enterprise "Dialek". This is a drug in the gel form Diavitol. The main active ingredient of the drug is a deproteinized extract from embryos and calf blood.

Analogues by scope, list:

• Divaza
• Anantavati
• Mexidol
• Noben
• Cinnarizine
• Armadin Solution
• Nootropil
• Vinpotropil
• Stugeron
• Metapainting
• Cardionate
• Dmae (Dmae)
• Tanakan

When choosing analogues, it is important to understand that the instructions for use of Actovegin, the price and reviews for drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Prices in Russian pharmacies: Actovegin, tablets 50 pcs. - 1612 rubles, solution for injection, 40 mg / ml ampoules 5 ml 5 pcs - 519 rubles.

Store in a place protected from light, at a temperature of 18–25 °C. Leave in pharmacies by prescription.

The composition of this tool is included as an active substance deproteinized hemoderivate from calf blood .

The injection also contains sodium chloride and water as additional substances. OKPD code 24.42.13.815.

Release form

There are the following forms of the drug:

• Solution for injection 2 ml, 5.0 No. 5, 10 ml No. 10. It is contained in colorless glass ampoules that have a breaking point. Packed in a blister pack of 5 pieces.
• The solution for infusion (Actovegin intravenously) is placed in 250 ml bottles, which are corked and placed in a cardboard box.
• Actovegin tablets have a round biconvex shape, covered with a yellow-green shell. Packed in dark glass bottles of 50 pieces.
• Cream Actovegin is packaged in tubes of 20 g.
• Gel Actovegin 20% is packaged in tubes of 5 g.
• Actovegin eye gel 20% is packaged in tubes of 5 g.
• Ointment 5% is packaged in tubes of 20 g.

pharmachologic effect

Wikipedia indicates that this medicine activates metabolic processes in body tissues, activates regeneration processes and improves trophism. Active substance gemoderivate obtained by dialysis and ultrafiltration.

Under the influence of the drug, the resistance of tissues to hypoxia increases, since this drug stimulates the process of utilization and consumption of oxygen. It also activates energy metabolism and glucose uptake. As a result, the energy resource of the cell increases.

Due to the increase in oxygen consumption, the plasma membranes of cells in people suffering from ischemia and the formation of lactates is also reduced.

Under influence Actovegina not only increases the glucose content in the cell, but also stimulates oxidative metabolism. All this contributes to the activation of the energy supply of the cell. This confirms the increase in the concentration of free energy carriers: ADP, ATP, amino acids, phosphocreatine.

Actovegin has a similar effect also in the manifestation of peripheral circulatory disorders and with the consequences that are manifested as a result of these violations. It is effective in accelerating the wound healing process.

In people with trophic disorders , , ulcers of various etiologies under the influence of Actovegin, both morphological and biochemical parameters of granulation are improved.

Since Actovegin affects the absorption and utilization of oxygen in the body and exhibits insulin-like activity, stimulating transport and oxidation glucose , then its influence is significant in the course of therapy diabetic polyneuropathy .

In people suffering diabetes , in the process of treatment, disturbed sensitivity is restored, the severity of symptoms associated with mental disorders decreases.

Pharmacokinetics and pharmacodynamics

The abstract indicates that the pharmacokinetic characteristics of the drug cannot be studied, since it contains only physiological components that are present in the body. Therefore there is no description.

After parenteral administration Actovegina the effect is noted after about 30 minutes or earlier, its maximum is noted after 3 hours on average.

There was no decrease in the pharmacological efficacy of gemoderivatives in people who suffer from renal and hepatic insufficiency, as well as in the elderly, newborns, etc.

Indications for use Actovegin

The use of the drug is carried out according to the doctor's prescription for a number of diseases and disorders.

Indications for use Actovegin tablets

• complex treatment of vascular and metabolic brain disorders (ischemic , , insufficiency of blood flow in the brain TBI );
• diabetic ;
• arterial and venous vascular disorders, as well as the consequences associated with such disorders ( trophic ulcers , angiopathy ).

A dropper and injections of Actovegin are prescribed for similar diseases and conditions of the body.

Ointment Actovegin, indications for use

• inflammatory processes of the skin and mucous membranes, wounds (with burns , abrasions , cuts , cracks and etc.);
• weeping ulcers, varicose origin, etc.;
• to activate tissue regeneration after burns;
• for the treatment and prevention bedsores ;
• in order to prevent manifestations on the skin associated with the influence of radiation.

With the same diseases, Actovegin cream is used.

Indications for use Gel Actovegin are similar, but the drug is also used to treat the surface of the skin before starting the process of skin transplantation in the treatment of burn disease.

The use of medication in different forms for pregnant It is carried out with similar indications, but only after the appointment of a doctor and under his control.

Actovegin for athletes is sometimes used to improve their performance.

From what ointment Actovegin , as well as other forms of drugs are still used, and why this or that form helps, the attending physician will advise.

Contraindications

Contraindications for use are defined as follows:

• oliguria ;
• pulmonary edema;
• fluid retention;
• anuria ;
• if a dropper is used - decompensated heart failure;

Side effects of Actovegin

Side effects of injections and other forms of the drug are rare, as in most cases it is well tolerated.

When using the drug, the following side effects may occur:

• : in rare cases, it is possible to develop , , heavy sweating, fever, hot flashes;
• gastrointestinal function : vomiting, nausea, dyspepsia, pain in the epigastric region, ;
• the cardiovascular system : , pain in the region of the heart, pale skin, shortness of breath, arterial hypertension or hypotension;
• functions nervous system : weakness, , , agitation, loss of consciousness, tremor, paresthesia;
• functions respiratory system : feeling of constriction in the area chest, rapid breathing, difficulty swallowing, sore throat, feeling of choking;
• musculoskeletal system : back pain, feeling of pain in the joints and bones.

If there are indications for the use of the drug, but the indicated side effects, you need to stop taking the medication and apply symptomatic therapy.

Application instruction of Actovegin (Method and dosage)

The medicine is prescribed in the form that will be most effective for a particular disease.

Actovegin injections, instructions for use

The drug in the form of a solution for injection can be administered intravenously, intra-arterially or intramuscularly.

Injections, depending on the severity of the disease, are carried out at a dose of 10-20 ml intravenously, after which a slow introduction of 5 ml of the solution intravenously is practiced. The drug in ampoules should be administered every day or several times a week.

Ampoules are prescribed for disorders of metabolism and blood supply and brain . Initially, 10 ml of the drug is administered intravenously for two weeks. Further, within four weeks, 5-10 ml are administered several times a week.

Sick with ischemic stroke intravenously drive 20-50 ml of Actovegin, previously diluted in 200-300 ml of infusion solution. For two to three weeks, the drug is administered every day or several times a week. Similarly, treatment is carried out for people suffering from arterial angiopathy .

Patients with trophic ulcers or other sluggish ulcers or burns prescribe the introduction of 10 ml intravenously or 5 ml intramuscularly. This dose, depending on the severity of the lesion, is administered once or several times a day. Additionally, local therapy is carried out with an agent.

For prevention or treatment radiation damage to the skin applied every day 5 ml of the drug intravenously, during the intervals between exposure to radiation.

Solution for infusion, instructions for use

Infusions are carried out intravenously or intraarterially. The dose depends on the diagnosis and condition of the patient. As a rule, 250 ml is prescribed per day. Sometimes the initial dose of a 10% solution is increased to 500 ml. The course of treatment can be from 10 to 20 infusions.

Before infusion, you need to make sure that the vial has not been damaged. The flow rate should be approximately 2 ml per minute. It is important that the solution does not get into extravascular tissues when injected.

Instructions for use Actovegin tablets

It is necessary to take the tablets before meals, they do not need to be chewed, they should be washed down with a small amount of water. In most cases, 1-2 tablets are prescribed three times a day. Therapy usually lasts 4 to 6 weeks.

