Lindinet - instructions for the use of birth control pills, the composition of hormones, side effects and analogues. Lindinet contraceptive - an effective monophasic contraceptive What is better Lindinet 20 or 30

"Lindinet 20" is a combined drug, presented in the form of small round tablets. Tablets are distinguished by their contraceptive effect, they are used for permanent planned contraception for women.

"Lindinet 20" and analogues in the rating of sold drugs as contraceptives occupy a leading position. This is explained by the fact that studies conducted by scientists have confirmed that these drugs are highly effective in protecting against unplanned pregnancy. With their use, pregnancy rates do not exceed 0.05 per hundred women during one year of studies.

What drugs can replace the reception of "Lindinet 20"?

Unconditional analogues of "Lindinet 20" according to active substance in the composition, dosage form and regimen for today are considered:

"Logest" is a drug that is also an oral contraceptive. Tablets white color produced in France by Delpharm.
"Femoden" is a highly effective estrogenic drug. Analogue of "Lindinet 20" in composition, but the dosage is increased. Produced in Germany by the Bayer team.
"Gestarella" is a monophasic low-dose contraceptive drug. Producer - "Abbot Laboratories" in Germany.

Of all the analogues presented, Lindinet 20 is the cheapest, but more on that below. The German pharmaceutical company "Gedeon Richter" also manufactures a drug with the same name but with a high content of the active element ethinylestradiol up to 0.03 mg per tablet - "Lindinet 30". Above in the photo is an analogue of "Lindinet 20" - "Logest".

Composition of contraceptives

"Lindinet 20" and similar drugs in composition contain only 2 active ingredients - ethinylestradiol 0.02 mg and gestodene 0.075 mg. These two elements guarantee a reliable contraceptive result. The effect of estrogen-gestagen tablets makes it possible to suppress the pituitary secretion of gonadotropins. In simple terms, the effect of the drug is that both of these components do not allow the egg to form and mature. This effect prevents the possibility of fertilization.

The estrogenic effect of "Lindinet 20" and analogues causes a highly effective component - ethinyl estradiol. it hormonal agent estrogen series, which is produced naturally by the ovaries and adrenal glands in the body of a woman. Together with progesterone, its tasks include stabilizing the woman's menstrual cycle, and, among other things, also dividing, multiplying endometrial cells and stimulating the development of the uterus in case of insufficiency of the gonads. Auxiliary function of ethinyl estradiol is to lower the level of cholesterol in the blood.

Gestodene is an artificial substance similar in structure to levonorgestrel. It inhibits the synthesis of follitropin and blocks natural monthly ovulation. With the exception of the effects described above, birth control pills increase the viscosity of mucus in the cervix, preventing sperm from entering there.

From customer reviews: "Lindinet 20" and analogues, when used systematically, give not only the effect of a contraceptive, but also restore menstrual cycle. They significantly reduce the risk of developing neoplasms in the pelvic organs and diseases. reproductive system women. "Lindinet 20" and analogues of the active substance are drugs from the prescription group and can be used strictly as prescribed by the attending physician after a thorough examination of the patient.

Release form of the drug

Dosage form It is sold in the form of glossy tablets of a pale yellow hue, film-coated. Tablets of rounded shape without inscriptions. The drug is produced in cardboard packaging. Inside the package there may be one or three blisters with tablets. It can be 21 tablets or 63. The manufacturing company Lindineta 20 is from Hungary.

Indications for use

"Lindinet 20" and analogues are prescribed as modern facility contraception. Can be used to normalize the menstrual cycle.

Contraindications and restrictions

The drug is not indicated for girls before puberty and women after menopause. Contraindications to taking Lindinet 20 are the following chronic pathologies or diseases in history:

hypersensitivity to single components of the drug or a combination of hormones from the composition;
a clear predisposition or existing circumstances that provoke the formation of thrombosis;
unstable performance blood pressure;
ischemic disease hearts;
frequent migraines with neurological symptoms;
thrombotic or thromboembolic lesions of veins and arteries;
thromboembolic lesions of the veins in immediate family members;
surgical intervention causing prolonged immobility of the patient;
damage to small vessels against the background of developing diabetes mellitus of all types;
the state of inflammation of the pancreas, when the level of triglycerides in the blood is significantly elevated;
the formation of fatty deposits on the walls of blood vessels - dyslipidemic syndrome;
diseases or severe inflammation of the liver and kidneys;
yellow skin due to steroid medications;
cholelithiasis;
progressive genetic disease - ;
neoplasms on the liver;
capsule lesion inner ear;
hormone-sensitive neoplasms on the organs of the reproductive system or mammary glands;
bleeding from the vagina;
prolonged smoking;
pregnancy and the period after childbirth;
lactation period.

In the following situations, according to the reviews of doctors, "Lindinet 20" and analogues are allowed to be taken, but only if precautions are observed and under the supervision of the attending gynecologist:

the age of the patient is more than 35 years;
conditions that provoke the occurrence of thrombotic lesions of the veins;
being overweight or obese;
migraine;
hypertension;
diabetes if vascular damage is excluded;
ulcerative lesions of the colon;
hereditary angioedema;
diseases of the liver and kidneys;
diseases that have worsened during pregnancy or from taking hormonal drugs;
severe trauma;
varicose veins veins;
pathological processes of heart valves;
change in indicators biochemical analysis blood;
sudden onset of seizures;
violations heart rate;
prolonged immobility of the patient;
extensive surgery;
Libman-Sachs disease (lupus erythematosus);
cardiac ischemia;
severe depression;
Crohn's disease;
hereditary violation of the structure of the hemoglobin protein;
elevated level triglycerides in the patient's blood;
atypical hemolytic-uremic syndrome;
a short period of time after childbirth.

