Amosin from what these pills. Amosin instructions for use, contraindications, side effects, reviews

Amosin is a broad spectrum antibiotic penicillin series. The active substance of Amosin is amoxicillin. This is a broad-spectrum antibiotic, semi-synthetic penicillin, which slows down the synthesis of the bacterial cell wall, as a result of which the microorganism dies.

It is ineffective against strains that have beta-lactamase enzymes, as they destroy the antibiotic, as well as against bacteria that do not have a cell wall (for example, Mycobacterium tuberculosis).

Nevertheless, Amosin has a bactericidal effect on a large number of microorganisms, among them: gonococci and meningococci, some types of enterobacteria, some strains of staphylococci and streptococci, corienbacteria, listeria, Haemophilus influenzae, salmonella, shigella, pale treponema, clostridia and some others.

Amosin quickly penetrates into body fluids and tissues, except for cerebrospinal fluid, if the meninges are not inflamed. It is processed in the liver, excreted by the kidneys, partly with bile.

Amosin's testimony

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

gynecological infections (, cervicitis);

infections of the skin and soft tissues (, secondarily infected dermatoses);

Dosing regimen

The drug is taken orally, before or after a meal. The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years old (weighing more than 40 kg) are prescribed 500 mg 3 times / day, in severe cases of the disease - 0.75-1 g 3 times / day. Children aged 5 to 10 years are prescribed 250 mg 3 times / day, aged 2 to 5 years - 125 mg 3 times / day, under the age of 2 years - 20 mg / kg / day in 3 divided doses. The course of treatment is 5-12 days.

For children under 5 years of age, the drug is prescribed in the form of a suspension. For the treatment of acute uncomplicated gonorrhea, the drug is prescribed at a dose of 3 g once; in the treatment of women, repeated administration of the indicated dose is recommended.

For acute infectious diseases Gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times / day or 1-1.5 g 4 times / day. With leptospirosis, adults are prescribed 500-750 mg 4 times / day for 6-12 days.

With salmonella carriage in adults - 1.5-2 g 3 times / day for 2-4 weeks.

For the prevention of endocarditis in minor surgical interventions, adults are prescribed at a dose of 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is halved.

In patients with impaired renal function (CC - 15-40 ml / min), the interval between doses is increased to 12 hours, in the terminal stage of chronic renal failure (CC less than 10 ml / min), the dose of Amosin should be reduced by 15-50% or the interval should be increased. between doses up to 24 hours, with anuria - the maximum dose is 2 g / day.

Side effect

Allergic reactions: urticaria, skin hyperemia, erythema, angioedema, conjunctivitis are possible; rarely - fever, joint pain, eosinophilia, exfoliative dermatitis, erythema multiforme exudative, Stevens-Johnson syndrome, reactions similar to; in isolated cases - anaphylactic shock.

From the side digestive system: dysbacteriosis, change in taste, vomiting, nausea, diarrhea, abnormal liver function, moderate increase in liver transaminases; rarely - pseudomembranous enterocolitis.

From the CNS and peripheral nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, convulsive reactions.

From the urinary system: rarely - interstitial nephritis. From the hemopoietic system: leukopenia, neutropenia, anemia. Other: shortness of breath, tachycardia, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications

Allergic diathesis; , hay fever; Infectious mononucleosis; lymphocytic leukemia; liver failure; a history of gastrointestinal disease (especially colitis associated with the use of antibiotics); lactation period (breastfeeding); hypersensitivity to the components of the drug; hypersensitivity to other penicillins, cephalosporins, carbapenems); childhood up to 3 years (for tablets and capsules).

With caution, the drug should be prescribed during pregnancy, renal failure, and also with indications of a history of bleeding.

The use of Amosin during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother outweighs the potential risk to the fetus. Use during lactation is contraindicated. If necessary, use during lactation should be discontinued. breast-feeding.

Special instructions for use

When conducting a course of treatment with Amosin, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibiotic therapy.

When treating patients with bacteremia, a bacteriolysis reaction rarely develops (the Jarisch-Herxheimer reaction).

In patients who have hypersensitivity to penicillins, possible cross allergic reactions with cephalosporin antibiotics.

At treatment of mild diarrhea against the background of the use of Amosin, the appointment of antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used. For severe diarrhea, it is necessary to differential diagnosis and prescribe appropriate therapy.

Treatment should be continued for another 48-72 hours after the disappearance clinical signs diseases. With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use additional methods contraception.

Overdose

Symptoms: nausea, vomiting, diarrhea, disturbance of water and electrolyte balance (as a result of vomiting and diarrhea).