People suffering diabetic polyneuropathy , the drug is initially administered intravenously at 2 g per day for three weeks, after which tablets are prescribed - 2-3 pcs. per day for 4-5 months.

Gel Actovegin, instructions for use

The gel is applied topically to cleanse wounds and ulcers, as well as their subsequent treatment. If there is a burn or radiation injury on the skin, the product should be applied in a thin layer. In the presence of an ulcer, the gel is applied in a thick layer and covered with a compress on top, which is saturated with Actovegin ointment.

The bandage should be changed once a day, but if the ulcer gets very wet, then this should be done more often. For patients with radiation injuries, the gel is applied in the form of applications. For the purpose of treatment and prevention of bedsores, dressings should be changed 3-4 times a day.

Cream Actovegin, instructions for use

It is used to activate the healing process of wounds, weeping ulcers. After the end of treatment with Actovegin gel, it is used to prevent the development of bedsores. For the treatment and prevention of radiation injuries, the use of the cream 2-3 times a day is indicated.

Ointment Actovegin, instructions for use

The ointment is indicated for long-term therapy of ulcers and wounds, it is used after the completion of treatment with gel and cream. The ointment is applied to skin lesions in the form of bandages that need to be changed up to 4 times a day. If the ointment is used to prevent bedsores or radiation injuries, the bandage should be changed 2-3 times.

Actovegin ointment for burns should be applied very carefully so as not to damage the skin, for which it is best to initially apply the ointment to the bandage.

Overdose

If the use of the drug was carried out in too large doses, then the development of negative effects from the gastrointestinal tract is possible. In this case, symptomatic treatment is practiced.

In order to avoid overdose, it is important to take into account the indications for the use of the drug, to know how to inject Actovegin intramuscularly, intravenously, in what doses, and also how any other form of drug release is correctly applied.

Interaction

There are no data on the interaction of Actovegin and other drugs. But, since the possibility of pharmaceutical incompatibility still exists, the Actovegin dropper should not be mixed with other drugs.

Terms of sale

In pharmacies, all forms of the drug are sold by prescription, the doctor writes out a prescription in Latin.

Storage conditions

The medicine should be stored in a dark place, the temperature should not exceed 25 degrees Celsius.

Best before date

All forms of the drug can be stored for 5 years, a solution for infusion 10% can be stored for 3 years. After the vial has been opened and Actovegin has been injected intravenously, the remnants of the drug should not be stored. Ampoules of Actovegin also need to be used completely and do not store leftovers.

special instructions

Actovegin should be administered parenterally very carefully, as there is a possibility of anaphylactic reactions. Before starting treatment, a test injection should be performed.

If develop allergic reactions , it is better to use a drug substitute. If necessary, allergic reactions are stopped by the use of antihistamines or corticosteroids.

When determining whether it is possible to inject intramuscularly or inject a drug solution intravenously, it should be taken into account that the solution may have a slight yellowish tint. In this case, the intensity of the shade may be different, depending on the production batch.

As evidenced by the reference book of Vidal preparations, when the drug is administered parenterally repeatedly, it is necessary to clearly control the water balance, as well as the electrolyte composition of the serum.

Actovegin in gynecology applied on the recommendation of the attending physician. In particular, its ability to improve blood circulation and metabolism plays an important role in IVF.

In sports, the drug is used to improve the performance of athletes, but doctors do not recommend uncontrolled use of the drug. Injections in bodybuilding can lead to the manifestation side effects.

For the eyes, only a special gel contained in tubes of 5 g can be used.

Dragee contains sucrose, this should be taken into account for people with fructose intolerance, malabsorption of sucrase-isomaltase or glucose-galactose.

There is no data on how the use of the drug affects the ability to concentrate and drive.

Actovegin's analogues

On sale there are both more expensive and cheaper analogues of this drug, which can replace injections and tablets. Analogues of Actovegin are drugs , Vero-Trimetazidine , , , .

However, when discussing analogues of Actovegin in ampoules, it should be noted that a similar active substance is present only in the preparation Solcoseryl . All other drugs listed above have only similar indications for use. The price of analogues depends on the manufacturer.

Which is better - Actovegin or Solcoseryl?

As part of the medicine Solcoseryl - the same active ingredient that is made from the blood of calves. But Actovegina longer shelf life as it contains preservative. However, some experts note that the preservative can adversely affect the human liver.

Cortexin or Actovegin - which is better?

Cortexin is also a drug of animal origin. But it is obtained from the cerebral cortex of piglets or calves. Which drug is appropriate to prescribe in a particular case, only a specialist should determine.

Which is better - Cerebrolysin or Actovegin?

Cerebrolysin in the composition contains a hydrolyzate of the brain substance freed from protein. Which of the drugs to prefer, only the doctor determines, depending on the indications. In some cases, these funds are prescribed simultaneously.

children

For children, the drug is prescribed for diseases of a neurological nature, which were the result of complications of pregnancy or problems during childbirth. The remedy in the form of injections can be prescribed to children under one year old, but during treatment it is necessary to adhere to the prescribed scheme very precisely.

With mild lesions, a pill is prescribed - 1 tablet per day. If Actovegin injections are prescribed intramuscularly, the dosage depends on the condition of the baby.

Actovegin for newborns

For newborns, as a rule, the drug is prescribed at a dose of 0.4-0.5 ml / kg once a day, administered either intravenously or intramuscularly.

With alcohol

Drug compatibility with alcohol is not described in the instructions. But, despite the absence of explicit prohibitions on alcohol intake during treatment with Actovegin, doctors do not recommend drinking alcohol, since alcohol almost completely neutralizes the effect of treatment.

Actovegin during pregnancy

Actovegin is not contraindicated for pregnant women. Why pregnant women are prescribed this drug depends on the state of health of the woman during the period of bearing the child. Mainly during Actovegin is used to prevent fetal developmental disorders in placental insufficiency .

Also, the drug is sometimes prescribed when planning a pregnancy. For expectant mothers, a dropper, injections or tablets during pregnancy are prescribed in order to activate the uteroplacental circulation, normalize the metabolic functions of the placenta, and gas exchange.

Since the drug consists of natural ingredients, it does not have a negative effect on the fetus, as evidenced by reviews during pregnancy.

During pregnancy, a dose of Actovegin solution is administered intravenously from 5 to 20 ml, intravenous administration is practiced every day or every other day. Intramuscularly, the agent is prescribed in an individual dosage, depending on what this medicine is prescribed for during pregnancy. Treatment usually lasts 4 to 6 weeks.

Actovegin (lat. Actovegin) is a deproteinized (purified from protein) hemodialysate (extract) obtained from the blood of dairy calves. It is a generic of the Swiss drug Solcoseryl.

By pharmacological properties, it belongs to the group of tissue regeneration stimulants. It improves the flow of oxygen and glucose into cells, accelerates metabolism and healing processes, and increases the energy resources of the body.

It is used in neurology, ophthalmology, transplantology, dermatology and therapy. In the sports world, it is known as one of the doping drugs.

An extract from the blood of calves was first proposed for medical use by specialists from the Swiss pharmaceutical company Solco.

The reason for the creation of the drug was the stories of Alpine shepherds, who claimed that wounds and scratches in dairy calves heal much faster than in adult cows.

After studying the blood of young animals, scientists suggested that it contains a certain factor that accelerates the healing process.

An injectable form of a purified calf blood extract was registered in Switzerland in 1957 under the trade name Solcoseryl. In the 60s, the development company brought to the market an ointment and gel for external use, in the 70s - eye gel, adhesive paste and tablets.

In 1976, Solcoseryl was registered in the USSR. By 1990, the drug was already presented in 50 countries, including the USA and Canada.

In 1996, in connection with the epidemic of bovine spongiform encephalopathy * in Switzerland, the release of medicines made from the tissues of cattle. For this reason, Solco moved the production of its products to Germany.

