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Many doctors rarely explain to their patients the mechanism of action of certain drugs. Most government specialists simply do not have time for this, because they have literally a few minutes for each patient, during which they need to do a lot. Therefore, leaving the doctor's office, many people do not even know what drugs are written in their prescription, how they act on the body and what exactly they treat. Today we will talk about such a drug as Phezam. Do you know what Phezam helps with, reviews about its use, what do they say? We will also discuss the contraindications of the drug.

Phezam is a drug that improves blood circulation and metabolism in the brain. This drug consists of two main components - piracetam and cinnarizine. The first of them has long been known as an effective nootropic agent, and the second has proven itself in complex treatment failures cerebral circulation. The combination of these two components gives a strong antihypoxic effect and reduces the tone of smooth muscles in the vessels of the brain.

Phezam is a drug with moderate antiplatelet activity, in other words, it is able to reduce thrombosis due to inhibition of platelet adhesion processes. Such a medicine activates metabolic processes in the central nervous system, optimizes the integrative properties of the brain and improves memory by an order of magnitude. Phezam is able to facilitate the learning process in children.

The drug Phezam: what helps it?

This drug is often prescribed to patients with a diagnosis of chronic cerebrovascular insufficiency, which can be caused by atherosclerosis of the cerebral vessels or a previous stroke and other factors. It helps to cope with the consequences of brain injuries. Phezam can be used to treat patients with inflammatory, intoxication and infectious diseases. nervous system. It contributes to the treatment of migraine, psycho-organic syndrome and depressive states, including those that do not respond to antidepressant therapy.

Phezam is used in the treatment of Meniere's syndrome.

Such a drug does an excellent job if there is a violation of concentration and memory. It eliminates increased irritability.

Phezam is sometimes used as an integral part complex therapy with schizophrenia.
Also, this drug helps to cope with violations of the functions of the vestibular apparatus.
In some cases, Phezam is used in pediatrics - to optimize learning and improve memory in children with intellectual retardation.

Phezam often becomes the drug of choice in those patients in whom Piracetam itself provokes insomnia and tension.

Does Phezam have contraindications for use?

Phezam is a fairly safe drug, but in some situations its use is strictly prohibited. Of course, such a drug is not used if the patient has an individual intolerance to its components. Contraindications also include severe liver failure and severe renal failure (CC code less than 20 ml / min). In addition, Phezam cannot be used if the patient is diagnosed with psychomotor agitation by the time the medication is prescribed. Such a remedy is categorically contraindicated in Huntington's chorea, it is not used during the period of bearing a child and at the stage breastfeeding. Another contraindication to its use is childhood up to five years.

Additional Information

Phezam is prescribed with particular caution to patients suffering from kidney and liver ailments. Patients with kidney failure it should not be taken in high dosage.
It should be noted that such a drug contains cinnarizine, which can cause positive reactions in athletes in the results of a doping test. Also, the dyes contained in the capsule shell contain a certain amount of iodine. Accordingly, taking Phezam can lead to a distortion of the results of studies in which radioactive iodine is used.

When prescribing Phezam, doctors should remind patients that such a medicine can significantly enhance the sedative qualities of drugs that depress the central nervous system (if taken simultaneously). Also, this drug enhances the properties of tricyclic antidepressants, nootropic and antihypertensive drugs. It should not be used in parallel with the intake of alcohol. It is also worth noting that vasodilator drugs enhance the effectiveness of Phezam, and hypertensive drugs, on the contrary, weaken it.

Phezam is usually prescribed to adults one or two capsules at a time, taken three times a day. Children are most often prescribed one capsule once or twice a day. The duration of treatment is selected on an individual basis and usually ranges from one to three months.

Phezam - reviews:

Patients respond to the effectiveness of Phezam in completely different ways. Most of them claim that the medicine really gives positive result, but only under the condition of long-term course use. Only a few do not notice the effect of its use. At the same time, many patients taking Phezam note that the drug causes drowsiness and lethargy. In a small number of people, more serious side effects were observed, represented by dyspepsia, allergies, headache, and decreased pressure.

