Sulfamonomethoxine (Sulfamonomethoxine) - instructions for use, description, pharmacological action, indications for use, dosage and method of application, contraindications, side effects. Sulfamonomethoxine (Sulfamonomethoxine) - instructions for use

Sulfadimethoxine is a chemical analogue of para-aminobenzoic acid, a substance that is vital for bacteria and some protozoa (Toxoplasma) for the synthesis of their DNA.

Sulfadimethoxine is absorbed by bacteria, disrupts the formation of nucleic acids, as a result, the pathogen cell cannot multiply and function normally.

The drug is active against gram-positive and gram-negative microorganisms: streptococci, staphylococci, Proteus, Escherichia coli, Klebsiella, Shigella and Salmonella, Vibrio cholerae, gonococcus, Toxoplasma, the causative agent of trachoma.

Clinical and pharmacological group

Antibacterial agent, a derivative of sulfanilamide.

Terms of sale from pharmacies

Can buy by prescription.

Price

How much does Sulfadimetoksin cost in pharmacies? The average price is at the level of 35 rubles.

Composition and form of release

Dosage form of Sulfadimethoxine release - tablets: white or white with a creamy tint, flat-cylindrical shape, with a risk and a chamfer (in blister or non-cell packs of 10 pcs., in a cardboard bundle 1 or 2 packs; in polymer cans of 10 pcs., in 1 bank in a cardboard box; 15 pieces in a polyethylene case; 20 pieces in dark glass jars, 1 bank in a cardboard box).

Composition of 1 tablet:

active substance: sulfadimethoxine - 0.2 or 0.5 g;
auxiliary components (0.2 / 0.5 g of active ingredient): aerosil (colloidal silicon dioxide) - 0.000 44 / 0.001 1 g; potato starch of the "Extra" variety - 0.016 92 / 0.042 3 g; calcium stearate - 0.002 2 / 0.005 5 g; medical gelatin - 0.000 44 / 0.001 1 g.

pharmachologic effect

The drug is effective against bacterial infections. Its mechanism of action is to inhibit the enzyme glucose-6-dehydrogenase, which is responsible for the synthesis of dihydrofolic acid (a type of folic acid). It is necessary for bacteria to produce purines and pyrimidines, which are part of the DNA of the cell. Active substance The drug stops reproduction, and does not kill encapsulated bacteria that are dormant in the body, does not cause resistance.

The active ingredient is an analogue of para-aminobenzoic acid, disrupts the metabolism of bacteria and the production of phosphatase enzymes. Sulfadimetoksin inhibits the reproduction of gram-positive staphylococci, streptococci, gram-negative coli, Friedlander's sticks, Klebsiella, pneumococci, pathogens of dysentery and other shigellosis infections. The drug inhibits the growth of chlamydia, has little effect on proteas.

The drug is detected in the blood half an hour after ingestion, reaches a maximum concentration after 8-12 hours, does not penetrate the blood-brain barrier well, therefore it is ineffective against meningitis (caused by meningococcus) and inflammatory processes brain. The active substance of the composition shortly after absorption in the gastrointestinal tract is found in the articular and peritoneal fluid, pleural effusion, exudate of the middle ear. The metabolism of the component occurs in the liver, it is excreted in the urine and bile.

Indications for use

What helps? Sulfadimethoxine is used to treat infectious and inflammatory diseases (caused by microorganisms sensitive to sulfadimethoxine), such as:

pyoderma,
trachoma,
acute respiratory diseases,
inflammatory diseases of the urinary and biliary tract,
dysentery,
drug-resistant forms of malaria (in combination with antimalarial drugs),
inflammatory lesions of the central nervous system, wound infections.

Contraindications

According to the instructions, Sulfadimethoxine is contraindicated in the following cases:

azotemia;
porphyria;
pregnancy and lactation (the appointment of Sulfadimethoxine is possible only in cases where the expected benefit exceeds the possible harm);
age up to 3 months;
disease thyroid gland;
oppression of bone marrow hematopoiesis;
congenital deficiency of glucose-6-phosphate dehydrogenase;
liver / kidney failure;
chronic heart failure;
individual intolerance to the components of the drug.

Caution when using Sulfadimethoxine (relative contraindications) is required in the presence of the following diseases / conditions:

anemia with a reduced color index;
functional disorders of the liver / kidneys;
folate deficiency.

Appointment during pregnancy and lactation

Sulfadimethoxine is highly undesirable to use during pregnancy and during breastfeeding, since it penetrates well through the placenta and into breast milk, and can cause dyspepsia, liver and kidney disorders, kernicterus, or hemolytic anemia in a child.

Dosage and method of application

As indicated in the instructions for use, before taking it, it is necessary to check the sensitivity of pathogenic microflora to this drug. It does not make sense to use sulfadimethoxine in the absence of sensitivity, since the harm caused active substance the body outweighs the benefits of fighting pathogenic bacteria.