In the same year, the Austrian branch of the Swiss corporation Nikomed released a generic of Solcoseryl under the brand name Actovegin. The CIS and Asian countries became the main sales market for the new drug.

In 2000, one of the participants in the Tour de France - Lance Armstrong - was accused of using Actovegin in order to improve sports performance.

Against the background of the scandal that broke out, the International Olympic Committee added the drug to the banned list. However, already at the beginning of 2001, the drug was excluded from the list due to lack of evidence of a doping effect.

*Spongiform encephalopathy ("mad cow disease", prion disease, Creutzfeldt-Jakob disease) is a neurodegenerative disease that leads to irreversible changes in the cerebral cortex. Found among humans, cattle and sheep. The causative agent is a special type of high molecular weight protein - a prion. The disease is manifested by dementia, mental disorders, visual impairments. Previously, it was believed that prions arise spontaneously in the human body or their formation is due to hereditary factors. In 1995, a new form of human pathology was described in the UK, the development of which was associated with the consumption meat products from cows infected with encephalopathy.

Properties

Active ingredient: deproteinized standardized hemodialysate (otherwise gemoderivate) from the blood of dairy calves (highly filtered extract obtained from calf blood).

international generic name: No.

The drug is a combination of various biologically active compounds:

• amino acids (ornithine, leucine, alanine, glutamate, proline, glycine, taurine, etc.),
• oligopeptides,
• lipids
• oligosaccharides,
• nucleosides (adenosine, uridine),
• antioxidant enzymes,
• electrolytes (sodium, chlorine, potassium, magnesium, calcium, phosphorus, iron),
• trace elements (copper, silicon, selenium, zinc).

Organic matter is up to 30% of the dry weight of the extract.

The blood of calves younger than 3 months is used as a feedstock for the preparation of the drug. The extract is produced by ultrafiltration, which, according to the manufacturer, ensures the absence of pathogens of prion diseases in it.

Application in different countries

As of 2015, Actovegin is used in 17 countries:

• Russia,
• Ukraine,
• Belarus,
• Kazakhstan,
• Kyrgyzstan
• Tajikistan,
• Uzbekistan
• Turkmenistan
• Moldova
• Armenia,
• Georgia,
• Azerbaijan,
• Latvia,
• Lithuania,
• Estonia,
• South Korea
• China.

About 70% of drug sales are in countries former USSR.

For a long time, Actovegin was also used in the USA and Canada. In 2011, these countries introduced a ban on the import, sale and use of the drug.

It turned out that in countries where the drug is used, mental disorders were recorded 1.3 times more often than in countries where it was never used. Doctors suggested that this situation may be due to the presence of prion infection pathogens in the drug.

The sale of drugs made from bovine tissues was also restricted in a number of other states, including Russia, Ukraine and the Republic of Belarus. However, none of the countries of the former USSR included Actovegin among the prohibited drugs.

Calf's blood extract has never been used as a medicine in Western Europe (with the exception of Switzerland), Japan and Australia.

Clinical researches

The use of Actovegin does not comply with the principles evidence-based medicine fully. The drug has no active ingredient, and its safety and efficacy have not been confirmed according to international standards.

Most of the trials were conducted on a limited number of patients, so their results cannot be considered sufficiently convincing.

There are separate works that describe the effectiveness of Actovegin in patients with cognitive disorders. In 2002, European physicians V. Jansen and G. V. Bruckner published the results of the use of Actovegin in patients with cerebrovascular pathology.

120 volunteers took part in the experiment and were divided into 3 groups. The first took the drug in 2 tablets. 3 times a day, the second - 2 tablets. 2 times a day. Patients of the 3rd group received a placebo. After 3 months therapy, the authors noted that both dosing regimens of Actovegin significantly improved attention and memory in elderly patients.

In several experiments, the effectiveness of the use of the drug in the acute period of a stroke was noted (Fedin A. I., Rumyantseva S. A. 2001-2004), with acute craniocerebral injuries (Mikhalovich N., Hack J., 2004) and diseases of the peripheral nervous system (Shmyrev V.I., Bobrova T.A., 2002).

The first multicenter, double, placebo-controlled study of Actovegin was conducted under the patronage of Nycomed in 2008. The drug was used in 569 patients with diabetic polyneuropathy.

The effectiveness of therapy was assessed using the TSS (Total Symptom Score) scale. At the end, the volunteers noted a decrease in the severity of pain, burning sensation and an improvement in overall well-being.

In April 2012, another 2-year multicenter study of the drug started, organized by the American organization FDA. Its results have not yet been published in international publications.

Composition, forms of release, packaging

Actovegin is produced in the form:

• 4% solution for injection,
• 10% solution for infusion (in sodium chloride solution 0.9% or dextrose solution),
• 20% solution for infusion (in sodium chloride solution 0.9%),
• film-coated tablets with an active substance content of 200 mg,
• 5% cream for external use,
• 5% ointment for external use,
• 20% gel for external use,
• 20% eye gel.

The injection solution is packaged in ampoules of 2, 5 and 10 ml and then in boxes of 5 or 25 ampoules. The infusion solution is poured into colorless glass bottles of 250 ml.

External gel, cream and ointment are available in aluminum tubes of 20, 30, 50 and 100 g. Eye gel - in a tube of 20 g.

Tablets are packed in dark glass bottles of 10, 30 or 50 pcs.

Mechanism of action

Actovegin stimulates the flow of oxygen and glucose into cells, which leads to increased synthesis of ATP energy molecules. Thus, the drug acts as a kind of energy stimulator, activating the work of all body systems.

An increase in oxygen transport to brain cells has a positive effect on memory and learning processes. Against the background of taking the drug in patients, restoration of impaired cognitive functions and an increase in the resistance of brain tissues to hypoxia were recorded.

According to the ability to stimulate the uptake of glucose by cells, Actovegin is only 2 times inferior to insulin. At the same time, its action is also manifested in patients with diabetes mellitus, contributing to the weakening of their symptoms of polyneuropathy.

By improving energy metabolism in the walls of blood vessels, the drug enhances the release of endogenous vasodilators - nitric oxide and prostacycline. This effect leads to vasodilatation, a decrease in total peripheral resistance and an improvement in the blood supply to organs.

Activation of energy metabolism entails increased synthesis of carbohydrates and proteins. The result of this is the acceleration of tissue healing. In animal experiments, it was shown that the most pronounced regenerative effects of Actovegin in relation to the liver, heart muscle and skin.

Metabolism and excretion

Actovegin is a multicomponent drug, which includes compounds originally contained in the human body, so it is not possible to study its pharmacokinetics.

In laboratory experiments, it was found that when used intravenously, the drug begins to act 5 minutes after administration, and the peak of its activity is observed after 120 minutes.

In patients with renal or hepatic insufficiency, decreased pharmacological effects Actovegin was not seen.

Indications for use

The grounds for prescribing parenteral forms are:

• acute and chronic disorders of peripheral and cerebral circulation,
• dementia (dementia),
• traumatic brain injury,
• ulcers of various origins,
• long-term non-healing wounds,
• burns,
• radiation damage to the skin or mucous membranes,
• radiation neuropathy.

• angiopathy,
• dementia,
• traumatic brain injury,
• trophic ulcers, etc.

External soft forms (gel, cream, ointment) are used as wound healing agents for various skin lesions:

• abrasions, cuts, wounds,
• burns
• varicose ulcers,
• bedsores (including for the purpose of prevention),
• radiation damage.

Additional indications for Actovegin gel are pre-treatment of the skin before transplantation and treatment of burn disease.

Eye gel is indicated for the following conditions:

• burns (chemical, radiation, thermal) and corneal injuries,
• corneal ulcers,
• keratitis of various origins,
• corneal dystrophy,
• dry keratoconjunctivitis,
• selection contact lenses(to prevent injury).

Contraindications

A common contraindication for all forms of Actovegin is hypersensitivity to the drug.