Folk recipes

Herbal medicines can also be used to improve cerebral circulation. So an excellent effect is given by the usual coltsfoot drug. Brew a tablespoon of crushed leaves with a glass of boiling water and leave for half an hour to infuse. Take the finished medicine in a tablespoon an hour before each meal.

Before using funds traditional medicine and before treatment with any drugs (including Phezam), it is extremely important to consult with your doctor.

Ekaterina, www.site

Photo of the drug

Latin name: Phezam

ATX Code: N06BX

Active substance: Piracetam + Cinnarizine (Piracetam + Cinnarizine)

Manufacturer: Balkanpharma-Dupnitza (Bulgaria)

The description applies to: 18.10.17

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The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Composition, names and formulations Phezam

Phezam contains two active ingredients:
1. Cinnarizine - 25 mg;
2. Piracetam - 400 mg.

This means that each capsule contains 400 mg of Piracetam and 25 mg of Cinnarizine. Due to this content of active substances, the drug in slang medical workers often referred to as Phezam 400 + 25. When a person sees a similar name, do not be afraid, since we are talking about the same Phezam.

Phezam contains the following substances as auxiliary components:

• Silicon dioxide colloidal;
• magnesium stearate.

Phezam capsules are dense, cylindrical in shape, painted in White color. Inside the capsules is a powdery mixture, painted in white or cream color. The powder inside the capsules may have small lumps, which, when lightly pressed with a dense object (for example, a spoon, glass rod, etc.), crumble and turn into powder. Phezam is available in packs of 60 capsules.

Phezam - mechanisms of action and scope of therapeutic application

Since Phezam is combination drug, which includes two active components, then consider the properties of each of them and their resulting cumulative effect.

Piracetam is a nootropic that improves brain activity by providing positive impact on metabolic processes. Piracetam increases the rate of consumption of glucose, which is the main nutrient for the brain, since the cells of the central nervous system are not able to receive the energy necessary to maintain life and function from any other compounds. That is, under the influence of Piracetam, brain cells begin to actively feed, producing more energy, which is quite enough to ensure the intensive work of the organ. It is thanks to this that the speed of transmission of impulses between neurons increases, memory is activated, attention is concentrated and there is a general improvement in intellectual function.

In addition, Piracetam improves blood flow to various areas of the brain in which there is vascular damage and moderate or weak oxygen starvation(ischemia). Due to the improvement of microcirculation in the brain, ischemia zones suffering from oxygen deficiency disappear, and the entire volume of neurons is included in intensive work. Improving blood flow is achieved not only through direct effects, but also indirectly, which consists in inhibiting platelet adhesion and, consequently, in preventing the formation of blood clots. Thus, Piracetam improves not only blood circulation, but also the properties of blood, making it as suitable as possible for circulation through microvessels. In areas of the brain prone to ischemia, Piracetam has a protective effect, increasing the resistance of neurons to hypoxia and death.

That is, Piracetam is able not only to improve cerebral circulation, but also to enhance the integrative function of the brain (the ability to synthesize and analyze, generalize, non-standard solutions, etc.), increase the productivity of intellectual work, consolidate memory, facilitate the learning process and the assimilation of new material and to restore and maintain brain function in the elderly.

Cinnarizine is a substance that has a pronounced effect directly on the vessels of the brain. Thus, cinnarizine dilates the vessels of the brain, reducing the tone of smooth muscles, as well as the severity of their reaction to biologically active substances constricting blood vessels. Cinnarizine dilates blood vessels, due to which the blood flow is activated, and the supply of various parts of the brain with oxygen and nutrients is significantly improved. By improving blood circulation, the substance increases the resistance of brain tissues to a lack of oxygen. However, despite the vasodilating effect, Cinnarizine does not affect intracranial and arterial pressure.

Together, Cinnarizine and Piracetam enhance the effects of each other, so the severity of the resulting action of Phezam is higher compared to the use of drugs in isolation with a separation in time of administration. However, in Phezam, the sedative effect of Cinnarizine prevails, due to which a person does not feel psychomotor agitation, as when using Piracetam.

