10 tablets of phenibut at a time. Phenibut - instructions for use

INN: γ-amino-β-phenylbutyric acid hydrochloride (Gamma-amino-beta-phenylbutyrate hydrochloridum).

One Phenibut tablet contains 0.25 g phenibut as an active substance. Also, the composition of the drug includes a number of auxiliary components:

• microcrystalline cellulose (Cellulosum microcrystallicum);
• colloidal silicon dioxide (Colloidal anhydrous Silica);
• sodium starch glycolate;
• calcium stearate (Calcium stearate).

Release form

The drug is available in the form of flat-cylindrical tablets, the color of which can vary from white to slightly yellowish. Each tablet has a risk and a chamfer.

pharmachologic effect

The drug belongs to the group psychostimulating And nootropic medicines.

Pharmacological action provided by Phenibut:

• nootropic ;
• anxiolytic .

Pharmacodynamics and pharmacokinetics

What is Phenibut?

Wikipedia states that Phenibut is a phenyl derivative in its structure gamma-aminobutyric acid - a substance that performs the function of an inhibitory mediator of the central nervous system in the human body. Phenibut can also be considered as a derivative phenethylamine .

The substance is a white powder with a crystalline structure and a sour taste. The powder is highly soluble in water and alcohols. The hydrogen index (pH) of an aqueous solution of phenibut is in the range from 2.3 to 2.7.

Pharmacodynamics

Acting like nootropic , Phenibut renders positive influence on the higher integrative activity of the human brain. It stimulates mental activity, cognitive functions, memory function, and also helps to increase the resistance of the brain to the effects of various damaging factors, including extreme stress and oxygen starvation.

Phenibut reduces the severity of the effects serious illnesses associated with traumatic brain injury , damage spinal cord, intoxication of the brain, etc..

In patients with severe traumatic brain injury , while taking the drug, the amount mitochondria in the area of ​​perifocal changes and improves the dynamics of energy processes occurring in the brain, processes of tissue respiration, utilization glucose brain and blood supply.

In addition, the drug helps to strengthen cortico-subcortical connections , that is, in other words, connections between the cerebral cortex and its subcortical regions.

The pharmacological activity of Phenibut is expressed in the ability to:

• to have a corrective effect on higher cortical functions disturbed due to local lesions of the brain;
• improve critical capabilities and improve judgment;
• improve cortical activity control subcortical zones ;
• to influence the processes associated with the function of memory (memorization and recollection, the ability to learn);
• increase the level of wakefulness, influence the state of oppressed or clouded consciousness, increasing its clarity;
• increase the level of the body's overall resistance to the effects of stress factors;
• render anti-asthenic action , which is expressed in a decrease in weakness, elimination of symptoms mental And physical asthenia , reducing lethargy, etc.;
• stimulate mental activity (the drug reduces the severity of mental retardation, increases volitional activity, stimulates motor and speech activity, etc.);
• render antidepressant action ;
• render sedative And tranquilizing action reducing irritability and emotional excitability.

The stimulating effect of Phenibut is not accompanied by an increase in speech or motor excitation, depletion of the functional reserves of the body, addiction to the drug and the development of dependence on it.

Like other nootropics, the tool is characterized low toxicity , good compatibility with drugs of other pharmacotherapeutic groups, as well as the absence of serious side effects and complications.

The therapeutic effect of taking Phenibut develops gradually over, as a rule, several weeks. For this reason, the drug is recommended to take long courses.

Anxiolytic action the drug is realized by reducing the excitability of the subcortical structures of the brain (including the structures limbic complex , and ), which are responsible for emotions, inhibition of their interaction with the cerebral cortex, as well as suppression spinal reflex activity (in particular, it depresses polysynaptic spinal reflexes ).

By directly acting on γ-aminobutyric acid receptors, Phenibut facilitates GABA-mediated transmission of nerve impulses to the CNS. The active substance of the drug has the ability to improve the functional state of the brain by normalizing the metabolic processes occurring in it and improving cerebral circulation.

At the same time, the patient shows an improvement in performance hemodynamics (in particular, the volumetric and linear velocity of blood flow increases), the indicators of vascular resistance decrease, the microcirculation (including in the tissues of the eye) and create conditions that prevent spontaneous and induced aggregation (which in turn reduces the likelihood of formation blood clots in people suffering from circulatory disorders in the brain).

In addition, Phenibut has antioxidant And anticonvulsant action .

When treating patients with the drug old age in the latter, there is no depression of the CNS function, a decrease in muscle tone and an increase in general lethargy.

The drug reduces the inhibitory effect of ethyl alcohol on the central nervous system.

Pharmacokinetics

Once in the body, Phenibut is well absorbed and then just as well distributed in its various tissues. The substance easily passes through the BBB, which is a physiological barrier between the blood vessel system and the central nervous system.

Approximately 0.1% of the administered dose of the drug enters the brain tissue. Moreover, this figure is higher for young and old people.

Phenibut is characterized by the ability to be evenly distributed in the liver and kidneys. Biotransformation of the substance by 80-95% is carried out in the liver tissues. The resulting products have no pharmacological activity.

Cumulation of the substance in the body is not observed. The process of removing Phenibut from the body begins after about three hours. Moreover, the concentration of the substance in the brain tissues does not decrease. It can be detected in the brain for another six hours.