For infusion solutions, the following are additionally indicated:

• pulmonary edema,
• fluid retention in the body
• urinary disorders (oligo- or anuria),
• decompensated heart failure.

Pregnancy and lactation

Actovegin is allowed to be used during pregnancy and lactation.

Dosage and administration

The drug is used parenterally, orally and topically.

Inside take 1-2 tablets. 3 times a day for 4-6 weeks.

Injections are made intravenously (in / in), intramuscularly (in / m) or intra-arterially (in / a). Dosages depend on the severity of the clinical picture. For the first time, 10-30 ml of the drug is administered intravenously or intravenously, then 5-10 ml intravenously or intramuscularly 1 time per day. The course of treatment is 2-4 weeks.

Infusions are carried out in / in drip or in / a jet. Enter 250-500 ml of solution per day. Infusion rate - 2 ml / min. The course of treatment includes 10-20 procedures.

The ointment/cream/external gel is applied in a thin layer to the cleaned damaged areas of the skin 2 times a day. The course of therapy is at least 12 days. Treatment of ulcers begins with the use of a gel, gradually moving to a cream and then to an ointment.

In order to prevent radiation injury, a cream or ointment is rubbed in between sessions of radiation therapy.

The eye gel is injected into the conjunctival sac 1 drop 2-3 times a day until the symptoms of the pathology disappear.

Side effects

Actovegin is well tolerated by most patients. A small number of patients may experience allergic reactions (skin rash, hyperthermia, redness of the skin). In such situations, standard symptomatic therapy is carried out.

When treating with a 20% external gel, slight swelling of the skin and the occurrence of pain are possible, which disappear as therapy continues.

When the eye gel is injected, a short-term weak burning sensation and lacrimation are felt.

special instructions

With prolonged therapy with an infusion solution, it is necessary to monitor the water and electrolyte balance of the blood.

Do not use a cloudy infusion solution or a preparation containing suspended particles.

To reduce the risk of developing anaphylactic shock, injection solution must be injected slowly. When using for the first time, it is recommended to do a test injection (inject 2 ml of the solution in / m).

Tablets and injection solution should be used with caution:

• during pregnancy or lactation,
• in patients with diabetes mellitus, hyperglycemia,
• in patients with heart failure of 2-3 degrees,
• with pulmonary edema,
• with fluid retention in the body and urinary disorders.

Overdose

There were no cases of overdose when using Actovegin.

Interaction with other drugs

Not currently installed.

Holiday conditions

Cream, ointment, gel for external use are available without a prescription. Tablets, solution for infusion, solution for injection and eye gel - by prescription.

Storage

The drug is stored in a dry, dark place. Ointment, cream, gel for external use, tablets and injection solution - at a temperature of 18-25ºС, solution for infusion and eye gel - at a temperature not exceeding 25ºС.

in pharmacies and medical institutions tablets and injection solution are stored according to the conditions of list B.

Best before date

For cream, ointment, solution for injection, solution for infusion (in 0.9% sodium chloride solution) - 5 years.

For gel for external use, ophthalmic gel, tablets, solution for infusion (in dextrose solution) - 3 years.

Eye gel after opening can be stored for no more than 4 weeks.

Manufacturer

From 1996 to 2011, Actovegin was produced by Nycomed Austria GmbH, which was a subsidiary of the Swiss corporation Nycomed.

Some batches of drugs released at that time (2010-2011) may still be available in retail.

In September 2011, Nycomed was bought out by the Japanese pharmaceutical giant Takeda Pharmaceutical Company Limited for 9.6 billion euros.

Currently, Actovegin continues to be produced at the same Austrian plant, but under the Takeda brand. The substrate for its manufacture is purchased in Australia and France. The production is organized in accordance with the rules of the international GMP standard.

Analogues

The only full-fledged replacement for Actovegin can be considered the original extract from calf blood Solcoseryl, which is now produced by the German company Valeant.

The instructions for both drugs indicate similar therapeutic properties, indications for use and side effects. However, comparative clinical research no analogues have been conducted, therefore, their biological equivalence has not been officially confirmed.

There are differences in product portfolios of brands and concentrations of identical dosage forms. So, in the assortment of Solcoseryl there is no cream for external use and a 10% solution for infusion, but an adhesive dental paste is presented.

Solcoseryl injection solution is available at a concentration of 4.25%, and a skin gel at a concentration of 10%.

Analogues of local forms of Actovegin also include the Belarusian gel Diavitol, produced by UE "Dialek". It consists of deproteinized hemodialysate from the blood of cow embryos and the blood of young calves.

When comparing pharmacological descriptions 3 drugs show discrepancies in age restrictions, drug interactions and the possibility of use during pregnancy and lactation.

Comparative characteristics of Actovegin and its analogues:

Publication date: 2015-07-3
Last modified: 2020-01-31

Dear visitors of the site Farmamir. This article is not medical advice and should not be used as a substitute for consultation with a physician.

), Actovegin has an antihypoxic (improves the utilization of oxygen by the body) effect, which manifests itself 30 minutes after parenteral administration, reaching a maximum after 2-6 hours.

Parenteral administration of drugs is a method of introducing drugs into the body, in which they bypass the gastrointestinal tract. Parenteral administration of the drug is carried out using injections (injections in ampoules) and infusion therapy ( intravenous administration solution for infusion).

Actovegin has an antihypoxic, antioxidant, wound-healing effect, stimulates the processes of functional metabolism (metabolism in the body) and anabolism (absorption of substances by the body). The drug improves blood microcirculation in the vessels of the legs, starting the process of tissue regeneration when their nutrition suffers in case of damage to the veins (chronic venous insufficiency, thrombophlebitis, varicose veins veins).

Actovegin increases the concentration of phosphocreatine (creatine phosphoric acid), adenosine diphosphate (ADP), adenosine triphosphate (ATP), amino acids gamma-aminobutyric acid, aspartate (aspartic acid), glutamate (glutamic acid).

Actovegin is used for diseases of the heart and blood vessels, lesions of the central nervous system, for injuries, ulcers. The versatility of the remedy is due to the fact that Actovegin increases the transport of glucose and oxygen to the cells of organs, enhancing their energy resources, increasing functional abilities and survival in conditions where oxygen supply is insufficient and cells are unable to fully function. By facilitating the active entry of glucose into cells, Actovegin has an effect. The agent is an important component of the therapy of patients with diabetes mellitus, including the treatment of diabetic polyneuropathy (DPN).

Diabetic polyneuropathy is characterized by damage to the human nervous system, develops in people with diabetes mellitus due to stable high sugar(glucose) in the blood (hyperglycemia). The most significant mechanisms for the development of DPN are ischemia and metabolic disorders in the nerve.

The use of Actovegin reduces the symptom of DPN in the form of paresthesia (burning, tingling, crawling, numbness in the lower extremities).

Taking Actovegin helps to reduce sensitivity disorders, improve the mental well-being of the patient.

The duration of the course of treatment with Actovegin is determined by the doctor individually according to the symptoms and severity of the disease.

Anatomical Therapeutic Chemical Classification (ATC)

Anatomical-therapeutic-chemical classification (anatomical-therapeutic-chemical, ATC) is an international classification system for medicines. The main purpose of ATC is to provide statistical data on the consumption of medicines.

According to the ATC, Actovegin drugs, depending on the form of release, belong to the following groups:

• Tablets (dragged), solution for infusion, solution for injection in ampoules - B06AB Other blood preparations,
• Gel, creams and ointments for external use - D11AX Other preparations for the treatment of skin diseases,
• Eye gel - S01X Other drugs for the treatment of diseases of the eyes (currently not assigned a code).

Pharmacological group

Actovegin, a drug that activates tissue metabolism, improves trophism and stimulates the regeneration process, refers to the following: pharmacological groups, depending on the release form.

Actovegin tablets, infusion solution and injection solution in ampoules:

• angioprotectors and microcirculation correctors,
• regenerants and reparants.

