Antihistamines Claritin. Claritin (tablets): instructions for use

Pharmacodynamics. Claritin - antihistamine, a selective blocker of peripheral H1-histamine receptors. AT clinical research it was shown that improvement in the condition of most patients began during the first 30 minutes of Claritin use. The antiallergic effect develops during the first 30 minutes after taking the drug, reaches a maximum within 8-12 hours and lasts 24 hours. Loratadine and its metabolites do not penetrate the BBB. Claritin does not affect the central nervous system, does not show anticholinergic and sedative effects, does not affect the speed of psychomotor reactions. In a clinical study in which Claritin was used for 90 days at a dose that exceeded the therapeutic dose by 4 times, a clinically significant prolongation of the interval Q-T was not detected on the ECG.
Pharmacokinetics. Claritin is rapidly absorbed from the gastrointestinal tract. The time to reach the maximum concentration of loratadine in the blood plasma is 1-1.3 hours, and the time to reach the maximum concentration of the main metabolite - desloratadine - is approximately 2.5 hours. Eating increases the time to reach the maximum concentration of loratadine and desloratadine by 1 hour. The maximum concentration of loratadine and Desloratadine is not dependent on food intake. The maximum concentration increases in elderly patients, patients with chronic renal failure or alcoholic liver damage.
In almost all cases, the level of influence of metabolites is higher than the level of influence of the parent substance. Determined concentrations appear in the blood plasma within 15 minutes after taking the drug inside. A comparative study of the use of Claritin syrup and tablets in adequate doses showed that the plasma concentration profile of desloratadine for both dosage forms comparable.
When researching in vitro It was found in human liver microsomes that loratadine is metabolized to desloratadine mainly under the influence of cytochrome P450 3A4 (CYP 3A4) and to a lesser extent cytochrome P450 2D6 (CYP 3D6). The elimination half-life is 8.4 hours for loratadine, 28 hours for its metabolites. About 27% of the administered dose is excreted in the urine during the first day. In the presence of ketoconazole, an inhibitor of CYP 3A4, loratadine is converted to desloratadine mainly under the influence of CYP 3D6. The elimination half-life increases with alcoholic liver damage and does not change in the presence of chronic renal failure.
The pharmacokinetics of Claritin in children aged 1-2 years when administered as a single dose of 2.5 mg does not differ from that in adults and older children.

Indications for the use of the drug Claritin

Seasonal (polynosis) and year-round allergic rhinitis and allergic conjunctivitis - elimination of symptoms associated with these diseases: sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching of the eyes, lacrimation. Chronic idiopathic urticaria. Skin diseases of allergic origin.

How to use Claritin

Tablets
Adults and children ≥12 years old - 10 mg (1 tablet) 1 time per day;
children aged 2-12 years with a body weight of 30 kg - 10 mg (1 tablet) 1 time per day, with a body weight ≤30 kg - 5 mg (1/2 t of tablet) 1 time per day;
children aged 1-2 years - 2.5 mg (1/4 t of tablet) Claritin 1 time per day.
Syrup
Adults and children aged ≥12 years - 10 mg (2 scoops - 10 ml of syrup) 1 time per day;
children aged 2-12 years with body weight ≥30 kg - 10 mg (2 scoops - 10 ml of syrup) 1 time per day, ≤30 kg - 5 mg (1 scoop - 5 ml of syrup) 1 time per day;
children aged 1-2 years - 2.5 mg (1/2 scoop - 2.5 ml of syrup) 1 time per day.

Contraindications to the use of the drug Claritin

Hypersensitivity (or idiosyncrasy) to any of the components of the drug.

Side effects of Claritin

The incidence of side effects with Claritin is approximately the same as with placebo. Such side effects like fatigue, headache, drowsiness, dry mouth, gastrointestinal disorders (nausea, gastritis), allergic rash. During the studies, isolated cases of alopecia, anaphylaxis, liver dysfunction, tachycardia and palpitations were observed.

