Tsetrin and pregnancy: concepts are incompatible. Cetrin and allergies: what is more dangerous during pregnancy? Is Cetrin pregnant or not?

Among the many antihistamines medicines Cetrine is the most popular. The drug is intended to eliminate year-round or seasonal allergies. Cetrin is a second-generation antiallergic drug.

The active substance of the drug is cetirizine, which blocks H1 - histamine receptors. Cetirizine is not able to block cholinergic and serotonin receptors.

The active substance prevents the appearance of edema, helps relieve spasm of smooth muscles. The drug reduces the blood levels of substances such as neutrophils, basophils, eosinophils, etc. In asthma medium degree severity, the drug reduces bronchoconstriction.

The drug has an antiexudative and antipruritic effect.

Cetrin helps to eliminate the appearance of skin reactions that have arisen due to various factors: cooling, allergens or the introduction of histamine.Cetrin has a high absorption capacity and good absorption from the gastrointestinal tract. After taking the drug, plasma concentrations are reached after an hour.

In addition to cetirizine, the composition of the drug includes the following substances:

Sorbic acid
Talc
Lactose
Corn starch
Magnesium stearate
Hypromelase
Povidone

The drug begins to act after consumption in the form of a tablet or syrup after 30 minutes. Cetrin in not in large numbers metabolized in the liver and excreted along with stool. The half-life in adults is about 7-10 hours, and in children - 6 hours. At correct use and observing the indicated dose, the drug does not cause a sedative effect.

When using the drug during breastfeeding, there is a possibility of penetration active substance into breast milk.After the end of taking the drug, its effect persists for another 3 days.

Prescribing the drug

The drug Tsetrin is prescribed in the following cases:

allergic conjunctivitis and
Allergic form of dermatosis
Atopic dermatitis
Chronic urticaria
hay fever

The active substance of the drug eliminates all signs of allergies: itching, redness, swelling, rashes. You can use the drug at various stages of the manifestation of allergic reactions.

Dosage

The drug can be used not only in medicinal purposes to eliminate symptoms, but also preventive, to avoid allergic reactions.

You can use the drug for children over 6 years old. Dose antihistamine for children from the age of 6 and adults per day is 10 mg. This is one drug. Adults should take the remedy in one dose, and for children the dose can be divided into two doses: 1/2 of the tablet in the morning and in the evening.

In renal insufficiency, the dosage is reduced by half. Take the tablet with clean drinking water.

Cetrine syrup is taken with or without food. It is better to give medicine to children in the evening before going to bed. for adults and children over 6 years old is 10 ml. It is possible to use syrup for children under 6 years of age. The dosage of the drug is prescribed by the doctor: 5 ml or 2.5 ml, depending on the degree of manifestation of allergy symptoms.

More information about allergies can be found in the video.

The course of taking the drug is prescribed for each individually and is basically 1 month. If the allergic condition is very severe, then the period of taking Cetrin is extended to 3-6 months.

Stop taking the drug a few days before the allergy test.During treatment, you should stop drinking alcohol. Alcohol and antihistamines do not go together. If during the reception antihistamine drug drink alcohol even in small quantities, then this combination acts depressingly on the nervous system. As a result, hallucinations and delusions may occur.

Side effects

When using the drug, they rarely occur. While taking Cetrin, the following side reactions may occur:

Headache
Dizziness
Migraine
Drowsiness
Weakness
Abdominal pain
Flatulence

If you follow all the doctor's instructions for the use of the drug, then an overdose is not observed. Neglecting the recommendations of a specialist and using therapeutic doses higher than prescribed can lead to skin rashes, itching, urinary retention, tachycardia, constipation, tremors, etc.

If these signs are observed against the background of the use of Cetrin, you should stop taking the antihistamine and wash the stomach.

If necessary, symptomatic therapy is prescribed using drugs such as Enterosorb, Polysorb, Laktofiltrum, etc. After that, the patient's condition returns to normal.The use of the drug is contraindicated in case of intolerance to the components that make up the drug.

The effect of the active substance is reduced with the simultaneous use of Cetrin and Theophylline. Caution should be exercised when using Cetrin together with sedatives.

Use during pregnancy and lactation

Cetrin during pregnancy and lactation

During and during breastfeeding, the use of the drug is prohibited. Almost all antihistamines are not used during pregnancy. This is due to the penetration of the active substance through the placenta, which can affect the development and formation of the fetus. This will mainly affect the formation of the head and spinal cord.

Histamine is a necessary element during pregnancy. With his participation, the egg after fertilization is attached to the wall of the uterus. Also, this component takes part in the development of the embryo. Histamine is able to regulate the metabolism of the fetus.

You should know that taking medications that suppress the production of histamine is strictly prohibited, as this may not be the best way to affect the condition of the fetus.

The use of Cetrin by a pregnant woman will adversely affect the functioning of the kidneys and liver. Compared to other antihistamines, Cetrin has a clear advantage. Doctors prescribe medicine in rare cases, so a pregnant woman should take it with great care and under the supervision of a doctor. In the first trimester of pregnancy, the drug is not used.

With lactation active substance in large quantities passes into breast milk. Therefore, with milk, the child will receive the drug, which should not be allowed.If during the period a woman has an allergic reaction, then you should consult a doctor for a drug that is not contraindicated during pregnancy.

The antihistamine Cetrin is available in the form, which have a biconvex shape and are covered with a white shell. One tablet contains 10 mg of the active substance cetirizine.

For children with allergic reactions, Cetrin is used in the form. In this form, the drug is convenient to give to children. The syrup is transparent, sometimes yellowish in color, with a fruity aroma. The package includes a measuring spoon.

When ingested, the drug immediately acts and prevents the further development of allergies. You can use the drug for no more than 6 months.

The shelf life of the antihistamine is 2 years.

You can not use the drug after the specified period. When storing the drug, be sure to leave the leaflet. It is recommended to store the drug in a dark place, and avoid direct sunlight. The optimum temperature for storing the drug is 15-25 degrees.

Drug analogues

Types of analogues of Tsetrin - antiallergic drugs

Cetrin has many analogues that differ in therapeutic activity.

Similar antihistamines, where the active ingredient is cetirizine, include Zodak, Zirtek, Cetirinax, Allertec, Rolinoz, etc. This is the latest generation of antiallergic drugs. Antihistamines do not affect the nervous system and are characterized by a powerful therapeutic effect. These drugs are closer to Tsetrin not only in composition, but also in the concentration of substances and the form of release.

The price of such drugs is higher, unlike other drugs that have the same effect:

Loratadine
Ketotifen
Suprastin
Claridol
Diazolin

These are inexpensive analogues of Tsetrin, which belong to the first generation. Basically, these drugs cause various side effects and have low therapeutic effects.

The replacement of the drug can only be made by the attending physician, taking into account the sensitivity to the components of the drug and the patient's condition.

Antihistamines latest generation much more efficient. Before taking any antihistamine, you should read the instructions.

Thanks

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

medicinal product Tsetrin represents antihistamine, which is designed to eliminate the symptoms of an allergic reaction in children and adults. Cetrin belongs to a group of selective (selective) antihistamines, which are also called histamine blockers . The drug does not have a strong sedative effect and depression of the central nervous system therefore it is used mainly as an antiallergic agent from 2 years of age.

Release forms

The drug Cetrin is produced by the Indian Pharmaceutical Corporation DR. REDDY`S LABORATORIES, LTD in the form of tablets and syrup. The syrup is often referred to as "children's Cetrin" because it is this form that is used to treat allergy symptoms in a child. You can also find the common name "Cetrin drops" instead of the correct "syrup", which is used to refer to the liquid dosage form of the drug. In this case, "Cetrin drops" = "Cetrin syrup", that is, we are talking about the same dosage form, just named differently.

Cetrin syrup is available in dark glass bottles of 30 and 60 ml. Each vial comes with a measuring spoon. The syrup is transparent, uncolored (a slight yellowish tint is allowed), homogeneous, does not contain suspended particles. A slight opalescence is possible. Has a pleasant fruity scent.

Tablets are sold in packs of 10, 20 and 30 pieces. The tablet itself has a round, biconvex shape and a risk on one side. From above it is covered with a film cover of white color.

Composition and dosage

The tablets and syrup contain the active ingredient cetirizine. The dosage of cetirizine in one tablet is 10 mg, and in syrup - 1 mg per 1 ml. Therefore, if you need to take Cetrin in small doses (less than 10 mg), it is better to use syrup rather than tablets. In this case, you can always measure the exact amount of syrup in ml, which will contain the required dose of the active substance. A tablet can only be broken in half.
The syrup contains the following substances as auxiliary components:

glycerol;
sucrose;
benzoic acid;
sodium edetate;
sorbitol;
sodium citrate;
fruit flavor.

Tablets as auxiliary components contain the following substances:

lactose;
corn starch;
povidone;
magnesium stearate.

Cetrin - a generation of antihistamines

To date, there are only three generations of antihistamines. Tsetrin refers to the second. Consider general characteristics and the main differences between the three generations of histamine blockers from each other.

First generation antihistamines(Suprastin, Tavegil, Diazolin, Fenistil, etc.) has a non-selective effect on receptors. That is why drugs block histamine receptors located in the central nervous system and organs of the digestive tract. The consequence of this non-selectivity is a powerful inhibitory effect of drugs, which is the most significant side effect (drowsiness). Briefly, first-generation antihistamines are characterized by a powerful anti-allergic effect and a pronounced side effect in the form of drowsiness.

Second generation antihistamines(Zirtek, Zodak, Cetrin, Cetirizine, Parlazin, etc.) is characterized by a significantly lower effect on the central nervous system due to selective action on receptors. This means that the side effect in the form of CNS depression and drowsiness in second-generation drugs is much less pronounced than in the first. Unfortunately, the antiallergic effect of the second generation drugs is also less pronounced than that of the first. So the short answer is: less drowsiness and less efficacy on allergy symptoms compared to first generation drugs.