Treatment: gastric lavage, Activated carbon, saline laxatives; measures aimed at maintaining water and electrolyte balance; hemodialysis.

drug interaction

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group, while used, slow down and reduce the absorption of amoxicillin; ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) show synergism with amoxicillin; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Amoxicillin with simultaneous use increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermenstrual bleeding), as well as drugs, during the metabolism of which para-aminobenzoic acid is formed.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, NSAIDs and drugs that block tubular secretion, while used with Amosin, reduce tubular secretion, increase the concentration of amoxicillin.

With the simultaneous use of Amosin with allopurinol, the risk of developing a skin rash increases. Amoxicillin with simultaneous use reduces clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous use enhances the absorption of digoxin.

Amosin price

Price 27–92 rubles.

Amosin's analogs

• Amoxicillin;
• Ranoxyl;
• Flemoxin Solutab;
• Ospamox.

When a child is very ill, only a competent doctor can help. With luck, the child will get off with several doses of antiviral drugs. If the doctor has even the slightest concern about possible complications He will most likely prescribe an antibiotic.

Recently, according to the Ministry of Health, seasonal "sores" mutate and are more severe, especially in children aged 2-3 years. It is at this time that babies begin to visit Kindergarten, actively explore the world, contact with peers. And there is a fertile soil for the mutual exchange of bacteria. As a result, mom has to go on sick leave with enviable regularity.

What diseases are most common little man? Local pediatricians know the answer to this question for sure. The most common among children in winter and off-season are bronchitis, tonsillitis, pharyngitis, different forms otitis media, tonsillitis. If a child rolls on an ice slide or skating rink, another nuisance can happen - hypothermia often causes inflammation of the genitourinary system. The doctor's conclusion then sounds different - cystitis, pyelonephritis. Babies often suffer intestinal diseases(they are usually "brought" from the kindergarten). There is an exit. In all these unpleasant cases, it effectively helps modern antibiotic broad action "Amosin".

What it is?

Let's try to explain this in simple terms. If your child is reluctant to take this drug now, read this and then tell him the tale of the courageous protector of all sick children Amosin. Believe me, you will no longer have to persuade the baby to take the next dose. He will gladly drink the medicine himself.

So, "Amosin 250" is a modern broad-spectrum antibiotic. It is closely related to semi-synthetic penicillins. Works like a riot police - quickly and decisively. The active substance is amoxicillin. Its goal is harmful microbes of various origins. The drug enters the body, after 15-20 minutes it penetrates the cell of a harmful bacterium and reduces the speed of all chemical processes that occur in it. Destroys the structure, membrane, enzymes.

The "evil" cell also wants to live, it begins to actively resist and, as a result, spends the last of its strength. "Amosin" is adamant. Its action lasts up to 8 hours. Some "enemy" cells try to attack it with acid. But the valiant antibiotic is resistant to it. So he wins 100% of the time. It is excreted from the body rather quickly, with the formation of inactive metabolites. This means that the decay products are not toxic.

In addition to otitis media, bronchitis and a host of other colds, the remedy successfully copes with such “serious” rivals as sinusitis, salmonellosis and meningitis. Deals with skin infections. Most often, the drug is recommended specifically for angina, since this disease is caused by bacteria of various types.

Instructions for use

"Amosin 250" is different: powder, granules. There is a solution for intramuscular and intravenous use. But for children, most often the remedy is prescribed in tablets. Babies aged 2-3 years are usually recommended to take an antibiotic in the form of a suspension. It is easy to drink, it is quite pleasant in taste and smell due to the vanillin added by the manufacturer to the main composition. In the form of syrup "Amosin" is not available.

The dosage is determined by the doctor. It depends on the age of the child. "Amosin 250" can be given even to newborns from the first days of life.

Parents will have to prepare the suspension for children on their own. To do this, the powder is simply added to chilled boiled water. "Amosin 125" (drug containing active active ingredient in the amount of 125 mg) should be diluted in 2.5 ml. water. For a 250 mg product, 5 ml of water will be required, respectively. For 500 mg - 10 ml. liquids.

The dosage and schedule of administration is usually the same.

• Babies from birth to 2 years old: three times a day. The total daily dosage is 20 mg suspension per kilogram of patient weight.
• Preschoolers up to 5 years old inclusive can take 125 mg. suspension three times a day.
• Children from 5 to 10 years old: three times a day, 250 mg.
• Schoolchildren over 10 years old 500 mg of "Amosin" also three times a day.