Special instructions for the use of the drug Claritin

Claritin does not produce a clinically significant sedative effect when used at recommended doses (10 mg once daily). Claritin does not potentiate the effects of alcohol. At recommended doses does not affect the ability to drive vehicles or work with complex mechanisms.
Claritin should be discontinued at least 48 hours prior to skin diagnostic allergy tests to prevent false results.
For patients with severe violation liver function, the initial dose should be reduced due to a possible decrease in the clearance of loratadine (an initial dose of 5 mg 1 time per day or 10 mg every other day is recommended).
Application in children. The efficacy and safety of Claritin in children under the age of 1 year have not been proven. It should be noted that the pharmacokinetics of Claritin in children aged 1-2 years when prescribing a single dose of 2.5 mg does not differ from the pharmacokinetics of adults and older children.
Use during pregnancy and lactation. The safety of using the drug during pregnancy has not been established, so Claritin should only be used if the benefit to the mother outweighs the potential risk to the fetus. Since loratadine is excreted from breast milk, a choice should be made between taking the drug and breastfeeding.

Interactions with Claritin

While taking loratadine with ketoconazole, erythromycin, cimetidine, an increase in the concentration of loratadine in blood plasma was noted, but this increase did not manifest itself clinically, including according to ECG data.

Overdose of the drug Claritin, symptoms and treatment

Overdose may cause drowsiness, tachycardia and headache. With a single dose of 160 mg, no side effects not noted (including ECG changes). In case of overdose, symptomatic and supportive treatment is recommended. Standard measures are recommended for removing unabsorbed drug from the stomach: gastric lavage, taking activated carbon. Loratadine is not excreted by hemodialysis. After rendering emergency care the patient must remain under medical supervision.

Storage conditions of the drug Claritin

In a dry place at a temperature not exceeding 25 ° C.

List of pharmacies where you can buy Claritin:

• St. Petersburg

Tablets.

Basic physical and chemical properties: oval tablets white or almost white color with a "flask and bowl" sign, a break line and the number "10" on one side and a flat surface on the other side.

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Pharmacological group

Antihistamines for systemic use.

ATX code R06A X13.

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Pharmacological properties

Pharmacological.

Loratidine (the active ingredient of Claritin®) is a tricyclic antihistamine with selective activity for peripheral H1 receptors.

In most patients, when used at the recommended dose, loratadine does not have a clinically significant sedative and anticholinergic effect. During long-term treatment was not observed clinically significant changes in terms of vital functions of the body, laboratory research, physical examination or ECG. Loratadine has no significant influence on H2-histamine receptors. The drug inhibits the absorption of norepinephrine and has little effect on the function of the cardiovascular system or on the activity of the pacemaker of the heart.

Histamine skin test studies following a single 10 mg dose have shown that the antihistamine effect occurs after 1-3 hours, peaks at 8-12 hours, and lasts more than 24 hours. There was no development of resistance to the drug after 28 days of loratadine use.

Clinical efficacy and safety.

More than 10,000 people (aged 12 years and over) have been treated with loratadine (10 mg tablets) in controlled clinical trials. Loratadine (tablets) 10 mg once daily was more effective than placebo and as effective as clemastine in improving symptoms (nasal and non-nasal) of allergic rhinitis. In these studies, drowsiness occurred at a lower rate with loratadine than with clemastine and at about the same rate as with terfenadine and placebo.

Among the participants in these studies (aged 12 years and older), 1000 patients with chronic idiopathic urticaria were enrolled in placebo-controlled studies. Loratadine at a dose

10 mg once daily was more effective than placebo in the treatment of chronic idiopathic urticaria, as evidenced by the relief of pruritus, erythema, and allergic rash. In these studies, the incidence of drowsiness was similar between loratadine and placebo.

Children.

Approximately 200 children (aged 6 to 12 years) with seasonal allergic rhinitis received loratidine (syrup) at doses up to 10 mg once daily in controlled clinical trials. In another study, 60 children (aged 2 to 5 years) received loratadine (syrup) at a dose of 5 mg once a day. Unforeseen adverse reactions were not observed.