Third generation antihistamines(Claritin, Erius, Telfast, etc.) has a high selectivity of action on histamine receptors. Therefore, these drugs have practically no effect on the central nervous system, that is, they do not cause drowsiness. However, the severity of the antiallergic effect of the third generation drugs is not lower than that of the first. Thus, a brief description of these antihistamines is as follows: a powerful antiallergic effect and practically complete absence side effects on the CNS in the form of drowsiness.

Allergy tablets Cetrin (therapeutic effects)

The therapeutic effects of Cetrin are due to the active substance - cetirizine, which is a blocker of histamine receptors. This means that cetirizine binds to receptors and blocks them. As a result, the released histamine cannot bind to its receptors and has no effect. Namely, histamine is responsible for the development of manifestations of an allergic reaction (itching, redness, swelling, rash, etc.). Thus, Cetrin blocks the development of an allergic reaction at the cellular level and, thereby, prevents the formation of its external manifestations (pain, itching, swelling, etc.).

In addition, Cetrin reduces the amount of released histamine and reduces the migration of eosinophils to the site of an allergic reaction. A decrease in the number of eosinophils in the focus of allergic inflammation leads to a significant decrease in the severity of the late stages of the hypersensitivity reaction. Cetrin also has a general anti-inflammatory effect, inhibiting the production of cytokines that support the inflammatory response.

When used as courses prophylactic the drug has the ability to reduce the readiness for the development of an allergic reaction in the cells of the bronchi, which leads to a decrease in the frequency of attacks in patients with asthma. In the same way, Cetrin suppresses the development of an allergic skin reaction in people suffering from urticaria and dermographism.

The therapeutic effect of Cetrin begins 20 minutes after taking the drug, and lasts up to 24 hours. Therefore, it is enough to take it only once a day. After stopping the use of the drug, the readiness for the development of allergic reactions is restored after three days.

Thus, the main therapeutic effects of Cetrin are as follows:
1. Eliminates itching.
2. Removes and prevents swelling.
3. Relieves spasm of smooth muscles.
4. Reduces the permeability of capillaries and the release of fluid into the tissue.

Indications

Syrup and tablets are used to eliminate allergy symptoms in the following conditions:

seasonal or year-round runny nose;
allergic conjunctivitis;
hay fever;
urticaria of any type;
dermatoses with severe itching (for example, neurodermatitis, atopic dermatitis, etc.);
pruritus of any origin, except for that caused by cholestasis;
bronchial asthma;

Tsetrin - instructions for use (how to take)

Both tablets and Cetrin syrup are taken orally, regardless of food, with a small amount of plain water. Syrup can be given to children from 2 years of age, and tablets - only from 6 years. Since the drug has a long-term effect, it can be taken only once a day. Moreover, it is better to do this in the evening, before going to bed, so that during the day you do not experience any discomfort associated with possible drowsiness.

How to take Cetrine Syrup

The dosage is determined by the age of the person:
1. Children from 2 to 6 years old take 5 ml of syrup (5 mg) once a day, in the evening. If the child does not tolerate such a dose, it can be divided into two doses - 2.5 ml of syrup 2 times a day, morning and evening.
2. Children over 6 years of age and adults take 10 ml of syrup (10 mg) once a day, in the evening, at bedtime. If necessary, you can distribute a dose of 10 mg into two doses - 5 ml of syrup in the morning and evening.

Elderly people who do not suffer from kidney disease can take Cetrin at the usual adult dosage.

Patients suffering from renal insufficiency should use Cetrin in doses that depend on the value of the glomerular filtration coefficient, determined using the Rehberg test. Dosage of Cetrin for people suffering kidney failure, is reflected in the table:

If a hypersensitivity reaction develops in response to taking Cetrin syrup, the use of the drug should be stopped immediately.

Before conducting allergy tests (Prik test), it is necessary to stop taking Cetrin 3 to 4 days in advance in order not to get false negative results.

Adults should refrain from drinking alcohol while using Cetrin. Also, against the background of the use of the drug, it is necessary, if possible, to abandon any activity that requires an increased concentration of attention and a high speed of reactions.

Interaction with other drugs. Combined use with theophylline leads to a prolongation of the action of Cetrin for more than 24 hours.

Overdose Tsetrina is possible with a single dose of more than 50 ml of syrup. Overdose symptoms are:

drowsiness;
cessation of urine output;
restlessness and increased irritability.

When treating an overdose, first of all, gastric lavage is performed to remove drug residues from the body. Hemodialysis in this case is ineffective. If necessary, symptomatic drugs are used to maintain normal pressure, urination, breathing, etc.

How to take Cetrin tablets

Children can take the drug in the form of tablets only from the age of 6. Tablets are taken orally, not chewed, but simply swallowed and washed down with a small amount of plain water. Since the drug acts for a long time, the tablet should be taken only once a day. It is best to take Cetrin in the evening, so as not to experience discomfort from possible daytime drowsiness.

The dosage of tablets is the same for adults and children over 6 years of age. Usually adults take 1 tablet (10 mg) once a day (preferably in the evening). And for children, a daily dose of 10 mg is divided into two doses - half a tablet (5 mg) twice a day, in the morning and in the evening.

Patients with impaired renal function should take Cetrin tablets at half the dosage, that is, half a tablet (5 mg) once a day. In the presence of renal insufficiency, there may be an accumulation of the drug in the blood, which increases the risk of side effects.

With the development of a hypersensitivity reaction while taking the tablets, you should immediately stop using them and consult a doctor. Before carrying out allergy tests (Prik test), it is necessary to stop using Cetrin tablets at least 3 days in advance.

During treatment, alcoholic beverages should be avoided. Since the drug can lead to the development of drowsiness, any activity that requires a high concentration of attention and speed of reactions should also be avoided.

Overdose Cetrin is possible when taking more than 3 to 4 tablets at a time. Symptoms given state are drowsiness, anxiety, pruritus, rash, urinary retention, fatigue, tremor (shaking limbs), tachycardia (palpitations). To treat an overdose, first of all, the remains of the drug should be removed from the body by gastric lavage. Hemodialysis should not be performed as this procedure is not effective in removing Cetrin from the blood. If necessary, use symptomatic drugs that support basic vital functions.

Interaction with other drugs has not been identified. However, it is recommended to carefully combine the simultaneous use of Cetrin tablets and drugs with a sedative effect.

Tsetrin for children

Cetrin is allowed to be used in children from 2 years of age. From 2 to 6 years old, Cetrin is allowed to be used exclusively in the form of a syrup, and after 6 years old children can also take tablets.

The use of the drug allows you to quickly eliminate the excruciating itching in a child, to whom he delivers particularly severe discomfort. After all, a child is often simply unable to restrain his desire to "scratch", he literally scrapes the skin with his nails. As a result, numerous wounds and scratches form on the skin, into which the infection easily penetrates. As a result, an allergic reaction is complicated by an infectious process. Removing the painful itching, Cetrin normalizes the child's sleep and indirectly prevents the development of skin infections.

In addition, the drug has the ability to reduce the allergic activity of the skin and bronchi. With regular use, this reduces the risk of attaching respiratory symptoms (bronchospasm, larynx, difficulty breathing, shortness of breath, swelling of mucous membranes, etc.) of an allergic reaction to existing skin reactions (itching, redness, swelling, rash). That is, Cetrin prevents the transition of dermatitis to serious illness- bronchial asthma or allergic rhinitis. This spread of symptoms of an allergic reaction from the skin to the respiratory organs is called atopic march. That is why doctors talk about the ability of Cetrin to prevent atopic march in young children.

The dosage of the drug is determined by the age of the child. Possible options for the use of tablets and syrup Cetrin in children are shown in the table:

Cetrin tablets must be taken twice a day, since the child should not be given the entire daily dose at one time.

If the child has impaired renal function, then the daily dosage of Cetrin should be reduced by half. This means that children 2-6 years old can take a maximum of 2.5 ml of syrup per day. Children over 6 years of age can take a maximum of 5 ml of syrup per day, or one tablet every two days.

Doctors recommend using Cetrin syrup for children, since it is more convenient to dose it, and it is better perceived by the child. The baby is more likely to drink a pleasantly smelling syrup than a pill, which is associated with bitter medicine. Therefore, in order not to cause unnecessary psychological trauma to the child, it is recommended to give him the drug in the form of a syrup.

If one dose of the drug has been missed, nothing needs to be done. Just continue giving your child Cetrin at the usual dosage the next day without increasing it.

Application during pregnancy

Both syrup and Cetrin tablets are contraindicated for use during pregnancy and during lactation. This is due to the fact that the drug crosses the placenta and can have a negative impact on the formation of the child's brain. When breastfeeding, the drug passes into the mother's milk in large doses. That is why Cetrin is prohibited for use by pregnant women and nursing mothers.

How many days to take Cetrin?

The duration of the use of Cetrin depends on a number of factors, the determining of which is the severity and nature of the course of an allergic disease.

So, Cetrin is used to relieve an acute allergic reaction for a maximum of 10 to 14 days. If the symptoms of an allergic reaction disappear faster than after 10 days, then the drug is stopped earlier. Thus, in the treatment of an acute allergic reaction, the duration of administration is determined by the rate of disappearance of symptoms. As soon as the allergy symptoms disappear, you can immediately stop taking the drug. However, in this case, continuous use of Cetrin for more than 14 days is not allowed.

