Herbal preparations for the liver. Modern drugs for the treatment and restoration of the liver: features of use, evaluation of effectiveness and cost

The main drugs for the liver are hepatoprotective drugs, the action of which is aimed at restoring the functions of the most important organ. Such funds promote the regeneration of liver cells, restore its structure, protect against the influence of toxic substances that come with drugs, harmful and unhealthy foods, and protect against other damaging factors. Hepatoprotectors are prescribed for hepatitis (toxic, viral, alcoholic), cirrhosis, hepatosis and other diseases.

Since the liver has a unique ability to regenerate, such medicines have positive influence on the mechanisms of metabolism and help reverse pathological processes, increasing the resistance of the body to the effects of adverse factors. List medicines for the treatment of the liver is very wide, so choose best option treatment should be a doctor. Since treatment with hepatoprotectors is long, patients are more likely to accept herbal medicines that have a minimal risk of side effects. How to treat the liver with drugs, and which remedy will be the most effective and safe, we will tell in our article.

Medicines for the liver - the mechanism of action of hepatoprotectors and their classification

The best medicines for the liver should have the following therapeutic effect:

from accumulated ballast substances and toxins;
accelerate the regeneration and restoration of damaged cellular structures;
stimulate intracellular metabolism;
activate the processes of synthesis of protein compounds and enzymes in liver cells;
improve the separation of bile;
stop the inflammatory process;
protect liver cells from harmful factors.

All drugs with a hepatoprotective effect that contribute to the restoration of the liver are divided into the following groups:

Essential phospholipids (Essentiale Forte, Essliver Forte, Phosphogliv, Rezalyut);
Derivatives of amino acids (Heptral, Gala-Merz);
Bile acids (Ursofalk, Ursoliv, Ursosan, Urdox);
Preparations plant origin(Karsil, Gepabene; Silimar, Hofitol, Tykveol);
Medicines of animal origin (Progepar, Sirepar, Hepatosan);
Homeopathic remedies (Galsten, Hepel);
Dietary supplements (Liv-52, Gepatril, Ovesol).

As a rule, taking medicines from any drug group is carried out long time, usually throughout the entire period in which there is an adverse effect on the liver of a certain factor. At the same time, it should be borne in mind that an ideal tool that allows you to quickly and effectively restore a damaged organ has not yet been created. Hepatoprotective agents only complement the scheme complex treatment liver and their one-time intake after a plentiful feast, alcohol poisoning or treatment with toxic drugs will not give the desired result.

Therefore, you should not self-medicate, you need to take medicines only after a full examination and the correct diagnosis. At the same time, you will have to completely change your lifestyle: give up bad habits (alcohol, smoking), follow a sparing diet, avoid overeating and promptly treat concomitant diseases associated with impaired functions of others. digestive organs(gall, bladder, pancreas, intestines).

The best drugs that treat the liver - a list with names

Let us dwell in more detail on the properties and features of the use of the most popular drugs for the treatment of the liver.

Phospholipids

Animal products

Medicines of this group are used only in medicinal purposes and appointed at fatty hepatosis, hepatitis and cirrhosis. They are produced from porcine liver cells or a hydrolyzate isolated from the liver of cattle. Such drugs are taken strictly according to the doctor's prescription, since they have a high allergenic risk and can cause serious complications.

The composition of the drug includes cattle liver hydrolyzate, inositol, cyanocobalamin. This is a good medicine for liver pain, which is prescribed in the composition complex therapy chronic and toxic hepatitis, cirrhosis, fatty degeneration of the liver. The drug is contraindicated in childhood, during pregnancy and in case of hypersensitivity to its components.

Can cause allergic reactions. The course of treatment is selected by the doctor individually. The price of Progepar is quite high, the packaging of the drug costs on average from 1000 rubles.

Medicines for the liver after alcohol

Almost all hepatoprotectors can be taken for the prevention and treatment of alcoholic liver damage. Which remedy should be preferred by the attending physician, taking into account the severity of the condition, individual features patient and the presence of comorbidities. In addition to the main course of treatment, you can use preparations for cleaning the liver, which must be taken simultaneously with hepatoprotectors.

These funds include:

syrup Holosas,
sodium thiosulfate,
magnesia,
Sorbitol or preparations with absorbent properties ( Activated carbon, Polysorb, Enterosgel).

Before taking medication, consult a doctor who will help you choose the optimal therapy regimen for cleansing the liver after alcohol libations.

The website "Gorzdrav" presents a large selection of hepatoprotectors in different price categories. You can choose a remedy for protecting the liver from us by placing an order online. The list of medicines can be immediately sorted by active substance and price. To help the user, each drug is offered its analogues. After placing an order, payment for tablets takes place at the checkout in a pharmacy branch of the network convenient for you.

Order medicines for the liver

Gorzdrav is a pharmacy chain with more than 750 branches. We work in Moscow and St. Petersburg and the Moscow and Leningrad regions. A convenient filter system allows you to quickly find the right medicine for the liver and compare prices in different pharmacies. You can immediately choose a suitable branch and place an order online. Each tool must be accompanied detailed instructions indicating indications for use, possible side effects and contraindications. Only certified drugs are presented in our network, all certificates can be viewed on the website.

The use of drugs for the liver

The liver has to constantly struggle with the influence of harmful substances. It is involved in the processes of detoxification, processing of trace elements and digestion. Hepatoprotectors help protect the liver from harmful effects, prevent the destruction of its structure and accelerate regeneration[i].

Due to the constant heavy load, serious diseases can develop. The main causes of liver disease are:

Alcohol and drug use;
Improper nutrition;
Unfavorable ecological situation;
Medical treatment;
Genetics;
Lack of sufficient physical activity.

Sometimes pain occurs after quitting smoking or switching to a new diet. To protect and maintain functioning, preparations for the liver are prescribed. List possible drugs large, so before buying it is better to consult a doctor in order to choose a suitable effective remedy.

Release forms

Medicines are available at the pharmacy different form release. Each option differs in the rate of absorption and the concentration of the active substance. In addition to tablets for the liver, manufacturers offer:

capsules,
solutions,
powders,
suspensions,
cream,
pastes.

