When using ketotifen, the therapeutic effect develops. Ketotifen tablets: the use of a powerful weapon against allergies

Modern market medicines offers a wide range of allergy medications. One of them is "Ketotifen", which is often used for adults with allergic dermatitis, bronchial asthma, allergic rhinitis and other diseases that provoke allergens. Not everyone knows whether it is possible to give such a medication to children when it is used in childhood and what analogues can be replaced.

Release form

Ketotifen is produced by several domestic companies, but our market also has a Bulgarian drug called Ketotifen Sopharma. They are represented by two forms that are used for children of different ages:

• Syrup. It is a viscous transparent liquid of a yellowish color or without color, which smells of vanillin or strawberries. One vial contains 50 or 100 ml of this medicine. A 5 ml measuring spoon or measuring cup is attached to the bottle.
• Tablets. They have a white color, a round flat shape and a slight specific smell. They are packaged in blisters of 10 pieces and are sold in packs of 10-60 tablets.

Compound

The main component of the drug is ketotifen fumarate or hydrofumarate. In terms of ketotifen, its dosage in 5 milliliters of syrup, as in one tablet, is 1 mg. Auxiliary substances of the syrup can be sodium saccharinate, citric acid, ethyl alcohol, sucrose, sorbitol, purified water and other compounds. The solid drug may further include milk sugar, magnesium stearate, MCC, starch, and other ingredients.

Operating principle

Ketotifen has the ability to influence mast cells (stabilize their membranes). This action prevents the release of histamine and other active substances from these cells. Since this release occurs when allergic reaction, the drug effectively eliminates different symptoms allergies.

In addition, "Ketotifen" prevents the accumulation of eosinophils in tissues respiratory tract and is able to prevent asthma attacks (prevent bronchospasm, but do not expand them). Such a drug blocks histamine receptors, which is also important for eliminating or preventing an allergic reaction.

The drug taken orally is very quickly and almost completely absorbed, and meals do not affect the absorption of the drug.

The maximum concentration of its active substance is determined in the blood 2-4 hours after ingestion, but the therapeutic effect does not appear immediately, but after 6-8 weeks from the start of use. After metabolic changes, most of the drug is excreted in the urine.

Indications

"Ketotifen" is in demand:

• For the prevention of asthma attacks as part of complex treatment.
• With allergic bronchitis.
• With atopic dermatitis.
• With allergic rhinitis.
• With hay fever.
• With urticaria.
• With inflammation of the conjunctiva of an allergic nature.

At what age is it allowed to take?

"Ketotifen" is not prescribed in the first 6 months of life. Babies older than six months are prescribed medicine in the form of a syrup. The tablet form of the drug is used in the treatment of children who are 3 years old. If a child over 3 years of age has difficulty taking solid medicine, syrup may be given.

Contraindications

The drug is not prescribed if a small patient has hypersensitivity to any of its ingredients. With epilepsy or liver disease, the use of "Ketotifen" should be monitored by a doctor.

Side effects

• Taking "Ketotifen" can cause drowsiness and affect the speed of mental reactions, slowing it down. The drug can cause mild dizziness. Such negative symptoms usually occur at the beginning of treatment and soon disappear.
• Sometimes a child's body may react to syrup or tablets with increased appetite, dry mouth, or dyspeptic symptoms.
• In rare cases, the drug provokes weight gain, the appearance of cystitis, or a decrease in platelet levels.

Instructions for use and dosage

• The medication is given to children twice a day - in the morning and in the evening. Eating does not affect the treatment with Ketotifen, but it is recommended to take the drug with meals.
• For children aged 6-36 months, a single dosage is 500 mcg, which corresponds to 2.5 ml of syrup.
• A child older than 3 years is given 1 mg of the drug at a time. This dose of the drug is contained in 5 ml of syrup or in one tablet.
• The remedy is often prescribed for a long course of 2-3 months, and "Ketotifen" is canceled gradually, reducing the dosage over several weeks.

Overdose

A very large dose of "Ketotifen" causes drowsiness, disorientation, bradycardia, shortness of breath, convulsions and others. dangerous symptoms. In children, an overdose is often manifested by increased excitability. If it is detected, you need to provoke vomiting and give the baby laxatives or Activated carbon immediately calling an ambulance.

Interaction with other drugs

Taking the medicine enhances the therapeutic effect of many drugs, including sedatives, antihistamines or sleeping pills. If with bronchial asthma or allergic bronchitis "Ketotifen" is used together with bronchodilators, their dosage can be reduced. The simultaneous appointment of "Ketotifen" and oral hypoglycemic agents leads to reversible thrombocytopenia.