Tablets and capsules of the drug are not given to children under 2 years old!

Sometimes "Amosin" is prescribed to children for the prevention of endocarditis or surgical infection. In this case, doctors recommend starting with half the adult dose.

Contraindications

Be sure to tell the doctor who prescribes Amosin to your child if the baby has at least one of these diseases:

• allergic diathesis;
• allergy to flowering (hay fever);
• bronchial asthma;
• liver failure;
• kidney disease;
• recurrent bleeding.

All these diagnoses are a strict contraindication to taking this antibiotic.

The drug should not be taken also by children who have ever had colitis or are allergic to antibiotics.

Side effects

Do not forget that, like any powerful antibiotic, the remedy can cause side effects. The instructions for use describe the following symptoms:

• disorders of the gastrointestinal tract;
• nausea;
• allergic rhinitis;
• the appearance of a rash and itching;
• shortness of breath, sleep disturbance, depression of the central nervous system, tearfulness of the child.

If your son or daughter has any of the above, be sure to tell the doctor about it - he will adjust the dosage and give the necessary recommendations.

Overdose

If it so happens that the child has taken a dose of the drug in excess of that prescribed by the doctor, carefully observe him. " ambulance» should be called when symptoms such as nausea, severe vomiting, abdominal pain, dizziness appear. Only emergency specialists can help in this situation, because a powerful antibiotic acts quickly, and there is simply no antidote for it. Doctors promptly wash the stomach saline solution and remove the toxicity of the body. Self-medication in this case is extremely dangerous.

Price

"Amosin" is more than affordable. Its average cost in Russian pharmacies is about 70 rubles (sachets for preparing a suspension), 27-40 rubles (tablets). A little more than 60 rubles is the drug in capsules. Prices in different regions of the country and pharmaceutical chains may differ, however, slightly.

Shelf life and storage conditions

The drug should be stored in a place protected from moisture and direct sunlight, at a temperature not higher than + 25C and not lower than + 15C, no more than 2 years from the date of manufacture. The drug is released strictly according to the prescription.

Analogues

Amosin 250 is an antibiotic of domestic production. The manufacturer is the pharmaceutical company Sintez AKO JSC (Kurgan region).

The situation with analogues is quite interesting. Usually original drug costs more than analogues. But here it's the other way around. Drugs with a similar effect are as follows:

Flemoxin Solutab. Produced in Holland. A pack of tablets (20 pieces) costs more than 300 rubles.

Augmentin. An antibiotic of bacterial action comes from England. A pack of tablets (20 pieces) costs more than 250 rubles. By the way, pediatricians often like to prescribe Augmentin to their patients. In order not to overpay, it makes sense for parents to check with the doctor if it can be replaced with our original Amosin, which costs almost 5 times cheaper.

Amoxiclav. Another drug with a similar effect. Produced in Slovenia. It costs more than other analogues. For a package of 14 tablets, you will have to pay 250 rubles.

Infectious diseases are known to be quite dangerous and insidious. And the most unpleasant thing is the complications that they can cause. The causes of infectious pathologies are hidden in the penetration of harmful bacteria into the body. The patient can be cured only with antibiotics. One of these drugs is the drug "Amosin" 500 mg. Instructions for use will allow you to study this tool in more detail.

Description of the drug

So, let's consider how the drug "Amosin" is positioned by the instructions for use (indications, release forms). The drug is a Distinctive characteristic of the drug - a wide range of effects and a high bactericidal effect.

The antibiotic is able to fight a variety of gram-negative and gram-positive microorganisms:

• streptococci;
• staphylococci;
• Klebsiella;
• salmonella;
• helicobacter pylori;
• gonococci;
• listeria;
• causative agents of meningitis, anthrax.

The drug "Amosin" inhibits the synthesis of substances that are the basis of cell membranes. As a result, their integrity is violated. This leads to the death of bacteria.

As evidenced by the instructions for use attached to the drug "Amosin" (500 mg), the drug has an effect on the body within 15-30 minutes after its use. The beneficial effect lasts for 8 hours.

The drug, getting into the body, is quickly and almost completely absorbed in the gastrointestinal tract. The active substance of the drug enters not only into the blood. It penetrates into mucous membranes, bones, organs, fluids.

Release forms

The main active ingredient of the drug is amoxicillin. It is this that has a healing effect on the body. So says the instructions attached to the drug "Amosin".

The release form of the drug allows you to choose essential medicine for any category of patients.