When taking Cetrin as a prophylactic to prevent exacerbations of allergic diseases (for example, runny nose, hay fever, dermatitis, etc.), a longer course of treatment is required. Usually the prophylactic course of the drug is 1 - 1.5 months. Doctors recommend taking Cetrin for prevention throughout the entire period of the presence of a potential allergen in the surrounding space. For example, if you are allergic to flowering plants, you need to take Cetrin in May-June until all the trees have faded.

Cetrin can also be used to treat bronchial asthma as a basic antihistamine in combination with other drugs. In this case, the drug is taken in a course of 15 to 20 days, then they take a break for 1 week. After the break, the reception is resumed again. This method of taking Cetrin in the treatment of bronchial asthma has been practiced for years.

Children early age(up to 7 years old), prone to allergic reactions like dermatitis, can take Cetrin prophylactically 3-4 times a year, in short courses of 10-14 days. Such prophylaxis is necessary to prevent the atopic march in children prone to true allergic reactions.

Side effects

Tablets and syrup Cetrin have exactly the same side effects, which appear mainly from the central nervous system. Side effects of both dosage forms of Cetrin on the part of various organs and systems are presented in the table:

Contraindications

Contraindications to the use of syrup and Cetrin tablets are also the same. The drug should not be used in the presence of the following conditions:

hypersensitivity or allergy to the components of the drug;
period of pregnancy;
children's age under 2 years (for syrup);
children under 6 years of age (for tablets).

Relative contraindications to the use of Cetrin are renal failure and elderly age person. In these cases, the drug can be used by reducing the usual adult dose, and organizing medical supervision of the patient's condition.

Analogues

Cetrin in the domestic pharmaceutical market has both analogues and synonyms. Analogues include all drugs from the pharmaceutical group of antihistamines (histamine blockers). Synonyms of Cetrin include antihistamines, which also contain cetirizine as an active ingredient.

So, the following drugs are synonymous with Tsetrin:

Alerza tablets;
Tablets Allertec;
Tablets Levocetirizine-Teva;
Cetirizine DS tablets;
Tablets Cetirinax;
Cetirizine-OBL tablets;
Cetirizine-Teva tablets;
Tablets and drops Zyrtec;
Drops, syrup and tablets Zodak;
Solution and tablets Letizen;
Drops and tablets Parlazin;
Cetirizine tablets;
Drops, syrup and tablets Cetirizine Geksal;
Syrup and tablets Cetrin;
Syrup and tablets Zetrinal;
Syrup and tablets Zincet.

Analogues of Tsetrin include the following drugs:

Tablets Alerpriv;
Tablets Allerfeks;
Bexist-sanovel tablets;
Tablets Glenset;
Gistafen tablets;
Gifast tablets;
Diacin tablets;
Tablets Dimebon;
Tablets Dimedrohin;
Dinox tablets;
Dramina tablets;
Desloratadine-Teva tablets;
Tablets Clallergin;
Clarifer tablets;
Ketotifen-Ros tablets;
LoraGeksal tablets;
Tablets Loratadin Stada;
Tablets Loratadin-Verte;
Tablets Loratadin-Teva;
Tablets Loratadin-OBL;
Tablets Lordestin;
Rupafin tablets;
Ciel tablets;
Tablets Telfast;
Caeser tablets;
Feksadin tablets;
Fexo tablets;
Fexofast tablets;
Fexofenadine tablets;
Drops and tablets Ksizal;
Drops and tablets Claritin;
Syrup and tablets Clargotil;
Syrup and tablets Claridol;
Syrup and tablets Clarisence;
Syrup and tablets Clarotadine;
Syrup and tablets Kestin;
Syrup and tablets Ketotifen;
Syrup and tablets Ketotifen Sopharma;
Syrup and tablets Loratadine;
Syrup and tablets Loratadin-Hemofarm;
Syrup and tablets Peritol;
Drops and tablets Suprastinex;
Syrup and tablets Erius;
Syrup and tablets Erolin;
Lomilan tablets, lozenges and suspension;
Dragee and Diazolin tablets;
Capsules Rapido;
Semprex capsules.

Quincke's edema;

How to use Cetrin

Goods for Health and Beauty, Sports and Leisure. Delivery across Russia.

Website Neboleem-net.ru

Copying materials is prohibited.

Before using medicines, consult with your doctor. 18+

Is it possible to drink "Cetrin" during pregnancy?

Against the background of increased production of histamine, nasal congestion, lacrimation are observed, natural breathing is disturbed, there is a feeling of itching and burning in paranasal sinuses. The development of side effects is highly undesirable during the period of gestation.

The therapeutic regimen for pregnant women includes sparing antihistamines of the 3rd generation, among which Cetrin is widely used. The active ingredients are devoid of cardiotoxic sedative effect, have high selectivity, and are not addictive. Is it possible to drink "Cetrin" during pregnancy, and in what doses / course, so as not to harm the health of the baby and mother?

The feasibility of taking "Cetrin" at different gestation periods

The drug is presented on the pharmacological market as syrup and tablets coated with a multicomponent soluble coating. Regardless of the form of release, the main composition forms a competitive histamine antagonist - cetirizine.

Find out here which drops can be used during pregnancy to restore nasal breathing.

The H1 blocker of histamine receptors exhibits antipruritic, antiexudative and antiallergic activity. The therapeutic effect is enhanced by the presence of excipients in the composition: corn starch, lactose, povidone KZO.

"Cetrin" relieves the symptoms of an allergic reaction, prevents the development of pathological changes in the influence of antigens. The action of the drug is aimed at inhibiting the synthesis of stimuli, reducing the cells of the leukocyte germ, increasing the capacity of the capillaries.

The components are rapidly absorbed in the gastrointestinal tract, the medical effect occurs within an hour after ingestion, lasts up to 24 hours.

The productivity and safety of "Cetrin" explains the fact that it does not affect serotonin and cholinergic nerve endings. Research that would prove possible harm maternal and unborn child health have not been conducted on patients.

For reference! The constituent components can be excreted with milk during breastfeeding, so antihistamines are prohibited during lactation.

According to the instructions for use of "Cetrin" during pregnancy, the drug is included in the therapeutic regimen at all stages of gestation, when the threat to the health of the mother and child exceeds potential harm from taking medication.

In order to prevent the risk of side effects, it is necessary to take an allergic agent according to the doctor's recommendations and under medical supervision.

The use of "Cetrin" in the 2nd trimester has a minimal toxic effect on the fetus. Bookmark internal organs completed, the placenta is formed, the fetus is protected from the effects of the components of the drug.

Contraindications

Due to the fact that the drug is excreted from the body mainly by the kidneys, it is prescribed with caution to patients with a history of renal and hepatic insufficiency.

For reference! In the therapeutic scheme of the elderly, "Cetrin" is included in a reduced dosage.

In pediatrics, a pharmaceutical product is allowed from the age of six, mainly in the form of a syrup. With hypersensitivity of the body to individual components or overdose, the development of the following disorders is noted:

headaches;
signs of intoxication;
depressive state;
dizziness;
elevated blood pressure, tachycardia;
tremor of the upper limbs;
feeling of dryness in the mouth.

"Cetrin" during early pregnancy

After fertilization of the egg, the period of embryo formation begins, which covers the first 13 weeks. At this time, the laying of organs and systems takes place. Reproducing fetal cells are sensitive to external factors impact.

The use of pharmacological products at an early gestational age is fraught with serious pathological disorders.

A weak placental barrier does not create any hope of protection against the penetration of medicinal components, as a result - the development of fetal hypoxia, spontaneous abortion.

The ability of an antihistamine drug to affect the fetus is determined by the physiological characteristics of the patient and the state of the placenta, course and dosage.

Contraindications "Cetrin" during pregnancy in the 1st trimester indicate an increase in the likelihood of side effects, but this does not mean that pathological changes characteristic of each clinical case.

Therefore, in order to prevent the risk of a defective unborn child, it is advisable to take increased care of your health and your baby in order to eliminate the need for medical treatment.

Method of application and dosage

The tablet form of release of an antiallergic product has become widespread in ENT practice. 1 tablet contains 10 mg. cetirizine dihydrochloride. This is a one-time rate for adults. With reduced kidney function, the dose is halved - half a tablet (5 mg). The daily multiplicity is limited to two receptions.

For reference! In chronic renal failure, "Cetrin" is prescribed 5 mg. in one day.

The duration of the drug regimen determines the form of the lesion, the etiology of the pathogen, the general course clinical picture. In order to prevent the course of application varies from 2 weeks to a month.

For therapeutic purposes, it is prescribed for a cycle of 14 days to six months. medicinal effect persists for the next 3 days after discontinuation of the drug.

The digestion process does not slow down the absorption period active components therefore, it is allowed to take the tablets before or after meals, drinking plenty of water.

The scheme for taking the liquid form does not differ from the previous variation. From the age of twelve appoint 10 ml. syrup twice a day, provided there are no pathological disorders of the kidneys.

Conclusion

Before using "Cetrin" it is recommended to study the annotation to prevent the development of side effects. 3rd generation antihistamine shows high therapeutic effect in a sparing form for allergic rhinitis, conjunctivitis, hay fever, dermatosis, in complex therapy at bronchial asthma.

Minimal development risks side effects from the use of the drug are observed in the 2nd trimester of pregnancy. Therefore, early and late terms are contraindications for the appointment.

Directory of major ENT diseases and their treatment

All information on the site is for informational purposes only and does not claim to be absolutely accurate. medical point vision. Treatment must be carried out by a qualified doctor. By self-medicating, you can harm yourself!

Cetrin during pregnancy

The body of a pregnant woman reacts in a peculiar way to previously familiar products and phenomena. Therefore, it is not surprising that expectant mothers are subject to allergic reactions much more often than others: allergies are manifested in them both in mild and severe forms and depend on the use of certain drugs, the use of certain foods, or on a certain period of time when plants bloom or fruits ripen.