Terms of sale

The drug belongs to prescription drugs, therefore, before purchasing it, you need to visit a doctor with your child and take a prescription. The average price of 30 tablets of "Ketotifen" is 30 rubles. A syrup of both Russian and Bulgarian production costs about 75 rubles per bottle.

Storage conditions

The shelf life of unopened syrup and Ketotifen tablets is 3 years (Sopharma tablets - 4 years). Until it expires, the medicine can be kept in a dry place at room temperature. In this case, the drug should be protected from sunlight and inaccessible to a small child. After opening the bottle, the syrup is stored for only 1 month.

Reviews

There is a lot about the treatment with Ketotifen good reviews. They confirm the effectiveness of such a tool in different forms allergies and praise the drug for an affordable cost. According to parents, the medicine helps to get rid of allergic cough, dermatitis, runny nose and other manifestations. allergic diseases. Moms like that for little patients the medicine is released in the form of a syrup, the taste of which does not cause protest in most children.

There are also negative reviews. Some note the lack of the expected effect. Sometimes parents complain that the remedy helped only at the first dose, and re-treatment turned out to be ineffective. Many mothers speak badly about the medicine because of the appearance side effects- For example, drowsiness and nervousness. Parents do not like the need to take the drug for a very long course.

Analogues

Instead of "Ketotifen", drugs with the same effect can be used - for example, products based on cromoglycic acid ("Intal", "Krom-allerg", "KromoGEKSAL"). In addition, children with allergies may be prescribed drugs with antihistamine action.

The most popular are:

• Syrup "Claritin", active substance which is loratadine. This remedy does not provoke drowsiness and can be used for hives, allergic conjunctivitis, atopic dermatitis and other diseases. The drug is used from the age of two and is also available in tablets, which are prescribed to children over 3 years of age.
• Drops "Zirtek". This is one of the cetirizine preparations approved for children from 6 months of age. The drug is in demand for seasonal rhinitis, Quincke's edema, food allergies, urticaria and other diseases. In solid form (coated tablets), it is prescribed from the age of 6.
• Tablets "Suprastin". The main component of this drug is chloropyramine. The drug is prescribed for children over 3 years old. The drug is also available in an injectable form, which is in demand for high temperature body that poses a danger to the child (used together with "Analgin").
• Syrup "Erius". Such a sweet medicine based on desloratadine is used for itching, sneezing, rashes and other manifestations of allergies in children older than a year. "Erius" is also available in coated tablets, approved from 12 years of age.
• Drops "Fenistil". The main advantage of such a drug containing dimethindene is the possibility of use for children from 1 month. The medicine is also represented by local forms (gel, emulsion) prescribed for allergic skin lesions.

Doctor Komarovsky will tell you which antiallergic drugs are best used to treat a child in the following video.

Ketotifen is a mast cell membrane stabilizer; antiallergic agent.

Release form and composition

• Tablets - 10 pcs. in blister packs, in a cardboard pack 1, 2, 3, 4 or 5 packs;
• Syrup for oral administration - 100 ml in dark glass bottles, in a cardboard pack 1 bottle complete with a measuring cup.

The active substance of the drug is ketotifen (in the form of fumarate): in 1 tablet and 5 ml of syrup - 1 mg.

Indications for use

Ketotifen is for long-term treatment and prevention of exacerbation of the following diseases:

• allergic bronchitis;
• Atopic bronchial asthma;
• allergic dermatitis;
• allergic conjunctivitis;
• allergic rhinitis;
• Acute and chronic urticaria;
• Hay fever (pollinosis) and its asthmatic complications.

Contraindications

• Children's age up to 3 years - for tablets, up to 6 months - for syrup;
• Lactation (or breastfeeding should be stopped);
• Taking sedatives;
• Hypersensitivity to the components of the drug.

Patients with hepatic insufficiency and epilepsy should be under special supervision during the treatment period.

Although no effect of Ketotifen on pregnancy, peri- and postnatal development has been noted in animal studies, the safety of its use in humans has not been established. For this reason, pregnant women, especially in the first trimester, the drug is prescribed only in cases of extreme necessity, after a careful assessment of the ratio of expected benefits to the mother and potential risks to the fetus.

Method of application and dosage

The drug should be taken orally with meals.