About 5% of Phenibut is excreted from the body kidneys in its pure form, partially the substance is excreted along with the bile.

Indications for the use of Phenibut

Indications for the use of Phenibut are:

• decrease in intellectual activity;
• decreased emotional activity;
• memory disorders;
• symptoms asthenic syndrome ;
• anxiety disorders ;
• fears, including nightmares ;
• increased anxiety, restlessness;
• decreased concentration;
• alcohol dependence, as well as psychopathological and somato-vegetative disorders arising as a result of alcohol withdrawal (in combination with other therapeutic measures);
• Meniere's syndrome ;
• caused by vestibular dysfunction caused by diseases vascular system, injury or infectious disease;
• prevention of motion sickness caused by motion sickness (kinetosis) ;
• in the cervical and / or thoracic spine and in women (the drug is prescribed in combination with other therapeutic measures);
• stuttering , hyperactivity and tics in children.

Phenibut tablets in combination with others detoxification agents also used to treat alcohol withdrawal with delirium (delirious syndrome - illusory-hallucinatory stupefaction, which is accompanied by disorientation in time, place and in some cases in one's own personality) and alcoholic predilirious state .

The indication for the drug Phenibut is also the prevention of stressful conditions, which are often observed in patients before surgical operations and painful diagnostic studies.

Contraindications

The abstract lists the following contraindications to the appointment of Phenibut:

• individual hypersensitivity to phenibut or any of the excipients that make up the drug;
• pregnancy ;
• lactation ;
• age up to eight years;

With caution, Phenibut is prescribed to patients with pathologies digestive system And erosive and ulcerative lesions of the gastrointestinal tract . This category of patients is shown in reduced doses of the drug, since the latter is characterized by the ability to irritate the mucous membranes.

Side effects

Usually, side effects after taking Phenibut, they occur only in the initial stages of therapy. Most often, patients experience increased drowsiness, seizures occur nausea , headache , there are jumps in indicators.

In certain groups of patients, Phenibut provokes the following side effects:

• increased irritability;
• increased levels of anxiety;
• increased arousal;
• dizziness;
• individual allergic reactions.

Instructions for use Phenibut (Method of administration and dosage)

Instructions for the use of Phenibut tablets indicate that the drug is intended for oral administration in courses, the duration of which varies from one to one and a half months.

The maximum allowable single dose of a drug for an adult patient under 60 years of age is a dose equal to 0.75 g of phenibut. Older people are not recommended to take more than 0.5 g of phenibut at a time.

Phenibut tablets: instructions for use and dosage for various diseases

Patients suffering from dizziness due to inflammation inner ear and people diagnosed with Meniere's syndrome Phenibut is prescribed according to the following scheme: during periods of exacerbations of the disease, the drug is taken 0.75 g three times a day for five to seven days; with a decrease in the severity of symptoms vestibular dysfunction the dose is reduced to 0.25-0.5 g three times a day (in this dosage, the drug is taken for five to seven days); further treatment is continued for another five days, taking 0.25 g of phenibut once a day.

If the disease proceeds in a relatively mild form Phenibut is recommended to be taken in a daily dose of 0.5 g for five to seven days. The dose is divided into two doses. Further, the treatment is continued for another one to three weeks, taking 0.25 g of the drug once a day.

For the treatment of dizziness caused by trauma or vascular diseases , the drug is prescribed in a daily dose of 0.75 g of phenibut. It is recommended to divide it into three doses. The duration of the therapeutic course is usually up to two weeks.

For treatment osteochondrosis cervical and/or thoracic spine and relieve symptoms climacteric syndrome in women, Phenibut is prescribed in combination with other therapeutic measures.

During the first two weeks, the drug should be taken one tablet three times a day (daily dose of the drug is 0.75 g). Further, the number of doses is reduced to two, the dose remains the same - one tablet for each dose (the daily dose of the drug is 0.5 g).

In case of moderate pain syndrome at vertebral pathology or climacteric syndrome Phenibut is prescribed to be taken in combination with other drugs, one tablet twice a day (0.5 g per day). The recommended duration of treatment is four weeks.

Like its analogues, Phenibut is used prophylactically to prevent the so-called travel sickness or, in other words, motion sickness syndrome arising during an airplane or sea voyage.

For prevention motion sickness syndrome at seasickness Phenibut is taken as a single dose about an hour before the planned trip or if the first symptoms appear kinetosis . The optimal dose is 0.25-0.5 g (or one or two tablets). The effect of the drug is dose-dependent.

However, when severe symptoms of motion sickness appear (for example, severe vomiting ) even a dose of 0.75-1 g is ineffective.

For the prevention of motion sickness air sickness Phenibut is recommended to be taken according to the above scheme. That is, 1-2 tablets about an hour before the planned trip.

Instructions for use Phenibut for children

The drug is not intended for the treatment of children under eight years of age.

For children aged eight to fourteen years, the daily dose of Phenibut is 0.75 g, that is, three tablets of 0.25 g per day. It should be divided into three doses.

In cases where it is necessary, it is allowed to take the drug in the highest single dose, which is 0.3 g.

How to take Phenibut when you miss the next dose?

If the patient missed the next dose of the drug one or more times, the course of treatment is continued in accordance with the previously prescribed dosing regimen.