Pregnant women try to realize the natural desire to eliminate unpleasant symptoms and live a full life through anti-allergic drugs, but is it possible to use strong enough drugs, most of which have the ability to block histamine?

Cetrin from a number of antihistamines

The drug is excreted in the urine.

Indications for use

allergic rhinitis;
allergic conjunctivitis;
itching of various adventures;
hives;
angioedema.

Tsetrin by trimesters

1 trimester

2 trimester

3rd trimester

The baby's body is almost formed, but this is not a reason to take a drug that is undesirable for pregnant women. Cetrin is prescribed only in exceptional cases and therapy is carried out under the strict supervision of a physician.

Cetrin: indications for use, analogues

Hello friends! Today I want to tell you about the drug cetrin, the indications for the use of which promise to cope with allergies.

It's no secret that there are a lot of drugs that stop allergic attacks, but I want to talk about this remedy: its advantages and disadvantages.

In the next article, by the way, you can read what Cetrin tablets are prescribed for.

Cetrin indications for use

Beforehand, I consider it necessary to write 2 medical facts:

Any irritants, getting inside, meet a powerful rebuff from immune cells.
There are situations when the immune system weakens and then the control over the production of histamines disappears: they begin to form in large quantities and adversely affect all human tissues and organs.

Antihistamines come to the rescue in such situations. Today at clinical practice use antihistamines of three generations. The first generation includes:

tavegil,
fenistil,
diazolin

Reading the indications for the use of each of them, one can come to the conclusion that they all have a powerful suppressive effect.

But, unfortunately, this affects the manifestation of an equally strong side effect - drowsiness.

Third generation drugs (claritin, telfast, erius) have the same strong qualities in suppressing the production of histamine, and are practically devoid of side effects.

And what are the specific indications for use of tsetrin?

It belongs to the second generation of antihistamines and has a wider spectrum of action. It does not have a very pronounced side effect, but it also affects the receptors more gently.

The active substance, cetirizine, binds to receptors and prevents histamine from reaching them. This means that such allergic manifestations how:

hyperemia,
Rash,

And this happens already at the cellular level. In addition, it does not allow eosinophils to accumulate in the focus of inflammation, and, accordingly, prevents the development inflammatory process at the site of an allergic reaction.

Due to such qualities and indications, it can be prescribed for the treatment of allergies not only for adults, but also for children over 2 years old.

Let's now try to figure out: what is said in the indications for use about pregnancy ...

Cetrin during pregnancy

Before talking about the possibility of its use during pregnancy, I want to tell you: why, in general, antihistamines are forbidden to be taken by expectant mothers.

During pregnancy, histamine becomes a very necessary component. With its assistance, the fertilized egg is attached to the wall of the uterus.

It promotes the development of the embryo, and further regulates the metabolism of the fetus. The formation of tissues and organs of the baby depends on it.

Taking medications that suppress the production of histamine can have a tragic effect on the condition of the child, his physical and mental development.

Here are the indications for use during pregnancy:

if you start using it, it can negatively affect the functioning of the kidneys and liver. Therefore, tsetrin during pregnancy has, of course, advantages over other drugs, but is used with great care.

ALWAYS, you need to consult with a specialist in the place, and then, if you are allowed to use it, do it under the strict supervision of a doctor.

The drug has few side effects, and does not affect the quantitative production of histamines.

But, nevertheless, during the first 12 weeks, its use is generally prohibited. And in the future, doctors look at the health of the mother and fetus.

It is also worth mentioning that the drug is produced by an Indian pharmaceutical company, but are there any analogues in domestic production?

Cetrin analogues

Comparing the indications for use of cetrin and looking through the reference books, I found a number of domestically produced medicines that are similar in their effect.

All dosage forms, produced on the basis of cetirizine, and being histamine blockers can be considered analogues.

If we compare in general the indications for the use of some other drugs, which are sometimes called "synonyms", this is another separate list.

This includes all drugs based on cetirizine, and slightly different additional components.

Alerza,
cetirizine,
Letizen,
Zyrtec.

The list can go on for a very long time. Now, knowing what indications Cetrin has for use, you must decide: do you want to start using it?

Girls, did anyone drink Tsetrin during pregnancy?

Need Ginipral tablets!

Comments

Oh thank you girls for your replies. At least I started to worry less.

The allergist told me that in the first trimester only diazolin is allowed, in the second trimester suprastin and nothing else, the rest is only at my own responsibility

Saw, what to do. But not longer than 3-4 days in a row. Both last pregnancy and this one.

Well, how are you, okay? Did it affect the baby?

Well, at least I don't know about it.

Better go to an allergist. Here it is necessary to find out what the allergy is and to exclude the allergen, and not to suppress the pills. They are highly undesirable and are drunk only when there is no other way out. Tsetrin seems to belong to the latest generation, but still ideally get by

And by the last generation, does that mean you can drink?

No, this means that if you can't go anywhere without pills, then these are better than some kind of tavegil or suprastin.

I also constantly have allergic blisters all over my body, I have no idea from what, I’m allergic in life, enterosgel saves, the same polysorb, it really helps and is not harmful, I don’t drink or drink any anti-allergic, it’s scary,

And how many days do you drink Entorosgel? And how long does it all take? It's the first time I've encountered such a problem. The rash looks like a hives, my daughter had this 2 times, but it went away in 3 days.

I drink for 10 days, and it starts to pass on day 4-5, it also helps with allergies on day 4-5, but not all pills are suitable, some no longer help, addiction has gone

Maybe someone else drank during pregnancy?

Erius (but its price is high) and citrine all the first B. I am allergic, I can be allergic to everything. Now I drink too. A child of almost 4 has no allergies at all, if only there will be a lot of sweets for 3 days (thanks to my beloved great-grandmother). In general, I think that if the mother feels bad, then the baby in the tummy is not good either (my G is of the same opinion). Therefore, I drank it and an anesthetic pill when the tooth ached for 3 days, I also drank it.

Cetrin says that its use during pregnancy can affect the development of the baby's brain and spinal cord. That's why I'm scared for him. I rummaged through the entire Internet, and the reviews of pregnant women are positive for Tsetrin.

Girls, before pregnancy, hives with itching began, I drink diazolin, then claritin, then tsetrin every two to three days. Without them, crazy itching, neither sleep nor eat (((Who drank antihistamines throughout pregnancy, share your experience.

Girls, tell me, please, did anyone have allergic dermatitis during pregnancy? I have spots that itch terribly on my thighs and up to my knees. Today, spots began to appear on the hands (still barely noticeable). About stretch marks in the lower abdomen.

Are there any allergy sufferers among you or friends? What did you do during pregnancy? I drink cetrin every day, if I don’t drink it, it’s terrible all over my body. I don’t know what the allergy is, but it has been with me since school. There were years.

Hello, there is a sign that you can’t embroider during pregnancy, supposedly the baby will get tangled in the umbilical cord. I started embroidering when I was pregnant with my first child. So, as soon as I started sewing, my daughter started kicking me hard and what.

can be accepted or not? As such, I did not find contraindications, perhaps I was looking badly. Interested in collagen which is taken orally - ie. in the form of powders and capsules. Because during 1 pregnancy (26 years) I had.

the doctor prescribed herbs and it and there are contraindications for pregnancy

I thought so, and decided a couple of months before the next pregnancy I would get vaccinated against tetanus, a month from the flu or something, and then I will plan. I don’t really believe in the flu shot, I’ll probably just be careful.

I had allergies before pregnancy. For a lot. Rescued with antigestamines. as soon as I found out that I was expecting a baby, I immediately stopped taking them (there are all contraindications for pregnancy). And now I don't know how to deal with it.

I started drinking Magnesium B6 back in the first trimester. From what vomited appeared the tone of the uterus. Been drinking for a while. On the trail. examination at G, she told me to continue drinking, tk. there is some tone. When was.

Thus ended my March 8th. After the children's sleep, we had lunch and went to grandma's for pies. already on the way it was not good, I thought I overate. my grandmother had already started vomiting, diarrhea ((she drank coal at home, but she still vomited half the night (((drank.

Can Cetrin be pregnant?

Cetrine is a modern antihistamine drug that has antiallergic, antiexudative, antipruritic effects. The drug is manufactured by the Indian pharmaceutical company Dr. Reddy's Laboratories Ltd.

In the pharmacy chain, Cetrin is presented in the form of tablets containing 10 mg of Cetirizine, 20 tablets in a blister pack and in the form of a syrup containing 1 mg of Cetirizine in 1 ml.

How does Cetrin work for allergies?

The active substance of Cetrin is cetirizine (hydroxyzine metabolite), which is a blocker of H1-histamine receptors, a competitive histamine antagonist. Ceterizine effectively stops the manifestations of allergies, and also prevents its development. Possessing anti-exudative and antipruritic action, Ceterizine helps to limit the release of inflammatory mediators, prevents the release of histamine, serotonin, bradykinin by mast cells, reduces capillary permeability, prevents the migration of neutrophils, basophils, eosinophils, relieves smooth muscle spasm. In the treatment of mild bronchial asthma, Cetrin reduces histamine-induced bronchospasm.

When taking therapeutic doses of Cetrin, there is no sedative effect. The therapeutic effect after taking 10 mg of the drug is noted after a minute and lasts 1 day. Addiction to the antihistamine effect at therapeutic dosages does not develop. After stopping taking Cetrin, the effect persists for 3 days.

Active components are a part of Tsetrin:

Tablets: the active substance is cetirizine dihydrochloride (10 milligrams); excipients: starch, povidone, lactose, magnesium stearate, macrogol 6000, hypromellose, talc, titanium dioxide, polysorbate.
Syrup: 1 ml contains 1 mg of cetirizine dihydrochloride; excipients: sucrose, glycerol, disodium edetate, benzoic acid, sodium citrate, 70% sorbitol solution, purified water, flavor.

