Whether can from tablets Mexidol. What is Mexidol prescribed for? Succinic acid - oral dosage (tablets)

Mexidol is a drug that stops destructive processes in the body, restores tissues and nourishes them. beneficial substances. In order not to harm the body at the time of treatment, you need to know exactly how to take such a drug. We will talk about the action of Mexidol, describe it beneficial features and contraindications.

The medicine includes the active substance ethylmethylhydroxypyridine, sodium metabisulfite, povidone, lactose, polyethylene glycol, titanium dioxide.

Description of the drug

Mexidol increases the body's resistance to various injuries, protects against shock, ischemia and nervous disorders. It is an anticonvulsant and nootropic agent. The drug increases the content of dopamine in the brain, improves blood circulation and microcirculation. It has an effective anti-stress effect.

Mexidol release form

The medicine can be purchased in the form of tablets and ampoules for injection. They produce packs of tablets of 50 or 30 pieces. The medicine is covered with a white shell. Store drugs at a temperature not exceeding 25 degrees in a dark place. The standard shelf life of the drug is 3 years.

Indications for the use of Mexidol

The doctor can prescribe Mexidol therapy only after a complete examination of the patient, diagnosis and testing. The drug has a wide spectrum of action and is prescribed in such cases:

• After ischemic attacks in the body.
• In violation of blood circulation in the patient's brain.
• As a prophylaxis of ischemic stroke.
• After trauma to the head and skull.
• With the syndrome of vegetative dystonia.
• In the moment nervous disorders when feeling anxious.
• To combat withdrawal symptoms in alcoholism.
• It is prescribed after severe intoxication in the body.
• When defeated nervous system strong stress.
• After strong psychological stress.
• At the time of myocardial infarction.
• With a purulent process in the abdomen.
• At the time of glaucoma of different stages.

Contraindications to taking medication

The doctor must warn the patient when it is forbidden to take Mexidol. If you neglect these recommendations, you can significantly harm your health. So, the drug is prohibited in such cases:

1. If the patient has kidney problems, liver failure.
2. With increased sensitivity to the composition of the drug. The patient may be allergic to one of the components of Mexidol. In this case, you need to stop therapy with this drug.
3. Prohibited for children under 16 years of age.
4. Should not be taken by pregnant women.
5. Dangerous for the baby during breastfeeding. Substances of the drug can get through the milk to the child and greatly harm his health.

In case of individual intolerance to the remedy, you should immediately inform the doctor. He can prescribe analogues of Mexidol, which will help with illness and will not harm the body.

Side effects from Mexidol

The doctor is obliged to tell the patient about possible side effects. They may not appear, but you still need to get information about them. Please note that side effects can be very harmful to the body. Therefore, with a sharp deterioration in the condition, you should immediately inform the doctor. Here are the main side effects of Mexidol:

1. Nausea or vomiting.
2. Great dry mouth, constant feeling of thirst.
3. Allergy on the body.
4. Fatigue, constant sleepiness during the day.
5. Fear, anxiety and depression.
6. Emotional activity.
7. Hyperhidrosis.
8. Patient has frequent headaches.
9. Poor coordination, a person may even fall.
10. Overpressure.
11. Dizziness.

If side effects appear immediately, the doctor should urgently reduce the dose of the prescribed drug or, in extreme cases, stop therapy with this drug.

How to use Mexidol tablets?

Doctors usually prescribe the drug in tablets of 250 mg no more than 3 times a day. Mexidol tablets should be taken orally and washed down with plenty of water. The maximum dose per day is 800 mg. This is about 6 tablets. It is not recommended to exceed this limit without a doctor's prescription.

The usual course of treatment with Mexidol lasts about 4 weeks. To stop alcohol withdrawal, it is enough to take the drug for a week.

The course of treatment for cardiac ischemia usually lasts 2 months. The doctor may prescribe a second course of Mexidol. It is best to reapply in the spring or fall.

How to use Mexidol in ampoules

The doctor may prescribe Mexidol injections intravenously or intramuscularly. The dose of the drug is prescribed by a specialist individually according to the diagnosis of the patient and the stage of the disease. Sometimes it is necessary to dilute the agent with sodium chloride during injection, using 200 ml per ampoule.