Efficacy in children was similar to that in adults.

Pharmacokinetics.

Suction. Loratadine is rapidly and well absorbed. The use of the drug during meals may slightly delay the absorption of loratadine, but this does not affect the clinical effect. The bioavailability of loratadine and its active metabolite is dose proportional.

Distribution. Loratadine binds actively (from 97% to 99%) with plasma proteins, and its active metabolite - with moderate activity (from 73% to 76%).

In healthy volunteers, the plasma half-life of loratadine and its active metabolite is approximately 1 and 2 hours, respectively.

Metabolism. After oral administration, loratadine is rapidly and well absorbed and extensively metabolized during the first pass through the liver, mainly by CYP3A4 and CYP2D6. The main metabolite of desloratadine is pharmacologically active and is largely responsible for the clinical effect. Loratadine and desloratadine reach maximum plasma concentrations (Tmax) after 1-1.5 hours and 1.5-3.7 hours, respectively, after the use of the drug.

Conclusion. Approximately 40% of the dose is excreted in the urine and 42% in the feces within 10 days, mainly in the form of conjugated metabolites. Approximately 27% of the dose is excreted in the urine during the first 24 hours. Less than 1% active substance output in unchanged active form- as loratadine or desloratadine.

In adult healthy volunteers, the half-life of loratadine was

8.4 hours (range 3 to 20 hours) and the main active metabolite 28 hours (range 8.8 to 92 hours).

Impaired kidney function. In patients with chronic renal impairment, the AUC and maximum plasma concentration (max) of loratadine and its active metabolite increased compared to those in patients with normal renal function. The half-life of loratadine and its active metabolite did not differ significantly from that of healthy people. In patients with chronic hepatic impairment, hemodialysis does not affect the pharmacokinetics of loratadine and its active metabolite.

Impaired liver function. In patients with chronic alcoholic liver disease, the AUC and maximum concentration of loratadine were two times higher, and their active metabolite did not change significantly when compared with such indicators in patients with normal liver function. The half-life of loratadine and its active metabolite is 24 and 37 hours, respectively, and increases with the severity of liver disease.

Elderly patients. The pharmacokinetics of loratadine and its active metabolite were similar in healthy adult volunteers and healthy elderly volunteers.

Indications

Symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.

Contraindications

Claritin ® is contraindicated in patients with hypersensitivity to the active substance or to any other component of the drug.

Interaction with other medicinal products and other forms of interaction

With simultaneous use with alcohol, the effects of the drug Claritin ® are NOT enhanced, which is confirmed by studies of psychomotor function.

Potential interactions may occur with all known inhibitors of CYP3A4 or CYP2D6, leading to increased levels of loratadine, which in turn may be the cause of an increased incidence of adverse reactions.

In controlled studies, an increase in the concentration of loratadine in blood plasma after simultaneous use with ketoconazole, erythromycin and cimetidine was reported, which was not accompanied by clinically significant changes (including ECG).

Children. Interaction studies with other drugs have only been performed in adult patients.

Application features

Claritin ® should be used with caution in patients with severe hepatic impairment.

The composition of the drug includes lactose. For this reason, patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency and glucose-galactose malabsorption should not use this medicine.

The use of Claritin ® must be discontinued at least 48 hours before skin testing, as antihistamines may neutralize or otherwise weaken positive reaction when determining the skin reactivity index.

Use during pregnancy or lactation

Pregnancy. There are very few data on the use of loratadine in pregnant women. Animal studies have shown no direct or indirect adverse effects regarding reproductive toxicity. It is advisable, as a safety measure, to avoid the use of Claritin ® during pregnancy.

Lactation. Physicochemical data suggest that loratadine/metabolites are excreted in breast milk. Since a risk to the baby cannot be ruled out, Claritin should not be used during breastfeeding.