For whom

The drug is prescribed not only on the basis of symptoms, but also taking into account the age of the patient. There are separate groups:

for adults;
for children under 12;
for children over 12 years old.

A separate series are drugs for the prevention of liver diseases. They contain amino acids, useful microelements, natural components.

Contraindications

Each tool has certain restrictions on admission. Common risk factors when taking hepatoprotective drugs for the liver are:

individual intolerance to the components;
age discrepancy;
pregnancy and lactation;
kidney failure.

Certificates

Some certificates of goods presented in our catalog.

BEFORE USING THE DRUGS, READ THE INSTRUCTIONS FOR USE OR CONSULT WITH A SPECIALIST.

Bibliography:

[i] Hepatology issues: tutorial/ ed. V. V. Maleeva. - St. Petersburg: SpecLit, 2016. - 367 p.

Liver diseases are one of the common causes of disability and mortality in all countries, despite their economic development and climatic conditions. Every year, about 1 million people fall ill with liver diseases, among which the majority are young, able-bodied people.

Experts note that the development the latest drugs, vaccination and modern methods diagnostics do not give a positive trend: people continue to get hepatitis, cirrhosis, cancer, which is associated with many factors: alcoholism, unbalanced nutrition, poor ecology, chronic diseases.

To alleviate the condition of the victims and prevent the destruction of hepatocytes, many drugs have been developed, in particular, hepatoprotectors. Together with dietary nutrition and basic therapy, they normalize the basic functions of the liver, help restore its structure, and protect against the toxic effects of harmful compounds.

Any disease that affects the liver causes a serious disorder in almost all body systems, since the organ performs a number of important functions, in particular, the liver:

responsible for protein, carbohydrate, lipid, pigment metabolism;
neutralizes the harmful effects of toxins and drugs;
stores vitamins and minerals;
produces cholesterol and lipids;
regulates blood clotting;
responsible for products bile acids and transport them to the gallbladder;
stimulates the work of the intestines;
synthesizes and inactivates some hormones, including sex hormones;
produces enzymes;
is a repository of blood.

Nature, endowing the liver with so many functions, took care of its integrity. This is the only organ that can recover even after partial removal. But the body cannot always cope with some factors on its own, namely, with:

obesity;
alcohol;
medicines;
genetic factors;
drug use;
bad ecology;
diabetes mellitus;
hypodynamia;
improper nutrition.

Although the liver is able to recover, prolonged unbearable loads sooner or later disrupt its activity. Hepatoprotectors are designed to protect the liver from such factors. They, of course, will not replace basic therapy, but will complement the effect of prescribed drugs and can improve the function of liver cells.

With liver pathologies (hepatitis, hepatosis, fibrosis, cirrhosis, liver failure, cancer, etc.) and forced prolonged intake of certain drugs (anticonvulsant, antitumor, painkillers), the doctor must prescribe hepatoprotectors.

Recently, a myth has formed that this class of drugs is just an invention of "greedy" pharmacists who want to cash in on the grief of the sick and produce drugs with dubious effectiveness. Opponents of these drugs rely on the fact that in Europe and the USA liver treatment with such medications is not carried out, since they do not exist in the list of pharmacological agents.

But in the same list there is another group of medicines - cytoprotectors that have a positive effect on the metabolism of the liver, kidneys, heart, dermis, which include hepatoprotectors known to all.

In addition, abroad, hepatoprotectors are called pharmaceuticals, and some companies, for the benefit and convenience of registration, position them as biologically active additives(dietary supplements). Not very honest manufacturers under such hepatoprotectors-dietary supplements really produced drugs that were ineffective, which caused distrust of patients and practitioners.

Meanwhile, acquiring dietary supplements that have not passed clinical trials, which are not effective and do not help, patients are wasting time (for most liver diseases, there is a period when a relapse of the pathology is possible, and then only organ transplantation), hoping that one tablet will solve all their problems .

Patients should clearly understand that the use of clinically proven hepatoprotectors does accelerate liver recovery, but does not cancel diet and basic medications.

Modern hepatoprotectors can mitigate and alleviate liver disease, but they have their own limits of effectiveness, and it is impossible to hope that this is a panacea for all problems with the organ.

Properties and types

There are several classes of hepatoprotectors based on different components and having a specific mechanism of action, but they all have similar properties:

they are based on natural ingredients;
they restore the work of a diseased organ and normalize metabolism;
remove toxins and neutralize their action;
accelerate the regeneration of hepatocytes, increase their resistance to harmful factors.

According to the mechanism of action, 6 types of hepatoprotectors are distinguished, based on:

ursodeoxycholic acid;
flavonoids of other plants;
animal components;
essential phospholipids;
amino acids.

Based on ursodeoxycholic acid

The functions of ursodeoxycholic acid, formerly extracted from bear bile and now synthesized in laboratories, include:

liver protection. With the help of acid, special particles are produced that neutralize the harmful effects of toxins;
restoration of bile outflow and liquefaction of the secret, which contributes to normal digestion and its discharge into the intestine;
lowering cholesterol due to a decrease in its synthesis and dissolution of cholesterol stones;
strengthening immunity;
positive effect on the bile ducts.

Ursodeoxycholic acid hepatoprotectors, in addition to the listed properties, have an antioxidant effect. Due to this, liver cells and the whole body are less susceptible to aging. Indications for the appointment of such drugs are:

toxic liver damage, including alcohol and drugs;
hepatitis;
biliary dyskinesia;
hepatosis;
stagnation of bile;
cholangitis;
cystic fibrosis;
reflux gastritis;
dyspeptic syndrome.

The most famous are:

They may be assigned to long-term treatment(from 3 to 6 months), and are allowed for children. The disadvantage of the main ingredient is that it cannot be prescribed for:

acute conditions of the intestine and gallbladder;
problems with the work of the pancreas;
renal pathologies;
pregnancy and HB.

With prolonged treatment, side effects (indigestion) are noted. Therefore, it is not recommended to self-prescribe a medicine to improve health and strengthen the liver. Only the doctor determines the dosage and duration of the course of therapy, depending on the individual characteristics of the patient and the diseases detected.