Ceterizine after oral administration is absorbed fairly quickly, the maximum plasma concentration is observed after 60 minutes. The drug is recommended to be taken before meals, as the processes of digestion slow down its absorption.

A small amount of cetirizine is metabolized in the liver. The drug does not have a cumulative effect (does not accumulate in organs and tissues), penetrates into breast milk, and is excreted from the body mainly by the kidneys.

If the excretory function of the kidneys is impaired, the half-life of the drug increases.

For what diseases is Cetrin prescribed?

Indications for the use of Cetrin are allergic diseases:

Seasonal and year-round rhinitis, conjunctivitis;
Drug and food allergies;
Dermatoses of allergic genesis (in complex treatment);
Chronic recurrent urticaria;
Quincke's edema;
Atopic dermatitis (in complex treatment).

Contraindications for prescribing and side effects

When treating with Cetrin, side effects may occur: headaches, dizziness, drowsiness, insomnia, hand tremors, depressive states. Also possible: dry mouth, nausea, vomiting, increased heart rate, increased blood pressure, allergic reactions.

Contraindications to the appointment of Tsetrin are:

Intolerance to the components of the drug;
Pregnancy and lactation;
For children under 6 years of age, Cetrin is prescribed as a syrup.

How to use Cetrin

Cetrin tablets are taken orally before meals with a small amount of water.

Adults and children over 12 years of age are prescribed 1 tab. (10 milligrams) once a day.

For children over 6 years old, give half a tablet (5 milligrams) twice a day.

Cetrin syrup is prescribed for adults and children over six years of age from 1 to 2 teaspoons (5-10 milligrams) once a day. For children from two to five years old, give ½ teaspoon. spoon once a day.

In case of liver and kidney failure, adults are prescribed half a tablet (5 milligrams) once a day.

The course duration of treatment is 1-4 weeks. In the treatment of chronic allergic diseases, the duration of therapy can be increased up to 6 months. Before taking Cetrin, read the instructions for use.

Is it possible to prescribe Cetrin during pregnancy and lactation?

The active substance Cetirizine crosses the placental barrier and is found in breast milk, exerting a negative impact on the condition of the fetus and newborn, so the drug is contraindicated in pregnancy and lactating breast milk.

Interaction with other drugs

Cetrin is used with caution simultaneously with sedatives. With simultaneous appointment with theophylline, cumulation of cetirizine and overdose phenomena may occur.

An overdose of the drug is possible if the recommended dose is accidentally exceeded, accompanied by drowsiness, increased heart rate, hand tremors, skin itching, urinary retention. It is recommended to cancel the drug, gastric lavage, as well as taking enterosorbents: Polysorb, Enterosgel, Enterosorb, Laktofiltrum, Activated carbon. There is no specific antidote.

Are there analogues of Tsetrin?

Similar pharmacological properties possess antihistamines: Zirtek, Zodak, which include Cetirizine, as well as Loratadine, Clarotadine, Claritin, the main active ingredient of which is Loratadine, Erius (Desloratadine), Ketotifen. Medicines of the first group belong to the latest generation of antiallergic drugs, their price in pharmacies is somewhat higher. The lowest cost among analogues of Cetrin is in the drug Loratadin Verte. The effectiveness of the latest generation of antihistamines is slightly higher.

How to store the medicine?

Cetrin is stored in a place protected from light. Storage temperature from 15 to 25 degrees Celsius. The shelf life of the drug is two years.

The price of the drug in the pharmacy chain

Cetrin can be bought at most drugstores. The average cost of the drug is:

Cetrin syrup, 60 ml (1 mg / ml) - 95 - 105 rubles;
Cetrin tablets (10 mg), No. 20 - 160 - 170 rubles.

Tsetrin and pregnancy: concepts are incompatible

Allergy in pregnant women is most often manifested in the form allergic rhinitis or conjunctivitis. Rarely, these are skin rashes and bronchial asthma. In all these cases, obstetrician-gynecologists recommend preparing for pregnancy, visiting an allergist in advance and, if necessary, conducting a course of specific treatment.

What to do if allergies increase during pregnancy

First of all, no initiative: all treatment should take place only under the supervision of a doctor. First, the doctor will try to cope with the allergy in non-drug ways: a hypoallergenic diet, excluding possible household allergens (including dust, particles of animal hair, fish scales, and so on).

If it is not possible to help a woman in this way, then drug treatment, including the safest antihistamines.

What are the dangers of antihistamines during pregnancy

Antihistamine drugs are used during pregnancy, but only under strict indications. The fact is that the drugs of this group block the action of histamine, a biologically active substance that is not completely superfluous in the body of a pregnant woman.

With the assistance of histamine, the fertilized egg is introduced into the wall of the uterus and the embryo develops in it. For more later dates Pregnancy histamine easily crosses the placenta and regulates the metabolism between the organisms of the mother and fetus. The process of laying tissues and the development of fetal organs depends on its impact.

The use of antihistamine drugs can disrupt all these processes. And since there are practically no clinical trials on pregnant women, no one can say for sure how this or that antihistamine drug will affect the condition of the woman and the fetus.

In the first 12 weeks of pregnancy, these drugs can not be used categorically, but in the future they are used with caution, taking into account all indications and contraindications, the condition of the woman and the fetus is still sometimes used. But since there are no carefully tested and absolutely safe among antihistamines, their use should be under the constant supervision of a doctor.

How does tsetrin affect pregnancy

Cetrin is devoid of many of the shortcomings of its predecessors, but, just like them, cetrin suppresses the action of histamine, therefore it cannot be absolutely safe. Manufacturers of the drug (Indian Pharmaceutical Dr. company Redi`s Laboratories LTD) takes into account possible consequences the use of this antihistamine on a pregnant woman and fetus and therefore does not recommend its use during pregnancy.

How dangerous is cetrin for a pregnant woman and fetus? No one will answer this question, since adequate clinical research this drug has not been tested in pregnant women. In clinical practice, there is also not yet sufficient experience with its use in pregnant women, since this is a relatively new drug.

The main thing that a pregnant woman should know is that she can take any pills only as directed by a doctor, but not on her own.

Questions and answers

How quickly does Cetrin ® start to work?

Cetrin ® begins to act within 20 minutes after ingestion and quickly relieves various symptoms allergies.

Unless otherwise advised by the doctor, Cetrin ® is taken 1 tablet 1 time per day. The tablet is swallowed whole, without chewing, washed down with a glass of water. You can take Cetrin ® regardless of the meal (both on an empty stomach and during or after a meal), which is very convenient.

The duration of the use of the drug Cetrin ® is determined in each case by the doctor, depending on the symptoms of the disease and its severity. Can be assigned:

Addiction to the drug Cetrin ® does not develop, therefore, if necessary, it can be used for a long time. For such courses, a package containing 30 tablets is convenient - it is enough for a month of regular intake.

Yes. Cetrin ® tablets can be used in children from the age of six.

* Fedoskova T.G. Cetirizine in the treatment of patients with perennial allergic rhinitis associated with atopic bronchial asthma // Russian Allergological Journal. 2007. No. 6.

Yes, you can. In addition, just such a combined method is preferable for severe and moderate forms of allergic rhinitis*. Due to the impact on various mechanisms of an allergic reaction, both external and systemic agents, a more pronounced therapeutic effect can be obtained.

* Markova T.P. Bulkina O.Z. Prevention and treatment of allergic rhinitis // RMJ. 2011. No. 7.

There are no restrictions for the combined use of Cetrin ® and antibiotics. It is only important that this is the recommendation of your doctor.

1. Pharmacological action

The active substance Cetrin has a blocking effect on histamine receptors, thereby lowering the severity and manifestation of allergic reactions. In addition, Cetrin reduces the secretion of discharge and the synthesis of chemicals that promote inflammation, eliminates spasm of smooth muscles, reduces capillary permeability and cell movement. immune system throughout the body, eliminates the causes of itching.

2. indications for use

Seasonal and year-round manifestation of allergic rhinitis and conjunctivitis;
Various skin allergic reactions (as part of a drug complex);
Quincke's edema and chronic urticaria.

3. How to use

Children aged 6-12 years take Cetrin half a tablet 2 times a day. Children over 12 years of age and adults take the drug 1 tablet per day. In both cases, Cetrin is washed down with a small amount of drinking water. The duration of treatment - on average does not exceed 1 month, but if necessary, it can last up to six months. Patients suffering functional disorders kidneys, take the drug in half the dose; Patients suffering from functional disorders of the liver, dose adjustment is not made. Persons whose work is associated with an active type of activity, the management of complex mechanisms, including various vehicles Cetrine should be taken with caution. In the case of use in patients under 6 years of age, it is recommended to use the drug in the form of a syrup. It is forbidden to take alcoholic beverages during treatment with Cetrin!

4. Side effects

Violations of the nervous system (drowsiness, increased fatigue, increased nervous excitability, trembling of the limbs, mood changes, insomnia, changes in taste perception);
When taking Cetrin, violations are possible digestive system(swelling of the tongue, inflammation of the stomach, impaired liver function, stomatitis, dry mouth, stool disorders);
Violation of cardio-vascular system(persistent increase in blood pressure, change heart rate);
Violations of other organs and systems (urinary retention, pain in the muscles and blood vessels, inflammation of the pharynx);
Various allergic reactions.

6. During pregnancy and lactation

Cetrin is contraindicated in pregnant women and nursing mothers. If necessary, use breast-feeding throughout the treatment must be discontinued.

7. Interaction with other drugs

With simultaneous use with Theophylline, the formation of Cetrin accumulations is possible;
Simultaneous use with sedative drugs should be under the supervision of the attending physician.