Fertility. There are no data on the effect of the product on female or male fertility.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms

Claritin ® does not affect or slightly affects the ability to drive vehicles or operate other mechanisms. However, the patient must be informed that drowsiness has been reported very rarely, which may affect the ability to drive vehicles or use machines.

Dosage and administration

Mode of application .

Orally. The tablets can be taken with or without food.

Dosage .

Adults and children over 12 years of age should take 1 tablet (10 mg loratadine) once daily.

For children aged 2 to 12 years, the dosage depends on body weight. With a body weight of more than 30 kg

10 mg (1 tablet) 1 time per day. For children weighing less than 30 kg, use the drug in the form of a syrup.

Elderly patients .

Dose adjustment is not required for the elderly.

Patients with impaired liver function .

Patients with severe hepatic impairment should be prescribed the drug at a lower initial dose, since they may decrease the clearance of loratadine. For adults and children weighing over 30 kg, the recommended starting dose is 10 mg every other day.

Patients with impaired renal function .

There is no need for dose adjustment for patients with impaired renal function.

Children

The efficacy and safety of loratadine in children under 2 years of age has not been established.

The drug Claritin ® , tablets, is prescribed for children weighing more than 30 kg.

Overdose

An overdose of loratadine increases the incidence of anticholinergic symptoms. In case of overdose, drowsiness, tachycardia and headache have been reported. In case of overdose, symptomatic and supportive treatment is recommended for the required period of time. It is possible to use activated carbon in the form of an aqueous suspension. You can also do gastric lavage. Loratadine is not excreted from the body during hemodialysis; the effectiveness of peritoneal dialysis in removing the drug is unknown. After emergency care, the patient should remain under control.

Treatment allergic reactions organism requires the use of special antihistamines, blocking the work of histamine receptors and removing not only the main symptoms of the disease, but also struggling with them. Among the new medicines, which have a pronounced effect and are distinguished by practically absent side effects, is the medicine Claritin.

Description of the drug

Claritin, as well as other antihistamine drugs, blocks the production of H1-histamine receptors, due to which a long-term and, most importantly, rapid anti-allergic effect is formed. On average, the onset of action of the drug is 30 minutes. The composition of Claritin is similar to the composition of many antihistamines that are popular today. In one tablet 10 mg active substance, the same amount will be in two tablespoons of syrup.

The effect of the reception is achieved in five to eight hours and will be fully preserved with a stable condition of the patient throughout the day.

Interesting to know

Loratadine, being the active substance of Claritin, does not adversely affect nervous system.

At oral administration Claritin is evenly distributed in the gastrointestinal tract. Excretion occurs through the biological fluids of the body (urine and bile). Metabolism takes place unchanged. The elimination period of the drug varies from 6 to 90 hours and depends on the age of the patient, his physiological characteristics. health conditions, including the presence of chronic diseases.

Indications for use

It is important for patients to understand that any (even short-term) use of Claritin tablets is allowed only according to the instructions! There is a limited list of diseases in which the use of this drug is indicated. It:

• allergic rhinitis of a seasonal or year-round nature;
• allergic inflammation of the conjunctiva;
• urticaria in adults and children in the chronic, acute stage;
• any rash on skin provoked by an allergy to external and internal irritants;
• angioedema;
• pseudo-allergic reaction that occurs against the background of taking medical preparations for internal and local application, food and external allergens (pollen of flowers, plants, etc.).

Instructions for use

The dosage of the drug will depend entirely on the general well-being of the patient, his age, the presence of chronic / recurrent diseases.

note

Syrup Claritin is prescribed for children. The daily dosage is selected taking into account the weight of the child, age.

Claritin tablets are prescribed for adult patients. If the child has reached the age of 12 years, he can also be given tablets in the "adult" daily dose of 10 mg. For patients with problems with the liver and kidneys, the dosage is adjusted - 10 mg is taken every other day. The drug must be taken with plain water.

The appointment of Claritin and dose adjustment for patients with liver and kidney disease should be based on laboratory tests performed (Reberg's test). The dosage regimen changes as follows: 10 mg of the drug is taken on the first, third, fifth and subsequent days. You can divide the dosage by two and take it daily - i.e. 5 mg of the drug once a day, regardless of the time of day.