Overdose

An overdose of the drug is accompanied by the following symptoms:

• decline blood pressure ;
• nausea ;
• vomiting ;
• development kidney failure .

Treatment involves gastric lavage, induction of vomiting and the appointment of symptomatic therapy. The drug has no specific antidote.

Since Phenibut is a low-toxic compound, only its long-term use in doses significantly exceeding the therapeutic ones (from 7 to 14 g per day) can provoke the development hepatotoxic effects .

In particular, in a patient, the amount of eosinophils in the peripheral blood, and may also develop steatosis (fatty infiltration) of the liver — chronic illness due to accumulation in liver tissue a large number triglycerides and characterized by fatty degeneration of organ cells.

Interaction

For the purpose of mutual potentiation pharmacological effects combination of Phenibut with others is allowed psychotropic drugs . In this case, the dose of Phenibut and the drugs combined with it should be reduced.

The drug is characterized by the ability to enhance and increase the duration of action sleeping pills , narcotic analgesics , neuroleptic And anticonvulsant drugs .

The possibility of lengthening and enhancing the therapeutic effect of taking antiepileptic drugs makes Phenibut a first-line drug if it is necessary to prescribe nootropic therapy to patients who are sick.

Enhances the toxic effects and effects of alcohol. In addition, there is evidence that under its influence the action is also enhanced. antiparkinsonian drugs .

Terms of sale

The drug is released without a prescription.

Storage conditions

Phenibut should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25 ° C.

Best before date

The drug retains its pharmacological properties within 36 months from the date of manufacture. After this period, it cannot be used. Оlainfarm ”.

Synonyms issued under a different name are Noobut ​​IC . When choosing which is better - Noofen or Phenibut, Phenibut or Noobut ​​- you should remember that all these drugs contain the same amount phenibut as the active substance and are interchangeable.

Phenibut for children

Phenibut and alcohol

However, this is not evidence of its compatibility with alcohol. The use of the drug for therapeutic purposes in alcohol dependence is justified and gives a positive effect only in cases where the patient is undergoing treatment in a hospital setting or is under constant medical supervision.

Despite the fact that the instruction does not directly prohibit taking alcohol during treatment with Phenibut, doctors have a negative attitude towards such a combination.

First, alcohol in doses exceeding the minimum has a depressing effect on the central nervous system. Phenibut, on the one hand, acts as tranquilizer , on the other hand, has a pronounced sedative action , which is especially pronounced in the first days of the course of treatment.

That is, while taking the drug with alcoholic beverages, the effect of the latter on the body is greatly enhanced. Intoxication comes on more quickly and in a stronger form compared to the typical.

As a result, the symptoms in this case are expressed more powerfully, and addiction to the drug develops faster than usual. Reviews indicate that it is rather difficult to refuse such a potent combination, and often one cannot do without qualified help.

Secondly, the combination of alcoholic beverages with Phenibut during therapy not related to the treatment of alcoholism revealed a similarity of mechanisms. metabolism almost all funds from the group tranquilizers And nootropics And ethanol .

This leads to mutual competition of the active substance of the drug and alcohol in all metabolic processes occurring in the body, which in turn provokes a change in the action of Phenibut and the appearance of undesirable side effects.

Thus, the combination of Phenibut and alcohol is a rather unpredictable combination, the consequences of which can be of the most serious nature.

Prescribing the drug during pregnancy

Phenibut is contraindicated in pregnancy and women who are breastfeeding. The exception is when the expected benefit to the mother outweighs the potential risks to the child.

Store in a dry, dark place, out of the reach of children, at temperatures up to 25°C.

Product description

Pills

pharmachologic effect

Nootropic agent, is a gamma-amino-beta-phenylbutyric acid hydrochloride. Facilitates GABA-mediated transmission of nerve impulses to the central nervous system (direct effect on GABA receptors), also has tranquilizing, psychostimulant, antiplatelet and antioxidant effects.
Improves the functional state of the brain by normalizing tissue metabolism and influencing cerebral circulation(increases the volumetric and linear velocity of cerebral blood flow, reduces the tone of cerebral vessels, improves microcirculation, has an antiplatelet effect). Helps reduce or disappear feelings of anxiety, tension, anxiety and fear, normalizes sleep, has some anticonvulsant effect.
Does not affect cholinergic and adrenergic receptors.
Lengthens the latent period and shortens the duration and severity of nystagmus.
Reduces the manifestations of asthenia and vasovegetative symptoms (including headache, feeling of heaviness in the head, sleep disturbances, irritability, emotional lability), increases mental performance.
Improves psychological indicators (attention, memory, speed and accuracy of sensory-motor reactions).
With a course intake, it increases physical and mental performance, improves memory, normalizes sleep; improves the condition of patients with motor and speech disorders. Patients with asthenia feel better from the first days of therapy; increases interest and initiative (activity motivation) without sedation and excitation. When applied after severe TBI increases the number of mitochondria in the perifocal areas and improves the course of bioenergetic processes in the brain.
With neurogenic lesions of the heart and stomach, it normalizes the processes of lipid peroxidation. In the elderly, it does not cause congestion and excessive lethargy, a relaxing aftereffect is most often absent. Improves microcirculation in the tissues of the eye, reduces the inhibitory effect of ethanol on the central nervous system. Low toxicity.