8. Overdose

Drowsiness, trembling of the extremities, skin itching, urinary retention, increased heart rate, urticaria. There is no antidote for Cetrin. If overdose symptoms occur, the patient undergoes a gastric lavage, and laxatives and drugs that can bind various chemical substances followed by their removal from the body. Monitoring of the cardiovascular and respiratory systems should also be carried out.

9. Release form

Tablets Tsetrin, 10 mg - 20 or 30 pcs. Syrup, 1 mg/1 ml - vial. 30 ml or 60 ml.

10. Storage conditions

The drug is stored at room temperature without access to light.

11. Composition

1 ml syrup:

cetirizine dihydrochloride - 1 mg;
Excipients: glycerol, sucrose, benzoic acid, disodium edetate, sorbitol solution, sodium citrate, fruit flavor, purified water

1 tablet Cetrin:

cetirizine dihydrochloride - 10 mg;
Excipients: lactose, corn starch, povidone (K-30), magnesium stearate.

12. Terms of dispensing from pharmacies

The drug is released without a prescription.

Which is better: Suprastin or Cetrin

Both drugs are antiallergic drugs, but which one is better? Let's do a little comparison. Instructions for use of the drug Cetrin indicates the main active ingredient - cetirizine dihydrochloride, and for Suprastin - chloropyramine.

Suprastin is an older drug that often causes side effects and has a sedative effect. In this case, the drug has a stronger therapeutic effect.

Cetrin more modern drug does not cause drowsiness and rarely causes side effects.

The choice of drug depends on the severity of the disease. With severe allergy symptoms and good tolerance, Suprastin is better suited. Cetrine, on the other hand, has a milder effect, while also coping well with allergies.

Compatibility of Tsetrin with alcohol

The instructions indicate that you should refrain from taking alcohol for the entire duration of treatment with Cetrin, and there are reasons for this:

Alcohol, when released into the bloodstream, releases toxins, which in turn can trigger allergies. In this regard, the treatment of the underlying disease will come to naught;
In the presence of such a disease as bronchial asthma, against the background of alcohol intake, a severe attack may begin;
Alcohol increases the burden on the kidneys and liver, and can also cause side effects from taking the drug.

It is not known exactly what consequences the simultaneous intake of Tsetrin with alcohol will lead to, therefore it is better to refuse alcohol.

How many days can you drink Cetrin

The duration of the drug depends on the type and severity of the symptoms of the disease, as well as on its severity.

To eliminate acute allergies, the course of treatment is no more than a day. Usually, the drug is stopped as soon as the manifestations of allergies disappear. Continuous treatment with citrine for acute allergic disease should not be more than 14 days.

In a chronic allergic disease, the duration of treatment, when prescribed by a doctor, can reach up to 6 months.

In bronchial asthma, complex treatment taking the drug can reach the absence. Then, after a week break, treatment is continued.

For prevention seasonal allergies doctors can prescribe the drug for 1-1.5 months.

Cetrin or Loratadine

Both medicines belong to the second generation drugs, have almost the same effectiveness and are prescribed for the treatment of adults and children.

The instructions for Cetrin indicate that its main active ingredient is cetirizine, and Loratadine is loratadine. Despite the different active substance, both drugs have a similar effect, blocking H1 receptors, which contribute to the production of histamine.

It is difficult to say which drug is better, because Cetrin and Loratadin do their job quite effectively. The choice of drug depends largely on individual features body, one is more suitable for Cetrin, and for others Loratadin.

How long does Cetrine work?

When using an antihistamine, it is especially important for a person to know when its therapeutic effect will come.

The time of onset mainly depends on the individual characteristics of the body and in some people it may come earlier, while in others later. On average, the drug Cetrin begins its therapeutic effect after a single dose at a concentration of 10 mg after a minute. The maximum concentration in the blood is reached 1 hour after ingestion.

The effectiveness of Cetrin lasts for more than 24 hours. After a course of treatment, its effectiveness remains for another 3 days.

Take Cetrin before or after meals

The instructions for the Cetrine preparation indicate that the drug can be taken regardless of the meal. This is due to the fact that food does not affect the completeness of absorption.

Therefore, Cetrin can be taken on an empty stomach, during or after a meal.

Found an error? Select it and press Ctrl + Enter

The pharmacokinetic parameters of cetirizine change linearly when the drug is administered at a dose of 5-60 mg.

After oral administration, cetirizine is rapidly and completely absorbed from the gastrointestinal tract. Eating does not affect the completeness of absorption, although the rate of absorption decreases and the value of C max decreases by 23%. In adults, after a single dose of the drug in a therapeutic dose, Cmax in blood plasma is reached after 1 ± 0.5 h and is 300 ng / ml.

Plasma protein binding is 93 ± 0.3% and does not change at cetirizine concentrations in the ng / ml range. V d is 0.5 l / kg. When taking the drug at a dose of 10 mg for 10 days, no accumulation of cetirizine is observed. Cetirizine is excreted in breast milk.

In small amounts, it is metabolized in the body by O-dealkylation (unlike other histamine H 1 receptor antagonists, which are metabolized in the liver with the participation of the cytochrome P450 system), with the formation of a pharmacologically inactive metabolite.

In adults, T 1/2 is approximately 10 hours. About 2/3 of the accepted dose of the drug is excreted in the urine unchanged, 10% - with feces. Systemic clearance - 53 ml / min.

Pharmacokinetics in special groups of patients

In elderly patients and patients with chronic diseases liver with a single dose of the drug at a dose of 10 mg T 1/2 increases by about 50%, and systemic clearance is reduced by 40%.

T 1/2 in children aged 6 to 12 years is 6 hours, aged 2 to 6 years - 5 hours, aged 6 months to 2 years - 3.1 hours.

In patients with mild renal insufficiency (CC> 40 ml / min), pharmacokinetic parameters are similar to those in patients with normal renal function. In patients with moderate renal insufficiency and in patients on hemodialysis (QC<7 мл/мин), при приеме препарата внутрь в дозе 10 мг Т 1/2 удлиняется в 3 раза, а общий клиренс снижается на 70% (составляет 0.3 мл/мин/кг), относительно пациентов с нормальной функцией почек, что требует соответствующего изменения режима дозирования. Цетиризин практически не удаляется из организма при гемодиализе.

In patients with chronic liver diseases (hepatocellular, cholestatic or biliary cirrhosis), there is a 50% T 1/2 prolongation and a 40% decrease in total clearance (adjustment of the dosing regimen is required only with a concomitant decrease in GFR).

What is histamine and its role in the body of a pregnant woman

In addition to the fact that histamine is a well-known mediator of allergic reactions, it is also an equally well-known regulator of physiological processes. In a pregnant body, histamine becomes a very important hormone, in the earliest stages, thanks to this component, a fertilized egg attaches to the wall of the uterus, and in later periods, histamine contributes to the normal development of the fetus and becomes the main regulator of metabolism.

It depends on the amount of histamine in the mother's body in the future how adequately the tissues and organs of the baby will be formed.

Cetrin from a number of antihistamines

But such an availability of the drug should, at a minimum, make the future mother think and consult a doctor.

Only a specialist can dissuade women who are too keen on self-medication of the need for therapy with conventional drugs. During pregnancy, you need to switch to less aggressive and more appropriate medicines for the current state of the woman.

Cetrin is excluded from their number, but if other anti-allergic drugs do not help, doctors make an exception by prescribing Cetrin to pregnant women, provided that they are taken with great care and constant monitoring on their part.

Cetrin represents the second generation of antihistamines and differs from the first generation drugs in a milder effect on receptors and less side effects.

Composition, effects and pharmacokinetics of the drug

The active ingredient in Cetrin is cetirizine.

The active substance at the cellular level binds to receptors and blocks the flow of histamine and prevents the manifestation of rash, itching, hyperemia.

Another feature of the effect of the drug is to effectively counteract the accumulation of eosinophils in the focus of inflammation and prevent the development of the inflammatory process.

Cetrizine is absorbed from the gastrointestinal tract, and food intake has little effect on absorption, so there is not much difference when taking the pill: before, after or during meals.

Metabolic processes are concentrated in the liver, the half-life is from 5 to 12 hours, depending on the age of the patient (the older he is, the longer the excretion).

The drug is excreted in the urine.

Indications for use

Allergic reactions that are seasonal or chronic in nature:

allergic rhinitis;
allergic conjunctivitis;
itching of various adventures;
hives;
angioedema.

Pregnancy as a contraindication

In the instructions for the drug, pregnancy and the lactation period are indicated by contraindications to the use of Cetrin. And any physician will confirm that taking drugs that suppress the effect of histamine in pregnant women can cause such negative consequences as a violation of the mental and physical development of the fetus.

As for the mother's well-being, pregnant women taking Cetrin often complain about the negative effect of the drug on the functioning of the kidneys and liver.

Therefore, even if the allergy is too painful, do not take the drug on your own - an easy solution can later be very expensive.

Tsetrin by trimesters

1 trimester

Up to and including the 12th week of pregnancy, Cetrine is strictly contraindicated. In the body of a pregnant woman during this period, such important processes as the fixation of the egg and the development of the embryo are carried out, so it is impossible to reduce the level of histamine.

2 trimester

The development of the organs and systems of the fetus is very active, as are the metabolic processes that allow the baby to fully receive all the essentials from the mother's body. Histamine is involved in these processes, so blocking this component can lead to a lack of nutrients for the baby and slow development.

Against the background of increased production of histamine, lacrimation is observed, natural breathing is disturbed, there is a feeling of itching and burning in. The development of side effects is highly undesirable during the period of gestation.

The feasibility of taking "Cetrin" at different gestation periods

The drug is presented on the pharmacological market syrup and tablets coated with a multicomponent soluble shell. Regardless of the form of release, the main composition forms a competitive histamine antagonist - cetirizine.