With milk thistle

The most trusted drugs with vegetable base. Particularly popular are the fruits of milk thistle, in which many biologically active compounds have been found. active components(microelements, vitamins, organic acids).

Preparations based on milk thistle significantly reduce the toxic effect on the liver, promote the regeneration of cellular structures. In damaged hepatocytes, protein production is stimulated, cell membranes are stabilized, and the loss of trace elements stops, thereby increasing the natural regeneration of liver cells.

Of the most popular drugs can be called:

They are shown with:

hepatitis;
cirrhosis;
steatosis;
drastic weight loss.

These drugs are used to prevent liver pathologies with long-term medication and chronic alcoholism. They are often well tolerated by patients and rarely cause side effects.

Flaws:

decrease in the effectiveness of oral contraceptives when taken together;
are not prescribed for lactating and pregnant women;
are not prescribed for diseases of the female reproductive system ( benign tumors, hormonal disorders, malignant neoplasms);
not compatible with a number of drugs, such as Diazepam, Ketoconazole, (may enhance their effect).

With flavonoids from other plants

Milk thistle tablets are not the only herbal remedies that restore and protect the liver. Celandine, artichoke, pumpkin seeds, fumes officinalis can act as active ingredients in a number of hepatoprotectors.

They are distinguished by a minimum number of side effects, the ability to eliminate spasm of the gallbladder, improve the outflow and production of bile. For example, Allohol, which is not a hepatoprotector, also consists of herbal ingredients, but causes a lot of side effects. These drugs are prescribed for:

hepatitis of various origins;
dyskinesia of the gallbladder;
cholecystitis;
cirrhosis;
hepatosis;
exhaustion.

Among the shortcomings, the ability to provoke allergies and upset stools is noted. Not intended for pregnant and lactating women. The list of popular drugs includes:

With ingredients of animal origin

Preparations made from porcine liver are able to regenerate human liver hepatocytes, since they are as similar as possible in composition. Due to the detoxification and antioxidant action, they treat hepatitis, hepatosis and cirrhosis of the liver. Of the positive qualities note:

the ability to remove toxins from the body;
accelerate the regeneration of hepatocytes;
restore lost liver function.

high risk of allergies;
the risk of developing immunopathological syndromes in acute forms hepatitis A;
they are not suitable for the prevention of liver disease.

Clinically tested hepatoprotectors of this group include:

Sirepar, which has a detoxifying, liver-restoring effect.
Hepatosan with metabolic, restoring the functions of hepatocytes, action.

With essential phospholipids

According to statistics, these drugs are most common in the post-Soviet regions. They are obtained from soybeans. Phospholipids are products of lipid metabolism, which are a kind of bricks for building cells.

These substances are involved in the transport of nutrients, cell division and differentiation, they activate various enzymatic systems. The advantages of hepatoprotectors based on essential phospholipids include:

the ability to quickly restore hepatocytes at the molecular level;
protection against toxins and viruses;
improving the action of interferons;
preventing the formation of scar tissue.

These medicines include:

They are prescribed for:

acalculous cholecystitis;
hepatitis;
hepatosis;
cirrhosis;
neurodermatitis;
psoriasis.

Of the shortcomings, the need for prolonged use of drugs is noted in order to feel their effectiveness. Sometimes phospholipids cause bile stasis. In addition, they are quickly broken down in the stomach, and only a small proportion active substances gets to destination - in a liver.

Other types

In the liver, amino acids are involved in the production of phospholipids, break down fats, quickly restore hepatocytes, and remove toxins. The most popular acid in this class of hepatoprotectors is ademetionine, an amino acid involved in various biochemical processes in the body. It improves the quality of bile, reduces its toxicity, and promotes the rapid outflow of bile acids. Also used:

Used in the treatment of:

fatty hepatosis;
hepatitis A;
pancreatitis.

The list of essential drugs includes:

These drugs are more likely to cause side effects than others. These include the occurrence of such violations:

diarrhea;
nausea;
pain in the epigastric region.

Patient experience

Consider the opinions of patients regarding the effectiveness of hepatoprotectors:

Anton: “I have had epilepsy since I was 21. As soon as anticonvulsant therapy was selected, the neurologist prescribed Karsil. I did not believe that I would need it, since I drank handfuls of AEDs and did not want to add more drugs to them. But after 3 years, the liver tests worsened, and the liver had to be cleaned. Since then, I drink hepatoprotectors twice a year and follow diet number 5.

Anna: “Six months after giving birth, I was diagnosed with gallstone disease due to polyhydramnios during gestation. The uterus blocked the discharge of bile, because of which stagnation occurred and stones formed. I could not be fully treated, since most of the drugs cannot be taken by lactating women, so I kept to a diet and drank Borjomi.

No-shpu was prescribed as an anesthetic. All this time I felt disgusting, experienced colic, nausea, heaviness in my side and pain. When I stopped feeding, I went for an ultrasound. They said that from my 0.2 cm stones, they turned into 0.6 cm stones.

The doctor prescribed Ursofalk 2 capsules at night. After 3 months, I underwent a second examination, which showed that my stones began to dissolve. I have been taking the drug for a year now, and I hope that the next diagnosis will show a positive result.”

Vera Olegovna: “She was registered with her illness and regularly donated blood. Phosphogliv was prescribed to me by my doctor. I can’t say that he somehow protected my liver and improved my condition. It happened that I did not drink hepatoprotectors for years, and sometimes I drank it regularly. Didn't notice any difference.

Each time I used them, I felt sick and, interestingly, I got a runny nose. When finally the diagnosis was removed and the main treatment stopped, the liver tests returned to normal. This was not associated with hepatoprotectors. It was worth giving up the drugs - and everything returned to normal. I consider these drugs the usual pumping of money.

Today there is a huge number of hepatoprotectors. Attitudes towards them are different for both patients and doctors. Experts consider Heptral, Hofitol, Essentiale, Ursosan, Karsil, Silimar to be the most effective of them and recommend taking it for any liver dysfunction.