Method of application and dosage of the medicinal product and its analogues

According to the instructions, "Lindinet 20" and analogues are taken orally with a moderate amount of water or other liquid. Reception is carried out regardless of meals, one tablet once a day, preferably at the same time. After 21 days from the moment you start taking the pills, you must definitely take a break for seven days. During the seven-day break from the use of hormones, withdrawal bleeding (imitation of menstruation) occurs. Then the tablets from the new blister are taken on the eighth day of the break.

If Lindinet 20 is taken for the first time, then it is advisable to take the initial blister tablet from the first to the fifth day from the onset of menstruation. In the first two weeks from the start of taking "Lindinet 20" and analogue tablets, it is important to take advantage of auxiliary contraceptives in order to avoid unwanted pregnancy.

Switching from other contraceptives

If the drug "Lindinet 20" is used as a replacement for another contraceptive, then the reception is started without a seven-day interval. That is, when drinking the final pill from the pack of the previous drug, it is very important to start taking Lindinet 20 the next day. It is allowed to switch to "Lindinet 20" from contraceptive preparations "mini-drank" any day. Nevertheless, in the first week of using Lindinet 20, you should not rely on it, so it is better to use additional methods contraception.

With the appearance of sudden vomiting or diarrhea some time after taking the pill, the absorption of the drug is defective. If the symptomatology ended within twelve hours, then it is advisable to take another pill and continue taking it according to the scheme. If the symptoms last more than twelve hours, then additional contraception is absolutely necessary for the next seven days.

Abortion in the first trimester

After an abortion in the first trimester, Lindinet 20 is prescribed from the first day, immediately after the mechanical abortion. In this case, there is no need for additional contraception.

Use after childbirth or after an abortion in the second trimester

Use "Lindinet 20" and analogues can be started 21-28 days after childbirth or abortion. It is allowed to start taking after childbirth only if the woman is not breastfeeding. If you start taking the pills later than the specified period, then you will need additional barrier protection against pregnancy during the week.

Postponement of menstruation

In case of urgent need to delay menstruation and prolong the cycle, you can resume taking the tablets from the next package without a seven-day break. The appearance of the smearers blood secretions in this case does not reduce the contraceptive effect.

From the instructions for use of "Lindinet 20" and analogues: if the tablet was not taken on time, and no more than twelve hours have passed since the missed tablet, then you need to drink the missed tablet and continue taking the drug "Lindinet 20" according to the scheme. If more than twelve hours have passed, then the effectiveness of the drug as a contraceptive decreases, and it is recommended to use additional funds barrier contraception, such as a condom.

Missed tablet in the first and second week of the cycle: the next day, take two tablets at once and continue the regular intake of the drug according to the scheme, applying additional protection until the end of the cycle. Missed tablet in the third week of the cycle: take a tablet and do not take a seven-day break before the next pack.

Side effects

While taking "Lindinet 20" and analogues, there are often disturbances in the work of the following body functions:

mammary glands: aching pain from the side and from above, an increase in breast volume, discomfort, a feeling of heaviness, discharge from the nipples.
Reproductive system - a change in libido (a decrease occurs much more often), inflammation in the vagina, lack of menstruation after discontinuation of the drug, non-cyclic bloody spotting from the vagina.
Disorders of the gastrointestinal tract: pain in the stomach, nausea, vomiting, diarrhea, inflammation of the colon, liver damage, bile stasis, development cholelithiasis.
Skin: rashes, pigmentation, alopecia.
Neurology: headaches, psycho-emotional instability, depressive states, migraine.
Metabolism: rapid weight gain without change in diet, edema due to fluid retention, increased blood glucose, increased triglycerides in the blood.
Sense organs: discomfort in the eyes, hearing impairment.

Rarely occurring side effects from "Lindinet 20" and analogues of the drug:

Thromboembolic damage to the veins and circulatory system, including the brain.
Damage to the veins of the lower extremities.
Complication of lupus erythematosus.

Extremely exceptional violations:

Damage to the arteries of the kidneys and liver.
Retinal injury.

Cancellation of the drug is indicated in case of development of the following disorders:

Sustained increase in blood pressure.
progression of porphyria.
Blockage of blood vessels by blood clots.
Hearing loss due to otosclerosis.

Strengthening the symptoms of one of the above diseases during the use of hormones requires urgent discontinuation of the drug and the use of non-hormonal contraception.

Special instructions before using oral contraceptives

During the period of pregnancy and lactation, the described remedy is strictly contraindicated. Therefore, some time before the start of the reception, it is better to do a pregnancy test or donate blood for hCG. Reason: in the first months of pregnancy, sluggish menstruation is possible.

Before using Lindinet 20, it is important to collect all the required information about the health status of the patient and immediate family members. While taking "Lindinet 20" and analogues in the reviews and instructions, it is said that every six months it is necessary to undergo a medical examination, as well as a gynecological examination for the timely identification of possible risk factors.

Since the persistent contraceptive effect of the pills is achieved two weeks after the start of use, doctors recommend that additional non-hormonal methods be adopted these days to protect against pregnancy. The use of hormonal contraceptives is individual in each individual case.

Before starting, it is important to evaluate all the possible advantages and disadvantages of using the drug, after consulting in person with the attending gynecologist. Before you start taking drugs, it is important to consider that the relationship between taking oral hormonal contraceptives and the occurrence of thrombosis has been scientifically confirmed.

The risk of developing thromboembolic lesions is due to provoking factors:

mature age of the patient;
prolonged smoking;
heredity;
hypertension;
diabetes;
prolonged immobility of the patient.