Adults are prescribed a dose of 1000 mg on the first day, then 500 mg per day. In the case of a severe course of infection, it is possible to increase the starting dose to 2 mg, and the daily dose to 1 mg. Take the medicine once a day, after meals. The duration of treatment is 7-10 days.
For children, the drug is prescribed at a dose of 25 mg / kg of body weight on the first day, and 12.5 mg / kg per day on the following days.
Reception of the drug must necessarily take another 2-3 days after the decrease in body temperature. During the use of the drug, it is necessary to limit the patient's exposure to the sun, or his exposure to ultraviolet radiation.

It is necessary to strictly observe the time interval for taking the tablets. Do not take a double dose if the drug was not taken on time. In this case, you should drink it as quickly as possible, and not move the dose too close to the next one in order to avoid overdose.

In the veterinary medicine of small animals, children's dosages of the drug are used.

Side effect

The use of Sulfadimethoxine can cause the following side effects:

Central nervous system: possible headache.
Hematopoietic system: rarely - agranulocytosis, leukopenia.
Digestive system: cholestatic hepatitis, nausea, dyspeptic symptoms, vomiting.
Allergic manifestations: drug fever, skin rashes

Overdose

The state of oversaturation of the body with the drug is clinically manifested in intense thirst, severe dryness in the mouth, a small amount of rich yellow-brown urine, pain in the right hypochondrium (projection of the liver) and lower back (renal localization). Biochemical analysis will reveal a significant increase in enzymes such as AST, ALT and acid phosphatase.

Therapeutic measures for overdose:

Reflexogenic initiation of vomiting.
Gastric lavage or high cleansing enema.
Astringents and adsorbents orally.
Salt laxatives.
Forced diuresis, if the drug has been completely absorbed from the gastrointestinal tract.

special instructions

It is used externally as part of combined preparations.

Interaction with other drugs

Sulfadimetoksin reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins).

"Sulfamonomethoxine" used in the treatment and/or prevention the following diseases(nosological classification - ICD-10):

Molecular formula: C11-H12-N4-O3-S

CAS code: 1220-83-3

Description

Characteristic: White or off-white crystalline powder. Very poorly soluble in cold water, bad - in alcohol, easily soluble in dilute hydrochloric acid.

pharmachologic effect

Pharmacology: Pharmacological action - antimicrobial, antibacterial (bacteriostatic). It is an antagonist of para-aminobenzoic acid and competitively inhibits dihydropteroate synthetase, which provides the synthesis of folates in a bacterial cell (folic and dihydrofolic acids). A decrease in the amount of dihydrofolic acid and its active metabolite, tetradihydrofolic acid, leads to a violation of the transfer of one-carbon fragments and stops the formation of purines, pyrimidines and DNA: the growth and reproduction of most gram-positive and gram-negative microorganisms, chlamydia, plasmodium, toxoplasma stops.

After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. Bioavailability is 70-100%. In the blood, it binds to plasma proteins by 50-60%. It penetrates well into various organs and tissues. Passes through the placental barrier, penetrates into breast milk. Through the intact BBB does not penetrate. Undergoes biotransformation in the liver by acetylation with the formation of inactive metabolites. Excreted by the kidneys as metabolites. If the urine is acidic, it can contribute to stone formation.

Indications for use

Application: Bronchitis, tracheitis, pharyngitis, laryngitis, otitis media.

Contraindications

Contraindications: Hypersensitivity, impaired liver and kidney function, blood diseases, megaloblastic anemia, porphyria, glucose-6-phosphate dehydrogenase deficiency, pregnancy, breast-feeding (stop treatment for the duration breast-feeding), childhood(up to 14 years old).

Side effects

Side effects: Headache, dizziness, lethargy, dyspepsia (nausea, vomiting, diarrhea), interstitial nephritis, tubular necrosis, crystalluria, hematuria, liver damage, photosensitivity, thyroid dysfunction, hypocoagulation, agranulocytosis, leukopenia, methemoglobinemia, anemia, allergic reactions: Lyell's syndrome, Stevens-Johnson syndrome, urticaria, anaphylactic shock.

Interaction: Enhances the effects of anticoagulants, anticonvulsants and oral hypoglycemic agents, methotrexate, phenylbutazone, as well as the risk of developing side effects when prescribing myelodepressants, oral contraceptives, hemolytic and hepatotoxic medicines. Reduces the effectiveness of cyclosporine and bactericidal drugs.

Dosage and method of application

Dosage and administration: inside. For adults: on the first day 1 g, on the following days 500 mg 1 time per day. Children: on the first day, 25 mg/kg, on the following days, 12.5 mg/kg orally 1 time per day. The course of treatment is 7-14 days.

Name: Sulfamonomethoxin (Sulfamonomethoxinum)

Pharmacological effect:
Long-acting sulfonamide drug. Rapidly absorbed; penetrates the blood-brain barrier (the barrier between blood and brain tissue). Relatively low toxicity. According to the spectrum of antibacterial action and indications for use, it is close to sulfapyridazine.