But, despite the popularity and apparent safety of these drugs, treatment should not be started without consulting a specialist. Each medication has its own indications and contraindications. With an illiterate approach and non-compliance with the recommendations, you can aggravate your condition and cause irreparable harm to health.

A hepatoprotector is a medicine for the liver that can restore the structure of its cells and prevent irreversible consequences. There are many such drugs, but only a few of them have proven effectiveness, for example, ademetionine and ornithine aspartate. Some categories of medicines have not been researched at all, these include herbal and animal medicines and homeopathy.

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Indications for admission

The liver is constantly exposed to toxins, alcohol and various diseases that lead to the death of its cells. In this case, hepatoprotectors help.

To date, no drug has been developed that would optimally restore the liver tissue in the required time frame to prevent the death of the organ. But there are drugs that help to a certain extent improve the regeneration process.

In some cases, hepatoprotectors can be prescribed to people who are exposed to negative factors to maintain a healthy liver, but their main task is to resist serious illnesses. Medicines are not the main means of treatment, only auxiliary.

Diseases for which such drugs are taken:

Disease	Description
Viral hepatitis	A hepatoprotector is prescribed if antiviral drugs are ineffective or if they cannot be taken. As part of complex treatment, they are used to prevent cirrhosis.
Alcoholic hepatitis	This disease can be complicated by cirrhosis. The situation requires the complete exclusion of alcoholic beverages, since hepatoprotectors will not work
Fatty degeneration of the liver	Pathologies are susceptible to people with non-insulin-dependent diabetes mellitus or obesity. It develops due to the formation of fat cells in the liver, destroying it. The hepatoprotector is prescribed in conjunction with other drugs that enhance its effectiveness. To improve the effectiveness of therapy, it is necessary to monitor nutrition and exercise.
drug-induced hepatitis	Also known as toxic. Hepatoprotector acts as part of complex therapy

Principles of use

All drugs are prescribed by a doctor. The benefits of many dietary supplements are questionable, so the patient decides to take them at home on his own. Tell your doctor about any herbal remedies you use, as some of them can be toxic to the liver.

Any hepatoprotectors are only an auxiliary medicine. The main focus should be on eliminating the disease ( antiviral therapy with hepatitis, etc.)

The effect of taking drugs will not be, if not eliminated bad habits that aggravate liver damage - alcohol, malnutrition, sedentary lifestyle. In parallel, other organs are being treated - the pancreas and gallbladder.

Hepatoprotectors with proven effectiveness

The only hepatoprotector that has been successfully tested is ademetionine.

The drug is released under various trade names:

Ademetionine is a substance that is produced in the human liver from foods containing methionine: milk, meat, or fish.

Due to a series of chemical reactions, glutathione is formed from it. It is involved in detoxification various types poisoning. Ademetionine is a precursor of glutathione.

With alcoholic liver disease

Alcoholic liver disease develops as a result of the toxic effect of the decomposition product of ethyl alcohol - acetaldehyde. It reduces the content of glutathione, an antioxidant that protects cells from toxins. Due to its lack, the production of substances that take part in oxidative reactions and kill hepatocytes increases. Cell membranes are damaged, collagen is overproduced. Fibrous tissue grows, fibrosis is formed.

The goal of treatment is to prevent the development of fibrosis, which eventually ceases to cirrhosis. Therapy is used to restore biochemical indicators blood, eliminate pain, improve metabolism. The drugs are used as part of a comprehensive treatment.

The intake of ademetionine compensates for the lack of substances involved in the life of the liver and the rest of the body. Studies support its effectiveness in the treatment of alcoholic liver disease. It has been proven that it has a positive effect on the survival of patients, especially in complex forms of the disease.

The probability of a cure when taking ademetionine increases by 2 times during the treatment of liver cirrhosis with alcohol damage in the first and second stages.

With chemotherapy

Almost all cancer-fighting drugs break down in the liver, which destroys it. When damaged by drugs, a closed effect is created, when, due to the destruction of liver cells in the blood plasma, the accumulation of the drug increases, which increases the toxic effect on the organ.

Studies have shown that ademethionine is indeed effective in reducing chemotherapy-induced hepatotoxicity.

Among the indications for taking such drugs include:

hepatic encephalopathy;
fibrosis and cirrhosis;
alcoholic liver disease;
any type of hepatitis;
acute liver failure;
hepatocellular cholestasis.

Ademetionine should not be used in the first two trimesters of pregnancy and in the presence of individual intolerance. It can provoke heartburn, epigastric pain, diarrhea, allergic reactions.

Hepatoprotectors requiring additional evidence of effectiveness

These include ursodeoxycholic acid (UDCA) and l-ornithine-l-aspartate.

Ursodeoxycholic acid

Medicines are manufactured under the following trade names:

Name of the drug	Release form	Manufacturer	Price	Image
Ursofalk	Capsules, 250 mg	Dr. Falk Pharma GmbH (Germany)	1500 rubles (50 pieces)
Urdox		JSC "Pharmaceutical enterprise "Obolenskoye""	1300 rubles (100 pieces)
Ursodez		CJSC "Northern Star"	1200 rubles (100 pieces)
Ursosan		PRO. MED. CS Praha a.s. (Czech Republic)	1600 rubles (100 pieces)
Ursoliv		AVVA-RUS OJSC (Russia)	1400 rubles (100 pieces)
Choludexan		World Medicine (Egypt)	500 rubles (20 pieces)
Exhol			1500 rubles (100 pieces)
Grinterol		Grindeks Rus LLC (Latvia)	900 rubles (50 pieces)
Livodex	Capsules, 300 mg	Sun Pharmaceutical Industries Ltd.(India)	750 rubles (100 pieces)

UDCA is allowed to drink to children at any age. But it has contraindications for use during pregnancy. According to some reports, it has a toxic effect on the fetus.

Ursodeoxycholic acid belongs to the group of bile acids. The mechanism of its work is not fully understood, since it is complex. It is supposed to protect the liver tissue and inhibit the absorption of bile acids in the lower segment. small intestine.The acid does the following:

Reducing the level of cholesterol in bile. It inhibits its absorption in the intestine and suppresses its production in the liver.
Increasing the solubility of cholesterol.
Decreased tendency of bile to form stones.