The postpartum period significantly increases the risk of thromboembolism. Unfortunately, there is information about the increased incidence of cervical cancer in the case of prolonged use of hormonal contraceptives. However, research data contradict each other, since there are many conditions for the development of cervical cancer, and the effect of oral contraceptives will not necessarily be dominant. It is also known that the regular use of oral contraceptives can cause the development of breast cancer.

When taking "Lindinet 20" and analogues in composition, it is important to remember that the drug is not able to protect against infection with HIV and other types of sexually transmitted diseases. condom - The best way protection from infection.

The effectiveness of hormonal contraceptives can decrease if:

missing pills;
vomiting;
repeated diarrhea;
a long period of time between taking pills;
the use of drugs that reduce the effect of contraceptives.

After a long time after taking Lindinet 20, the effectiveness of the drug may decrease. If non-cyclic bleeding of unknown origin appears and does not stop until the end of the blister, then it is necessary to stop taking the drug and not resume until pregnancy is excluded at the gynecologist's appointment.

The estrogens contained in Lindinet 20 can affect the performance of laboratory tests of organs such as the kidneys and liver, thyroid, adrenals. Viral liver damage delays taking the drug for six months.

Smoking while taking Lindinet 20 birth control pills and analogues increases the occurrence of possible vascular diseases, which is extremely dangerous for patients over 35 years of age. There is no research data regarding the safety of reception when driving a motor vehicle and other activities that require increased concentration and speed.

Hormone overdose

Medicine is not aware of cases of serious side effects from a significant increase in the daily dosage of oral contraceptives. In isolated cases, situations are possible when nausea or vomiting occurs. In young girls, slight bleeding from the vagina is possible. However, exceeding the dosage of the drug is a reason for an urgent visit to the doctor to inform him about it.

Interaction with other drugs

The semi-synthetic antibiotic "Rifampicin" reduces the contraceptive effect and increases the occurrence of breakthrough bleeding, and also provokes menstrual irregularities. "Carbamazepine" and "Primidon" also reduce the effect of the drug "Lindinet 20". In this regard, for the period of therapy with these drugs, it is necessary to use additional measures for pregnancy protection.

Laxatives lower the level of hormones in the blood. "Fluconazole" increases the level of ethinylestradiol in the patient's blood. Antibiotics of the tetracycline series reduce the level of estradiol in the blood. St. John's wort and drugs based on it can not be combined with oral contraceptives.

Storage conditions

According to the manufacturers, "Lindinet 20" is suitable for use within three years from the date of production, which is indicated on the carton of the drug. After the expiration date, the use of the drug and its analogues is strictly prohibited. If a day is not specified, then the expiration date is the last day of the marked month.

Proper storage medicines:

avoid direct sunlight and moisture on medicines and even packaging;
Keep out of the reach of children;
the optimum storage temperature should not be less than 15 degrees and not exceed 25 degrees.

Disposal of tablets

In order to be able to properly dispose of medicines, you can seek advice from a pharmacist. This knowledge will help protect environment.

Judging by the reviews, the rating of analogues and Lindinet 20 is quite high, the last remedy occupies a leading position due to its low price. The average cost of Lindinet 20 tablets, from customer reviews, varies greatly across the country and depends on the region. So, for example, in Moscow, prices for a pack of 21 tablets vary from 450 to 570 rubles. For a package with three blisters (63 tablets), you will have to pay from 960 to 1220 rubles.

After analyzing the pharmaceutical market, we can conclude that "Lindinet 20" cheaper than analogues. For example, the average cost of a package of "Logest", where 21 tablets, is as much as 740 rubles.

How effective is a drug like Lindinet 30? Reviews of gynecologists about the mentioned medicine are presented in this article. It also considered detailed instructions this remedy, its indications, side effects And so on.

The form of the drug, its description and composition

What is a medicine like "Lindinet 30"? Reviews of gynecologists report that this medication is produced in the form of yellowish, round and biconvex tablets, without any inscriptions.

The active components of the agent in question are gestodene and ethinylestradiol. Also, the composition of the tablets includes such auxiliary elements as lactose monohydrate, sodium calcium edetate, corn starch, magnesium stearate, povidone and colloidal silicon dioxide.

The action of the drug

How does Lindinet 30 work? Reviews of gynecologists, instructions report that this remedy is an oral monophasic contraceptive that is able to inhibit the secretion of pituitary hormones (gonadotropic). The contraceptive properties of this drug are associated with several mechanisms.

The estrogenic component of this medication is ethinyl estradiol. This is a synthetic analogue of the hormone estradiol (follicular), which, together with the hormone corpus luteum takes part in the regulation of the monthly cycle.

As for the progestogen component, it includes gestodene, which is a derivative of 19-nortestosterone. In its selectivity and strength of action, it surpasses not only progesterone (or the so-called natural hormone of the corpus luteum), but also other synthetic progestogens, including levonorgestrel.

Due to the high activity, the mentioned component is used only in low doses, in which it will not be able to show androgenic properties and will not have any effect on carbohydrate and

Features of the tool

What is remarkable about the medicine "Lindinet 30"? Reviews of gynecologists claim that in addition to the central and peripheral mechanisms that prevent the maturation of the egg, the contraceptive properties of this medication are also due to the fact that it reduces the susceptibility of the endometrium to the blastocyst. Also, taking this remedy increases the viscosity of the mucus that is in the cervix, which contributes to sperm obstruction.

Other properties

It should also be noted that in addition to the contraceptive properties, the drug in question also has therapeutic effect. It normalizes the menstrual cycle and prevents the development of a number of gynecological diseases, including tumors.

Kinetic ability

How is the absorption of a drug such as "Lindinet 30"? The instruction indicates that after taking the medicine, its main substances are quickly absorbed from the gastrointestinal tract.

With a single dose of the drug, its peak concentration in the blood is reached after 1 hour. The bioavailability of this drug is 98.9%.