Pharmacokinetics

Absorption is high, it penetrates well into all tissues of the body and through the BBB (about 0.1% of the administered dose of the drug penetrates into the brain tissue, and in young and old people to a much greater extent). It is evenly distributed in the liver and kidneys. Metabolized in the liver - 80-95%, metabolites are pharmacologically inactive. Does not accumulate. After 3 hours, it begins to be excreted by the kidneys, while the concentration in the brain tissue does not decrease and it is found in the brain for another 6 hours. About 5% is excreted by the kidneys unchanged, partially with bile.

Indications for use

Asthenic and anxiety-neurotic states, anxiety, fear, obsessive-compulsive disorder, psychopathy. Stuttering and tics in children, enuresis. Urinary retention due to myelodysplasia. Insomnia and nightmares in the elderly. Prevention of anxiety conditions that occur before surgical interventions and painful diagnostic studies (premedication).
Meniere's disease, dizziness associated with dysfunctions of the vestibular analyzer various genesis(including with otogenic labyrinthitis, vascular and traumatic disorders); prevention of motion sickness in kinetosis.
Primary open-angle glaucoma (as part of combination therapy).
As an adjuvant therapy in the treatment of alcoholism (for the relief of psychopathological and somatovegetative disorders in withdrawal symptoms).
Treatment of predelirious and delirious conditions in alcoholism (in combination with conventional detoxification agents).

Use during pregnancy and lactation

Use with caution during pregnancy, lactation.

special instructions

Use with caution in erosive and ulcerative lesions of the gastrointestinal tract, liver failure.
With prolonged use, it is necessary to monitor liver function and peripheral blood picture.
It is ineffective for severe symptoms of motion sickness (including indomitable vomiting, dizziness).
Influence on the ability to drive vehicles and control mechanisms
During the treatment period, it is necessary to refrain from potentially hazardous activities that require heightened attention and high speed of psychomotor reactions.

With caution (Precautions)

Use with caution in liver failure.

Contraindications

Hypersensitivity to phenibut.

Dosage and administration

Inside, regardless of the meal. The dose, frequency of administration and duration of treatment depend on the indications, the age of the patient, and tolerability. A single dose for adults varies from 20 mg to 750 mg, for children - from 20 mg to 250 mg.

Overdose

Symptoms: drowsiness, nausea, vomiting, arterial hypotension, kidney failure. With prolonged use of Phenibut in a daily dose of 7-14 g, the development of a hepatotoxic effect (including fatty degeneration of the liver), eosinophilia is possible.
Treatment: gastric lavage, symptomatic and supportive therapy.

Side effect

From the side of the central nervous system: increased irritability, agitation, anxiety, dizziness, headache, drowsiness.
From the digestive system: nausea (at the first dose).
Allergic reactions: skin rash, itching.

Compound

γ-amino-β-phenylbutyric acid hydrochloride 250 mg

Interaction with other drugs

Extends and enhances the action of hypnotics, narcotic analgesics, antiepileptic, antipsychotic and antiparkinsonian drugs.

Release form

tablets 1 tab.
γ-amino-β-phenylbutyric acid hydrochloride 250 mg
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (1) - packs of cardboard.

Thank you

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Release forms and composition of Phenibut

In the composition of Phenibut as active ingredient included gamma-amino-beta-phenylbutyric acid , which is briefly called aminophenylbutyric acid . The following substances are included in Phenibut tablets as auxiliary components:

• Lactose(milk sugar);
• Potato starch;
• Polyvinylpyrrolidone low molecular weight;
• Stearic calcium.

Despite the fact that the drug is produced by different factories, the composition and ratio of auxiliary components are usually the same, since the same technology is used.

Dosage and manufacturers

Phenibut is produced by several pharmaceutical plants in the countries former USSR. Currently, pharmacies have Phenibut from the following manufacturers:

• Olainfarm (Latvia);
• Belmedpreparaty RUP (Belarus);
• LLC "Ozon" (Russia, Zhigulevsk, Samara region);
• OOO "Organika" (Russia, Novokuznetsk);
• OOO "Mir-Pharm" (Russia, Obninsk, Moscow region).

Phenibut - therapeutic effect (from which pills)

Some scientists prefer to classify Phenibut as a tranquilizer rather than a nootropic, as they consider the anxiolytic effects to be more important and necessary for the treatment of various anxiety disorders. However, this approach seems to be one-sided, since the drug combines the properties of both a nootropic and a tranquilizer. The most rational classification position is to classify Phenibut as a group of nootropics with weak tranquilizer properties, effective in the presence of neurosis-like conditions in a person, characterized by the simultaneous presence of a feeling of internal tension with tearfulness, mood lability, weakness and excessive emotional reaction to stimuli.

It is the unique spectrum of therapeutic activity of Phenibut, which combines the activating effects of a nootropic and anti-anxiety tranquilizer, that makes it possible to use the drug in conditions when a person needs to get rid of anxiety, but at the same time work highly efficiently and productively with the tension of intellectual abilities. In other words, if a person's work is associated with a constant strong stress, but at the same time requires excellent mental performance and results, then Phenibut is the drug of choice, which simultaneously stops anxiety and anxiety and will increase the intellectual-mnestic function of the brain.