At the molecular level, Actovegin promotes an increase in oxygen consumption and utilization (increases resistance to hypoxia), increases energy metabolism and glucose consumption.

Nosological classification (ICD-10)

The International Classification of Diseases, Tenth Revision (ICD-10) is a standard assessment tool in the field of health management, medicine, epidemiology, and analysis general condition population health. According to ICD-10, medicinal product Actovegin, depending on the form, can be used for below the following diseases and states.

Actovegin coated tablets:

• F03 Dementia, unspecified
• I73 Other peripheral vascular diseases,
• S06 Intracranial injury.

Actovegin gel, cream and ointment for external use:

• L90.8 Other atrophic changes in skin
• L98.4 Chronic skin ulcer, not elsewhere classified
• L98.4.2* Skin ulcer, trophic,
• T14.0 Superficial injury of body region unspecified
• Z100* CLASS XXII Surgical practice.

Infusion solution and injection solution in ampoules Actovegin:

• I63 Cerebral infarction,
• I25.2 Past myocardial infarction,
• I67.9 Cerebrovascular disease, unspecified
• I69 Sequelae of cerebrovascular diseases,
• I73.9 Peripheral vascular disease, unspecified
• I79.2 Peripheral angiopathy in diseases classified elsewhere
• I87.2 Venous insufficiency (chronic) (peripheral)
• I99 Other and unspecified disorders of the circulatory system,
• L58 Radiation dermatitis, radiation,
• L89 Decubital ulcer (traumatic ulcer, bed sore),
• L98.4.2* Skin ulcer, trophic,
• S06 Intracranial injury,
• T14.1 Open wound of body region unspecified
• T30 Thermal and chemical burns, unspecified
• T79.3 Post-traumatic wound infection, not elsewhere classified

The term "specified" disease (condition) is used in cases where the doctor has a complete package of medical documents that allow the most objective assessment of the development of the disease (condition). In a situation where this set of documents is missing, and as internal organs the course of the disease cannot be determined, the diagnosis is made unspecified».

Composition Actovegin

As part of the drug Actovegin, as an active substance, there is deproteinized hemoderivative of calf blood, obtained by means of ultrafiltration (compounds with a molecular weight of less than 5000 daltons pass), containing exclusively physiological substances.

• 1 tablet (dragee) contains 200 mg,
• 1 gram of gel for external use contains 8 mg,
• 1 gram of topical cream contains 2 mg,
• 1 gram of ointment for external use contains 2 mg,
• 1 ml solution for injection contains 40 mg,
• 1 ml solution for infusion contains 4 mg (in a 10% solution) or 8 mg (in a 20% solution),
• 1 gram of eye gel contains 8 mg.

Auxiliary substances in the composition tablets Actovegin are:

• magnesium stearate,
• povidone-K90,
• talc.

As part of shells Actovegin tablets additionally present:

• mountain glycol wax,
• gum arabic (acacia gum),
• diethyl phthalate,
• dye quinoline yellow varnish aluminum,
• macrogol-6000,
• titanium(IV) oxide (titanium dioxide),
• povidone-K30,
• sucrose,
• talc,
• hypromellose phthalate.

The composition of the cream for external use additionally contains benzalkonium chloride 0.2 mg per 1 gram of the drug.

Excipients in the composition of the infusion solution of Actovegin and the drug in the form of ampoules with a solution for injection are sodium chloride and water for injection. The solution for infusion in a dextrose solution additionally contains dextrose.

Release form and dosage Actovegin

The drug Actovegin is available in the form of tablets (pellets), gel, cream, ointment, ampoules for injection, solution for infusion, ophthalmic gel.

Actovegin coated tablets (dragees):

• tablets in a bottle of 200 mg, No. 10,
• tablets in a bottle of 200 mg, No. 30,
• tablets in a bottle of 200 mg, No. 50,
• tablets in a bottle of 200 mg, No. 100.

Packing of tablets (drops) includes:

• bottle (vial) of dark glass with a screw neck, sealed with an aluminum cap with first opening control, containing round biconvex shiny tablets coated with greenish-yellow color,
• a cardboard pack with a pasted transparent protective sticker of a round shape with holographic inscriptions and control of the first opening.

Actovegin gel for external use:

• gel in a tube 20%, 20 grams,
• gel in a tube 20%, 30 grams,
• gel in a tube 20%, 50 grams,
• gel in a tube 20%, 100 grams.

Gel packaging includes:

• aluminum tube containing the gel,
• instructions for medical use,
• cardboard pack.

Actovegin cream for external use:

• cream in tube 5%, 20 grams,
• cream in tube 5%, 30 grams,
• cream in a tube 5%, 50 grams,
• cream in tube 5%, 100 grams.

Cream packaging includes:

• aluminum tube containing permanent cream white color, with no taste and smell,
• instructions for medical use,
• cardboard pack.

Actovegin ointment for external use:

• ointment in a tube 5%, 20 grams,
• ointment in a tube 5%, 30 grams,
• ointment in a tube 5%, 50 grams,
• ointment in a tube 5%, 100 grams.

Ointment packaging includes:

• an aluminum tube containing a constant white ointment with no taste and smell,
• instructions for medical use,
• cardboard pack.

Actovegin solution for injections in ampoules (injections):

• solution for injection 80 mg (40 mg/ml, 2 ml ampoule),
• solution for injections 200 mg (40 mg/ml, 5 ml ampoule),
• solution for injection 400 mg (40 mg/ml, 10 ml ampoule).

Ampoule packaging includes:

Actovegin solution for infusions:

• solution for infusion in sodium chloride solution 0.9% 1000 mg (4 mg / ml, 250 ml),
• solution for infusion in sodium chloride solution 0.9% 2000 mg (8 mg / ml, 250 ml),
• solution for infusion in dextrose solution 1000 mg (4 mg/ml, 250 ml).

Solution packaging for infusion includes:

• a colorless glass bottle (type II according to the European Pharmacopoeia) with a transparent, colorless to slightly yellow solution, corked with a cork and an aluminum cap for running in, closed on top with a lid that provides control of the first opening,
• instructions for medical use,
• a cardboard pack with a pasted transparent protective sticker of a round shape with holographic inscriptions and control of the first opening.

Actovegin eye gel:

• gel for instillation into the eyes 20%, 5 grams.

Eye gel packaging includes:

• aluminum tube containing ophthalmic gel,
• instructions for medical use,
• cardboard pack.

At the moment, Actovegin ophthalmic gel to Russia not supplied.

The most common forms of release and dosage of Actovegin found in pharmacies:

• Tablets number 50,
• Solution in 80 mg ampoules (40 mg / ml, 2 ml ampoule),
• Ointment 5%, 20 grams,
• Gel 20%, 20 grams.

pharmachologic effect

The pharmacological action of Actovegin is metabolic, which consists in accelerating the processes of oxygen and glucose utilization at the molecular level, thereby increasing resistance to hypoxia. The drug Actovegin has a wound-healing effect, enhances the energy state of the cell, improves blood circulation in tissues.

Indications for use Actovegin

Actovegin is indicated for use in the following diseases and conditions:

Actovegin solution for injection in ampoules and solution for infusion in sodium chloride solution additionally indicated for diabetic polyneuropathy.

Actovegin ophthalmic gel is indicated for lesions and eye diseases:

• in case of damage (burns with alkali, acid) of the cornea (cornea) and sclera (protein coat),
• with corneal ulcers of various etiologies,
• with keratitis (inflammation of the cornea), including after corneal transplantation,
• with corneal abrasion in patients using contact lenses,
• in order to prevent lesions, when choosing contact lenses in patients with ongoing dystrophic processes in the cornea.

Contraindications Actovegin

The main contraindication to the use of Actovegin is hypersensitivity to the components of the drug.

Other contraindications to taking Actovegin are:

• anuria (lack of urine flow to the bladder),
• oliguria (reduced amount of urine excreted by the kidneys),
• decompensated heart failure II and III degree,
• pulmonary edema,
• fluid retention in the body.