Standard treatment begins with 100 mg of Mexidol 2-3 times a day. The doctor may gradually increase the dose if side effects are not observed. The maximum dose of the drug is 800 mg. Mexidol can be administered:

1. Jet. It is necessary to inject slowly, about 7 minutes.
2. Drip. Enter 50 drops in 1 minute.

Basic doses for diseases

It is important to use Mexidol correctly for each disease:

• In case of skull injuries, Mexidol injections should be given for 2 weeks. You will have to inject 300 mg of the drug 3-4 times a day.
• If you need to improve blood circulation in the brain, use the drug for 10 days. Administer 300 mg once daily by drip. Then you can enter intramuscularly the agent three times a day, 100 mg each.
• In case of myocardial infarction, it is recommended to administer Mexidol intramuscularly for 14 days. In doing so, you need to use complex treatment.
• Glaucoma requires treatment for at least 14 days. Enter intramuscularly 200 mg of Mexidol 2 times a day.
• At the time of alcohol withdrawal syndrome, it is necessary to inject the drug intravenously 2 times a day. The course of treatment is 7 days.
• With severe intoxication by other means, Mexidol should be administered intravenously at 100-200 mg. The course of treatment lasts at least 10 days.
• With pancreatitis, it is required to administer 400 mg of the drug 2 times a day. It is advisable to gradually reduce the dose until recovery.

If you take too many pills or give a large injection dose, complications can begin. Most often, a person begins severe drowsiness. However, other side effects from the drug can become more complicated and cause great harm to health.

Medication and driving

Doctors do not recommend driving and driving a car at the time of treatment with Mexidol. The medicine slows down a person's natural reactions and reduces concentration. This may lead to an accident and other dangerous consequences. It is also not recommended to engage in other activities that may require a lot of concentration from a person.

Interaction of tablets with other drugs

Mexidol goes well with other drugs and does not weaken their effect. The tool will reduce the effect and toxicity of ethyl alcohol. The drug will enhance the effect of antidepressants and anticonvulsants.

Prices for drugs Mexidol

You can buy Mixidol tablets and ampoules at every pharmacy without a doctor's prescription. Prices vary everywhere, but you can note the average cost of a medicine:

• Mexidol in tablets of 0.125 g - 50 pieces cost 410-460 rubles.
• Mexidol in tablets of 0.125 g - 30 tablets will cost 270-300 rubles.
• Mexidol in ampoules of 5 ml - 5 pieces cost -450-500 rubles.
• Mexidol in ampoules of 2 ml - 10 ampoules cost 460-510 rubles.

Mexidol analogues

The doctor may prescribe another drug that, in terms of properties and active ingredients, will be similar to Mexidol. Now there are such analogues of this tool:

• Antifront.
• Armandine.
• Glycine.
• Glycised.
• Glutamic acid.
• Instenon.
• Keltikan.
• Mexiprim.
• Memory plus.
• Rilutek.
• Tenoten.
• Tryptophan.
• Cytoflavin.

Mexidol reviews

Since the drug has a wide spectrum of action, you can find a lot of patient reviews about it. To learn about the real effect of Mexidol, we recommend reading some of them:

• Yana, 37 years old. The doctor prescribed me to take Mexidol for osteochondrosis in order to improve my nervous condition. At the time of illness, I often experienced bouts of depression, fear, especially at my advanced stage. There was no desire to start treatment and go to procedures. After the first week of taking Mexidol, my condition immediately improved, my mood improved, and motivation appeared. More strength appeared, and I stopped being afraid of sudden back pain. At the same time, I began to comprehensively treat osteochondrosis, do gymnastics and undergo physiotherapy.
• Anton, 29 years old. I started taking Mexidol to cope quickly with attacks at the time of vegetovascular dystonia. This disease causes a sharp feeling of fear, chest pain, panic and shortness of breath. It feels like you are dying. The doctor advised me to take Mexidol for a month. I drank 1 tablet a day and immediately noticed improvements. At night I began to sleep well, I was no longer tormented by insomnia and fear. I took the remedy for a month and even forgot about my attacks. I stopped worrying and took up my favorite hobbies.