For a child, the dosage is selected taking into account his weight: less than 30 kilograms - a one-day dose in one dose will be 5 mg. For small patients, syrup treatment is preferable. The liquid form will allow you to accurately measure the dose. With a body weight of more than thirty kilograms - a dose of 10 milligrams of the drug, i.e. 1 tablet or two spoons (10 ml).

Overdose

Claritin has side effect in case of violation of the dosing regimen. If the dose in one dose is increased, undesirable symptoms may appear, expressed in increased fatigue, drowsiness, dizziness, migraine, increased blood pressure. AT childhood overdose is manifested by characteristic symptoms:

• tachycardia;
• weakening of muscle tone;
• slow flexion of the hands and fingertips;
• the appearance of asymmetry in the face;
• lip tremor;
• nervous tics;
• trembling of the head and parts of the body.

In no case should you ignore the appearance of side effects associated with an overdose of the drug! If any symptoms suggestive of an overdose occur, seek immediate medical attention. medical care, where a set of measures aimed at gastric lavage with subsequent intake of absorbents will be carried out.

Release form

White tablets with a slightly bitter taste and syrup - the main forms of release this medicine. Tablets are packaged in blisters from seven to fifteen pieces. The syrup is available in two volumes of 60 and 120 grams. For ease of dosing, there is a special spoon.

Regardless of the form, the drug has the same effectiveness. In childhood, the pediatrician selects the dosage. The use of Claritin tablets is recommended only according to the instructions, and the dosage should not exceed the established daily allowance. The syrup is prescribed for small patients 2-12 years old.

Claritin for allergies

Medicines related to the past generation, for example, Suprastin, do not act on the same principle as Claritin. That is why they often cause a “side effect”: drowsiness and general weakness.

The main purpose of the drug is to urgently relieve symptoms, expressed in the form of sneezing, lacrimation, runny nose, skin itching, burning, sore throat. Claritin for adults, if you follow the instructions for use, does an excellent job with bronchospasm, against the background of viral and infectious diseases oral cavity and pharynx, as well as provoked by external and internal stimuli.

Interesting to know

Claritin, like any other antiallergic drug, can completely modify laboratory data. If an allergy test is to be taken in an adult patient or a child, Claritin should be completely stopped at least two days before the study. Otherwise, the test results will be distorted and not correspond to reality.

Claritin in the treatment of urticaria

Claritin belongs to a new generation of drugs and copes well with the symptoms of not only the "classic" types of allergies in the form of a runny nose, watery eyes, nasal congestion, sneezing, but also with urticaria - a disease that has a rather specific, but recognizable clinical picture. Urticaria is characterized by itchy skin rashes. Small spots turn into blisters and burst, which causes serious discomfort for the sick person.

Itching and blisters do not disappear on their own, requires therapeutic treatment, which consists in the use of the drug Claritin according to the instructions attached to the drug or other antihistamines. Claritin is better than other drugs, since it does not have a “side effect”, it allows you to remove the symptoms of the disease (itching) within half an hour after drinking the pill, and also reduce inflammatory process on the skin. Urticaria is divided into two stages: subacute and chronic.

note

The subacute stage is curable by complex therapy antihistamines orally and topically. Chronic urticaria is characterized by frequent relapses predominantly in the spring-summer period and are associated with exposure to internal and external stimuli. Chronic urticaria is quite treatable and it is difficult to talk about a complete recovery of the diseased.

In order to prevent the disease (for example, on the eve of flowering plants), it is necessary to start taking Claritin in advance, which has a cumulative effect. So it will be possible to either completely eliminate relapse or minimize the consequences of the disease, smoothing out its main symptoms.

What is the price. About the cost of medicine

The cost of Claritin in pharmacies for tablets varies:

• from 150 to 230 rubles (7 pieces in a package);
• from 200 to 250 rubles (for 10 pieces);
• from 500 to 670 rubles (for 30 pieces).