Ursodeoxycholic acid is indicated for men and women with the following pathologies:

biliary reflux gastritis;
small cholesterol stones in the gallbladder;
primary biliary cirrhosis.

It is also known that the drug has a regulatory effect on the immune system.

During treatment cholelithiasis experiments have been conducted that have proven that UDCA is effective in dissolving stones, especially when combined with chenodeoxycholic acid. However, the latter turned out to be toxic, so it was discontinued. Experiments have shown that taking ursodeoxycholic acid leads to the dissolution of stones in 40% of patients.

Its purpose is justified in diseases accompanied by intrahepatic cholestasis: cystic fibrosis, chronic hepatitis, sclerosing cholangitis, symptoms of the disease after organ transplantation, cholestasis with intravenous nutrition. Acid is ineffective in alcoholic liver pathology.

Primary biliary cirrhosis

This is a rare, difficult pathology to treat. Experiments have shown that in the case of taking ursodeoxycholic acid, jaundice and the content of serum enzymes are reduced. But the drug has no effect on itching, mortality, quality of life and the immune state.

Later it was proved that the effectiveness of the drug is observed only in the treatment of the disease at its initial stage. It has a positive effect on survival, but a negative effect on the liver in the presence of violations of its work.

The main disadvantages of the drug are the lack of injection and diarrhea when taken.

Globally, UDCA has shown a high level of efficacy in primary biliary cirrhosis. However, there is no evidence that it is effective in the treatment of other pathologies.

Contraindications to taking UDCA include serious illnesses liver and kidneys in the stage of decompensation, stones with a significant content of calcium, pregnancy and lactation. Among the side effects are disorders in the gastrointestinal tract.

L-ornithine-l-aspartate

Trade names of new generation drugs:

Namedrug	Release form	Manufacturer	Price	Image
Gepamerz	Granules for oral solution (3 g), concentrate for solution for infusion (500 mg/ml)	Merz Pharma GmbH & Co. KGaA (Germany)	2800 rubles (10 ampoules)
Larnamin		PJSC Farmak (Russia)	1000 rubles (10 ampoules)
Ornilatex	Concentrate for solution for infusion (500 mg/ml)	Sotex PharmFirma (Russia)	2000 rubles (10 ampoules)

Hepa-metz is considered the most effective drug.

Ornithine aspartate is separated into ornithine and aspartate and absorbed into small intestine. Amino acids are involved in the management of metabolic processes. In the rest of the liver cells, aspartate serves as a medium for the production of glutamine and the neutralization of ammonia, binding it in the tissues.

When the liver stops neutralizing toxins completely, it reduces the concentration of ammonia in the brain and other organs. The medicine is prescribed for cirrhosis, various forms of hepatitis and encephalopathy.

Contraindications to taking l-ornithine-l-aspartate include hypersensitivity, kidney failure, pregnancy and lactation, childhood. Side effects: diarrhea, flatulence, allergic reactions to the dye, pain in the extremities, nausea and vomiting.

Hepatoprotectors that do not have proven effectiveness

Essential phospholipids

The hepatocyte membrane contains 75% phospholipids. They carry out not only a building function, but also take part in the process of cell division, transport substances between them, and stimulate the activity of enzyme systems.

Toxins destroy membranes. This leads to a failure in the metabolic processes, the cell dies. Essential phospholipids strengthen the membrane. This property is the basis of the hepatoprotective mechanism - to save the liver from being converted into connective tissue. The drugs have contraindications for viral hepatitis, as they can reduce the production of bile and contribute to the destruction of cells.

Since 2003, essential phospholipids have not been used in the USA and the EU, they are sold as dietary supplements. As drugs, they are registered exclusively in the post-Soviet space. Few studies show that they improve well-being and some biological indicators.

Cons of funds:

Only strengthening the membrane of hepatocytes with essential phospholipids obtained from the outside is not enough to relieve inflammatory processes.
It has not been proven that they can be incorporated into the membrane.
There are no published works on the effectiveness of the drug.
Upon entering the body, phospholipids penetrate into the lymph, seep into the adipose tissue, where metabolic processes take place. Only small parts reach the liver, so they have low bioavailability.

Medicines do not have side effects. The only contraindication is individual intolerance.

List of modern drugs:

Name of the drug	Release form	Manufacturer	Price	Image
Essentiale forte	Capsules 300 mg	Aventis Pharma International (France)	670 rubles (30 pieces)
Esslial forte		Atoll OOO (Russia)	450 rubles (30 pieces)
Essliver forte		Nabros Pharma Pvt. Ltd (India)	200 rubles (30 pieces)
Rezalut pro		Berlin-Chemie/Menarini, Germany	1400 rubles (100 pieces)

Combined drugs:

Name of the drug	Active substance	Release form	Manufacturer	Price	Image
Phosfonciale	Essential Phospholipids + Silimar	200 mg + 70 mg capsules	Canonpharma production CJSC (Russia)	500 rubles (30 pieces)
Phosphogliv	Essential phospholipids + glycyrrhizic acid	35mg + 65mg capsules	Pharmstandard-Leksredstva (Russia)	500 rubles (50 pieces)
Hepatrin	Essential Phospholipids + Artichoke Extract + Milk Thistle + Vitamin E	180 + 90 mg + 67 mg + 10 mg capsules	Evalar (Russia)	300 rubles (30 pieces)

Essential phospholipids can be obtained from foods. Most of them are found in the yolk of an egg, fish, legumes and meat.

Milk thistle preparations

Silymarin flavonoids are the basis of milk thistle extract. Hepatoprotectors with a similar composition:

Name of the drug	Release form	Manufacturer	Price	Image
Karsil	Dragee, 35 mg	Sopharma JSC (Bulgaria)	700 rubles (180 pieces)
Legalon	Dragee, 70/140 mg	Madaus (Germany)	650 rubles (60 pieces)
Silimar	Dragee, 100 mg	CJSC "Pharmcenter VILAR"	100 rubles (30 pieces)

The complex drug is Gepabene. As an active ingredient, it contains an extract of fumes officinalis and milk thistle. The drug, produced in Germany, is available in the form of pills of 275 + 83 mg. Its cost is 400 rubles for a pack of 30 pieces.