Phezam - indications for use (from which Phezam tablets)

So, indications for the use of Phezam is the treatment of the following diseases or conditions:

• Cerebral circulation disorders of any origin (cerebrovascular atherosclerosis, subacute or chronic stroke, recovery period after hemorrhagic stroke, traumatic brain injury, osteochondrosis cervical region spine, etc.);
• Recovery after a traumatic brain injury;
• memory impairment;
• Violation of the mental function (it is difficult to clearly formulate a thought, it is impossible to find a solution to a simple problem or think about the situation from different points of view, etc.);
• Violation of concentration;
• mood disorders;
• Intoxication of any origin;
• Asthenia of psychogenic origin (anxiety, depression, feeling of emotional discomfort, irritability, lability);
• Encephalopathy of various origins (against the background of chronic hypertension, traumatic brain injury, infection, surgery, anesthesia, etc.);
• Dementia (dementia) due to vascular pathology;
• Psychoorganic syndrome with a predominance of asthenia and adynamia, provoked by infectious and inflammatory diseases of the nervous system;
• Labyrinthopathy (pathology of structures inner ear), manifested by tinnitus, nausea, vomiting, nystagmus, motion sickness;
• Meniere's syndrome;
• Aphasia (speech disorder) provoked by vascular pathology;
• Prevention of kinetosis (sickness, "seasickness", etc.);
• Prevention of migraine;
• Mild neurological pathology in children (poor learning, low concentration, insufficient long-term memory, etc.);
• In a comprehensive methodology for teaching children who have a lag in intellectual development.

Phezam (tablets) - instructions for use

Phezam capsules can be taken at any convenient time, regardless of the meal. However, if a person suffers from any diseases of the gastrointestinal tract, then it is better for him to take Phezam capsules 20 to 30 minutes after eating. And it's good enough for food. light snack, for example, an apple, banana or other fruit, a sandwich, a piece of meat, etc.

You should try to always take Phezam capsules at the same time, for example, every day at 9-00 am, or daily at 8-00 and 18-00, depending on how many times a day it is recommended to drink the drug. Moreover, if a person missed a dose at the set time, then you should drink the capsule immediately, if you didn’t come up next term taking Phezam. If, after the missed capsule, the time for taking the next one has come up, then you should drink only one, not two, without trying to compensate for the forgotten dose of the drug.

For the treatment of various diseases, adults should take Phezam 1 - 2 capsules three times a day, for one to three months. Children over 5 years old, but under 18 years of age, also for the treatment of various diseases and conditions, Phezam should take 1 - 2 capsules, but only once or twice a day for 1.5 - 3 months. The duration of the course of therapy is determined by the severity of the disease and the rate of clinical improvement. You can not take Phezam for more than three months without a break. If necessary, treatment courses can be repeated 2-3 times during one calendar year.

Phezam overdose

If any symptoms of an overdose appear in adults and children, it is necessary to carry out symptomatic treatment aimed at stopping discomfort. In addition, it is recommended to carry out gastric lavage. An overdose of Phezam can also be removed with hemodialysis.

Special instructions for the use of Phezam

In addition, the use of Phezam can give a false positive result of a study for the determination of radioactive iodine, since this microelement is contained in the capsule dye. Phezam also activates the thyroid gland, as a result of which a person may experience tremor (trembling) of various parts of the body and anxiety.

If Piracetam causes insomnia and tension in a person, then Phezam should be replaced, which in such situations is the optimal drug. Phezam is also the drug of choice if doctors have prescribed Cinnarizine and Piracetam at the same time (this may be the appointment of different doctors).

Against the background of the use of Phezam, care should be taken when working with various mechanisms, including when driving, since cinnarizine in the initial stages of therapy can provoke drowsiness.

While taking Phezam, you should refrain from drinking alcohol, as this will provoke a massive death of brain cells.

When Phezam is used in people suffering from liver diseases, the activity of transaminases (AST, ALT) should be monitored once a week. With an increase in transaminase activity by more than 1.5 times from the upper limit of the norm, Phezam should be discontinued.

If a person has kidney disease, before prescribing Phezam, creatinine clearance should be determined using the Reberg test. If the creatinine clearance is more than 60 ml / min, then Phezam can be taken at the usual dosage, monitoring this laboratory indicator every 3 to 4 days. If the creatinine clearance was initially less than 60 ml / min or fell during the use of the drug, then the Phezam dosage should be halved and the intervals between doses should be increased.