Phenibut has the following direct therapeutic effects:

• Reducing internal tension;
• Relief of anxiety;
• Relief of anxiety;
• Relief of fear;
• Normalization of sleep by eliminating fears and anxiety;
• Improves cerebral circulation (blood flow rate increases, microcirculation in the tissues of the brain and eyes increases and vascular resistance decreases);
• Improves the functional activity of the brain, due to which a person finds solutions to various problems faster and easier;
• Reduces the severity of speech and movement disorders;
• Reduces the manifestations of asthenia, increasing interest and motivation for various activities;
• Stops manifestations vegetative-vascular dystonia(such as headache, feeling of heaviness in the head, irritability, emotional instability and difficulty falling asleep);
• Increases mental performance;
• Improves memory, attention, as well as accuracy and speed of reactions;
• Reducing the inhibitory effect of alcoholic beverages on the central nervous system;
• It has a weak anticonvulsant effect;
• Prolongation and enhancement of the effects of hypnotic drugs, drugs and neuroleptics.

When Phenibut is used in elderly people over 65 years of age, it does not cause lethargy and a relaxing aftereffect, on the contrary, it stimulates a person to be active.

Phenibut - indications for use

• Asthenic condition (lethargy, apathy, feeling of exhaustion, etc.);
• Anxious-neurotic states;
• Constant incessant anxiety for various reasons;
• Feeling of fear;
• Feeling anxious;
• Insomnia, nocturnal restlessness and nightmares in the elderly;
• obsessive-compulsive disorder;
• Psychopathy;
• With strong excitement before a surgical operation or any other invasive diagnostic intervention;
• Meniere's disease and other pathologies of the vestibular apparatus caused by injuries, vascular and other disorders;
• Otogenic labyrinthitis;
• Dizziness due to disruption of the vestibular apparatus;
• Prevention of motion sickness;
• stuttering in children;
• Tics of various origins in children;
• Enuresis (urinary incontinence) in children;
• Alcohol withdrawal syndrome (in combination with other drugs);
• Predelirious state at alcoholism ;
• To enhance the effect of antiparkinsonian drugs.

Phenibut - instructions for use

General provisions

You can start taking Phenibut immediately at the full therapeutic dosage. You do not need to first take the drug in the minimum dosage and gradually increase it to the required therapeutic.

However, it is better to stop the course of therapy gradually, and not abruptly. Although scientists and many doctors say that Phenibut does not have a withdrawal syndrome, nevertheless, when the drug is abruptly stopped, a person may experience discomfort about which he started taking pills. This phenomenon is caused by the addiction of the human body to Phenibut, which supplies the brain with the necessary metabolites, and it does not begin to produce these substances on its own in the required amount.

Relatively speaking, Phenibut supplies the necessary substances to the brain from the outside, and nerve cells they are not produced. And if in such a situation you abruptly stop taking the drug, then the brain cells will not be able to quickly adapt to the changed circumstances and begin to independently produce the necessary substances. Therefore, brain cells need to be given a little time so that they gradually get used to a new state, when the supply of necessary substances first decreases, and then stops altogether. With a slow decrease in the dosage of Phenibut, the brain cells get used to stopping the supply of metabolic substances from the outside and learn to produce them on their own. Therefore, when the drug is completely canceled, the person does not begin to be tormented by painful symptoms due to the body's addiction and the impossibility of its instant restructuring to another mode of functioning.

To prevent this condition, it is recommended to stop taking Phenibut gradually, slowly, reducing the dosage over 1 to 2 weeks and, in the end, completely canceling the drug. It is recommended to reduce the dosage by half or a quarter of a tablet every 3 days.

With prolonged use of Phenibut, it is necessary to take a general examination once a week. blood analysis in order to identify possible eosinophilia. Also, once a week it is necessary to take a blood test for the activity of AST and ALT.

In the presence of diseases of the gastrointestinal tract, it is necessary to use Phenibut with caution, since the drug has an irritant effect on the mucous membranes. If, after taking Phenibut, a person feels discomfort and burning in the area stomach then the dosage should be reduced.

When using Phenibut with other psychotropic drugs, it is necessary to reduce the dosage of both drugs taken.

At motion sickness Phenibut must be taken 20 to 30 minutes before the trip, because only in this case it will be effective. If a person has symptoms of motion sickness ( vomit , dizziness and others), then it is useless to take Phenibut, since in this case it is ineffective.

Dosages, rules and duration of use

Usually, adults with various conditions are prescribed Phenibut 250-500 mg (1-2 tablets) three times a day. If necessary, the dosage is increased to 750 mg (3 tablets) three times a day. For children under 8 years of age, Phenibut is prescribed 20–150 mg 3 times a day, and for children aged 8–14 years, 250 mg 3 times a day. The maximum allowable dosage of Phenibut that can be taken at one time is 750 mg (3 tablets) for adults, 500 mg (2 tablets) for the elderly over 65 years old, 300 mg for children 8-14 years old and 150 mg for children under 8 years old .

Since the dosage of Phenibut for children is low, it is recommended that they be given the drug not in the form of ready-made tablets, but in the form of powders that are prepared in the prescription departments of pharmacies. In these powders, the dosage of the drug necessary for the child is maintained and the risk of overdose is minimized. To buy such a powder, you need a prescription from a doctor for Phenibut, which should indicate the recommended dosage of the drug.