The most inexpensive drug is Silimar. In fact, it is a complete analogue of the more popular Karsil. Milk thistle meal, which is a dietary supplement, is also used for treatment.

The instructions for the products state that silymarin is a natural antioxidant, regulates the activity of liver cells, and prevents the penetration of poisons into hepatocytes. The drugs trigger the synthesis of complex fats and proteins to restore cells. Medicines improve the condition of patients with liver damage by toxins, including alcoholism.

Minuses:

Silibinin, which has not been processed, has low availability - little active drug reaches the liver.
The drug should be taken with caution in patients with cholestasis.

Milk thistle preparations are safe, but ineffective. The results of the studies confirmed that silymarin has little effect on alcohol, hepatitis B and C.

Hepatoprotectors that have not passed reliable studies

There is not a single reliable study that would confirm the effectiveness of other drugs that claim to be hepatoprotectors.

Dietary supplements of plant origin:

Name of the drug	Release form	Active substance	Manufacturer	Price	Image
Hofitol	Tablets / solutions for injections	Artichoke Leaf Juice Extract	Laboratoires Rosa-Phytopharma (France)	700 rubles (180 pieces)
Liv 52	Tablets	Powder of prickly capers, chicory, black nightshade, arjun terminalia, western cassia, yarrow	Himalaya Drug Co.(India)	300 rubles (100 pieces)
Holosas	Solution for oral administration	Rosehip fruit extract	Altaivitamins (Russia)	120 rubles (300 g)
Tanacehol	Coated tablets	Tansy flower extract	Pharmaceutical center VILAR (Russia)	50 rubles (30 pieces)
Ovesol	Tablets	Herb extract of oats, turmeric, volodushka, immortelle, peppermint	Evalar (Russia)	250 rubles (40 pieces)

Extracts from the liver of cattle and components of bile:

Name of the drug	Active substance	Release form	Manufacturer	Price	Image
Progepar	Liver hydrolyzate	Dragee	Nordmark Artsnaimittel (Germany)	1000 rubles (50 pieces)
Allochol	Animal bile, garlic and nettle extract	Tablets	Veropharm OJSC (Russia)	100 rubles (50 pieces)
Holenzim	Dry bile and pancreas	Tablets	Biosintez OJSC (Russia)	150 rubles (50 pieces)

These drugs are not used anywhere, except for the CIS countries. Nevertheless, they occupy a significant place in the treatment of various pathologies of the liver and bile ducts.

Medicines based on bovine liver extract are hydrolases containing vitamin B12 and other components. The instructions indicate that the drug preserves and recreates the structure of hepatocytes, inhibits the formation of fibrosis, promotes the restoration of the parenchyma, promotes blood circulation in the liver tissue, increases the volume of urine and helps to improve the functioning of the organ. Means are recommended to be taken as part of complex therapy for viral and toxic hepatitis, fatty hepatosis, cirrhosis of the liver.

There have been no studies that could confirm or refute their effect. They are considered potentially dangerous, especially in active forms of hepatitis, when damage to the liver can be aggravated.

Bovine liver extract can transmit a prion infection to humans. It provokes the development of a serious disease of the central nervous system- spongiform encephalopathy (mad cow disease). Because of this, preparations based on this substance can be dangerous.

The effectiveness of such products of animal origin has not been proven, therefore, they cannot be used in medical practice. There is also a drug called Sibektan. It consists of plant components, one of which is St. John's wort. This is a hepatotoxic herb, the amount of poison in the medicine is comparable to chemotherapy for colon tumors, but it is classified as a hepatoprotector.

Homeopathic preparations

Homeopathic remedies do not have proven efficacy because experiments have not been carried out to test their effect. The essence of homeopathy is the treatment of like with like. Therefore, a substance is selected that causes the destruction of hepatocytes, and a homeopathic remedy is prepared from it.

As in the case of dietary supplements, it is impossible to confirm their effect. The World Health Organization does not recommend them for use. These drugs include:

Galstena. homeopathic remedy based on herbs. Ingredients: thistle, dandelion, celandine. Available in the form of drops based on ethyl alcohol (43%). It is used without restrictions in children, pregnant women. Produced in Austria. Cost - 200 rubles (for a bottle of 20 ml).
Hepel. Homeopathic preparation with complex action. Ingredients: celandine, cinchona, colocynth, club moss, nutmeg. Recommended for the treatment of children from birth. Producer - Germany. The cost is 250 rubles (for a bottle of 20 ml).

Additionally

There are drugs that cannot be attributed to the above.

These are herbal and synthetic products.

Antral

Synthetic drug, the active substance of which is a complex of aluminum and mefenamic acid. The manufacturer claims that the drug prevents the accumulation of lipids by liver cells, binds free radicals in the blood and stimulates oxygen metabolism in cells.

As a result of its use, the synthesis of phospholipids improves, hepatocytes are renewed. The tool was developed by Ukrainian scientists, clinical researches carried out only by them, in other countries it is not registered as a medicine.

Peponen

This is natural pumpkin seed oil. Contains unsaturated fatty acid, vitamin E, coenzyme Q, selenium. Reduces lipid content and prevents diseases such as diabetes and atherosclerosis.

It is prescribed for fatty degeneration of the liver. Producer - Israel. The cost is 25 rubles for 100 pieces.

Enzymes

In the treatment of liver pathologies, such drugs support the work of the pancreas, which is very important. Such medicines include:

Panzinorm;
Mezim;
Creon.

The composition of any preparations contains enzymes that promote the digestion of food. Their reception is also indicated in the presence of chronic pancreatitis.

Ultrasound doctor in multidisciplinary medical center Yanko Medical.

Participant international conferences, congresses, seminars devoted to the problems of gastroenterology and internal diseases. Expert and author of articles on the therapy of gastroenterology and hepatology.

Liver in human body is affected as a result of infection or overload, in the performance of its functions. Therefore, it is important which medicines for liver prevention to use in order to avoid deterioration in health.