Use during pregnancy and lactation

Since Phezam penetrates into milk, it is also contraindicated during breastfeeding. If a woman who is breastfeeding must take Phezam for any reason, then the baby should be transferred to artificial mixtures.

Interaction with other drugs

Taking drugs that dilate blood vessels and reduce pressure leads to an increase in all the effects of Phezam. Accordingly, drugs that narrow blood vessels and increase pressure, on the contrary, weaken the effects of Phezam.

Phezam improves the subjective tolerance of drugs from the group of neuroleptics and antidepressants.

Phezam: before or after meals - how to take

However, experienced doctors or people who have used this drug repeatedly recommend taking it half an hour after eating. This option was chosen empirically as the optimal one, when they tried various ways of taking Phezam - during, before or after meals. The empirical conclusion that it is best to take Phezam half an hour after a meal is based on the fact that it is with this option that side effects are the least likely to develop, and the drug is well tolerated.

If Phezam needs to be taken several times a day, and full meals are not possible for some reason, then you can just have a snack with something, for example, an apple, a banana, nuts, a bun, a sandwich, etc. instead of lunch, afternoon tea or dinner. A small amount of food that has entered the stomach will completely replace a full meal in terms of minimizing the discomfort from the use of Phezam. Remember that the phrase "after a meal" does not mean that you have to eat a complete lunch, dinner, breakfast or afternoon snack from your point of view. It only means that before taking the drug, you need to eat something, for example, a piece of bread, fruit, a sandwich, a piece of jelly or cold meat from soup, etc.

Phezam children

Phezam in children and adolescents normalizes sleep, eliminates nightmares, stops nighttime awakenings, reduces fatigue, increases efficiency, both mental and physical, and also relieves irritability, emotional instability, mood lability and excessive vulnerability. In addition, Phezam reduces the frequency of headaches in children, improves adaptation in a school or preschool team, stabilizes and maintains normal arterial pressure, preventing its jumps. In general, Phezam normalizes the neuropsychic status of children, especially those suffering from various disorders of the emotional-volitional sphere.

Currently, as a rule, Phezam is used to eliminate bad sleep, irritability, tearfulness, mood instability, hysteria, poor concentration of attention and other mild disorders of the emotional-volitional sphere in children of early and school age. The drug is usually prescribed by a neurologist, not a psychiatrist, since it is not suitable for the treatment of severe mental illness, and it can be used successfully for the elimination of mild disorders.

After the course of application, the child becomes balanced, less tearful, focused, attentive, he is not so quickly and easily upset, his mood does not change within one minute several times, he sleeps much more calmly at night, and mastering speech and other skills is more successful and faster. . Such positive changes, combined with good tolerability of the drug, allow doctors and parents to consider Phezam effective drug and use it to improve the mental performance and development of children.

In addition, Phezam is successfully used in children for the treatment of perinatal lesions of the central nervous system, recovery from traumatic brain injuries and infectious diseases. In such situations, the drug normalizes brain function, reduces headaches, stabilizes night sleep, and also improves adaptation in the team and the ability to learn. Phezam can also improve the condition and promote the recovery of children with autism and mild neurological disorders.

Phezam side effects

The side effects of Phezam include the following symptoms from various organs and systems:
1. From the side of the central nervous system:

• Hyperkinesis (twitching of limbs, excessive movements, etc.);

Phezam is based on substances such as piracetam and cinnarizine. These components have an antihypoxic effect that dilates blood vessels.

At the same time, the impact of these substances increases the efficiency of visual and auditory functions of the body, improves the quality of blood flow through the vessels. Given medication stimulates the metabolic processes of brain cells, intensively removes excess glucose, increases the protective functions of brain tissues.

Clinical and pharmacological group

A drug that improves blood circulation and brain metabolism.

Terms of sale from pharmacies

Can buy by prescription.

Price

How much does Phezam cost in pharmacies? The average price is at the level of 320 rubles.

Composition and form of release

Phezam is available in the form of capsules. The manufacturer presents two packages - for 20 and 60 pieces, which do not differ in dosage. Inside the capsules is a white powder, and the gelatin shell itself is also white.