Sulfamonomethoxin - indications for use:

infections respiratory tract, purulent infections of the ear, throat, nose, dysentery, enterocolitis (inflammation of the small and large intestine), infections of the gallbladder and urinary tract, pustular skin diseases, wound infection, generalized meningococcal infection(disease caused by meningococcus bacteria) purulent meningitis(purulent inflammation of the meninges), gonorrhea; to prevent purulent bacterial infection in the postoperative period.

Sulfamonometoxin - method of application:

Before prescribing a drug to a patient, it is desirable to determine the sensitivity of the microflora to it that caused the disease in this patient. Inside, 0.5-1 g 2 times on the first day of treatment, then 0.5-1 g once a day; children - 25 mg / kg on the first day of treatment and 12.5 mg / kg on subsequent days. The course of treatment is 7-14 days.
For meningitis on the first day, 2 g 2 times a day, then 2 g once a day. With gonorrhea, the first two days, 1.5 g 3 times a day and 1 g in the following days. The course of treatment is 5 days.

Sulfamonometoxin - side effects:

In some cases, nausea, headache, leukopenia (decrease in the level of leukocytes in the blood), allergic reactions.

Sulfamonometoxin - contraindications:

Allergic reactions to sulfonamides.

Sulfamonometoxin - release form:

Tablets of 0.5 g in a package of 15 pieces.

Sulfamonomethoxin - storage conditions:

List B. In a dark place.

Sulfamonomethoxin - synonyms:

Daimeton, Dufadin.

Important!
Before using the medicine Sulfamonomethoxine you should consult your doctor. This manual is for informational purposes only.

Gross formula

C 11 H 12 N 4 O 3 S

Pharmacological group of the substance Sulfamonometoxin

Nosological classification (ICD-10)

CAS code

1220-83-3

Characteristics of the substance Sulfamonometoxin

White or off-white crystalline powder. Very poorly soluble in cold water, poorly in alcohol, freely soluble in dilute hydrochloric acid.

Pharmacology

pharmachologic effect- antibacterial, bacteriostatic, antimicrobial.

It is an antagonist of para-aminobenzoic acid and competitively inhibits dihydropteroate synthetase, which provides the synthesis of folates in a bacterial cell (folic and dihydrofolic acids). A decrease in the amount of dihydrofolic acid and its active metabolite, tetradihydrofolic acid, leads to a violation of the transfer of one-carbon fragments and stops the formation of purines, pyrimidines and DNA: the growth and reproduction of most gram-positive and gram-negative microorganisms, chlamydia, plasmodium, toxoplasma stops.

Application of the substance Sulfamonometoxin

Bronchitis, tracheitis, pharyngitis, laryngitis, otitis media.

Contraindications

Hypersensitivity, impaired liver and kidney function, blood diseases, megaloblastic anemia, porphyria, glucose-6-phosphate dehydrogenase deficiency, pregnancy, breast-feeding (for the duration of treatment stop breast-feeding), children's age (up to 14 years).

Side effects of the substance Sulfamonometoxin

Headache, dizziness, lethargy, dyspepsia (nausea, vomiting, diarrhea), interstitial nephritis, tubular necrosis, crystalluria, hematuria, liver damage, photosensitivity, thyroid dysfunction, hypocoagulation, agranulocytosis, leukopenia, methemoglobinemia, anemia, allergic reactions: Lyell's syndrome, Stevens-Johnson syndrome, urticaria, anaphylactic shock.

Sulfamonomethoxin (Sulfamonomethoxinum)

pharmachologic effect

Long-acting sulfonamide drug. Rapidly absorbed; penetrates the blood-brain barrier (the barrier between blood and brain tissue). Relatively low toxicity. According to the spectrum of antibacterial action and indications for use, it is close to sulfapyridazine.

Indications for use

Respiratory tract infections, purulent infections of the ear, throat, nose, dysentery, enterocolitis (inflammation of the small and large intestine), infections of the gallbladder and urinary tract, pustular skin diseases, wound infection, generalized meningococcal infection (a disease caused by meningococcal bacteria), purulent meningitis ( purulent inflammation of the meninges), gonorrhea; for the prevention of purulent bacterial infection in the postoperative period.

Mode of application

For meningitis on the first day, 2 g 2 times a day, then 2 g once a day. With gonorrhea, the first two days, 1.5 g 3 times a day and 1 g in the following days. The course of treatment is 5 days.

Side effects

In some cases, nausea, headache, leukopenia (decrease in the level of leukocytes in the blood), allergic reactions.

Contraindications

Allergic reactions to sulfonamides.

Release form

Tablets of 0.5 g in a package of 15 pieces.

Storage conditions

List B. In a dark place.

Synonyms

Daimeton, Dufadin.

Attention

Before using the drug Sulfamonomethoxine you should consult your doctor. This manual is provided in a free translation and is intended for informational purposes only. For more information, please refer to the manufacturer's annotation.