After all, the drug is produced in the form:

1. Tablets. By appearance These are pills of a white shade, flat-cylindrical. They may contain the active substance in the amount of: 250 mg, 500 mg.
2. Capsule. These are gelatin containers, white color. They contain white granules. The dosage of the active substance is 250 mg.
3. powder. It is intended for independent production of suspension. The powder has a slightly yellowish tint. Has a specific smell. The prepared suspension retains its aroma and yellowish tint. The drug is produced in several dosages: 125, 250, 500 mg.

Indications for use

The drug is recommended for use in various bacterial infections that are provoked by sensitive microflora. The drug "Amosin" 500 mg instructions for use advises to use when multiple infections respiratory tract, skin, urinary tract.

The main indications for the appointment of the drug are:

• diseases respiratory organs(bronchitis, pneumonia);
• pathology of ENT organs (tonsillitis, sinusitis, pharyngitis, otitis media);
• ailments of the genitourinary system (pyelonephritis, urethritis, gonorrhea, pyelitis, cystitis);
• gynecological infections (endometritis, cervicitis);
• diseases of the digestive tract (peritonitis, enterocolitis, cholangitis, cholecystitis);
• pathologies of soft tissues and skin (erysipelas, impetigo, dermatoses);
• listeriosis;
• leptospirosis;
• borreliosis (Lyme disease);
• dysentery;
• meningitis;
• salmonellosis;
• endocarditis (for preventive purposes);
• sepsis.

How does the instructions for use advise taking the drug "Amosin" (in tablets and capsules)?

The summary of the medication gives the following recommendations:

1. In any form intended for oral administration"Amosin".
2. Capsules instructions for use advises not to chew or crush. They should be consumed before or after meals.
3. "Amosin 500" (tablets) instructions for use recommends taking regardless of food. Pills are allowed to be crushed, divided into parts.
4. Take the medicine at regular intervals.
5. The recommended course of therapy with this remedy is determined only by the doctor.
6. Adults and children from 10 years of age, if the body weight of the latter is above 40 kg, is prescribed 500 mg of the drug 3 times a day.
7. If the pathology is severe, the doctor may recommend a higher dose of the drug. In this case, the patient is prescribed 3 times a day to take 750-1000 mg.
8. How does the instruction for use recommend taking the medicine "Amosin" (in tablets for children from 5 to 10 years old)? Such patients are prescribed 3 times a day to use 250 mg.
9. On average, the duration of treatment is 5-12 days.

Specific treatment regimens

The dosage of the drug may vary depending on the pathology. It is necessary to take into account the condition of the patient, and age, and weight. That is why it is important for a specialist to choose a treatment regimen. Consider how it recommends taking the drug "Amosin" instructions for use. In tablets or capsules, it doesn't matter.

The following diagrams are shown:

1. At acute stage gonorrhea, the patient is prescribed a single dose of 3000 mg of the drug. For women, repeated administration of the drug at the same dosage may be recommended.
2. For the treatment of gastrointestinal diseases and gynecological ailments, it is recommended to use 1500-2000 mg 3 times a day. Another treatment regimen may be prescribed. In this case, the patient should take 1000-1500 mg 4 times a day.
3. Leptospirosis is cured by taking 500-750 mg of the drug. The multiplicity of the use of the drug - 4 times a day. Assign such treatment for 6-12 days.
4. If salmonellosis is detected, then it is recommended to use 1500-2000 mg 3 times a day. According to this scheme, the drug is used for 2-4 weeks.
5. For the prevention of endocarditis, as well as in the case of surgical operations the patient is prescribed 1 hour before the intervention, taking the drug at a dose of 3000-4000 mg.
6. Re-administration of the drug is possible only after 8-9 hours after the first dose.
7. For people who have impaired kidney function, the doctor will reduce the frequency of taking the medicine. In this case, the dosage of the drug is saved.
8. The maximum dose for patients with anuria is 2000 mg.

Features of taking the powder

The powder is used as follows:

1. The drug is intended, as mentioned above, for the manufacture of a suspension.
2. To prepare the solution, it is necessary to pour boiled water (chilled) in an amount of 10 ml into a glass. The contents of the sachet (500 mg of powder) are poured into it. Stir until a homogeneous suspension is formed. If you are using a preparation containing 125 mg of active ingredient, then 2.5 ml of liquid will be needed. For 250 mg of water powder take 5 ml.
3. The suspension is taken immediately after its preparation.
4. If you are using a drug packaged in vials or jars, then you need to pour the contents with water in an amount of 62 ml. Shake the container vigorously until the medication is completely dissolved. The prepared suspension contains 1 ml of 50 mg of amoxicillin.
5. Adults are recommended to take 500 mg of the drug 3 times a day. A single dosage corresponds to 1 sachet of powder.