The price of Claritin tablets is higher than similar drugs, the cost of which is 2-3 times cheaper.

The syrup is sold in two volumes - 60 and 120 ml. The price of Claritin in liquid form:

• 60 ml - from 250 to 300 rubles;
• 120 ml from 320 to 500 rubles.

A brief overview of analogues

Among the analogues of Claritin, several drugs can be distinguished that are in no way inferior to this drug in their effectiveness: Loratadin, Clarotadin, Desal, Erius, Telfast, Gistafen. Claritin and its analogues cost from 20 to 400 rubles, depending on the manufacturer.

Contraindications

Treatment with Claritin, regardless of the form of release, is completely contraindicated in the following categories of patients:

• children under two years of age;
• when breastfeeding;
• with hypersensitivity to the active active substance.

Side effects

Therapy with this drug can provoke the development of undesirable reactions of the body, expressed in:

• increased fatigue;
• digestive disorders;
• headache;
• weaknesses;
• feeling of dryness in the mouth.

In very rare cases, development anaphylactic shock, heart palpitations, malfunctions of the heart and liver.

In the treatment of children, care should be taken and general well-being should be monitored on the first day of taking Claritin. For young children, the appearance of increased anxiety, drowsiness, headache is characteristic.

A drug Claritin- an antihistamine, a selective blocker of peripheral H1-histamine receptors. In clinical studies, it has been shown that the improvement in the condition of most patients began during the first 30 minutes of using Claritin. The antiallergic effect develops during the first 30 minutes after taking the drug, reaches a maximum within 8-12 hours and lasts 24 hours. Loratadine and its metabolites do not penetrate the BBB. Claritin does not affect the central nervous system, does not show anticholinergic and sedative effects, does not affect the speed of psychomotor reactions. In a clinical study in which Claritin was used for 90 days at a dose that exceeded the therapeutic dose by 4 times, a clinically significant lengthening Q-T interval was not detected on the ECG.

Indications for use:
A drug Claritin prescribed for:
- seasonal (hay fever) and year-round allergic rhinitis and allergic conjunctivitis (to eliminate the symptoms associated with these diseases - sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching in the eyes, lacrimation);
- chronic idiopathic urticaria;
— skin diseases allergic genesis.

Mode of application:
A drug Claritin appoint inside, regardless of the meal.
Adults (including the elderly) and adolescents over the age of 12 years are recommended to take Claritin at a dose of 10 mg (1 tablet or 2 teaspoons / 10 ml / syrup) 1 time / day.
For patients with impaired liver function or kidney failure the initial dose should be 10 mg (1 tab. or 2 teaspoons / 10 ml / syrup) every other day.
For children aged 2 to 12 years, the dose of Claritin is recommended to be prescribed depending on body weight: with body weight less than 30 kg - 5 mg (1/2 tab. or 1 teaspoon / 5 ml / syrup) 1 time / day, with weight body 30 kg or more - 10 mg (1 tab. or 2 teaspoons / 10 ml / syrup) 1 time / day.

Side effects:
The frequency of occurrence of side effects when using Claritina about the same as with placebo. There were such side effects as fatigue, headache, drowsiness, dry mouth, gastrointestinal disorders (nausea, gastritis), allergic rash. During the studies, isolated cases of alopecia, anaphylaxis, liver dysfunction, tachycardia and palpitations were observed.

Contraindications:
A drug Claritin contraindicated:
- age up to 2 years;
- lactation period breastfeeding);
— hypersensitivity to loratadine or any other component of the drug.
With caution, the drug should be prescribed during pregnancy, liver failure.

Interaction with other drugs:
Claritin does not enhance the effect of ethanol (alcohol) on the central nervous system.
At joint admission Claritin with ketoconazole, erythromycin or cimetidine showed an increase in plasma concentrations of loratadine and its metabolite, but this increase was not clinically manifested, incl.

according to the ECG.