Adults are prescribed 1 mg of ketotifen - 1 tablet or 5 ml of syrup - 2 times a day (during breakfast and dinner). If necessary, the daily dose is increased to 4 mg (2 tablets or 10 ml of syrup twice a day). Patients prone to the development of a sedative effect should start taking the drug with a dose of 0.5 mg (1/2 table or 2.5 ml of syrup) 2 times a day, gradually increasing it to the recommended therapeutic dose.

Children over 3 years of age are prescribed 1 tablet or 5 ml of syrup twice a day.

For children 1-3 years old, Ketotifen is given only in the form of syrup. A single dose is 0.25 ml (0.05 mg) per kilogram of body weight, the frequency of doses is 2 times a day.

The minimum duration of treatment is 3 months. Cancellation of the drug is carried out gradually - reducing the dose within 2-4 weeks.

Side effects

• Nervous system: dizziness, drowsiness, slow reaction rate (as a rule, these symptoms disappear after a few days of treatment), fatigue, sedation; rarely - sleep disturbances, anxiety, nervousness (especially in children);
• Digestive system: increased appetite, dry mouth, nausea, vomiting, constipation, gastralgia;
• Urinary system: cystitis, dysuria;
• Other: weight gain, thrombocytopenia, allergic skin reactions.

Symptoms of acute overdose: disorientation, confusion, drowsiness, up to depression of consciousness, arterial hypotension, tachycardia, more often in children - irritability and convulsions. Possible coma.

If a little time has passed since taking a high dose of the drug, you should do a gastric lavage, take activated charcoal. Further treatment is symptomatic, under the control of functional parameters. of cardio-vascular system. With the development of a convulsive syndrome, anticonvulsants are prescribed - benzodiazepines or barbiturates. Dialysis is ineffective.

special instructions

When prescribing Ketotifen to patients with bronchial asthma it should be borne in mind that several weeks may pass before the full therapeutic effect is achieved. If an adequate response to ongoing therapy after this time still does not appear, it is not necessary to interrupt treatment, it is recommended to continue taking the drug for another 2-3 months.

Anti-asthma therapy should be continued for at least 2 weeks after starting Ketotifen.

In the case of previous treatment with glucocorticosteroids, beta-adrenergic stimulants or adrenocorticotropic hormone in patients with bronchial asthma and bronchospastic syndrome after the start of taking Ketotifen, they must be canceled within 2 weeks - gradually reducing the dose. Recurrence of asthmatic symptoms is possible within 2-4 weeks.

The drug is not intended for the relief of asthma attacks.

Ketotifen allows you to reduce the dose of bronchodilators taken at the same time.

Based on pharmacokinetic data and clinical observations, children may require higher doses than adults for optimal results. Tolerability of the drug in this case does not deteriorate.

During the period of treatment, you should refrain from drinking alcoholic beverages, potentially dangerous species activities that require speed of reactions and / or increased concentration of attention (including driving a car). Rating: 4.7 - 3 votes

Ketotifen

International non-proprietary name

Ketotifen

Dosage form

Tablets 1 mg

Compound

One tablet contains

active substance: ketotifen 1.0 mg (as ketotifen fumarate),

Excipients: microcrystalline cellulose, croscarmellose sodium, magnesium stearate, anhydrous colloidal silicon dioxide, lactose monohydrate.

Description

Tablets white or almost white color, odorless or with a slight specific odor, biconvex.

Pharmacotherapeutic group

Antihistamines systemic action. Other systemic antihistamines. Ketotifen.

ATX code R06AX17

Pharmacological properties

Pharmacodynamics

Pharmacological action - membrane-stabilizing, anti-allergic, antihistamine. It inhibits the release of histamine and other mediators (such as the slow reacting substance of anaphylaxis, lymphokines) from mast cells and basophils. It non-competitively blocks H1-histamine receptors, inhibits phosphodiesterase, increases the level of cyclic adenosine monophosphate in cells, blocks calcium channels in cells, and is a functional leukotriene antagonist. Suppresses the sensitization of eosinophils by cytokines, prevents eosinophilic infiltration in places of allergic inflammation in the respiratory tract. Prevents the development of symptoms of airway hyperreactivity due to platelet activating factor or exposure to allergens. Prevents the development of bronchospasm (does not have a bronchodilatory effect). It has a depressant effect on the central nervous system.