Treatment of babies

The annotation of the medication contains the following rules:

1. Patients over 10 years old, weighing more than 40 kg, are recommended to use the medicine in the same way as adults. It is prescribed 3 times a day to use 500 mg of the drug.
2. For children from 5 to 10 years old, it is better to use tablets containing 250 mg of amoxicillin or powder in the same dosage. Such children are recommended to take 1 pill (250 mg) 3 times a day or dilute 1 sachet of medicine.
3. Babies 2-5 years old are prescribed to take 125 mg three times a day.
4. For crumbs up to 2 years, the dosage is calculated taking into account body weight - 20 mg / kg.

Side effects

During treatment with the drug, unwanted reactions may occur. This is warned by the instructions for use attached to the drug "Amosin".

Tablets (500mg), capsules and powder can provoke problems from a number of systems. It:

1. Gastrointestinal tract and Against the background of therapy may appear: dysbacteriosis, diarrhea, vomiting, taste disturbance. Sometimes there is the occurrence of glossitis, stomatitis, nausea. In some cases, there is an increase in the activity of liver enzymes.
2. The blood system. Patients may experience the development of neutropenia. Sometimes the drug provokes leukopenia, anemia,
3. Nervous system. Patients may complain of arousal, increased anxiety, disturbed sleep. Some patients experience confusion, ataxia, depression, and behavioral changes. Headache, peripheral neuropathy, convulsions, dizziness may develop.
4. Allergic reactions. Therapy with this agent sometimes leads to the appearance of itching, rash, hyperemia of the integument, urticaria, erythema. Some patients may develop allergic conjunctivitis, rhinitis. There are cases when the drug caused anaphylactic shock and reactions resembling

In addition to the above negative signs may appear:

• labored breathing;
• arthralgia;
• interstitial nephritis;
• candidal vaginitis;
• tachycardia;
• superinfection.

If you have these symptoms, contact your doctor. He will cancel the drug and select another remedy for treatment.

Contraindications

The medication should not be taken for such ailments as:

• allergic diathesis;
• hay fever;
• lymphocytic leukemia;
• lactation period;
• ailments of the gastrointestinal tract in history;
• Infectious mononucleosis;
• liver failure;
• hypersensitivity;
• bronchial asthma;
• children's age, under 3 years (this applies to tablets, capsules).

In some patients, the question sometimes arises as to whether it is possible to combine alcohol-containing drinks with Amosin (500 mg) medication. Instructions for use and alcohol is important points that are worth paying attention to. The use of alcoholic beverages during treatment with the drug is prohibited.

In addition, you should limit activities associated with a high concentration of attention.

Very carefully, the medication can be prescribed to pregnant women, patients with renal insufficiency. special attention require patients who have a history of bleeding.

Overdose symptoms

If the patient takes high doses of the drug, the following symptoms may develop:

• diarrhea;
• vomiting, nausea;
• disturbed water and electrolyte balance;
• abdominal pain.

There is no specific antidote for this drug. Therefore, in case of overdose, symptomatic therapy is undertaken. Initially, the patient is washed out the stomach. The patient is shown the use of enterosorbent drugs.

It is important to protect the body from water and electrolyte imbalance. For this, the patient is recommended measures aimed at maintaining balance in the body. Salt laxatives are also prescribed.

To lower the plasma concentration of amoxicillin, your doctor may recommend hemodialysis.

Drug analogues

You can replace the original remedy with other, no less effective, medicines. However, remember that only your doctor can prescribe or cancel antibiotics.

Analogue drugs:

• "Flemoxin Solutab";
• "Ecoball";
• "Amoxicillin";
• "Amoxisar";
• "Hikoncil";
• "Gonoform";
• "Ospamox";
• "Danemoks";
• "Grunamox".

Medication opinions

Above, it is described how the drug "Amosin" (500 mg) is positioned for instructions for use. Reviews of people who took the drug are of great interest. Therefore, let us consider what the patients say about the medicine.

Opinions about the drug are quite ambivalent. Some people claim that the medicine was prescribed to them in severe stages of ailments, such as bronchitis, pneumonia, otitis media with complications. Such patients testify that the drug "Amosin" helped them to recover from serious pathologies. However, they claim that the improvement occurred in just a couple of days. Having drunk the medication according to the scheme prescribed by the doctor, they completely restored the body. However, they had no side effects.