Gestodene binds to globulin and albumin. It undergoes biotransformation in the liver and is excreted from the body only in the form of derivatives along with feces and urine.

As for ethinylestradiol, it undergoes aromatic hydroxylation. In this case, hydroxylated and methylated metabolites are formed. Ethinylestradiol is excreted only in the form of derivatives, together with bile and urine in a ratio of 3:2.

Indications for appointment

For what purposes is the drug "Lindinet 30" used? Reviews of gynecologists say that this is highly effective. It is taken by women of reproductive age in order to prevent unwanted pregnancy.

Prohibitions to receive funds

Under what conditions can not use the drug "Lindinet 30"? The use of this medicine is contraindicated:

Also, the drug should not be taken during pregnancy and during breastfeeding.

Medication "Lindinet 30": instructions for use

The drug in question is prescribed one tablet per day for 21 days, at the same time. After taking the last dosage, take a week break. Further, the use of the drug is resumed. The first tablet of this medication should be taken from the first to the fifth day of the monthly cycle.

If the patient switches to Lindinet 30 from another oral contraceptive, then the 1st tablet should be taken immediately after taking the last dose of another hormonal agent.

After an abortion at the very beginning of pregnancy, the use of the medication can be started immediately after the operation. There is no need to use other methods of contraception.

After childbirth or abortion in the second trimester, medication can be started as early as 22-28 days. In this case, other means of contraception must be used in the first week.

If you miss a dose, the tablet should be taken as soon as possible. If the interval between doses of the medication was less than 12 hours, then the contraceptive effect is not reduced. In this case, you do not need to use other methods of contraception.

If the interval is more than 12 hours, then the contraceptive effect of the drug may decrease. In this situation, additional methods of contraception should be used in the next week.

If diarrhea and vomiting begin within 4 hours after using the medicine, then its contraceptive effect may decrease. In such cases, you must follow the instructions for skipping pills.

To speed up the onset of menstruation, you should shorten the break in taking the medication. To delay the onset of menstruation, the medication should be continued without a week break.

Adverse reactions

What side effects can cause the drug "Lindinet 30"? Reviews of gynecologists (with fibroids, this medicine can only be taken on the advice of a doctor) argue that the medication in question should be immediately discontinued if it causes the following reactions:

arterial hypertension, hearing loss due to otosclerosis, venous and arterial thromboembolism;
hemolytic-uremic syndrome, venous or arterial thromboembolism of mesenteric, hepatic, retinal and renal veins and arteries;
porphyria, Sydenham's chorea, exacerbation of reactive lupus erythematosus.

Other side effects of this drug that do not require its withdrawal are the following:

migraine, candidiasis, acyclic bleeding from the vagina, galactorrhea, amenorrhea after drug withdrawal, pain, changes in vaginal mucus, breast enlargement, development of inflammation in the vagina, tension;
ulcerative colitis, headache, epigastric pain, cholelithiasis, nausea, hepatitis, vomiting, exacerbation of jaundice, Crohn's disease;
exudative erythema, depression, erythema nodosum, chloasma, rash, hair loss;
increased sensitivity of the cornea, hearing loss;
mood lability, reduced carbohydrate tolerance, water retention in the body, hyperglycemia, changes in body weight, increased TG levels;
allergy.

Modern women are protected from unwanted pregnancy. Reliable methods of contraception are considered barrier, including condoms, and hormonal pills.

In the article, we will consider what is the difference between Lindinet 20 and 30. The remedy is an oral monophasic contraceptive. It inhibits the secretion of pituitary hormones. Its contraceptive effectiveness is directly related to several mechanisms. The estrogenic ingredient of the drug is ethinyl estradiol, which is a synthetic analogue of follicular estradiol, which, together with the hormones of the corpus luteum, participates in the regulation of the cycle. Below is an instruction for the use of Lindinet 20 and 30. What is the difference between these drugs?

General rules for use

Drink tablets once for twenty-one days. It is necessary to drink the drug at the same time of day every day. For example, if a woman takes the first pill at nine o'clock, this means that they should be taken at this time all subsequent days. When all the tablets (twenty-one pieces) are drunk, a seven-day break is arranged, during which bleeding should occur.

Further, on the same day of the month when the first tablet was taken (for example, on the eighteenth of January), the drug is resumed again (on the eighteenth of February). And so monthly. The first birth control pill is taken from the first to the fifth day of menstruation.

How to choose - "Lindinet" 20 or 30? This is a common question.

In the case when a transition is made from one contraceptive (combined type) to Lindinet, the very first pill is drunk immediately on the second day after the completion of the previous one. contraceptive medicine. After an abortion that took place in the initial trimester, this remedy should be started on the second day or on the day after the operation. There is no need to resort to auxiliary methods of protection. And after abortions made in the second trimester, as well as after childbirth, the consumption of pills should be started no earlier than the twenty-first day. In this case, additional methods of contraception are required in the first week. Next, find out what the composition of this tool.

Compound

The drug "Lindinet 20" is a monophasic agent, in connection with this, the tablets in the package have the same dosage of hormones. One pill contains 20 micrograms of ethinyl estradiol and 75 micrograms of gestodene. What is the composition of Lindinet 30? This formulation contains 30 micrograms of ethinyl estradiol and 75 micrograms of gestodene.

pharmachologic effect

The presented medical product significantly reduces the secretion of gonadotropic hormones. The contraceptive action of Lindinet 30 and 20 is associated with a number of mechanisms. It is caused by a decrease in susceptibility to the endometrial blastocyst and an increase in the level of viscosity of the mucus in the uterus. In addition to contraceptive efficacy, this medicine also has medicinal properties. Now let's figure out what is the difference between Lindinet 20 and 30.