H1 blocker of histamine receptors exhibits antipruritic, antiexudative and antiallergic activity. The therapeutic effect is enhanced by the presence of excipients in the composition: corn starch, lactose, povidone KZO.

"Cetrin" relieves the symptoms of an allergic reaction, prevents the development of pathological changes in the influence of antigens. The action of the drug is aimed at inhibiting the synthesis of stimuli, reducing the cells of the leukocyte germ, increasing the capacity of the capillaries.

The constituents are rapidly absorbed in the gastrointestinal tract, the medical effect occurs within an hour after taking, lasts up to 24 hours.

The productivity and safety of "Cetrin" explains the fact that it does not affect serotonin and cholinergic nerve endings. Studies that would prove possible harm to the health of the mother and unborn child on patients have not been conducted.

For reference! The constituent components can be excreted with milk during breastfeeding, so antihistamines are prohibited during lactation.

According to the instructions for the use of "Cetrin" during pregnancy, the drug is included in the therapeutic regimen at all stages of gestation, when the threat to the health of the mother and child outweighs the potential harm from taking the medication.

To prevent the risk of side effects it is necessary to take an allergic agent according to the doctor's recommendations and under medical supervision.

The use of "Cetrin" in the 2nd trimester has a minimal toxic effect on the fetus. The laying of the internal organs is completed, the placenta is formed, the embryo is protected from the effects of the components of the drug.

Contraindications

Due to the fact that the drug is excreted from the body mainly by the kidneys, it is prescribed with caution to patients with a history of renal and hepatic insufficiency.

For reference! In the therapeutic scheme of the elderly, "Cetrin" is included in a reduced dosage.

headaches;
signs of intoxication;
depressive state;
dizziness;
high blood pressure, tachycardia;
tremor of the upper limbs;
feeling of dryness in the mouth.

"Cetrin" during early pregnancy

The use of pharmacological products at an early gestational age is fraught with serious pathological disorders.

A weak placental barrier does not create any hope of protection against the penetration of medicinal components, as a result - the development of fetal hypoxia, spontaneous abortion.

The ability of an antihistamine drug to affect the fetus is determined by the physiological characteristics of the patient and the state of the placenta, course and dosage.

Contraindications "Cetrin" during pregnancy in the 1st trimester indicate an increase in the likelihood of side effects, but this does not mean that pathological changes are characteristic of each clinical case.

Therefore, in order to prevent the risk of a defective unborn child, it is advisable to take increased care of your health and your baby in order to eliminate the need for medical treatment.

Method of application and dosage

The tablet form of release of an antiallergic product has become widespread in ENT practice. 1 tablet contains 10 mg. cetirizine dihydrochloride. This is a one-time rate for adults. With reduced kidney function, the dose is halved - half a tablet (5 mg). The daily multiplicity is limited to two receptions.

For reference! In chronic renal failure, "Cetrin" is prescribed 5 mg. in one day.

The duration of the drug regimen predetermines the form of the lesion, the etiology of the pathogen, the general course of the clinical picture. In order to prevent the course of application varies from 2 weeks to a month.

For therapeutic purposes, it is prescribed for a cycle from 14 days to six months. The drug effect persists for the next 3 days after discontinuation of the drug.

The process of digestion does not slow down the period of absorption of the active ingredients, so it is allowed to take the tablets before or after meals with plenty of water.

Conclusion

Before using "Cetrin" it is recommended to study the annotation to prevent the development of side effects. The 3rd generation antihistamine drug shows a high therapeutic effect in a sparing form for conjunctivitis, hay fever, dermatosis, in complex therapy for bronchial asthma.

Minimal risks of developing side effects from the use of the drug are observed in the 2nd trimester of pregnancy. Therefore, early and late terms are contraindications for the appointment.

Tsetrin ( Cetrine) - a modern antihistamine drug that has antiallergic, antiexudative, antipruritic effects. The drug is manufactured by the Indian pharmaceutical company Dr. Reddy's Laboratories Ltd.

In the pharmacy chain, Cetrin is presented in the form of tablets containing 10 mg of Cetirizine, 20 tablets in a blister pack and in the form of a syrup containing 1 mg of Cetirizine in 1 ml.

How does Cetrin work for allergies?

When taking therapeutic doses of Cetrin, there is no sedative effect. The therapeutic effect after taking 10 mg of the drug is noted after 30-60 minutes and lasts 1 day. Addiction to the antihistamine effect at therapeutic dosages does not develop. After stopping taking Cetrin, the effect persists for 3 days.

Active components are a part of Tsetrin:

Tablets: the active substance is cetirizine dihydrochloride (10 milligrams); excipients: starch, povidone, lactose, magnesium stearate, macrogol 6000, hypromellose, talc, titanium dioxide, polysorbate.
Syrup: 1 ml contains 1 mg of cetirizine dihydrochloride; excipients: sucrose, glycerol, disodium edetate, benzoic acid, sodium citrate, 70% sorbitol solution, purified water, flavor.

If the excretory function of the kidneys is impaired, the half-life of the drug increases.

For what diseases is Cetrin prescribed?

Indications for the use of Cetrin are allergic diseases:

Seasonal and year-round rhinitis, conjunctivitis;
Drug and food allergies;
Dermatoses of allergic genesis (in complex treatment);
Chronic recurrent urticaria;
Quincke's edema;
Atopic dermatitis (in complex treatment).

Contraindications to the appointment and side effects

In the treatment of Cetrin, side effects may occur: headaches, dizziness, drowsiness, insomnia, hand tremors, depressive states. Also possible: dry mouth, nausea, vomiting, increased heart rate, increased blood pressure, allergic reactions.

Contraindications to the appointment of Tsetrin are:

Intolerance to the components of the drug;
Pregnancy and lactation;
For children under 6 years of age, Cetrin is prescribed as a syrup.

How to use Cetrin

Cetrin tablets are taken orally before meals with a small amount of water.

Adults and children over 12 years of age are prescribed 1 tab. (10 milligrams) once a day.

For children over 6 years old, give half a tablet (5 milligrams) twice a day.

In case of liver and kidney failure, adults are prescribed half a tablet (5 milligrams) once a day.

Is it possible to prescribe Cetrin during pregnancy and lactation?

The active substance Cetirizine penetrates the placental barrier, is found in breast milk, having a negative effect on the condition of the fetus and newborn, so the drug is contraindicated in pregnancy and lactating breast milk.

Interaction with other drugs

Cetrin is used with caution simultaneously with sedatives. With simultaneous appointment with theophylline, cumulation of cetirizine and overdose phenomena may occur.

Are there analogues of Tsetrin?

Antihistamines have similar pharmacological properties: Zirtek, Zodak, which include Cetirizine, as well as Loratadin, Clarotadin, Claritin, the main active ingredient of which is Loratadin, Erius (Desloratadine), Ketotifen. Medicines of the first group belong to the latest generation of antiallergic drugs, their price in pharmacies is somewhat higher. The lowest cost among analogues of Cetrin is in the drug Loratadin Verte. The effectiveness of the latest generation of antihistamines is slightly higher.

How to store the medicine?

Cetrin is stored in a place protected from light. Storage temperature from 15 to 25 degrees Celsius. The duration of storage of the drug is two years.

The price of the drug in the pharmacy chain

Cetrin can be bought at most drugstores. The average cost of the drug is:

Cetrin syrup, 60 ml (1 mg / ml) - 95 - 105 rubles;
Cetrin tablets (10 mg), No. 20 - 160 - 170 rubles.

Home — Preparations

neboleem-net.ru

Tsetrin and pregnancy: concepts are incompatible

Allergies in pregnant women most often manifest themselves in the form of an allergic rhinitis or conjunctivitis. Rarely, these are skin rashes and bronchial asthma. In all these cases, obstetrician-gynecologists recommend preparing for pregnancy, visiting an allergist in advance and, if necessary, conducting a course of specific treatment.

What to do if allergies increase during pregnancy

If it is not possible to help a woman in this way, then medication is prescribed, including the safest antihistamines.

What are the dangers of antihistamines during pregnancy

With the assistance of histamine, the fertilized egg is introduced into the wall of the uterus and the embryo develops in it. At later stages of pregnancy, histamine easily crosses the placenta and regulates the metabolism between the mother and fetus. The process of laying tissues and the development of fetal organs depends on its impact.

How does tsetrin affect pregnancy

Cetrin is devoid of many of the shortcomings of its predecessors, but, just like them, cetrin suppresses the action of histamine, therefore it cannot be absolutely safe. Manufacturers of the drug (Indian pharmaceutical company Dr. Redi`s Laboratories Ltd.) take into account the possible consequences of the use of this antihistamine on a pregnant woman and fetus and therefore do not recommend its use during pregnancy.

How dangerous is cetrin for a pregnant woman and fetus? No one will answer this question, since there have been no adequate clinical studies of this drug in pregnant women. In clinical practice, there is also not yet sufficient experience with its use in pregnant women, since this is a relatively new drug.

The main thing that a pregnant woman should know is that she can take any pills only as directed by a doctor, but not on her own.

Questions and answers

How quickly does Cetrin ® start to work?

Cetrin ® begins to act within 20 minutes after ingestion and quickly relieves various allergy symptoms.

How should I take Cetrin ® tablets?

How long should I take Cetrin ® ?

The duration of the use of the drug Cetrin ® is determined in each case by the doctor, depending on the symptoms of the disease and its severity. Can be assigned:

a single dose of the drug or intake on demand - usually in the case of an acute reaction, when repeated exposure to the allergen is excluded, or for prophylactic purposes before the expected contact with the allergen;

a short course of treatment (1-3 weeks) - with an exacerbation of chronic allergic diseases (allergic rhinitis, dermatitis, etc.);

a long course of treatment (from several weeks to several months) - with chronic allergic diseases with a persistent course or with prolonged exposure to an allergen.