A slightly different opinion is shared by another category of people. They claim that they started taking the antibiotic without a doctor's prescription. Therapeutic effect they managed to achieve - the disease receded. But after therapy there were some consequences. Most patients complain about the appearance of dysbacteriosis. This category of people had to long time to fight with negative consequences self-treatment.

And of course, there are reviews indicating that taking the drug in the very first days provoked the development of side effects. Such people do not undertake to assert the effectiveness of the remedy, but they emphasize that the medication can become a source of rather unpleasant symptoms.

All infectious diseases are dangerous and are characterized by the ability to provoke a large number of complications even after recovery. The reasons for their development are pathogenic bacteria into the body.

Full treatment will not work without a course of antibiotics. One of effective and well-known drugs is Amosin 500mg.

In contact with

Composition, release forms

The product is available in coated tablets. They are flat-cylindrical, white, with a chamfer and a risk.

Amosin - an antibiotic with a wide range of effects from the penicillin group. Amoxicillin trihydrate in the preparation is the main active ingredient. Also included are additional substances:

• calcium stearate;
• magnesium stearate;
• magnesium hydrosilicate;
• potato starch;
• povidone.

After taking the Amosin tablet almost completely absorbed in the digestive system. Meal time does not correlate with absorption. At elevated concentrations, the drug is found in blood plasma, in urine, in sputum from the bronchi, in lung tissues, in the organs of the female reproductive system, and in the intestinal mucosa.

Important! At the stage of metabolism, the drug forms inactive metabolites. About 70% of the drug is excreted in the urine in its original form, 20% - through glomerular filtration, 20% - with bile.

Amosin tablets.

Indications for use

The main indications for use are described in the instructions for the antibacterial drug Amosin. What helps medicine:

1. Acute infections affecting the upper respiratory tract.
2. Acute forms of infections affecting the lower parts of the respiratory system - bronchitis or pneumonia.
3. Infectious pathologies of ENT organs - otitis media, sinusitis, tonsillitis.
4. Urogenital infections: urethritis, cystitis, gonorrhea, pyelonephritis.
5. Infections of the digestive system - typhoid fever, dysentery, cholecystitis or salmonellosis.
6. Meningitis.
7. Borreliosis.
8. Sepsis.
9. Diseases of the skin, soft tissues erysipelas, impetigo.
10. Prevention of infection in postoperative wounds.

In children after 7 years, the drug is used for the treatment of influenza and other acute respiratory viral infections.

Amosin - indications for use.

Treatment time and dosage

Instructions for use gives the following recommendations on how to use the drug:

• Any form of medication is intended for oral administration.
• Capsules are not recommended to crush, open or chew.
• Drink the medicine regardless of the meal.
• Tablets can be crushed or divided into parts.
• Antibiotics should be taken at regular intervals.
• The duration of therapy in accordance with the individual characteristics of the disease and the patient's body doctor sets.
• Children weighing more than 40 kg and adults are shown 500 mg tablets 3 times a day. Complications require an increase in dosage: 750 - 1000 mg 3 times a day.
• Children aged 5 to 10 years are recommended to take Amosin at a dose of 250 mg 3 times a day (half a 500 mg tablet). The average duration of therapy is 10 days.

How are special situations treated?

With the development of complications or non-standard situationsthe medicine is taken as follows:

1. With uncomplicated gonorrhea at the stage of exacerbation, 3000 mg is indicated once a day.
2. In diseases affecting the organs of the gastrointestinal tract or in gynecological bacterial pathologies, 1500-2000 mg is indicated 4 times a day.
3. For patients with kidney disease multiplicity changes taking pills, but be sure to save doses. The dosage selected by the doctor is taken with an interval of 12 hours.
4. For preventive treatment A child is started with only half the adult dose.
5. In children, there are no special instructions other than strict adherence to treatment instructions.
6. Amosin with angina helps well for the treatment of bacterial forms.

Amosin's reception in special situations.

Dosage for Amosin Powder

The powder is used to mix the suspension. To do this, 500 mg of powder is diluted in a glass with 10 ml of chilled boiled water. All stir until a homogeneous liquid. Amosin with angina in this form is easier to take than pills.

Important! For 125 mg of the active ingredient in powder, 2.5 ml of liquid is needed, for 250 mg - 5 ml of liquid, respectively.

The suspension must be consumed after preparation. Dosage Amosin for adults: 2 times a day - 500 mg.

Use in pregnant women and while breastfeeding

During pregnancy Amosin allowed to apply when the expected beneficial effect on the mother's body is higher potential harm for the future child.