Differences

Which pills are suitable for a particular patient can only be prescribed by a doctor, based on tests. The drug "Lindinet" 20 is more calculated on nulliparous young girls. The content of hormones in it is less than in the composition of "Lindinet" 30.

In the event that the peculiarity of the organism of each particular patient is not taken into account, then if the woman is twenty years old, then, most likely, the doctor will prescribe Lindinet 20, and after 30 Lindinet 30 will be prescribed accordingly.

Lindinet form acceptance mode 30

The medicine in question is prescribed one pill for twenty-one days. After the completion of the use of the drug "Lindinet" 30, it is necessary to take a week break, resuming the medication. Start receiving funds:

The first tablet is drunk on the first day of the cycle. Reception can be stretched from the first to the fifth day.
As part of the transition to the use of this drug from any other combined oral contraceptive, the initial tablet is taken immediately after the last pill of the analogue.
Against the background of the transition to taking this medication from drugs that contain only progestogen, the use of Lindinet 30 is started on absolutely any day of the cycle. The transition from the implant to this agent is possible immediately on the next day after its removal, and in the case of injections - on the eve of the last injection. In such a situation, additional methods of contraception should be used in the first week.
Following an abortion in the initial trimester of pregnancy, the medicine should be taken immediately immediately after the operation. No additional methods of contraception are needed.
After an abortion or childbirth in the second trimester, the medicine should be prescribed on the twenty-first day. Additional contraception will be required for the first week of use.

Tips for taking missed pills are as follows:

If a woman forgets to take a pill, then she needs to be taken immediately after she is remembered, in no case should she be delayed with this.
If the patient is less than twelve hours late in taking the pill, then the reliability of contraception can remain at the same level.
When the delay is more than twelve hours, the function of contraception can be much worse. The missed dosing of the drug does not need to be replenished, and it is recommended to take it as usual and use additional methods of contraception for the next week.

Rules for accepting Lindinet 20

Consider the instructions for use for "Lindinet" 20.

In the event that a woman is just starting to take the remedy, then the first pill from the blister should be drunk from the first to the fifth day of the cycle. As a result of using the first pills, menstruation may stop. This is not at all scary and is directly related to the effect of hormones on the body. During the first fourteen days of taking the tablets, it is recommended to use additional methods of contraception.

As the instructions for use for Lindinet 20 indicate, it is advisable to take these pills daily at approximately the same hour. Tablets must be drunk in the order indicated on the blister. But, when the patient mistakenly started taking the pills in the wrong order, nothing bad will happen, since all Lindinet 20 pills contain the same dosage of hormones. After drinking twenty-one tablets, a seven-day break should be taken, during which the pills are no longer necessary. During this week break, a woman may have her period.

At this time, you do not need to use additional methods of contraception. This is true only in cases where, after the end of the weekly pause, the patient starts drinking pills again. It is necessary to start using the first pill from the next blister on the eighth day after a seven-day pause. In this case, it does not matter at all whether the menstruation has already begun or ended.

Which is better - Lindinet 20 or 30?

Answering the question of which of these forms is better, it is worth saying that in this case the choice should be based solely on the age of the patient. Thus, it will be better if a woman chooses this drug for herself according to her age period.

As for the features, it must be said that when taking contraceptive pills of the “20” or “30” form, it is necessary to take into account the fact that if drugs are used in the form of Ampicillin, Tetracycline, Felbamate or Fluconazole , then the activity of the contraceptive drug in question decreases. Therefore, when women drink "Lindinet" along with these medicines, you need to take care of any other methods of contraception, for example, based on spermicides, or any of the barrier methods.

St. John's wort tea also lowers the level of "Lindinet" in the blood and it can cause intermediate bleeding or pregnancy. In this regard, in the case of taking Lindinet 20 or 30 together with other medicines you need to consult a doctor and make sure that they do not affect the decrease active component contraceptive pills.

It is also worth noting that the described remedy (20 and 30) should not be taken during pregnancy, diabetes, venous insufficiency, lactation, and in any disorder associated with the kidneys or liver.

Side effects

individual features each lady is superimposed and her own adverse reactions from taking Lindinet. If one or more of the adverse effects listed below occur, the drug in question should be discontinued. These include:

The occurrence of heart failure and vascular system. It occurs in the form of hypertension or thromboembolism.
Hearing loss along with Sindenham's chorea.
The appearance of candidiasis, bleeding, galactorrhea.
The occurrence of nausea and vomiting.
Breast enlargement along with pain in it.
The development of hepatitis, the appearance of a rash and erythema nodosum.
Headache and depression.
Significant weight gain.
Allergic reactions.

If the patient experiences something from this list after using the Lindinet contraceptive, then the attending physician should be urgently informed about this.

Menstruation while taking Lindinet

Menstruation during the use of this remedy may occur if the woman has violated the cycle of consumption of this contraceptive medication. But in any case, whether there was a failure in taking the pills or not, you should consult a gynecologist.

The cause of bleeding when using Lindinet can be pathologies of the genital tract. Therefore, it is immediately necessary to consult a doctor who, after examining, will find the true causes of bleeding.

When does the contraceptive effect of Lindinet come on?

Reliable contraceptive efficacy from Lindinet usually occurs after fourteen days of taking the pills. In the first two weeks of using the first package of the product, you must use any other methods of contraception.

Do I need to protect myself during the week break?

In the event that a woman took the previous package according to the rules and without any gaps, then in the seven-day break it is not necessary to use any other means of contraception. It will also not be required at the beginning of the next package.

How to switch to Lindinet 30?

Consider how to make the transition from Lindinet 20 to Lindinet 30 correctly.