Before finding out which pills to drink for the prevention of the liver, we will consider what functions it performs and what effects it undergoes.

A normally functioning organ is involved in the processes:

metabolism, i.e. influence on the metabolism in the body of hormones, proteins, vitamins, carbohydrates and other elements;
deposition (accumulation) of undigested fats, proteins, minerals, and so on;
secretions - the production of bile for digestion;
detoxification - filter functions, delaying and neutralizing poisonous elements;
excretion of toxic substances from the body.

Signs that signal kidney disease:

feeling of fatigue and loss of strength;
feel discomfort or spasms in the right hypochondrium;
loss of appetite, nausea;
the skin has changed color (a yellow tint, pigmentation has appeared).

When choosing which pills are best for prophylaxis for the liver, purchase products with a complex action, because they:

protect and restore broken cell membranes;
activate metabolism in each cell;
normalize the production of bile;
accelerate the synthesis of enzymes;
contribute to the removal of toxic substances.

Almost all tablets for the treatment and prevention of the liver contain essential elements that actively affect the functioning of the organ:

Glycyrrhizic acid has anti-inflammatory, antioxidant, hepaprotective effects. It counteracts cirrhosis and is part of the tablets for the prevention of the liver when drinking alcohol.
Phospholipids, which are involved in the regeneration of destroyed cells, are prescribed for a long course (up to 3 months) to achieve a therapeutic effect.
Ursodeoxycholic acids, which have a choleretic effect and contribute to the dissolution and removal of small stones. The best medicine for the prevention of the liver with this element - ursofalk, which is taken only as directed by a doctor.
Ademetionine is included in all drugs for the liver as a prophylaxis after alcohol, as it restores the activity of the organ after toxic damage.
Milk thistle extract is the most common natural element with an antioxidant effect, on the action of which are based inexpensive medicines for the prevention of the liver.
The extract of fumes officinalis is included in preparations for the prevention of the liver and gallbladder, as it relieves spasms and normalizes the formation of bile.

When comparing a list of drugs for liver prevention by price, the effectiveness of the ingredients and the effect they have should be taken into account in the first place.

Preparations for the prevention and treatment of liver diseases are divided into:

funds for maintaining the functions of the body while taking medications or medical procedures that adversely affect the liver (for example, during chemotherapy);
medicines for restoring the body after an illness (hepatitis, hepatic dystrophy, etc.);
drugs as liver prophylaxis before or after alcohol intake;
after receiving physical harm internal organs(trauma, surgery).

Help with appearance discomfort. Hepaprotectors are inexpensive drugs for the prevention of the liver, which have a preventive effect. Such pills for the prevention of the liver are sold without a doctor's prescription, as they have a mild effect.

Ovesol

Ovesol produces detoxification and restores the biliary tract. Inexpensive drug for the prevention of liver diseases, as it consists of natural components (immortelle, oats, peppermint, turmeric roots and others). Take 1 tablet or 15-20 drops 2 times daily with meals. Repeat the course of treatment 3-4 times a year for 20-30 days. Contraindicated: pregnant and lactating women, children, persons with hypersensitivity to one of the components.

Stabilin

The drug is made on the basis of natural natural ingredients:

amino acids that help produce new biologically active substances;
L-carotene warns oxygen starvation, increases the secretion of gastric juice;
L-tyrosine works as a fat burner;
B vitamins help normalize metabolic processes, participate in cell renewal;
extracts of artichoke, tryptophan and glycine improve the patency of blood vessels, accelerate metabolic processes.

All components are selected so as to be combined with each other and enhance the effect of each other. This provides a mild effect of the drug on the body.
Stabilin drops can be used for the prevention and periodic cleansing of the liver from toxins and toxins. Dissolve 3-5 drops in liquid (water, tea, juice). Take morning and evening.
Thanks to its natural composition, Stabilin has practically no contraindications. Pregnant and lactating women should always consult a doctor before use. The remedy is contraindicated for people with individual intolerance to the components of Stablen.

Stabilin Drops is a new generation hepatoprotector that facilitates and supports the work of the liver. For 1 course, the drug helps protect the liver from destruction. Stabilin drops replenish the supply of vitamins and nutrients.

Essentiale forte N

The drug is made from natural ingredients, practically does not cause negative consequences. It is recommended to take 2 tablets (capsules) 3 times a day (up to 6 tablets) per day. Analogues Essentiale forte N: Antraliv, Livolife, Essliver, Livenciale.

Leviron Duo

The Leviron Duo complex consists of two components:

Oil for the liver is taken on an empty stomach 3 times a day, 1 scoop.
Drops are taken 30 minutes before meals. Dissolve 10 drops in a glass of water.

The course of application is about a month.
The tool can be used for the complex treatment of liver diseases and for prevention, since many diseases can occur without symptoms in the initial stages. In addition, regularly undergo medical examinations for the timely detection of pathologies.

The composition of the drug includes:

polysaccharides quickly remove toxins and toxins;
larch bark extract slows down the aging process;
mineral-vitamin complex restores metabolic processes, strengthens the immune system.

Not only ordinary patients, but also celebrities leave positive for liver recovery. The supplement helps to solve liver problems in a month. In addition, many users note an improvement in skin condition, normalization of the digestive tract, and increased immunity.

Heptral

Heptral is recommended in case of damage to the organ by alcohol, drugs or toxic substances. The drug has concomitant antidepressant and antioxidant effects. It cleanses the liver and accelerates its regeneration, normalizes the gallbladder. How to take heptral tablets for liver prevention: 2-4 tablets of 400 mg between meals, without chewing. The drug has a number side effects from the nervous side (dizziness, insomnia, headache), digestive system(bloating, diarrhea, nausea, vomiting), etc. Consult your doctor before taking.

Karsil

Karsil - cheap pills for the prevention of liver disease. Allowed for children from 12 years old. Help to remove the effects of hepatitis, cirrhosis, alcohol poisoning. As a preventive measure, take 2-3 tablets a day before meals with water.