The composition of the capsules includes 2 main active ingredients, the content of which in one capsule is:

• Cinnarizine - 25 mg.
• Piracetam - 400 mg.

It also contains auxiliary components, which include colloidal silicon dioxide, titanium dioxide, lactose monohydrate, gelatin, magnesium stearate. Phezam capsules are packaged in a blister of 10 pieces.

Pharmacological effect

Phezam has a pronounced vasodilating, nootropic and antihypoxic effects. The components included in its composition cause a decrease in vascular resistance in the brain and increase blood flow in them.

Cinnarizine, which is part of Phezam, is a selective blocker of slow calcium channels, which inhibits the entry of calcium ions into cells and reduces their content in the plasma membrane depot. It reduces the tone of the smooth muscles of arterioles and their response to such vasoconstrictor substances as dopamine, epinephrine, vasopressin, norepinephrine, angiotensin. Cinnarizine dilates the vessels of the brain, enhancing the effect of piracetam, but without affecting blood pressure. At the same time, it has moderate antihistamine activity, reduces the tone of the sympathetic nervous system and the excitability of the vestibular apparatus. Increases the elasticity of erythrocyte membranes, reduces blood viscosity.

Piracetam improves brain metabolism by activating protein and energy metabolism, increasing cell resistance to hypoxia, and accelerating glucose utilization; improves regional blood flow in the ischemic zone and interneuronal transmission in the central nervous system.

Indications for use

Phezam is shown for use in the following diseases and brain dysfunctions

• Meniere's disease;
• circulatory disorders;
• migraine of various etiologies;
• encephalopathy of various types;
• visual impairment;
• asthenia.

Phezam's indications for use are violations of brain activity, memory and mental ability in children.

Contraindications

There are a number of pathological and physiological conditions of the patient's body, in which Phezam capsules are contraindicated:

• Pregnancy at any stage of the course and lactation period (breastfeeding period).
• The patient's age is up to 5 years.
• Severe violation of the functional activity of the liver and kidneys.
• Parkinsonism is a violation of the functional activity of the pyramidal system.
• Individual intolerance to any of the components of the drug.

With caution, the drug is used in Parkinson's disease. Before prescribing Phezam capsules, it is important to exclude the presence of contraindications.

Appointment during pregnancy and lactation

During experiments on animals, the absence of any negative effect of Phezam on the growth and development of the fetus was revealed. However, despite this, the drug is contraindicated for use during pregnancy. This is due to possible negative changes in the mental state of a woman, increased anxiety, lability of the emotional sphere and mood, which theoretically can have a bad effect on the course of pregnancy.

Since Phezam penetrates into milk, it is also contraindicated during breastfeeding. If a woman who is breastfeeding must take Phezam for any reason, then the baby should be transferred to artificial mixtures.

Dosage and method of application

As indicated in the instructions for the use of Phezam, it is recommended to take 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug is usually taken in courses - 2-3 courses annually.

Children over 5 years of age are indicated to take 1-2 capsules 1-2 times a day. Capsules are used for one and a half to three months. You need to take the capsules by swallowing them whole, without violating the integrity of the capsule. The tablet should be taken with half a glass of water, and it should not be hot.

Many users ask about the capsules, how to take it - before or after a meal. The instructions say that there is no particular difference in whether to take the remedy before meals or after meals. But it is optimal to drink capsules 20-30 minutes after a meal. It is advisable to drink the medicine at the same time every day.

Doctors warn that it is impossible to take the medicine for longer than 3 months - a break is needed between courses.

Adverse reactions

Phezam may cause side effects. Cases have been recorded when patients complained of changes in such organ systems:

1. Skin - dermatitis, hyperhidrosis, rash, itching.
2. Immune - allergic reactions, hypersensitivity.
3. Musculoskeletal - rigidity.
4. Nervous - headache, vestibular disorders, insomnia, tremor, fatigue, imbalance, worsening of epilepsy.
5. Digestive - dyspepsia, abdominal pain, nausea, cholestatic jaundice, dry mouth.

Also possible mental disorders: depression, irritability, anxiety, hallucinations. In some patients, in response to taking the drug, increased sweating, weight gain, hemorrhagic disorders, and sexual arousal appeared.