When lactation Amosin is contraindicated. If a course of drug treatment is required, then breastfeeding is stopped.

Contraindications for treatment with Amosin

To contraindications medicinal product relate:

• hay fever;
• allergic form of diathesis;
• bronchial asthma;
• liver failure;
• pathology of the gastrointestinal tract in the patient's medical history;
• lactation;
• lymphocytic leukemia;
• allergies to the composition of the drug;
• sensitivity revealed in a patient to other penicillin preparations;
• age under three years - for therapy with capsules or tablets.

Carefully and under the supervision of a specialist therapy is carried out during pregnancy, renal failure, with a tendency to bleeding.

Amosin has a number of contraindications for use.

Side effects

The annotation provides a list of what are side effects:

• Allergies: redness skin, urticaria, angioedema, runny nose, less often - joint pain, dermatitis.
• From the organs digestive systems: dysbacteriosis, disruption of taste buds, nausea with vomiting, diarrhea, liver dysfunction, glossitis, stomatitis, less often - pseudomembranous enterocolitis.
• In work central nervous system: overexcitation, persistent anxiety, sleep disturbance, clouding of consciousness, depression, headache, dizziness and convulsions.
• In the work of organs urinary system: in rare cases - interstitial nephritis.
• In work circulatory systems: leukopenia, anemia.
• Others: complicated breathing, increased heart rate.

special instructions

Take the medicine with extreme caution if a person has a tendency to hypersensitivity, patients under 18 years of age. People with impaired liver function it is forbidden to combine antibiotic along with metronidazole.

Due to the increase in the volume of bacterial microflora insensitive to the drug, the development of a super infection may occur, which involves the organization of urgent additional antibiotic therapy.

In case of abnormalities in the functioning of the kidneys the doctor reduces the dosage and increases the time interval between doses of the medicine. During the period of therapy, it is necessary to constantly monitor the functioning of the liver, circulatory system and kidneys. To reduce the risk of complications associated with digestion, the remedy should be drunk with meals.

There are no data on the prohibition of driving during the course of the drug.

Important! With an independent increase in the dose without consulting a specialist, nausea with vomiting, diarrhea, pain in the epigastric zone, and deviations in the water and electrolyte balance develop.

Overdose gastric lavage is carried out and treatment with enterosorbents is prescribed. In accordance with the nature of the symptoms, symptomatic treatment is implemented. It would be appropriate to take saline laxatives and implement procedures to normalize and maintain water and electrolyte balance.

Amosin, like other antibiotics, should be taken with caution.

Interaction

Interaction with other drugs:

1. Laxatives, antibiotics from aminoglycosides, antacids reduce the absorption of amoxicillin.
2. On the contrary, it increases absorption.
3. Bactericidal antibacterial medicines together with Amosin produce a double effect.
4. Bacteriostatic agents block the action of the drug.
5. Amosin enhances the effect of indirect anticoagulants.
6. The drug reduces the effect of oral contraceptives.
7. With simultaneous treatment with Allopurinol, the risks of developing skin rashes increase.
8. The active substance Amosin - amoxicillin - reduces the clearance and toxic effects on the body of Methotrexate.
9. Also, the drug enhances the absorption of Digoxin in the body.

Analogues

Amosin's analogs - drugs of the same group with a similar or identical effect. Amosin and

One tablet contains

active substance - amoxicillin trihydrate (in terms of amoxicillin) 250 mg, 500 mg,

excipients: potato starch, magnesium stearate, talc, povidone, calcium stearate.

Description

Tablets of white or almost white color, ploskotsilindrichesky with a facet and risk.

Pharmacotherapeutic group

Antibacterial drugs for systemic use. Beta-lactam antibacterial drugs- penicillins. Broad spectrum penicillins. Amoxicillin

ATX code J01CA04

Pharmacological properties"type="checkbox">

Pharmacological properties

Pharmacokinetics

Absorption - fast, high (93%), food intake does not affect absorption, is not destroyed in the acidic environment of the stomach. When taken orally at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 and 3.5-5 mcg / ml, respectively. The time to reach maximum concentration after oral administration is 1-2 hours.

It has a large volume of distribution: it is found in high concentrations in plasma, sputum, bronchial secretions (in purulent bronchial secretions, the distribution is weak), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid (with inflammation), bone, adipose tissue, gallbladder (with normal liver function), fetal tissues. When the dose is increased by 2 times, the concentration also increases by 2 times.