Actovegin should be taken with caution in patients with hyperchloremia (increased content of chlorine compounds in the blood) and hypernatremia (increased concentration of sodium in the blood plasma).

For Actovegin solution for infusion in a dextrose solution, an additional contraindication is diabetes mellitus - 1 vial of the drug contains 7.75 g of dextrose.

During pregnancy and lactation, the drug should be taken with caution.

Side effects of Actovegin

Side effects from taking Actovegin are extremely rare and are mainly due to hypersensitivity to the components of the drug.

Side effects of Actovegin include possible allergic reactions (, skin rash, hyperthermia (fever), up to. In such situations, treatment with Actovegin should be stopped, if necessary, use and / or.

In severe anaphylactic reactions, emergency therapy should be carried out (administer plasma substitutes, large doses, corticosteroids).

When using a gel, ointment or cream, side effects are possible in the form of itching and burning in the area of ​​application of the drug.

At the beginning of treatment with Actovegin gel, side effects may occur in the form of local pain due to increased secretion. This side effect is not evidence of drug intolerance.

When using the eye gel, lacrimation, injection (redness) of the vessels of the sclera is possible.

When adverse reactions you should stop taking Actovegin, contact a qualified medical specialist, doctor.

Overdose of Actovegin

To date, there has been no information on an overdose of Actovegin.

Tablets Actovegin (dragee)

Actovegin tablets (pellets) are used orally (by mouth) as maintenance therapy for disorders of cerebral metabolism and circulation, to continue infusion or injection treatment for disorders of cerebral circulation.

The instruction on Actovegin tablets

Reading these instructions for the use of Actovegin tablets does not exempt the patient from studying "Instructions for the medical use of tablets (pellets) Actovegin"

Dragee should be taken orally (by mouth) before meals, without chewing, with a small amount of water.

• 1-2 tablets three times a day.

The duration of treatment should be 4 to 6 weeks.

The drug begins to act 30 minutes after ingestion, the maximum effectiveness occurs after 3-4 hours: the heaviness in the legs decreases, pain, tingling, numbness of the lower extremities disappear. Children and adolescents should take one tablet of Actovegin once a day, treatment continues for 28-42 days.

The frequency of taking Actovegin tablets may vary depending on the clinical picture and the severity of the disease, determined by the doctor.

Gel Actovegin

Gel Actovegin is a soft form of a drug with a viscous consistency, plasticity, elasticity, and a pH close to the pH of the skin. The gel is evenly and quickly distributed over the surface of the skin without clogging the pores.

Actovegin gel is applied topically under the following circumstances and pathologies:

Actovegin gel is also used for the prevention and treatment of bedsores.

Instructions for Actovegin gel

Reading these instructions for the use of Actovegin gel does not exempt the patient from studying "Instructions for the medical use of Actovegin gel" in the manufacturer's carton.

When treating open wounds and ulcers, Actovegin gel should be applied in a thin layer to the affected areas 5-6 times a day.

When performing pre-treatment to clean ulcerative lesions, the gel must be applied in a thick layer, covering Actovegin ointment with a compress, or with a gauze bandage soaked in ointment (to prevent sticking to the wound). The bandage should be changed once every 24 hours, in the treatment of heavily weeping surfaces - 3-4 times a day. Further treatment should be continued with Actovegin in the form of a cream; treatment should be completed with Actovegin in the form of an ointment.

For burns and radiation injuries, the gel should be applied to the skin in a thin layer.

In the treatment of radiation injuries in patients, the remedy is used in the form of applications.

For the prevention and treatment of bedsores, Actovegin gel must be used 3-4 times a day, the course of treatment is from 3 to 60 days.

The frequency of application of the gel may vary depending on the clinical picture and the severity of the disease, determined by the doctor.

Cream Actovegin

Actovegin cream is applied topically under the following circumstances and pathologies:

• with ulcers of varicose origin, weeping ulcers,
• with wounds and inflammation of the skin and mucous membranes, burns, skin cuts, scratches, abrasions,
• in order to promote tissue regeneration after burns,
• at pretreatment wound surfaces before transplantation,
• for the prevention and treatment of mucosal and skin reactions caused by exposure to radioactive radiation.

Actovegin cream is also used for the prevention and treatment of bedsores.

Instructions for Actovegin cream

Reading these instructions for the use of Actovegin cream does not relieve the patient from studying "Instructions for the medical use of Actovegin cream" in the manufacturer's carton.

Actovegin cream should be used to accelerate the healing of wounds, including wounds with discharge (weeping ulcers).

Remedy applied at the second stage three-stage therapy with Actovegin after applying the gel. The cream is applied in a thin layer 2-3 times a day.

To prevent bedsores, Actovegin cream should be rubbed into the skin in high-risk areas.

When preventing the occurrence of radiation injuries, the agent should be applied in a thin layer immediately after radiation therapy, in the intervals between sessions.

The frequency of use of Actovegin cream may vary depending on the clinical picture and the severity of the disease, determined by the doctor.

After the first opening of the package, the drug should be used within four weeks.

Actovegin ointment is applied topically under the following circumstances and pathologies:

• with wounds and inflammation of the skin and mucous membranes, burns, skin cuts, scratches, abrasions,
• in order to promote tissue regeneration after burns,
• with ulcers of varicose origin, weeping ulcers,
• for the prevention and treatment of mucosal and skin reactions caused by exposure to radioactive radiation,
• during pre-treatment of wound surfaces before transplantation,

Also, the ointment is used for the prevention and treatment of bedsores.

The instruction on Actovegin ointment

Reading these instructions for use of Actovegin ointment does not exempt the patient from studying "Instructions for the medical use of Actovegin ointment" in the manufacturer's carton.

Ointment Actovegin should be used for long-term three-stage treatment of wounds and ulcers to accelerate and / or chemotherapeutic agents (mainly sulfonamides), antiseptics). The rate of administration is ~2 ml/min.

Do not use an opaque solution or a solution containing foreign particles. After opening the vial (ampoule), the solution can not be stored.

With intramuscular injections of Actovegin, the drug is administered slowly, not more than 5 ml. Due to the risk of an anaphylactic reaction, a test injection (2 ml per minute) is recommended.

After 30-40 minutes after using the product, an increase in body temperature, the appearance of rashes is possible. In such a situation, it is necessary to stop the course of treatment.

Actovegin solution for infusions

Actovegin 10% or 20% infusion (with or without glucose) solution is intended for intravenous or intra-arterial infusions. Actovegin infusion solution has a slightly yellowish tint. The color intensity may vary depending on the characteristics of the starting materials used, but does not adversely affect the activity of the drug or its tolerability.

The solution for infusion is used parenterally under the following circumstances:

• with violations of the peripheral (venous and arterial) circulation, their consequences in the form of leg ulcers, arterial angiopathy,
• in violation of cerebral metabolism and blood circulation (traumatic brain injury, ischemic stroke, cerebral insufficiency syndrome),
• with complications arising from wound healing (pressure sores, poorly healing wounds),
• with burns, ulceration of the skin,
• in skin transplantation,
• as a means of prevention and treatment of radiation damage to the skin, mucosa, and nervous tissue.

Instructions for the solution for infusion Actovegin

Reading these instructions for use of the solution for infusion Actovegin does not exempt the patient from studying "Instructions for the medical use of Actovegin infusion solution" in the manufacturer's carton.

Before using the solution, make sure that the vial is intact.

As a rule, the solution for infusion is used in a volume of 250 ml per day, intravenously or intra-arterially. The infusion rate should be ~2 ml/min. 10-20 infusions may be required to achieve maximum effect. It is allowed to increase the initial dose of 10% solution up to 500 ml.

When carrying out infusions, it is important to ensure that the solution does not enter extravascular tissues.

It is not allowed to add other drugs to the infusion solution of Actovegin.