Overdose

An overdose of Phezam during the entire period of use of the drug has been recorded in a very limited number of times.

The drug is safe, and even exceeding the therapeutic dosage by several times did not cause pronounced side effects that would force a person to stop taking Phezam. The only symptom of an overdose of Phezam in adults may be abdominal pain, which is usually well tolerated and does not require discontinuation of the drug. An overdose of Phezam in children is manifested by insomnia, agitation, irritability, tremors, nightmares, hallucinations or convulsions.

If any symptoms of an overdose appear in adults and children, it is necessary to carry out symptomatic treatment aimed at stopping discomfort. In addition, it is recommended to carry out a gastric lavage. An overdose of Phezam can also be removed with hemodialysis.

special instructions

Before you start using the drug, read the special instructions:

1. Use with caution in patients with liver and / or kidney disease.
2. In patients with impaired liver function, it is necessary to monitor the content of liver enzymes.
3. Patients should avoid drinking alcohol while taking Phezam.
4. The drug increases the activity of thyroid hormones and can cause tremors and restlessness.
5. In case of mild to moderate renal failure (CC less than 60 ml / min), the therapeutic dose should be reduced or the interval between doses of the drug should be increased.

While taking the drug Phezam, patients should be careful when driving vehicles and working with machines and equipment, since cinnarizine may cause drowsiness at the beginning of treatment.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Phezam potentiates the action of nootropic and antihypertensive drugs.
2. With the simultaneous use of vasodilators enhance the effect of the drug.
3. Phezam improves the tolerability of antipsychotic drugs and tricyclic antidepressants.
4. With simultaneous use with Phezam, it is possible to increase the sedative effect of drugs that depress the activity of the central nervous system, tricyclic antidepressants, and ethanol.

Phezam capsules contain two active ingredients - piracetam and cinnarizine .

As additional ingredients in the composition of the product are present: lactose monohydrate, magnesium stearate, colloidal silicon dioxide.

The capsule shell consists of gelatin and titanium dioxide.

Release form

Phezam is produced in the form of cylindrical capsules, gelatinous, hard, size No. 0. Capsules are white, inside is a mixture of powder, which has a white or almost white color. The composition of the contents inside may contain conglomerates that turn into powder if you press on them.

Contains in blisters on 10 pieces, blisters are put into cardboard packs.

pharmachologic effect

The abstract indicates that Phezam is a combined remedy that provides nootropic, antihypoxic and vasodilating effects. There is a mutual potentiation of a decrease in the resistance of cerebral vessels, improving blood flow in these vessels.

As Wikipedia informs, the therapeutic effect and its mechanism are determined by the main active substances that make up Phezam. The main effect that is noted after taking the medicine is an improvement blood circulation in the brain and metabolic processes in nerve fibers and brain cells.

Substance piracetam It has a nootropic effect, activating the activity of the brain, positively affecting the metabolism in the body. Under the action of the substance, the rate of consumption of glucose, which is the main nutrient for the brain, increases. Thus, under the influence of piracetam, more active cell nutrition occurs, which leads to the production of more energy and activation of brain function. Piracetam helps to increase the speed of transmission of impulses between neurons. As a result, memory increases, concentration of attention improves, which leads to an increase in intellectual function.

Also, piracetam helps to improve blood flow in those parts of the brain where there are damaged vessels, and it is also noted i.e. oxygen starvation. As microcirculation improves, the ischemia zones that have arisen due to lack of oxygen disappear, and the entire volume of neurons participates in the work of the brain.

In addition, there is an indirect effect of this component, which contributes to the activation of blood flow. It is provided by inhibiting the process of gluing platelets, which in fact is the prevention of the appearance of blood clots. That is, the piracetam component not only activates blood flow, but also improves its properties. Thus, the blood circulates more actively through the microvessels.

Under the influence of piracetam, the resistance of neurons to . Piracetam improves the integrative function of the brain, activates intellectual work, facilitates the process of assimilation of new material, and provides restoration and support of brain functions in elderly people.