Pharmacokinetics

Absorption - almost complete, bioavailability - about 50% (due to the presence of the "first pass" effect through the liver). The time to reach maximum plasma concentration is 2-4 hours, the connection with plasma proteins is 75%. Passes through the blood-brain barrier. Penetrates into breast milk. Metabolized in the liver. It is excreted by the kidneys in the form of metabolites (the main metabolite is ketotifen N-glucuronide, which is pharmacologically inactive). Within 48 hours, the main part of the dose taken is excreted by the kidneys (1% - unchanged and 60-70% - in the form of metabolites). Excretion is biphasic: the half-life of the first phase is 3-5 hours, the second is 21 hours. Pharmacokinetics in children older than 3 years does not differ from that in adults.

Indications for use

Symptomatic treatment of allergic conditions, including allergic rhinitis and conjunctivitis.

Dosage and administration

The drug is taken orally during meals.

Adults appoint 1 mg (1 tablet) twice a day (morning and evening).

With a pronounced sedative effect in the first two weeks, the drug is prescribed at a dose of 0.5 mg (1/2 tablet) twice a day. If necessary, the daily dose can be increased to 4 mg (4 tablets) and divided into two doses.

childrenagedolder6 years the drug is prescribed as follows:

with body weight up to 25 kg- 0.5 mg (1/2 tablet) twice a day (morning and evening);

with a body weight of more than 25 kg- 1 mg (1 tablet) twice a day. In case of insufficient therapeutic effect after 4 weeks of treatment in children weighing less than 25 kg, the dose of the drug can be increased to 1 mg (1 tablet) twice a day.

Treatment takes a long time therapeutic effect appears after a few weeks of treatment. Cancellation of therapy is carried out within 2-4 weeks, gradually reducing the dose. Do not use for asthma.

Side effects

To estimate the frequency of occurrence of the following adverse reactions the following gradations were used: very often (≥1/10), often (from ≥1/100 to<1/10), нечасто (от ≥ 1/1 000 до <1/100), редко (от ≥ 1/10 000 до < 1/1 000), очень редко (<1/10 000), включая отдельные сообщения, неизвестно - частота не может быть оценена на основании имеющихся данных.

Often:

Agitation, irritability, anxiety, sleep disturbances, nervousness (especially in children), insomnia, drowsiness, headache;

Infrequently:

Dizziness, slow reaction rate (disappear after a few days of therapy);

Dryness of the oral mucosa, increased appetite;

Rarely:

sedation, feeling tired;

Dysuria; at

Weight gain, thrombocytopenia;

Bronchospasm, status asthmaticus.

Very rarely:

Hepatitis, elevated liver enzymes;

Allergic skin reactions (erythema multiforme, Stevens-Johnson syndrome).

With unknown frequency:

convulsions;

Rash, urticaria;

Nausea, vomiting, gastralgia, constipation, diarrhea.

Contraindications

Hereditary fructose intolerance, lapp-lactase deficiency, glucose-galactose malabsorption,

hypersensitivity,

Pregnancy and lactation (if necessary, the use of the drug should stop breastfeeding),

Children's age up to 6 years,

thrombocytopenia.

Carefully: epilepsy, liver failure.

Drug Interactions

In combination with hypoglycemic drugs, the likelihood of developing reversible thrombocytopenia increases. In these patients, platelet count monitoring is recommended.

With the simultaneous use of atropine, atropine-like agents and ketotifen, the risk of side effects, such as urinary retention, constipation, dry mouth, increases.

Ketotifen may potentiate the effects of other drugs that suppress the central nervous system (sedatives, hypnotics).

Its simultaneous use with other antihistamines can lead to mutual potentiation of their effects.

The use of ketotifen concomitantly with bronchodilators may reduce the frequency of bronchodilator use.

During treatment with ketotifen, the use of ethanol should be avoided, as it enhances the depressive effect of ketotifen on the central nervous system.

special instructions

At the beginning of long-term treatment with ketotifen, therapy with other anti-asthma drugs, especially corticosteroids, should not be abruptly stopped. Patients with steroid dependence may develop adrenocortical insufficiency. Treatment is stopped gradually, within 2-4 weeks, gradually reducing the dose (possible recurrence of asthmatic symptoms).

For persons sensitive to sedation, in the first 2 weeks, the drug is prescribed in small doses.

Not intended for the relief of an attack of bronchial asthma.

In patients simultaneously receiving oral hypoglycemic drugs, the number of platelets in the peripheral blood should be monitored.

In the case of intercurrent infection, specific anti-infective therapy should be carried out.