The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and vessels of the umbilical cord, the concentration of amoxicillin is 25-30% of the level in the plasma of a pregnant woman. Poorly penetrates the blood-brain barrier, but with inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the plasma level. Communication with plasma proteins - 17%. Partially metabolized to form inactive metabolites. The half-life is 1-1.5 hours. It is excreted by 50-70% by the kidneys unchanged (by tubular secretion - 80% and glomerular filtration - 20%), by the liver - 10-20%. It is excreted in a small amount from breast milk. In case of impaired renal function (creatinine clearance (CC) less than or equal to 15 ml / min), the half-life increases to 8.5 hours.

Amoxicillin is removed by hemodialysis.

Pharmacodynamics

Amosin® is a broad-spectrum bactericidal antibiotic from the group of semi-synthetic penicillins. Violates the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, causes lysis of bacteria.

Active against: aerobic gram-positive microorganisms: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. and aerobic Gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Penicillinase-producing strains are resistant to the action of amoxicillin.

Indications for use

Bronchitis, pneumonia
- sinusitis, pharyngitis, tonsillitis, acute otitis media
- pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis
- cholangitis, cholecystitis, dysentery, salmonellosis, salmonella carriage
- erysipelas, impetigo, secondarily infected dermatoses
- leptospirosis
- listeriosis
- Lyme disease (borreliosis)
- endocarditis (prevention)

Dosage and administration

Inside, take regardless of the meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water.

Adults and children old

over 10 years (weighing more than 40 kg) appoint 500 mg 3 times a day; in severe infections - 750-1000 mg 3 times a day.

Children aged 6-10 years are prescribed 250 mg 3 times a day; in severe infections - 60 mg / kg / day 3 times a day. The course of treatment is 5-12 days.
In acute uncomplicated gonorrhea, 3000 mg is prescribed once; in the treatment of women, it is recommended to repeat the indicated dose every other day.
In acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, in gynecological infectious diseases for adults - 1500-2000 mg 3 times a day or 1000-1500 mg 4 times a day.
For leptospirosis adults - 500-750 mg 4 times a day for 6-12 days.
With salmonella carriage in adults - 1500-2000 mg 3 times a day for 2-4 weeks.
For the prevention of endocarditis in minor surgical interventions for adults - 3000-4000 mg 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the second dose is reduced by 2 times.
In patients with impaired renal function with CC 15-40 ml / min, the interval between doses is increased to 12 hours; with CC below 10 ml / min, the dose is reduced by 15-50%; with anuria - the maximum dose of 2000 mg / day.

Side effects"type="checkbox">

Side effects

Dysbacteriosis, change in taste, stomatitis, glossitis, vomiting, nausea, diarrhea, moderate increase in the activity of "liver" transaminases

Pseudomembranous enterocolitis

Agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, epileptic reactions

Leukopenia, neutropenia, thrombocytopenic purpura, anemia

Urticaria, skin hyperemia, erythematous rashes, angioedema, rhinitis, conjunctivitis; rarely - fever, arthralgia, eosinophilia, exfoliative dermatitis, exudative erythema multiforme (including Stevens-Johnson syndrome), reactions similar to serum sickness, very rarely - anaphylactic shock

Other: vaginal candidiasis, shortness of breath, tachycardia, interstitial nephritis, superinfection (especially in patients with chronic diseases or reduced body resistance)

Contraindications

Hypersensitivity to the drug (including other penicillins, cephalosporins, carbapenems)

Children's age up to 6 years (for this dosage form)

lactation period

Drug Interactions"type="checkbox">

Drug Interactions

Antacids, glucosamine, laxatives medicines, food, aminoglycosides slow down and reduce absorption; ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives; drugs, during the metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing breakthrough bleeding.

Amoxicillin reduces clearance and increases the toxicity of methotrexate; enhances the absorption of digoxin.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs, and other drugs that block tubular secretion increase the concentration of amoxicillin in the blood.

Allopurinol increases the risk of skin rashes.

special instructions"type="checkbox">

special instructions

Carefully: allergic diseases(including a history), diseases of the gastrointestinal tract in history (especially colitis associated with the use of antibiotics), kidney failure, severe violations liver function, infectious mononucleosis, lymphocytic leukemia.

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

When administered to patients with sepsis, it is possible to develop a bacteriolysis reaction (Jarish-Herxheimer reaction) (rarely).

In patients with hypersensitivity to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.

In the treatment of mild diarrhea against the background of course treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used.

For severe diarrhea, see a doctor.

Treatment necessarily continues for another 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods of contraception should be used whenever possible.