The duration of Phenibut therapy for various conditions ranges from 2-3 to 4-6 weeks. Courses of therapy can be repeated, observing intervals between them, equal in duration to the course of treatment. The dosage of the drug depends on the disease.

To prevent motion sickness, Phenibut should be taken one hour before the trip once at a dose of 250-500 mg (1-2 tablets). If the manifestations of motion sickness have already developed, then it is not necessary to take Phenibut, since in this case the drug is useless.

With discirculatory encephalopathy Phenibut should be taken at 250 mg once a day for 1 to 2 months. After 5-6 months, the course of therapy can be repeated.

For prevention migraine Phenibut is taken 150 mg once a day, and for the relief of an attack, 100-150 mg once.

In asthenic conditions and neuroses it is recommended to take the drug 250 mg 1-2 times a day for 1-1.5 months.

With anxiety, insomnia, nightmares and fussy anxiety in the elderly, it is necessary to take Phenibut 250 mg 2 times a day for 1.5 - 3 months.

To improve and restore mental performance, as well as at high loads, it is recommended to take Phenibut 250 mg once a day for 1-1.5 months. If the period of intensive work ended earlier, then the course of taking Phenibut is reduced.

With alcohol withdrawal Phenibut is recommended to take 250-500 mg 3 times a day, and an additional 750 mg before going to bed. Thus, the drug should be taken for 3-5 days, after which the fourth dose should be removed at a dosage of 750 mg at bedtime and left at 250-500 mg three times a day.

At Meniere's disease and otogenic maze in the first week Phenibut should be taken 750 mg 3-4 times a day, in the second week - 250-500 mg 3 times a day, and in the third week - 250 mg 1 time per day. If the disease is mild, then Phenibut is taken 250 mg 2 times a day during the first week, and then in the second week, 250 mg 1 time per day.

In case of violations of the vestibular apparatus, accompanied by dizziness and caused by vascular or traumatic causes, Phenibut should be taken 250 mg 3 times a day for 12 days.

Influence on the ability to control mechanisms

Overdose

• severe drowsiness;
• Vomit;
• Fatty degeneration of the liver (when taking more than 7000 mg per day);
• decline pressure ;
• Job disruption kidney ;
• Eosinophilia (increased eosinophils in blood).

Compatibility with other drugs

Phenibut should not be combined with alcoholic beverages. Care should be taken when combining Phenibut with drugs that have a toxic effect on liver and the blood system. To determine whether the drug has a similar effect, you must read the instructions for use, where indicated. With the rest medicines Phenibut is compatible and can be used simultaneously.

Phenibut for children and babies

For babies it is not recommended to give Phenibut, since this drug can have a multidirectional effect on the child, which cannot be predicted in advance. Therefore, psychiatrists advise to refrain from using Phenibut for at least two years. If the child is hyperactive, tearful, mobile and suffers from other functional behavioral disorders, then other drugs should be used, the effects of which are more predictable and understandable both for the doctor and for the baby's parents.

The above-described recommended use of Phenibut for children in practice is currently practically not observed due to the peculiarities diagnostics, perception and differentiation of the states of the norm and pathology of the behavior of babies. In the countries of the former USSR, the practice of overdiagnosis of various neurological, mental and behavioral disorders in children, especially young children, has developed. This means that in polyclinics, children are diagnosed with a disease that they do not have, and they begin treatment with potent drugs, including Phenibut. And if, with a really existing disease, Phenibut is effective and indicated, then in the case of overdiagnosis, the drug will not bring the child anything but possible side effects, a sense of inferiority and a possible aggravation of psychological disorders.

Most often, Phenibut is prescribed for hyperactivity, constant tantrums and neurosis, and the diagnosis is made on the basis of a simple examination of the child and from the words of the mother. That is, there is an exclusively subjective perception of the child's behavior, which is assessed from the position of the mother's and the doctor's ideas as "correct" or "wrong". And if the child's behavior is assessed as incorrect, then a clinical diagnosis is made and treatment with Phenibut or another nootropic drug begins, for example, Phenotropil. Meanwhile, such a diagnosis neurologist or a psychiatrist is unacceptable, since this is a profanity of medical science. Any neurological or psychiatric diagnosis is made only on the basis of objective test results, examination, examination and conversation with the child, as well as observation of him in various situations. If during all these examinations the doctor reveals really existing violations, then only in this case he can make an appropriate diagnosis.

If tests and conversations were not carried out, then the child cannot be diagnosed only from the words of the mother, who thinks that he does not cry like that, screams a lot, throws tantrums, etc. After all, there are no objective data for the presence of the disease, but there are only observations of the mother, which diverge from the ideas that have developed in her head about how the child should behave and respond to various stimuli. When, on the basis of such complaints of the mother, the doctor makes a clinical diagnosis of the child, then it is precisely overdiagnosis that takes place. Remember that even mental disorders are strictly classified and for their detection there are special tests and methods that exclude the subjectivity of the doctor's perception, and not just the mother's observation of the behavior of her child. Therefore, Phenibut should not be used for children. early age if there are no violations confirmed by surveys.

In most cases, children do not have severe disorders that are a clinical diagnosis. Usually the child suffers from a disorder of behavior or mental reactions, which are corrected by the correct behavior of the parent. In such situations, the use of tinctures is sufficient. valerian or motherwort to calm the child. However, in order to normalize the behavior of the child, parents will have to work by changing their behavior and habits, as well as carefully controlling their actions.