Due to the risk of developing anaphylactic reactions, it is recommended to test for the presence of hypersensitivity to the drug before infusion.

In case of violation of blood supply and metabolism of the brain, the dosage is:

• Initially, 250-500 ml (1000-2000 mg of the drug) intravenously per day for 2 weeks (with subsequent transition to the tablet form),
• Further, 250 ml intravenously 3-4 times a week (for Actovegin infusions in dextrose solution) for 30 days or more.

In case of ischemic stroke, the administration of Actovegin infusion solution is carried out in 250-500 ml intravenously daily or several times a week for 14 days, followed by the transition to a tablet form.

In case of arterial angiopathy, it is necessary to inject 250 ml (1000 mg) intra-arterially and intravenously daily or several times a week for four weeks, followed by the transition to a tablet form (for infusions in sodium chloride solution),

For Ulcus cruris (shin varicose ulcer), other indolent ulcers, burns, the solution for infusion should be administered 250 ml (1000 mg of the drug) intravenously daily or several times a week, depending on the rate of healing, in addition to local therapy Actovegin.

In case of diabetic polyneuropathy, 250–500 ml of a solution for infusion in sodium chloride solution should be administered intravenously daily for three weeks, followed by the transition to a tablet form (2–3 tablets three times a day for 4–5 months).

In the prevention and treatment of radiation damage to the skin and mucous membranes, 250 ml (1000 mg of the drug) is administered intravenously one day before it starts, daily during radiation therapy, for two weeks after it ends, followed by the transition to a tablet form. The rate of administration is ~2 ml per minute.

With repeated injections of Actovegin infusion solution, it is necessary to control the water and electrolyte balance of the blood plasma.

Do not use an opaque solution or a solution containing foreign particles.

The frequency, dose, method of administration of the solution may vary depending on the clinical picture and the severity of the disease, determined by the doctor.

Eye gel Actovegin

Eye gel Actovegin is applied topically for injuries of the cornea of ​​the eye:

• burns
• inflammation of various origins,
• in corneal transplantation in the preoperative and postoperative periods,
• in patients with defects in the corneal epithelium due to wearing contact lenses.

Eye gel Actovegin is used for prophylactic selection of contact lenses in patients with impaired corneal trophism (atrophic and dystrophic processes), with age-related atrophic inflammation of the cornea.

Instructions for eye gel Actovegin

Reading these instructions for the use of Actovegin eye gel does not exempt the patient from studying "Instructions for the medical use of Actovegin ophthalmic gel" in the manufacturer's carton.

Eye gel should be applied to the diseased eye 1-3 times a day, 1-2 drops. When using the product, there may be an increased secretion of secretion, causing discomfort and pain.

The frequency and duration of application of the eye gel may vary depending on the cause and severity of the disease, determined by the attending physician.

After the first opening of the package, the drug should be used within four weeks.

Actovegin during pregnancy

Actovegin during pregnancy is prescribed to women who have already had a miscarriage (spontaneous abortion) to maintain the health of the fetus, further stable pregnancy.

An extract from the blood of young calves is the main element of Actovegin. The medicine promotes the accumulation and transport of glucose, oxygen in the body of a pregnant woman, and improves cell metabolism. Actovegin in pregnant women improves blood circulation, increases the energy reserves of cells and accelerates metabolic processes. The action of the drug begins after 15-30 minutes from the moment of administration. Before taking Actovegin, a pregnant woman should consult a doctor.

Actovegin is prescribed for pregnant women if the following complications occur:

If side effects occur, it is necessary to interrupt the course of treatment, consult a medical specialist.

At the moment, there have been no cases of negative effects of Actovegin on the fetus and the body of a pregnant woman in medicine.

When using the drug in pregnant women, it is necessary to take into account the potential risk to the fetus.

During breastfeeding, there are no contraindications against taking the drug.

Actovegin for children

Actovegin is prescribed for children (usually in tablets) for traumatic brain injuries, metabolic disorders, and circulatory disorders of the brain.

Actovegin is used in ophthalmology for the treatment of children with damage to the cornea of ​​the eye, in the presence of burns, ulcers, abrasions, bedsores, and long-term healing wounds.

Actovegin is an extract from the blood of calves. Due to the physiological basis of the drug, the risk of side effects in children is minimal.

Actovegin is produced in the form of ointment, tablets, gel, cream and ampoules (injections). Depending on the type of disease, the duration of the course of the disease, the doctor prescribes the necessary type of medicine. Appointment of Actovegin to children is different from the use of this drug by adults.

The remedy in tablets is prescribed one piece once a day or half twice a day.

Actovegin injections for newborns are prescribed at a dose of 0.4-0.5 ml / kg once a day intramuscularly, for children aged one to three years - 0.4-0.5 ml / kg, three to six years - 0.25 -0.4 ml/kg once a day.

Before starting systematic injections of Actovegin in children, it is necessary to carry out a trial administration. Side effects of the drug are extremely rare, due to extreme sensitivity to individual components of the drug. Complications are manifested in the form of fever, skin hyperemia, urticaria. With such phenomena, it is necessary to stop taking the medicine, consult a doctor for symptomatic therapy.

Actovegin for atherosclerosis

The use of Actovegin in atherosclerosis avoids complications, surgical intervention. In atherosclerosis, the drug is initially used in the form of injections, then in the tablet form of the drug.

The formation of plaques in atherosclerosis occurs in the aorta, in medium and small arteries. During exercise, muscles require a significant amount of oxygen. Narrowed arteries impede blood supply, as a result, painful sensations arise. With a disease of the arteries of the lower extremities, a person constantly experiences pain, as a result, he needs constant stops, is not able to overcome significant distances on his own.

As a result of poor nutrition and oxygen supply, ischemic changes develop - ulcers and necrosis appear. With a long course of the disease and the absence of adequate treatment, a complete blockage of the vessel occurs, requiring emergency surgical operation to prevent the development of gangrene. After completing the course of treatment with Actovegin for atherosclerosis, a person gets the opportunity to move more without feeling pain and spasms in the legs. AT complex therapy Actovegin improves microcirculation, has a positive effect on the transport and absorption of glucose, and stimulates the uptake of oxygen by cells.

The course use of Actovegin in patients with chronic obliterating diseases (diseases of the arteries of the lower extremities) involves intravenous injections of 800-1000 mg - from 14 to 28 days, then 200 mg tablets 1-2 tablets 3 times a day for 30 days, as a result, it decreases pain syndrome, including when walking.

Actovegin for the brain

Actovegin for the brain is used for cerebrovascular insufficiency - a chronic circulatory disorder of the brain against the background of arterial hypertension, heart disease, venous pathology, atherosclerosis.

With these complications, the brain is constantly in conditions of oxygen and energy deficiency, its normal functioning is disrupted. Increased arterial pressure is a factor provoking these violations.

Actovegin is a neuroprotector that protects neurons from ischemia (insufficient blood supply to the organ), ensures the delivery of oxygen and glucose to neurons, satisfies the energy needs of the brain in conditions of " oxygen starvation". Due to the combination of antioxidant and antihypoxic properties, the action of the drug slows down pathological processes in the brain, provides regeneration (restoration) of damaged neurons and brain functions.

After completing a course of antihypertensive therapy together with Actovegin, improve neurological symptoms, memory, the ability to concentrate, headaches, insomnia stop, working capacity returns, vitality, mood normalizes.

In chronic cerebrovascular insufficiency, tablets and ampoules of Actovegin 10 ml should be taken, initially injections for 10 days. After a course of injections, take 1-2 tablets of the drug 3 times a day, before meals, drinking plenty of water. It must be taken within 1-2 months.

Actovegin for varicose veins

An important mechanism for the development of varicose veins (venous insufficiency) is a violation of microcirculation and a violation of the functions of the endothelium of venous vessels. With varicose veins, Actovegin provides an antihypoxic effect, improves cell metabolism and microcirculation parameters, accelerates healing and epithelialization in case of trophic ulcers. The complex action of Actovegin reduces symptoms (pain, swelling, "heavy legs syndrome"), prevents the progressive development of venous insufficiency.