As part of the transition, the first Lindinet 30 tablet must be taken the next day after the end of the pills from the previous package. Within fourteen days after starting a new form of medication, additional contraceptives should be used.

How the transition from Lindinet 20 to Lindinet 30 looks like is indicated in the annotation.

How do they switch to Lindinet 20 from a hormonal patch and the use of a vaginal ring?

The first pill "Lindinet" 20 is recommended to drink on the day of removing the hormonal patch or removing the ring. You can also start taking the contraceptive at the moment when it was necessary to attach a new patch, or once again put the vaginal ring.

Analogues "Lindinet 30 and 20"

According to the structure, the following analogues are distinguished:

Mirrel.
"Logest".
"Femoden".

In this article, you can read the instructions for use medicinal product Lindinet 20 and 30. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of specialist doctors on the use of Lindinet in their practice. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Lindinet analogs in the presence of existing structural analogs. Use of hormonal birth control for contraception in women, including during pregnancy and breastfeeding. Side effects (bleeding, pain).

Lindinet- monophasic oral contraceptive. It inhibits the secretion of gonadotropic hormones from the pituitary gland. The contraceptive effect of the drug is associated with several mechanisms. The estrogenic component of the drug is ethinylestradiol, a synthetic analogue of the follicular hormone estradiol, which, together with the corpus luteum hormone, participates in the regulation of the menstrual cycle. The progestogen component is gestodene, a derivative of 19-nortestosterone, which is superior in strength and selectivity of action not only to the natural hormone of the corpus luteum progesterone, but also to other synthetic progestogens (for example, levonorgestrel). Due to its high activity, gestodene is used in low dosages, in which it does not exhibit androgenic properties and has practically no effect on lipid and carbohydrate metabolism.

Along with the indicated central and peripheral mechanisms that prevent the maturation of an egg capable of fertilization, the contraceptive effect is due to a decrease in the susceptibility of the endometrium to the blastocyst, as well as an increase in the viscosity of the mucus in the cervix, which makes it relatively impassable for spermatozoa. In addition to the contraceptive effect, the drug, when taken regularly, also has a therapeutic effect, normalizing the menstrual cycle and helping to prevent the development of a number of gynecological diseases, incl. tumor nature.

The difference between Lindinet 20 and Lindinet 30

The main difference between both drugs lies in the different amounts of ethinylestradiol included in the component in one type of drug it contains 30 mcg, in the other 20 mcg. Hence the various names of similar nevertheless preparations. Also in the composition of both preparations there is gestodene in the amount of 75 mcg.

Pharmacokinetics

Gestodene

After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. Bioavailability - about 99%. Gestodene is biotransformed in the liver. It is excreted only in the form of metabolites, 60% - with urine, 40% - with feces.

Ethinylestradiol

After oral administration, ethinylestradiol is absorbed rapidly and almost completely. Ethinylestradiol is excreted only in the form of metabolites, in a ratio of 2:3 with urine and bile.

Indications

contraception.

Release form

Coated tablets.

Instructions for use and regimen

Assign 1 tablet per day for 21 days, if possible at the same time of day. After taking the last tablet from the package, a 7-day break is taken, during which withdrawal bleeding occurs. The next day after a 7-day break (i.e. 4 weeks after taking the first tablet, on the same day of the week), the drug is resumed.

The first tablet of Lindinet should be taken from the 1st to the 5th day of the menstrual cycle.

When switching to Lindinet from another combined oral contraceptive, the first Lindinet tablet should be taken after taking the last pill from the package of another oral hormonal contraceptive, on the first day of withdrawal bleeding.

When switching to taking Lindinet from drugs containing only progestogen ("mini-pili", injections, implant), when taking "mini-drink", you can start taking Lindinet on any day of the cycle, you can switch from using an implant to taking Lindinet on the next day after the removal of the implant, when using injections - on the eve of the last injection. In these cases, additional methods of contraception should be used in the first 7 days.

After an abortion in the 1st trimester of pregnancy, you can start taking Lindinet immediately after surgery. In this case, there is no need to use additional methods of contraception.

After childbirth or after an abortion in the 2nd trimester of pregnancy, the drug can be taken on the 21-28th day. In these cases, additional methods of contraception must be used in the first 7 days. With a later start of taking the drug in the first 7 days, an additional, barrier method of contraception should be used. In the case when sexual contact took place before the start of contraception, before starting the drug, pregnancy should be excluded or the start of the drug should be postponed until the first menstruation.

If you miss a pill, you should take the missed pill as soon as possible. If the interval in taking the tablets was less than 12 hours, then the contraceptive effect of the drug does not decrease, and in this case there is no need to use an additional method of contraception. The remaining tablets should be taken at the usual time. If the interval was more than 12 hours, then the contraceptive effect of the drug may decrease. In such cases, you should not make up for the missed dose, continue taking the drug as usual, but in the next 7 days, you need to use an additional method of contraception. If at the same time there are less than 7 tablets left in the package, the drug from the next package should be started without interruption. In this case, withdrawal bleeding does not occur until the completion of the second pack, but spotting or breakthrough bleeding may occur.

If withdrawal bleeding does not occur after the end of taking the drug from the second package, then pregnancy should be excluded before continuing to take the drug.

If vomiting and / or diarrhea begins within 3-4 hours after taking the drug, the contraceptive effect may decrease. In such cases, you should proceed in accordance with the instructions for skipping pills. If the patient does not want to deviate from the usual contraceptive regimen, the missed pills should be taken from another package.

To accelerate the onset of menstruation, you should reduce the break in taking the drug. The shorter the break, the more likely the occurrence of breakthrough or spotting bleeding while taking the pills from the next pack (similar to cases with delayed menstruation).