Substance cinnarizine expressed directly affects the vessels of the brain, expanding them. Also, under the influence of this substance, the tone of smooth muscles decreases, their reaction to active substances that constrict blood vessels decreases. Due to the fact that the substance expands the blood vessels, the blood flow is activated, and more oxygen and nutrients enter the brain. In view of the improvement in blood flow, the resistance of brain tissues to oxygen deficiency also increases. At the same time, despite the vasodilating effect, cinnarizine does not affect the indicators of arterial and .

The presence of two of these components in Phezam at once provides a mutual enhancement of effects active ingredients. Therefore, the severity of the effect of the drug is more pronounced compared to taking these components separately.

When taking Phezam, there is a predominance of the sedative effect of cinnarizine, from which the drug does not lead to the manifestation of psychomotor agitation, as happens when taking piracetam.

Pharmacokinetics and pharmacodynamics

After the patient has taken Phezam tablets, the active substances are completely absorbed from the gastrointestinal tract.

The highest concentration of piracetam in plasma is observed after 2-6 hours, cinnarizine - after 1-4 hours. The level of bioavailability of piracetam is 100%.

Piracetam does not bind to plasma proteins, cinnarizine binds by 91%. Penetrates through the BBB, is determined in all tissues and organs, passes through the placental barrier. Its selective accumulation in the cerebral cortex is noted.

The substance piracetam is not metabolized, the metabolism of cinnarizine occurs in the liver.

The half-life of piracetam is 4-5 hours (from the blood), 8.5 hours (from the cerebrospinal fluid). It is mainly excreted through the kidneys.

The half-life of cinnarizine is 4 hours. Metabolites are excreted for the most part in the urine, as well as in the feces.

In people with renal insufficiency, the half-life of piracetam is increased.

Phezam indications for use

Before using Phezam, the indications for use must be taken into account. The drug is prescribed in such cases:

• with insufficient blood flow in the brain (in the case of vessels, during the recovery period after suffering an ischemic or hemorrhagic , with encephalopathy of various origins, after traumatic brain injury);
• when intoxication ;
• in diseases of the central nervous system, in which there is a decrease in intellectual-mnestic functions, that is, a deterioration in attention, memory, mood;
• with psychoorganic syndrome, in which symptoms predominate asthenia and adynamia ;
• consequences of traumatic brain injury;
• labyrinthopathy (sensation of tinnitus, dizziness, nausea and vomiting);
• asthenic syndrome associated with psychogenic origin;
• Meniere's syndrome ;
• for the purpose of prevention , kinetosis ;
• in the complex therapy of children with psychoorganic syndrome, which led to low learning ability.

Contraindications

Phezam should not be taken in the following cases:

• at severe forms renal and hepatic insufficiency;
• during the period of increased psychomotor arousal;
• at chorea of ​​Huntington ;
• during pregnancy and breastfeeding;
• at the age of the patient up to 5 years;
• with high sensitivity to the components of the agent.

The drug is prescribed with caution to those patients who are diagnosed with , violations hemostasis , liver or kidney dysfunction, severe.

Phezam side effects

During treatment, the following side effects are possible:

• nervous system: nervousness, feeling of drowsiness, hyperkinesia; in rare cases - headaches, , , ataxia , agitation, anxiety;
• allergic manifestations: in rare cases - a rash on the skin, , swelling, itching, photosensitivity.
• digestive system: severe salivation, nausea, vomiting, abdominal pain, ;
• other manifestations: increased libido.

Phezam tablets, instructions for use (Method and dosage)

That instruction for the use of Phezam, which is provided in the annotation to the drug, indicates that the medicine should be taken 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug is usually taken in courses - 2-3 courses annually.

Children over 5 years of age are indicated to take 1-2 capsules 1-2 times a day. Capsules are used for one and a half to three months. You need to take the capsules by swallowing them whole, without violating the integrity of the capsule. The tablet should be taken with half a glass of water, and it should not be hot.

Many users ask about the capsules, how to take it - before or after a meal. The instructions say that there is no particular difference in whether to take the remedy before meals or after meals. But it is optimal to drink capsules 20-30 minutes after a meal. It is advisable to drink the medicine at the same time every day.

Doctors warn that it is impossible to take the medicine for longer than 3 months - a break is needed between courses.