Pregnancy:
Application Claritina during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.
The active components of the drug are excreted in breast milk, therefore, when prescribing the drug during lactation, the issue of stopping breastfeeding should be resolved.

Overdose:
Symptoms: drowsiness, tachycardia, headache.
Treatment: gastric lavage (preferably with 0.9% sodium chloride solution), intake of adsorbents (crushed activated carbon with water), symptomatic agents. Loratadine is not excreted by hemodialysis.

Storage conditions:
The drug should be stored out of the reach of children at a temperature of 2 ° to 30 ° C. Shelf life of tablets - 4 years, syrup - 3 years.

Release form:
Claritin tablets
Tablets of 10 mg, packing of 7; 10 or 30 pieces (blister pack). Tablets are white or almost white, marked with the number "10" on one side and the manufacturer's trademark (flask and bowl) on the other, have a risk on one side.
Claritin syrup
Syrup in dark glass bottles of 60 or 120 ml. The kit comes with a dosing spoon with labels. Yellowish or colorless syrup without impurities.

Compound:
Claritin tablets
Active ingredient (in 1 tablet): loratadine (10 mg).
Excipients: lactose, corn starch, magnesium stearate.

Claritin syrup
Active ingredient (in 5 ml of syrup): loratadine (5 mg).
Excipients: glycerol, propylene glycol, sodium benzoate, citric acid, granulated sucrose, artificial flavor (peach), water.

Additionally:
Use for impaired renal function
For patients with renal insufficiency, the initial dose should be 10 mg (1 tablet or 2 teaspoons / 10 ml / syrup) every other day.
Use in violation of liver function
Use the drug with caution in liver failure: the initial dose should be 10 mg (1 tablet or 2 teaspoons / 10 ml / syrup) every other day.

Analog:
Lorahexal, Lomilan, Lotharen, Clallergin, Clarisens, Claridol, Loratadin-Hemofarm.

Country of origin

Product group

Antiallergic agent - Hj-histamine receptor blocker.

Release forms

• 10 - blisters (1) - packs of cardboard. 10 - blisters (3) - packs of cardboard. 120 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard. 60 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard. 7 - blisters (1) - packs of cardboard.

Description of the dosage form

• a clear, colorless or yellowish syrup that does not contain visible particles. oval-shaped tablets of white or almost white color, not containing foreign inclusions, on one side there is a risk, the trademark "Cup and flask" and the number "10", the other side is smooth.

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• Loratadine 1 mg Excipients: citric acid, artificial flavor (peach), glycerol, propylene glycol, sodium benzoate, granulated sucrose, purified water. Loratadine 10 mg Excipients: corn starch, lactose, magnesium stearate.

Claritin indications for use

• - seasonal (hay fever) and year-round allergic rhinitis and allergic conjunctivitis (to eliminate the symptoms associated with these diseases - sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching in the eyes, lacrimation); - chronic idiopathic urticaria; - skin diseases of allergic origin.

Claritin contraindications

• - age up to 2 years; - lactation period (breastfeeding); - hypersensitivity to loratadine or any other component of the drug. With caution, the drug should be prescribed during pregnancy, liver failure.

Claritin dosage

• 1 mg/ml 10 mg

Claritin side effects

• In clinical studies involving children aged 2 to 12 years who took the drug Claritin® more often than in the placebo group, headache (2.7%), nervousness (2.3%), fatigue (1%) were observed. In clinical studies involving adults, adverse events, which were observed more frequently than with placebo ("dummy"), occurred in 2% of patients taking the drug Claritin®. In adults, when using the drug Claritin® more often than in the placebo group, headache (0.6%), drowsiness (1.2%), increased appetite (0.5%) and insomnia (0.1%) were noted. In addition, there were very rare reports in the post-marketing period (

drug interaction

Overdose

Storage conditions

• keep away from children

Synonyms

• Vero-Loratadin, Clarisens, Clarifer, Clarotadin, Lomilan, Loratadin 10-SL, Loratin, Loridin.