Returning to Phenibut, we can say that the drug is often prescribed to treat non-existent pathologies identified during "overdiagnosis". However, such use of the drug cannot be considered correct and justified, therefore, all recommendations remain on the conscience of a particular doctor and the child's parents.

Phenibut and alcohol

The fact is that Phenibut in combination with alcohol can cause rapid and severe intoxication or, on the contrary, help not to get drunk and maintain clarity of mind, and in the morning not to suffer from hangover. Basically, people try to take Phenibut with alcohol in order to prevent hangovers and severe intoxication. However, what effect Phenibut will have in each specific case is unknown and impossible to predict.

In addition, with the combined use of Phenibut and alcohol, a very quick addiction to the drug occurs, as a result of which it becomes very difficult to cancel its intake. Therefore, drinking alcoholic beverages while taking Phenibut is still not worth it, although if you do this, then there is no risk of death.

Side effects

• Drowsiness;
• Nausea;
• Headache (only at the first appointments);
• Increased irritability;
• Excitation;
• Anxiety;
• Dizziness;
• allergic reactions ( rash And itching skin).

Contraindications for use

• Individual sensitivity or intolerance to the components of the drug;
• Pregnancy and period breastfeeding ;

Phenibut: therapeutic effect, indications and contraindications - video

Phenibut - analogues

Synonyms of Phenibut are the following drugs:
1. Anvifen capsules;
2. Noofen capsules.

Analogues of Phenibut are the following medications:

• Adaptol pills;
• Afobazole pills;
• Divaza tablets;
• mebicar tablets;
• Mebix tablets;
• Neurofasol concentrate;
• Selank nasal drops;
• Stresam capsules;
• Tenoten and Tenoten children's lozenges;
• Tranquezipam tablets and solution for injection;
• Fezaneuf tablets;
• Fezipam tablets;
• Fenzit tablets;
• Phenazepam tablets and solution for injection;
• Phenorelaxan tablets and solution for injection;
• Elzepam tablets and solution for injections.

Trade name:

Group name:

Aminophenylbutyric acid

Dosage form:

pills

Composition per tablet

Each tablet contains:

Active substance:
Aminophenylbutyric acid hydrochloride 250mg (phenibut)

Excipients:
Lactose - 180 mg
Potato starch - 49.25 mg
Povidone K-25 - 15.75 mg
Magnesium stearate - 5 mg

Description

Round flat-cylindrical tablets with a chamfer and risk, white or yellowish-white color.

Pharmacotherapeutic group:

Other psychostimulants and nootropics.

ATC code:

Pharmacological properties

Pharmacodynamics
The active ingredient of aminophenylbutyric acid hydrochloride is a derivative of gamma-aminobutyric acid (GABA) and phenylethylamine. It has tranquilizing properties, stimulates memory and learning, increases physical capacity for work, eliminates psycho-emotional tension, anxiety, fear and improves sleep. Does not affect cholinergic and adrenergic receptors. Lengthens the latent period and shortens the duration and severity of nystagmus. Significantly reduces the manifestation of asthenia and vasovegetative symptoms, including headache, a feeling of heaviness in the head, sleep disturbance, irritability, emotional lability, increases mental performance, improves well-being, increases interest and initiative, motivation for vigorous activity without a sedative effect or arousal.

Unlike tranquilizers, under the influence of aminophenylbutyric acid, psychological indicators (attention, memory, speed and accuracy of sensory-motor reactions) improve. The formation of addiction and dependence to the drug, the syndrome of "cancellation" was not noted.

Pharmacokinetics
After ingestion, it is well absorbed and penetrates into all tissues of the body. About 0.1% of aminophenylbutyric acid from the accepted dose of the drug penetrates into the brain tissue; in patients at a young and old age, an increase in penetration through the blood-brain barrier is possible. After 3 hours, aminophenylbutyric acid is detected in the urine, at the same time, the concentration in the brain tissues does not decrease, it is detected in the brain after another 6 hours.

80-95% of the drug is metabolized in the liver to pharmacologically inactive metabolites. 5% is excreted from the body by the kidneys unchanged. The next day after taking the drug, aminophenylbutyric acid can only be detected in the urine; it is determined in the urine two days after ingestion, however, the detectable amount is 5% of the administered dose. The highest binding of aminophenylbutyric acid occurs in the liver (80%). With repeated administration, the drug does not accumulate in the body.

Indications for use

• asthenic and anxiety-neurotic conditions;
• stuttering, tics and enuresis in children;
• insomnia and night anxiety in the elderly;
• Meniere's disease, dizziness associated with dysfunctions of the vestibular analyzer of various origins;
• prevention of motion sickness with kinetosis;
• as part of complex therapy for alcohol withdrawal syndrome, for the relief of psychopathological and somatovegetative disorders.

Contraindications

• hypersensitivity to active substance or auxiliary components of the drug;
• acute renal failure;
• pregnancy;
• period breastfeeding;
• childhood up to 3 years;
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption syndrome.

Carefully

Patients with erosive and ulcerative diseases of the gastrointestinal tract due to the irritating effect of the drug are recommended to prescribe smaller doses of the drug.

Use during pregnancy and during breastfeeding

Use during pregnancy and lactation is not recommended, since there are not enough clinical observations.