Liv 52

Inexpensive and effective medicine for the prevention of the liver - made from plant materials (capers, chicory, yarrow). Recommended for cleansing the body after taking alcohol, antibiotics, oral contraceptives and other drugs. In the instructions for use, Liv 52 is allowed for children from 6 years old. For prevention, take 2 tablets 2 times a day, regardless of meals.

Phosphogliv

The drug Phosphogliv and analogues (hepalin, ursoliv, silegon, etc.). It is prescribed for alcohol damage and fatty liver diseases, viral hepatitis. It contains glycyrrhizic acid and phospholipids, the drug helps restore liver function, has antiviral and immunomodulatory effects. It is recommended to take 1-2 tablets 3-4 times a day with meals with water. The course of admission is up to 3 months. The price of Phosphogliv is from 491 rubles. per pack (50 capsules). Reviews of Phosphogliv claim that the drug has not only a preventive, but also a therapeutic effect.

Drugs for the prevention of the liver and pancreas

Often, liver disease is associated with damage to other organs. abdominal cavity also involved in digestion and body defense.

Phosphalugel

Phosphalugel has an absorbent and antacid effect. Recommended for gastritis, diseases of the biliary tract and liver, peptic ulcer. Instructions for the use of phosphalugel - adults and children over 6 years of age one or two sachets (no more than 6 sachets per day) 2-3 times a day. The course of treatment is up to two weeks.

tsikvalon

Tsikvalon, which has a choleretic effect, helps to normalize the production of bile and its excretion. Adults and children over 7 years of age are prescribed 2 tablets 3 times a day after meals. Children under 7 years old - 1 tablet. The course of treatment is 1 month, which must be repeated 3-4 times a year.

Preparations for cleansing the liver and kidneys

Preparations for regular cleaning are reliable prevention of the kidneys and liver.

Cheers Lax

Ura Lax is suitable for the selection of stones in urolithic pathologies, has anti-inflammatory and antibacterial effects. Take 1 capsule twice daily with meals (preferably in the morning and afternoon).

CystoTransit

CystoTransit is a preparation from a phytogroup based on knotweed, cranberries, chamomile and other medicinal plants, which ensures the dissolution and removal of stones. Take 1 tsp. (5 ml), dissolved in a glass of water (250 ml), 4 times a day. The duration of admission is 20 days. The course is repeated 4 times a year.

Gortex

Gortex - herbal remedy, which is based on the root of hydrangea. At the same time it has an antiseptic and analgesic effect. Take 2 capsules 3 times daily with meals. Duration of admission - 1 month. Contraindications: pregnancy, breast-feeding, individual intolerance to the components of the drug.

Holidays and feasts affect more than one organ, so deciding which inexpensive and effective drug to use for the prevention of the liver, take care of the pancreas and the gastrointestinal system as a whole. For these purposes, a few days before the holiday, take drugs that help stabilize the body:

Mezim,
Panzinorm,
Pancreatin,
allohod,
Holosas.

The most effective medicinal plant in this area - milk thistle. Used in medicines due to the presence in milk thistle of silymarin, a means of protecting and activating the activity and growth of cells. An extract from milk thistle is produced in the form of oil, capsules or other products from the group of dietary supplements.

Legalon

Legalon is prescribed for the prevention of the liver with toxic and medicinal injuries, with chronic hepatitis, cirrhosis, diseases of the biliary tract and gallbladder. Contraindicated only when hypersensitivity to one of the components of the composition. Take Legalon 70 1-2 capsules 2-3 times a day, Legalon 140 - 1 capsule 2 times a day.

Silimar

Suitable as a prophylaxis for intoxication of the body when taking drugs and alcohol. Adults and adolescents over 12 years old: 1-2 tablets 3 times a day for 25-30 days. At chronic diseases, repeat the reception of funds in 1-3 months.

Silymarin

Silymarin is indicated for liver damage by toxins, hepatitis, for correcting disorders of fat metabolism, for the prevention of liver diseases. For preventive purposes, take 70 mg of the drug 3 times a day. Contraindicated in children under 12 years of age, with intolerance to silibinin and analogues. For maximum effect, while taking Silymarin, refrain from drinking alcohol and follow a diet.

Gepabene

To enhance the action, an extract from the fumigus is added to the preparations, which relieves spasms and normalizes the passage of bile. With this composition, Gepabene is produced. Take 1 capsule (maximum 6 capsules) within 24 hours at regular intervals.

Hofitol

Artichoke-based products are produced under the names "Bitter Artichoke", Hofitol, etc. The active substance of this plant is cymarin. Eliminates alcohol intoxication and puffiness. Take 2-3 tablets or 2.5-5.0 ml of solution before meals 3 times a day. The course continues for 2-3 weeks.

Vitamins for the liver

For normal functioning of the liver, it is necessary to maintain the work of the organ. For this, take vitamins, phytocomplexes or G epiprotectors.

Popular vitamins for liver prevention with names:

Chepaguard;
Gepar active;
Legalon;
Rosanol;
Lipostabil.

Patient reviews for the listed funds for the prevention of the liver are positive, which confirms the effectiveness of the drugs.

In addition to drugs for the prevention and treatment of the liver, decoctions and infusions of medicinal herbs are used.

Infusion of corn stigmas

The most affordable and common composition is made from corn stigmas, which improve the passage of bile and the release of small stones from the ducts. To do this, pour 2 tablespoons of the crushed plant into a glass of boiled water and insist under the lid for at least half an hour. The prepared solution is filtered and drunk in three doses during the day.

Turmeric

Turmeric has a similar effect, which helps repair damaged liver cells. A quarter teaspoon of turmeric is poured with hot water, honey is added to taste (at least 1 teaspoon), stirred until dissolved and the whole glass is drunk at once. Prepare and drink this infusion 3 to 4 times a day.

milk thistle

AT folk recipes milk thistle seeds are used, which are ground in a coffee grinder. For half a liter of water, take 2 tablespoons of seeds ground into flour and boil for a long time over low heat until the liquid is reduced to the volume of a glass. The resulting broth is taken in a tablespoon every hour.

Each treatment with folk remedies is carried out from 2 weeks to 2 months. After that, a break is made for at least a month. Then the treatment is repeated or other medicinal herbs are used.