In very rare cases, seizures have been reported during treatment with ketotifen. Since ketotifen lowers the seizure threshold, it should not be used in patients with a history of seizures.

Use during pregnancy and lactation.

Although there is no evidence of a teratogenic effect, taking ketotifen during pregnancy is not recommended. Ketotifen is excreted in breast milk, so mothers receiving ketotifen should not breastfeed their baby.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms.

Given the possibility of developing side effects such as drowsiness, dizziness, impaired reaction rate during the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Overdose

Symptoms: drowsiness, nystagmus, confusion, disorientation, bradycardia or tachycardia, lowering blood pressure, shortness of breath, cyanosis, convulsions, irritability (especially in children), coma may develop.

Treatment: induction of vomiting, gastric lavage, administration of activated charcoal, saline laxatives; symptomatic treatment, with the development of a convulsive syndrome - short-acting barbiturates and benzodiazepines. Dialysis is ineffective.

Release form and packaging

10 tablets in a blister pack of polyvinyl chloride film and aluminum foil. 3 contour packs, together with instructions for medical use in Russian and the state language, are placed in a pack of cardboard box.

Storage conditions

Store in a place protected from moisture and light at a temperature not exceeding 25 ºС.

Keep out of the reach of children.

Termstorage

Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies

On prescription.

Manufacturer

RUE "Belmedpreparaty", Republic of Belarus

Legal address and address for accepting claims:

220007, Minsk, st. Fabricius, 30,

phone/fax: (+375 17) 220 37 16,

e-mail: [email protected]

Name and country of the marketing authorization holder

RUE "Belmedpreparaty", Republic of Belarus

Address of the organization accepting claims from consumers on the quality of products in the territory of the Republic of Kazakhstan:

KazBelMedPharm LLP, 050028, Republic of Kazakhstan,

Almaty, st. Beisebaeva, 151

Tel. 383-93-74

annotation

Ketotifen (pln in Latin "Ketotiphenum") is a new generation drug that is well used against allergies and asthma. It is not hormonal and not a drug. And so it suppresses the work of histamine receptors and stabilizes the membranes of mast cells. Description and properties are written below. (Wikipedia)

Composition of ketotifen tablets, syrup

Release form drug: as tablets and syrup, gel (ointment).

Active ingredient: ketotifen feromat. Its tablets contain 1.3 mg. Additionally potato starch, magnesium stereate and milk sugar. They look like white pills.

in syrup for every 5 ml 1 mg of the active substance. Additionally, there are flavors, glycerin, water, citric acid and others.

Manufacturer Russia, Bulgaria. From Germany there is "ketotifen stad". Packings are cardboard.

What is the price?

The cost of medicine in Tyumen, regardless of the form of release and country, is within 70 rubles.

What helps, indications for the use of ketotifen

This medicine is used for atopic dermatitis, for allergies, for urticaria, for conjunctivitis for the eyes (as eye drops), for bronchial asthma, for Quincke's edema, for weight loss. Also for prevention in the treatment of the common cold, with whooping cough, with obstructive bronchitis, with dry and severe cough, with laryngitis, so that other medications do not cause allergies. To take the medicine, you must have a doctor's prescription.

Analogues are cheap

Similar drugs are available in almost every pharmacy. There may be tablets, injections in ampoules or syrup, cheaper or more expensive. Sometimes they have different active substances, but the pharmacological group is the same, which means the names are synonyms .. But the action is the same. These are clenbuterol, pulmicort, yohimbine, fumarate, thyroxine, suprastin, zaditen, cetrine, theofedrine. They all give the same effect. But some do not cause drowsiness, while others act as sleeping pills. So are the differences in price. But before changing the medicine, consult a doctor.

Ketotifen sopharma

Sopharma produces ketotifen in Ukraine. It is also available for children and adults. In the form of tablets and syrup. The composition is the same as that of a conventional drug. Reception schemes are the same. The price in Zaporozhye is about 29 UAH. for 10 tablets.

Ketotifen instructions for use

The drug is taken with or after meals. Adults will be prescribed 1 tablet 2 times a day. If the disease is severe, you can drink 2 tablets. It must be remembered that it begins to act only after 3-4 weeks. And its effect lasts for a long time when properly taken. Therefore, it will not help from a sharp allergic attack.

The course lasts 3 months or more (depending on the recipe). Cancellation of the drug should be gradual. Tablets are allowed to drink from 3 years.

Ketotifen for children instructions for use

Children are given in the form of syrup.