IN experimental studies mutagenic, teratogenic and embryotoxic effects of the drug have not been established on animals.

Dosage and administration

Inside after eating, drinking water. Can't be chewed.

Asthenic and anxiety-neurotic conditions
Adults: 250-500 mg (in terms of the required number of tablets) 3 times a day. Higher single doses: for adults - 750 mg (in terms of the required number of tablets), for patients over 60 years old - 500 mg (in terms of the required number of tablets). If necessary, the daily dose is increased to 2500 mg (in terms of the required number of tablets). The course of treatment is 4-6 weeks.

Stuttering, tics and enuresis in children
Children: from 3 to 8 years - 125 mg (in terms of the required number of tablets) 2-3 times a day; from 8 to 14 years - 250 mg (in terms of the required number of tablets) 2-3 times a day; children over 14 years old - doses for adults.

Insomnia and nighttime anxiety in the elderly
250-500 mg (in terms of the required number of tablets) 3 times a day.

To eliminate dizziness in case of dysfunction of the vestibular analyzer of infectious genesis (otogenic labyrinth) and Meniere's disease
During the period of exacerbation, 750 mg (in terms of the required number of tablets) are prescribed 3 times a day for 5-7 days, with a decrease in the severity of vestibular disorders - 250-500 mg (in terms of the required number of tablets) 3 times a day for 5-7 days, then - 250 mg (in terms of the required number of tablets) 1 time per day for 5 days.

With a relatively mild course of diseases - 250 mg (in terms of the required number of tablets) 2 times a day for 5-7 days, then 250 mg (in terms of the required number of tablets) 1 time per day for 7-10 days .

To eliminate dizziness in dysfunctions of the vestibular analyzer of vascular and traumatic origin
Assign 250 mg (in terms of the required number of tablets) 3 times a day for 12 days.

For the prevention of motion sickness in kinetosis
250-500 mg (in terms of the required number of tablets) once one hour before the intended trip or when the first symptoms of motion sickness appear.

The anti-swaying effect of aminophenylbutyric acid increases with increasing dose of the drug.

With the onset of pronounced manifestations of motion sickness (“indomitable” vomiting and others), oral administration of aminophenylbutyric acid is ineffective even at a dose of 750-1000 mg (in terms of the required number of tablets).

As part of complex therapy for alcohol withdrawal syndrome in order to relieve psychopathological and somatovegetative disorders
In the first days of treatment, 250-500 mg (in terms of the required number of tablets) are prescribed 3 times a day during the day and 750 mg (in terms of the required number of tablets) at night with a gradual decrease in the daily dose to the usual for adults. Never take a double dose to make up for a missed dose!

In patients with renal and / or hepatic insufficiency with prolonged use, it is necessary to monitor indicators of kidney and / or liver function.

In case of impaired liver function, high doses of the drug can cause hepatotoxicity. Patients are prescribed less effective doses.

Side effect

Aminophenylbutyric acid, like all medicines, can cause side effects that may not affect everyone. In general, the drug is usually well tolerated.

Nervous system disorders:
frequency unknown: drowsiness and increased symptoms (at the beginning of treatment), dizziness, headache.

Gastrointestinal disorders:
frequency unknown: nausea (at the beginning of treatment).

Skin and subcutaneous tissue disorders:
rarely: allergic reactions (skin rash, itching).

Liver and biliary tract disorders:
the frequency is unknown: with prolonged use of high doses - hepatotoxicity.

If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Aminophenylbutyric acid has low toxicity. Data on cases of overdose have been reported.

Symptoms
Drowsiness, nausea, vomiting, dizziness. With prolonged use of high doses, eosinophilia, a decrease in blood pressure, impaired renal function, and fatty degeneration of the liver (taking more than 7000 mg) may develop.

Treatment
Gastric lavage, symptomatic treatment, maintenance of vital functions. There is no specific antidote.

Interaction with other drugs

In order to mutually potentiate aminophenylbutyric acid, it is allowed to combine it with other psychotropic drugs, reducing the doses of aminophenylbutyric acid and combined drugs.

Phenibut prolongs and enhances the action of hypnotics, antipsychotics and antiparkinsonian drugs.

special instructions

With prolonged use (more than 2-3 weeks), it is necessary to monitor peripheral blood parameters, liver function parameters every 2-3 weeks.

Influence on the ability to drive vehicles and / or work with mechanisms

During treatment, care must be taken when administering vehicles and occupation by other potentially dangerous species activities that require increased concentration of attention and speed of psychomotor reactions, since some patients may experience disorders of the central nervous system, such as drowsiness and dizziness.

Release form

Tablets 250 mg.
10 tablets in a blister pack made of PVC film and printed lacquered aluminum foil.
20, 50 tablets in a polymer jar made of polyethylene.
2 blister packs or 1 polymer can along with instructions for medical use placed in a cardboard box.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ° C.
Keep out of the reach of children.

Best before date

3 years.
Do not use after the expiry date stated on the package.

Holiday conditions

On prescription.

Registration certificate holder

Regana LLC, Russia
127018, Moscow, 3rd pr. Maryina Roshcha, 40, building. 1, floor 2, room II, com. 22.

Manufacturer/Organization accepting consumer claims

V-MIN LLC, Russia
141300, Moscow region, Sergiev Posad, Moscow highway, 68 km