Actovegin for bedsores

In the treatment of bedsores, all three forms of Actovegin for topical use (gel, cream and ointment) are used. It is allowed to use the drug in combination with other means (solutions of antiseptics).

In the stage of inflammation (first-fourth day), a twenty percent gel is applied to the wound, protecting it from infection. In the stage of granulation (formation of temporary tissue) on the first to fourteenth day, the wound surface of the bedsore is treated with a five percent cream. After the cessation of wet secretions and the beginning of epithelization (fourth to seventeenth days), Actovegin 5% ointment is applied. The combined use of all three forms of the drug contributes to faster and more active tissue regeneration.

Actovegin in diabetes mellitus

Actovegin in diabetes mellitus does not replace and does not compete with hypoglycemic therapy, it complements it. Actovegin saturates cells with glucose, without the risk of causing a sharp decrease in blood sugar. In effective therapeutic dosages, Actovegin does not cause the risk of hypoglycemia.

Blood glucose (blood sugar, glycemia) is the most important controlled variable in humans (homeostasis). The level of blood glucose is controlled by several physiological processes: it rises after eating, decreases due to catabolism, stress, physical activity. In diabetes, blood glucose levels remain constantly high.

Against the background of hyperglycemia in patients with diabetes mellitus, sugar in the urine (glucosuria) is detected.

Sugar in the urine (glucose in the urine, glucosuria, glycosuria) is a laboratory term meaning the presence of sugar in the urine in excess of physiologically justified values. The kidneys are able to return to the bloodstream the entire volume of glucose that has passed through the renal glomerulus. Normal at healthy person glucose in the urine is contained in small volumes (0.06 - 0.083 mmol / l), insufficient for determination in the laboratory.

The body, having lost the main source of energy, compensating for the deficiency, begins to secrete large amounts of hormones that mobilize fats, and primarily adrenaline and adrenocorticotropic hormone (ACTH). Under the influence of these hormones, endogenous fats (fats synthesized in the liver from carbohydrates) are intensively decomposed, and exogenous fats (fats from food) are not sufficiently utilized, which is accompanied by the synthesis of ketone bodies (acetone) in the liver, followed by excretion from the body with urine.

Acetone in the urine is a laboratory term meaning the detection of acetone in the urine in excess of physiologically justified values. Normally, in a healthy person, acetone is not detected in the urine, since it is utilized by the body, excreted with exhaled air, and in extremely small concentrations it can be excreted in the urine.

A systematic increase in sugar (glucose) with prolonged diabetes mellitus leads to disturbances in the functioning of the central nervous system. Nerves receive nutrition from blood vessels, in diabetes mellitus, due to oxygen starvation, this process is disrupted, the first symptoms of damage appear peripheral nerves- polyneuropathy. Damage to the nerves in diabetes mellitus leads to severe pain, impaired sensitivity, muscle cramps.

Diabetic polyneuropathy is one of the most frequent complications diabetes that significantly worsen the patient's quality of life, leading to the development of diabetic foot syndrome. The use of Actovegin in patients with diabetes mellitus improves the energy metabolism of tissues, increases the resistance of cells to ischemia and hypoxia, improves the transport and absorption of glucose, positively affecting the development of neurological symptoms.

Numbness of the legs in the evening is the first alarming symptom of the future occurrence of diabetic foot syndrome (ulcer-necrotic lesions of the skin, soft tissues, in severe cases, the bone tissue of the foot). With a decrease in sensitivity and insufficient blood supply, the healing process of microtraumas and calluses slows down, as a result, gangrene develops. Taking Actovegin in diabetes mellitus in combination with hypoglycemic therapy and diet compensates for the disease and prevents its complications. Under the action of Actovegin in diabetes mellitus, pain, paresthesia (goosebumps, numbness), cracks, ulcers disappear. The use of Actovegin (local and systemic forms) restores blood circulation in the ischemic zone, accelerates tissue regeneration in patients with ulcers, improves microcirculation processes, endothelial function.

Wound healing in gangrene is achieved when blood glucose levels return to normal. The stimulating effect of the drug on wound healing is due to improved glucose utilization, regardless of the genesis (origin) of the wound, and even in the presence of resistance (resistance) to insulin.

Actovegin's analogs

The analogue (synonym) of Actovegin in terms of the active substance is the drug Solcoseryl, manufactured by the pharmaceutical company Solco, Switzerland. Actovegin differs from its counterpart in an extended shelf life.

Price Actovegin

The price of Actovegin tablets, gels, ointments, creams, ampoules and solutions does not include delivery costs if the drug is purchased through an online pharmacy. Prices can vary significantly depending on the place of purchase, dosage and form of release.

The cost of Actovegin:

• Russia (Moscow, St. Petersburg) from 109 to 2150 Russian rubles,
• Ukraine (Kyiv, Kharkov) from 36 to 710 Ukrainian hryvnias,
• Kazakhstan (Almaty, Temirtau) from 513 to 10127 Kazakhstani tenge,
• Belarus (Minsk, Gomel) from 28667 to 565450 Belarusian rubles,
• Moldova (Chisinau) from 31 to 602 MDL,
• Kyrgyzstan (Bishkek, Osh) from 119 to 2344 Kyrgyz soms,
• Uzbekistan (Tashkent, Samarkand) from 4227 to 83377 Uzbek soums,
• Azerbaijan (Baku, Ganja) from 1.6 to 32.0 Azerbaijani manats,
• Armenia (Yerevan, Gyumri) from 749 to 14771 Armenian drams,
• Georgia (Tbilisi, Batumi) from 3.7 to 73.1 Georgian lari,
• Tajikistan (Dushanbe, Khujand) from 10.3 to 202.5 Tajik somoni,
• Turkmenistan (Ashgabat, Turkmenabat) from 5.3 to 103.8 new Turkmen manats.

Buy Actovegin

You can buy Actovegin in the form of tablets, gel, ointment, cream, in ampoules for injections, infusion solution at a pharmacy using the drug reservation service, including. Before you buy Actovegin, you should clarify the expiration dates. You can order Actovegin at any available online pharmacy, the sale is carried out with home delivery by courier, upon presentation of a doctor's prescription.

Producer Actovegin

The manufacturer of Actovegin is the pharmaceutical company Nycomed (Switzerland), which is part of Takeda Pharmaceutical (Japan). In Russia, Actovegin is produced at the Sotex Pharmaceutical Company, owned by Protek.

Takeda Pharmaceutical Company Limited (武,田,«220,Ø97,ð37,業,株,ó35,Ê50,社,) is the largest Asian pharmaceutical company, one of the 15 largest in the world. Takeda's areas of interest include: metabolic, respiratory, cardiovascular diseases, gastroenterology, immunology, neurology, oncology. Nycomed was acquired by Takeda in 2011 for 9.6 billion euros. Takeda's largest US partner is Eli Lilly.

Eli Lilly is an American pharmaceutical company that produces drugs used in oncology, psychiatry, neurology, cardiology, and urology. Eli Lilly became the first company in the twenties of the 20th century to mass-produce drugs used in the treatment of diabetes mellitus (in particular, insulins under the Iletin trademark).

Storage Actovegin

Actovegin should be stored in a dry place, protected from light, out of the reach of children, at a temperature of +5 to +25 °C. Not guaranteed to be saved medicinal properties the drug in case of violation of storage conditions, at a temperature regime that differs from that recommended by the manufacturer. Freezing of the drug is not allowed.

The shelf life of Actovegin is:

• Tablets (drops) - 36 months from the date of release of the drug,
• Gel - 36 months from the date of release of the drug,



Packing photo Actovegin cream 5% 20 grams.



Packing photo Actovegin ampoules 5 ml.