Overdose

As a rule, Phezam is well tolerated by patients and when taking large doses of the drug, there are no significant side effects which requires discontinuation of treatment. In case of overdose, patients may experience abdominal pain. When taking too large doses of the drug, you need to rinse the stomach, induce vomiting. If there is such a need - to carry out hemodialysis and symptomatic treatment. There is no specific antidote.

Interaction

Not all drugs can be taken Phezam tablets at the same time, from which the interaction of this drug with other drugs should be taken into account.

When taken simultaneously with Phezam, drugs that inhibit the action of the central nervous system, ethanol, tricyclic antidepressants, their sedative effect may increase.

When taking Phezam, the effect of nootropic and antihypertensive drugs is potentiated.

Vasodilator drugs enhance the effect of Phezam.

Due to the presence of cinnarizine in the composition of the drug, the activity decreases hypertensive drugs .

With the simultaneous administration of Phezam, an increase in the activity of thyroid hormones is noted, which can lead to the manifestation of tremor and anxiety.

Due to its antihistamine action, cinnarizine may mask the manifestation positive reactions in relation to reactivity factors skin during skin tests. To avoid this effect, it is necessary to stop using the drug 4 days before such tests.

Phezam may enhance the effect of oral anticoagulants.

Terms of sale

You can buy Phezam capsules by prescription.

Storage conditions

It is necessary to store the medicine at temperatures up to 25 ° C, in a dark place. Keep out of reach of children.

Best before date

The shelf life of the capsules is 3 years.

special instructions

If Phezam is prescribed to patients who have impaired liver function, it is necessary to monitor the content of liver enzymes.

The drug activates the functions of thyroid hormones, which is why patients undergoing treatment may experience a feeling of anxiety and tremor.

Since cinnarizine can provoke manifestations of drowsiness, during the period of treatment it is necessary to drive carefully and work with precise and dangerous mechanisms.

In the treatment of elderly people, it is necessary to regularly monitor the indicators of kidney function and, if necessary, adjust the dose.

Active components are able to penetrate through the filter membranes of devices for .

The medication should be avoided if porphyria .

When taking Phezam, a false positive result may occur during doping control among athletes, also, due to the presence iodine-containing dyes in the capsule shell, there may be a false positive result in the test for the determination of radioactive iodine.

Since piracetam reduces aggregation platelets , it is necessary to carefully prescribe it in violation of hemostasis in patients, as well as in conditions accompanied by hemorrhages. Do not take medicine for severe surgical operations, with a history of severe bleeding and hemorrhagic strokes.

Phezam can provoke irritation in the epigastric region, when it is used after eating, there may be a decrease in the severity of gastric irritation, for which the medicine should be carefully used by patients suffering from gastrointestinal diseases.

It should be noted that the composition of the product as an auxiliary component contains lactose .

Phezam's analogs

Both Phezam and its analogues should be prescribed by a doctor after exact definition diagnosis. Active ingredients similar to those contained in Phezam are included in the preparations combitropil , , NooKam . The price of analogues depends on the manufacturer of the drug and its packaging.

Also similar pharmachologic effect medicines are applied to the patient's body:, Vinpocetine , Demanol , Memotropil , combitropil , Pantogam , Pyriditol , Cellex , encephabol and etc.

Omaron or Phezam - which is better?

The tool is an analogue of this drug and has the same indications for use, contraindications and causes similar side effects. At the same time, the price of the medicine Omaron is lower compared to Phezam.

Alcohol compatibility

Alcohol and Phezam cannot be used at the same time, according to the instructions for the drug. With their simultaneous administration, the risk of stroke increases, and there is also a negative effect on the state of the liver. Therefore, during the treatment period, you must completely abandon alcohol.

children

Children under 5 years of age are not prescribed these capsules. Children after 5 years of age should be given the medicine strictly according to the scheme prescribed by the doctor. Reviews of doctors and parents indicate that with the help of this medicine in children of school age, sleep can be normalized, performance improved, and irritability relieved.

During pregnancy and lactation

The use of Phezam during pregnancy is contraindicated, although there is no information on the negative effect of the active components. Piracetam gets into breast milk Therefore, during lactation, the drug should not be used.