To delay the onset of menstruation, the drug should be continued from a new package without a 7-day break. Menstruation can be delayed as long as necessary until the end of the last pill from the second package. With a delay in menstruation, breakthrough or spotting bleeding may occur. Regular use of the drug Lindinet can be restored after the usual 7-day break.

Side effect

Side effects requiring discontinuation of the drug:

arterial hypertension;
arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, thromboembolism pulmonary artery);
arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins;
hearing loss due to otosclerosis;
hemolytic-uremic syndrome;
porphyria;
exacerbation of reactive systemic lupus erythematosus;
Sydenham's chorea (passing after discontinuation of the drug).

Other side effects (less severe):

acyclic bleeding/ bloody issues from the vagina;
amenorrhea after discontinuation of the drug;
change in the state of vaginal mucus;
development inflammatory processes vagina;
candidiasis;
tension, pain, breast enlargement;
galactorrhea;
pain in the epigastrium;
nausea, vomiting;
Crohn's disease;
ulcerative colitis;
the occurrence or exacerbation of jaundice and / or itching associated with cholestasis;
liver adenoma;
erythema nodosum;
exudative erythema;
rash;
chloasma;
increased hair loss;
headache;
migraine;
mood lability;
depression;
hearing loss;
increased sensitivity of the cornea (when wearing contact lenses);
fluid retention in the body;
change (increase) in body weight;
decreased tolerance to carbohydrates;
hyperglycemia;
allergic reactions.

Contraindications

the presence of severe and / or multiple risk factors for venous or arterial thrombosis (including complicated lesions of the valvular apparatus of the heart, atrial fibrillation, cerebrovascular disease or coronary arteries, arterial hypertension, severe or medium degree severity with BP ≥ 160/100 mm Hg);
the presence or indication in the anamnesis of the precursors of thrombosis (including transient ischemic attack, angina pectoris);
migraine with focal neurological symptoms, incl. in history;
venous or arterial thrombosis / thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower leg, pulmonary embolism) at present or in history;
the presence of venous thromboembolism in history;
surgery with prolonged immobilization;
diabetes mellitus (with angiopathy);
pancreatitis (including history), accompanied by severe hypertriglyceridemia;
dyslipidemia;
severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, incl. in history (before the normalization of functional and laboratory parameters and within 3 months after their normalization);
jaundice when taking GCS;
cholelithiasis at present or in history;
Gilbert's syndrome, Dubin-Johnson syndrome, Rotor's syndrome;
liver tumors (including history);
severe itching, otosclerosis or its progression during a previous pregnancy or taking corticosteroids;
hormone-dependent malignant neoplasms genital organs and mammary glands (including if they are suspected);
vaginal bleeding of unknown etiology;
smoking over the age of 35 (more than 15 cigarettes per day);
pregnancy or suspicion of it;
lactation period;
hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation.

In small quantities, the components of the drug are excreted in breast milk.

When used during lactation, milk production may decrease.

special instructions

Before starting the use of the drug, it is necessary to conduct a general medical (detailed family and personal history, measurement of blood pressure, laboratory research) and gynecological examination (including examination of the mammary glands, pelvic organs, cytological analysis of the cervical smear). A similar examination during the period of taking the drug is carried out regularly, every 6 months.

The drug is a reliable contraceptive: the Pearl index (an indicator of the number of pregnancies that occurred during the use of a contraceptive method in 100 women for 1 year) with correct application is about 0.05. Due to the fact that the contraceptive effect of the drug from the start of administration is fully manifested by the 14th day, in the first 2 weeks of taking the drug, it is recommended to additionally use non-hormonal methods of contraception.

In each case, before prescribing hormonal contraceptives, the benefits or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make the final decision on the preference for hormonal or any other method of contraception.

The state of health of women must be carefully monitored. If any of the following conditions / diseases appear or worsen while taking the drug, you must stop taking the drug and switch to another, non-hormonal method of contraception:

diseases of the hemostasis system;
conditions/diseases predisposing to the development of cardiovascular, renal failure;
epilepsy;
migraine;
the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;
diabetes mellitus, not complicated by vascular disorders;
severe depression (if depression is associated with impaired tryptophan metabolism, then vitamin B6 can be used to correct it);
sickle cell anemia, tk. in some cases (for example, infections, hypoxia), estrogen-containing drugs in this pathology can provoke thromboembolism;
the appearance of abnormalities in laboratory tests for assessing liver function.

Thromboembolic diseases

Epidemiological studies have shown that there is a connection between taking oral hormonal contraceptives and an increased risk of developing arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic disease has been proven, but it is significantly less than during pregnancy (60 cases per 100,000 pregnancies). When using oral contraceptives, arterial or venous thromboembolism of the hepatic, mesenteric, renal or retinal vessels is very rarely observed.

The risk of developing arterial or venous thromboembolic diseases increases:

with age;
when smoking (heavy smoking and age over 35 are risk factors);
if there is a family history of thromboembolic diseases (for example, in parents, a brother or sister). If a genetic predisposition is suspected, it is necessary to consult a specialist before using the drug;
with obesity (body mass index over 30 kg/m2);
with dyslipoproteinemia;
with arterial hypertension;
in diseases of the heart valves, complicated by hemodynamic disorders;
with atrial fibrillation;
with diabetes mellitus complicated by vascular lesions;
with prolonged immobilization, after major surgery, after surgery on lower limbs after a severe injury.

In these cases, a temporary discontinuation of the drug is expected (no later than 4 weeks before surgery, and resumed no earlier than 2 weeks after remobilization).

Women after childbirth have an increased risk of venous thromboembolic disease.

It should be borne in mind that diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia, increase the risk of developing venous thromboembolic diseases.