From 6 months to 3 years, 0.25 ml is calculated for each kilogram of the child's weight. Give 2 times a day. Older than 3 years appoint 5 ml morning and evening. The course also consists of 3 months or more.

How to take for weight loss?

Taken in sports for weight loss. Take 12-14 mg per day, for girls the dosage is 0.8 or 1 mg. You need to take it this way: take two weeks, rest two. And repeat again. In this case, you need to intensively drink protein and BCAAs.

During pregnancy, breastfeeding

Ketotifen is contraindicated in pregnant and lactating mothers.

Excipients: potato starch - 37.6 mg, lactose monohydrate (milk sugar) - 209.8 mg, magnesium stearate - 1.3 mg.

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (4) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.

pharmachologic effect

Mast cell membrane stabilizer, has moderate H 1 - histamine blocking activity, inhibits the release of histamine, leukotrienes from basophils and neutrophils, reduces the accumulation of eosinophils in the airways and the response to histamine, suppresses early and late asthmatic reactions to. Prevents the development of bronchospasm, does not have a bronchodilating effect. Inhibits phosphodiesterase, resulting in an increase in the content of cAMP in adipose tissue cells.

The therapeutic effect is fully manifested after 1.5-2 months from the start of therapy.

Pharmacokinetics

Absorption - almost complete, bioavailability - about 50% (due to the presence of the "first pass" effect through the liver). The time to reach C max is 2-4 hours, the connection with proteins is 75%.

Passes through the blood-brain barrier. Penetrates into breast milk.

Metabolized in the liver. It is excreted by the kidneys in the form of metabolites (the main metabolite is ketotifen N-glucuronide, which is pharmacologically inactive). Within 48 hours, the main part of the dose taken is excreted by the kidneys (1% - unchanged and 60-70% - in the form of metabolites). Removal - two-phase: T 1/2 of the first phase - 3-5 hours, the second -21 hours.

Pharmacokinetics in children older than 3 years does not differ from adults.

Indications

- pollinosis (hay fever);

- allergic rhinitis;

- allergic conjunctivitis;

- atopic dermatitis;

- urticaria.

Contraindications

- pregnancy;

- lactation period;

- children's age up to 3 years;

- hypersensitivity.

FROM caution- epilepsy, .

Dosage

Inside, while eating, adults- 1 mg 2 times / day in the morning and evening. If necessary, the dose is increased to 2 mg 2 times / day.

Children aged 3 and over- 1 mg 2 times / day.

The duration of treatment is at least 3 months. Cancellation of therapy is carried out gradually, within 2-4 weeks.

Side effects

So aspects of the nervous system: drowsiness, slow reaction rate (disappear after a few days of therapy), sedation, feeling of fatigue; rarely - anxiety, sleep disturbances, nervousness (especially in children).

So aspects of the digestive system: dry mouth, increased appetite, nausea, gastralgia, constipation.

So sides of the urinary tract: dysuria, cystitis.

Others: thrombocytopenia, weight gain, allergic skin reactions.

Overdose

Symptoms: drowsiness, confusion, disorientation, bradycardia or tachycardia, decreased blood pressure, shortness of breath, cyanosis, convulsions, irritability, coma.

Treatment: gastric lavage (if a little time has passed since ingestion), symptomatic treatment, with the development of convulsive syndrome - barbiturates or benzodiazepines. Dialysis is ineffective.

drug interaction

Enhances the effect of sleeping pills, antihistamines, ethanol.

In combination with hypoglycemic drugs, the likelihood of developing thrombocytopenia increases.

special instructions

It is undesirable to abruptly cancel the previous treatment with beta-adrenergic stimulants, glucocorticosteroids, adrenocorticotropic hormone (ACTH) in patients with bronchial asthma and bronchospastic syndrome after joining ketotifen therapy, cancellation is carried out for at least 2 weeks, gradually reducing the dose. Treatment is stopped gradually, within 2-4 weeks (possible recurrence of asthmatic symptoms).

For persons sensitive to sedation, in the first 2 weeks, the drug is prescribed in small doses.

Not intended for the relief of an attack of bronchial asthma.

In patients simultaneously receiving oral hypoglycemic agents, the number of platelets in the peripheral blood should be monitored.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Application in childhood

Children aged 3 and over- 1 mg 2 times / day.

For impaired liver function

FROM caution- liver failure

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

List B. Keep out of the reach of children, dry, dark place at a temperature not exceeding 25°C. Shelf life - 3 years.