Does addiction to the drug Cetrin ® develop?

Can Cetrin ® be used in children?

Yes. Cetrin ® tablets can be used in children from the age of six.

Can Cetrin ® be used by pregnant women?

Can Cetrin ® be taken with bronchial asthma?

Antihistamines are not included in the standard treatment regimens for bronchial asthma, but they are indicated in the presence of concomitant allergic rhinitis. Cetrin ® in this case not only relieves the symptoms of rhinitis, but also improves bronchial patency in mild asthma*.
* Fedoskova T.G. Cetirizine in the treatment of patients with perennial allergic rhinitis associated with atopic bronchial asthma // Russian Allergological Journal. 2007. No. 6.

Can Cetrin ® be combined with antiallergic nasal sprays?

Can Cetrin ® be combined with antibiotics?

There are no restrictions for the combined use of Cetrin ® and antibiotics. It is only important that this is the recommendation of your doctor.

vovremja-pregnancy.ru

1. Pharmacological action

The active substance Cetrin has a blocking effect on histamine receptors, thereby lowering the severity and manifestation of allergic reactions. In addition, Cetrin reduces the secretion of discharge and the synthesis of chemicals that promote inflammation, eliminates smooth muscle spasm, reduces capillary permeability and the movement of immune system cells throughout the body, and eliminates the causes of itching.

2. indications for use

Seasonal and year-round manifestation of allergic rhinitis and conjunctivitis;
Various skin allergic reactions (as part of a drug complex);
Quincke's edema and chronic urticaria.

3. How to use

Children aged 6-12 years take Cetrin half a tablet 2 times a day. Children over 12 years of age and adults take the drug 1 tablet per day. In both cases, Cetrin is washed down with a small amount of drinking water. Duration of treatment - on average does not exceed 1 month, but if necessary, it can last up to six months. Patients suffering from functional impairment of the kidneys take the drug in half the dose; Patients suffering from functional disorders of the liver, dose adjustment is not made. Persons whose work is associated with an active type of activity, the management of complex mechanisms, including various vehicles, should take Cetrin with caution. In the case of use in patients under 6 years of age, it is recommended to use the drug in the form of a syrup. It is forbidden to take alcoholic beverages during treatment with Cetrin!

4. Side effects

Violations of the nervous system (drowsiness, increased fatigue, increased nervous excitability, trembling of the limbs, mood changes, insomnia, changes in taste perception);
When taking Cetrin, digestive system disorders (swelling of the tongue, inflammation of the stomach, impaired hepatic functions, stomatitis, dry mouth, stool disorders) are possible;
Violation of the cardiovascular system (persistent increase in blood pressure, changes in heart rate);
Violations of other organs and systems (urinary retention, pain in the muscles and blood vessels, inflammation of the pharynx);
Various allergic reactions.

6. During pregnancy and lactation

Cetrin is contraindicated in pregnant women and nursing mothers. If necessary, breastfeeding should be discontinued throughout the course of treatment.

7. Interaction with other drugs

With simultaneous use with Theophylline, the formation of Cetrin accumulations is possible;
Simultaneous use with sedative drugs should be under the supervision of the attending physician.

8. Overdose

Drowsiness, trembling of the extremities, skin itching, urinary retention, increased heart rate, urticaria. There is no antidote for Cetrin. If symptoms of an overdose occur, the patient undergoes a gastric lavage, and laxatives and drugs that can bind various chemicals with their subsequent removal from the body are prescribed. Monitoring of the cardiovascular and respiratory systems should also be carried out.

9. Release form

Tablets Tsetrin, 10 mg - 20 or 30 pcs. Syrup, 1 mg/1 ml - vial. 30 ml or 60 ml.

10. Storage conditions

The drug is stored at room temperature without access to light.

11. Composition

1 ml syrup:

cetirizine dihydrochloride - 1 mg;
Excipients: glycerol, sucrose, benzoic acid, disodium edetate, sorbitol solution, sodium citrate, fruit flavor, purified water

1 tablet Cetrin:

cetirizine dihydrochloride - 10 mg;
Excipients: lactose, corn starch, povidone (K-30), magnesium stearate.

12. Terms of dispensing from pharmacies

The drug is released without a prescription.

Which is better: Suprastin or Cetrin

Suprastin is an older drug that often causes side effects and has a sedative effect. In this case, the drug has a stronger therapeutic effect.

Cetrin is a more modern drug that does not cause drowsiness and rarely causes side effects..

Compatibility of Tsetrin with alcohol

The instructions indicate that you should refrain from taking alcohol for the entire duration of treatment with Cetrin, and there are reasons for this:

Alcohol, when released into the bloodstream, releases toxins, which in turn can trigger allergies. In this regard, the treatment of the underlying disease will come to naught;
In the presence of such a disease as bronchial asthma, against the background of alcohol intake, a severe attack may begin;
Alcohol increases the burden on the kidneys and liver, and can also cause side effects from taking the drug.

It is not known exactly what consequences the simultaneous intake of Tsetrin with alcohol will lead to, therefore it is better to refuse alcohol.

How many days can you drink Cetrin

The duration of the drug depends on the type and severity of the symptoms of the disease, as well as on its severity.

To eliminate acute allergies, the course of treatment is no more than 10-14 days. Usually, the drug is stopped as soon as the manifestations of allergies disappear. Continuous treatment with Citrine in acute allergic disease should not be more than 14 days.

In a chronic allergic disease, the duration of treatment, when prescribed by a doctor, can reach up to 6 months.

In case of bronchial asthma, as part of complex treatment, the drug can be taken for 15-20 days. Then, after a week break, treatment is continued.

To prevent seasonal allergies, doctors may prescribe a drug for 1-1.5 months.

Cetrin or Loratadine

Both drugs are second-generation drugs, have almost the same efficacy and are prescribed for the treatment of adults and children.

It is difficult to say which drug is better, because Cetrin and Loratadin do their job quite effectively. The choice of the drug largely depends on the individual characteristics of the organism, Cetrin is more suitable for one, and Loratadin for the other.

How long does Cetrine work?

When using an antihistamine, it is especially important for a person to know when its therapeutic effect will come.

The time of onset mainly depends on the individual characteristics of the body and in some people it may come earlier, while in others later. On average drug Cetrin begins its therapeutic effect, after a single dose at a concentration of 10 mg after 20-30 minutes. The maximum concentration in the blood is reached 1 hour after ingestion.

The effectiveness of Cetrin lasts for more than 24 hours. After a course of treatment, its effectiveness remains for another 3 days.

Take Cetrin before or after meals

The instructions for the Cetrine preparation indicate that the drug can be taken regardless of the meal. This is due to the fact that food does not affect the completeness of absorption.

Therefore, Cetrin can be taken on an empty stomach, during or after a meal.

- Did you find a mistake? Select it and press Ctrl + Enter

pillsman.org

The pharmacokinetic parameters of cetirizine change linearly when the drug is administered at a dose of 5-60 mg.

Suction

Distribution

Plasma protein binding is 93 ± 0.3% and does not change at cetirizine concentrations in the range of 25-1000 ng / ml. V d is 0.5 l / kg. When taking the drug at a dose of 10 mg for 10 days, no accumulation of cetirizine is observed. Cetirizine is excreted in breast milk.

Metabolism

breeding

In adults, T 1/2 is approximately 10 hours. About 2/3 of the accepted dose of the drug is excreted in the urine unchanged, 10% in the feces. Systemic clearance - 53 ml / min.

Pharmacokinetics in special groups of patients

In elderly patients and patients with chronic liver diseases, with a single dose of the drug at a dose of 10 mg, T 1/2 increases by about 50%, and systemic clearance decreases by 40%.

T 1/2 in children aged 6 to 12 years is 6 hours, aged 2 to 6 years - 5 hours, aged 6 months to 2 years - 3.1 hours.

health.mail.ru

What is histamine and its role in the body of a pregnant woman

It depends on the amount of histamine in the mother's body in the future how adequately the tissues and organs of the baby will be formed.

Cetrin from a number of antihistamines

Which of the drugs to choose a pregnant woman with allergies? The first thing that comes to mind is Tsetrin. The medicine is effective, not very expensive, and advertising is placed in almost all mass media.
But such an availability of the drug should, at a minimum, make the future mother think and consult a doctor.

Cetrin represents the second generation of antihistamines and differs from the first generation drugs in a milder effect on receptors and less side effects.

Composition, effects and pharmacokinetics of the drug

The active ingredient in Cetrin is cetirizine.

Excipients:

lactose;
magnesium stearate;
povidone;
corn starch.

The active substance at the cellular level binds to receptors and blocks the flow of histamine and prevents the manifestation of rash, itching, hyperemia.

Another feature of the effect of the drug is to effectively counteract the accumulation of eosinophils in the focus of inflammation and prevent the development of the inflammatory process.

Cetrizine is absorbed from the gastrointestinal tract, and food intake has little effect on absorption, so there is not much difference when taking the pill: before, after or during meals.

Metabolic processes are concentrated in the liver, the half-life is from 5 to 12 hours, depending on the age of the patient (the older he is, the longer the excretion).

The drug is excreted in the urine.

Indications for use

Allergic reactions that are seasonal or chronic in nature:

allergic rhinitis;
allergic conjunctivitis;
itching of various adventures;
hives;
angioedema.

Pregnancy as a contraindication

As for the mother's well-being, pregnant women taking Cetrin often complain about the negative effect of the drug on the functioning of the kidneys and liver.

Therefore, even if the allergy is too painful, do not take the drug on your own - an easy solution can later be very expensive.