It should be borne in mind that resistance to activated protein C, hyperhomocysteinemia, deficiency of proteins C and S, deficiency of antithrombin 3, the presence of antiphospholipid antibodies increase the risk of developing arterial or venous thromboembolic diseases.

When evaluating the benefit / risk ratio of taking the drug, it should be borne in mind that targeted treatment given state reduces the risk of thromboembolism. The symptoms of thromboembolism are:

sudden chest pain that radiates to the left arm;
sudden shortness of breath;
any unusually severe headache that lasts for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of one side of the body, movement disorders, severe unilateral pain in the calf muscle, sharp abdomen.

Tumor diseases

Some studies have reported an increase in the incidence of cervical cancer in women who have taken hormonal contraceptives for a long time, but the results of the studies are conflicting. Sexual behavior, human papillomavirus infection and other factors play a significant role in the development of cervical cancer.

A meta-analysis of 54 epidemiological studies showed that there is a relative increase in the risk of breast cancer among women taking oral hormonal contraceptives, but higher detection of breast cancer could be associated with more regular medical examination. Breast cancer is rare among women under 40, whether they are taking hormonal birth control or not, and increases with age. Taking pills can be regarded as one of many risk factors. However, women should be advised of the potential risk of developing breast cancer based on a benefit-risk assessment (protection against ovarian and endometrial cancer).

There are few reports of the development of benign or malignant tumor liver in women taking long-term hormonal contraceptives. This should be kept in mind in the differential diagnostic evaluation of abdominal pain, which may be associated with an increase in the size of the liver or intraperitoneal bleeding.

Chloasma

Chloasma can develop in women who have a history of this disease during pregnancy. Those women who are at risk of developing chloasma should avoid contact with the sun's rays or ultraviolet radiation while taking Lindinet.

Efficiency

The effectiveness of the drug may decrease in the following cases: missed pills, vomiting and diarrhea, simultaneous use of other drugs that reduce the effectiveness of birth control pills.

If the patient is simultaneously taking another drug that can reduce the effectiveness of birth control pills, additional methods of contraception should be used.

The effectiveness of the drug may decrease if, after several months of their use, irregular, spotting or breakthrough bleeding appears, in such cases it is advisable to continue taking the tablets until they are finished in the next package. If at the end of the second cycle, menstrual bleeding does not begin or acyclic spotting does not stop, stop taking the tablets and resume it only after pregnancy has been ruled out.

Changes in laboratory parameters

Under the influence of oral contraceptive pills - due to the estrogen component - the level of some laboratory parameters (functional parameters of the liver, kidneys, adrenal glands, thyroid gland, indicators of hemostasis, levels of lipoproteins and transport proteins).

Additional Information

After an acute viral hepatitis the drug should be taken after the normalization of liver function (not earlier than after 6 months).

With diarrhea or intestinal disorders, vomiting, the contraceptive effect may decrease. Without stopping taking the drug, it is necessary to use additional non-hormonal methods of contraception.

Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35) and on the number of cigarettes smoked.

A woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Influence on the ability to drive vehicles and control mechanisms

Studies on the effect of the drug Lindinet on the ability to drive a car and work machinery have not been conducted.

drug interaction

The contraceptive activity of Lindinet is reduced when taken simultaneously with ampicillin, tetracycline, rifampicin, barbiturates, primidone, carbamazepine, phenylbutazone, phenytoin, griseofulvin, topiramate, felbamate, oxcarbazepine. The contraceptive effect of oral contraceptives is reduced with the use of these combinations, breakthrough bleeding and menstrual disorders become more frequent. While taking Lindinet with the above drugs, as well as within 7 days after completing the course of taking them, it is necessary to use additional non-hormonal (condom, spermicidal gels) methods of contraception. When using rifampicin, additional methods of contraception should be used within 4 weeks after completion of the course of its administration.

When used simultaneously with Lindinet, any drug that increases gastrointestinal motility reduces absorption active substances and their plasma levels.

Sulfation of ethinyl estradiol occurs in the intestinal wall. Drugs that also undergo sulfation in the intestinal wall (including ascorbic acid) competitively inhibit the sulfation of ethinylestradiol and thereby increase the bioavailability of ethinylestradiol.

Inducers of microsomal liver enzymes reduce the level of ethinylestradiol in plasma (rifampicin, barbiturates, phenylbutazone, phenytoin, griseofulvin, topiramate, hydantoin, felbamate, rifabutin, oscarbazepine). Liver enzyme inhibitors (itraconazole, fluconazole) increase plasma levels of ethinylestradiol.

Some antibiotics (ampicillin, tetracycline), preventing the intrahepatic circulation of estrogens, reduce the level of ethinylestradiol in plasma.

Ethinylestradiol, by inhibiting liver enzymes or accelerating conjugation (primarily glucuronidation), can affect the metabolism of other drugs (including cyclosporine, theophylline); the concentration of these drugs in the blood plasma may increase or decrease.

With the simultaneous use of Lindinet with St. John's wort (including infusion), the concentration of active substances in the blood decreases, which can lead to the appearance breakthrough bleeding, pregnancy. The reason for this is the inducing effect of St. John's wort on liver enzymes, which continues for another 2 weeks after the completion of the course of taking St. John's wort. This combination of drugs is not recommended.

Ritonavir reduces the AUC of ethinylestradiol by 41%. In this regard, during the use of ritonavir, a hormonal contraceptive with a higher content of ethinyl estradiol (Lindinet 30) should be used or additional non-hormonal methods of contraception should be used.

It may be necessary to correct the dosing regimen when using hypoglycemic agents, tk. oral contraceptives may reduce carbohydrate tolerance, increase the need for insulin or oral antidiabetic agents.

Lindinet's analogues

Structural analogues for the active substance:

Logest;
Mirelle;
Femoden.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.