• Irina, 41 years old. Mexidol was prescribed to me by a doctor along with complex treatment cervical osteochondrosis. At that moment, I had vertebral artery syndrome, which was accompanied by severe pain and impaired blood flow to the brain. Because of this, I suffered from headaches, depression, irritability and even dizziness. I was given regular injections of Mexidol in ampoules. The drug improved blood circulation, I again began to sleep easily and ceased to be nervous. After a long course of Mexidol, the pain subsided, vision improved, and the overall activity of the body increased. Immediately began to work productively, there was no unpleasant fatigue. Side effects did not bother me even after long injections.

Conclusion

Now you know how Mexidol works in the form of tablets and ampoules. We have described for which diseases such a drug is suitable and how to use it correctly for effective recovery. You met next side effects and contraindications to the drug. Mexidol really improves blood circulation, stops destructive processes in the body, and calms the patient's nervous system. But for such results, you need to take Mexidol exactly as prescribed by the doctor, do not exceed the dosage and inform the doctor about any changes in the body.

Mexidol is an indispensable tool in the treatment of many diseases - from stress and circulatory disorders in the brain to getting rid of alcohol poisoning. Nevertheless, Mexidol has side effects, so the uncontrolled use of the drug is categorically not welcome.

Mexidol is a drug artificially created on the basis of the chemical compound ethylmethylhydroxypyridine, which is the main active ingredient.

Mexidol is produced by the pharmaceutical industry in three forms, which differ from each other in the way of application, concentration active substance, as well as the content of additional ingredients:

1. Tablets Mexidol 125 mg.
2. Ampoules of 50 ml, intended for both intravenous and intramuscular injection, The substance contains, in addition to the main component, metabisulfide and water for injection.
3. Toothpaste Mexidol Dent.

The choice of the form in which the drug will be used depends entirely on the type of disease and the severity of its course.

Side effects and contraindications of Mexidol

Conducted studies of the drug and the practice of its use have shown that Mexidol is quite well tolerated by various categories of patients. And yet, although rare, negative consequences are possible.

For adults

The risk for adult patients when using this medicine is minimal.

The only side effects observed were:

• dry mouth;
• nausea;
• mild drowsiness.

Mexidol is considered a fairly safe drug, and therefore it is contraindicated only under certain conditions:

• acute form of renal failure;
• liver failure in the acute stage;
• an allergic reaction to any of the additional components of the product.

These include:

• patients suffering from hypertension, accompanied by crises;
• patients with low blood pressure.

Unpleasant manifestations in well-being may occur due to excess dosage.

If during treatment with Mexidol you notice difficulty concentrating while driving or performing high-precision actions, you should immediately inform your doctor about this so that he can adjust the daily dose of the drug.

In some cases, even the complete abolition of the drug is possible.

During pregnancy and lactation

Studies on the impact of Mexidol on the body of a pregnant woman, fetus and newborn baby, as well as during breastfeeding, have not been conducted due to high potential risks. Therefore, doctors do not recommend the use of Mexidol during these periods. If, nevertheless, for health reasons, treatment with this medication is required, then in each individual case, the ratio of the expected positive result with possible danger to mother and child. Only a specialist can do this, because self-treatment is strictly prohibited.

For kids

Due to the lack of research data on the effect of ethylmethylhydroxypyridine on a growing organism, pediatricians prefer to prescribe Mexidol only to adolescents over 12 years of age. If there are health problems in young children, then the doctor may prescribe this medicine, but only in exceptional cases, when the positive effect far outweighs all possible negative consequences.

Possible consequences of taking with alcohol

The unique properties of Mexidol make it an indispensable tool in the treatment of various pathological manifestations associated with intoxication, including alcohol.

Narcologists use the medication in order to quickly save the patient from the consequences of excessive drinking of strong alcoholic beverages.

This drug has an extremely beneficial effect on the body:

• promotes the restoration of liver cells;
• normalizes brain activity;
• improves the filling of cerebral vessels with blood;
• calms the nervous system;
• increases the saturation of cells with nutrients;
• helps to remove the feeling of fear;
• solves sleep problems;
• protects body tissues from oxidation.

However, it is precisely because of these properties of the drug that it is categorically not recommended to combine the intake of Mexidol with the use of any alcohol-containing drinks. Otherwise, not only will there be no positive effect, but unpleasant consequences are also possible. After all this medicine- it's artificial Chemical substance. And what reactions will occur when it interacts with ethanol, it is impossible to predict in advance.

It is important to remember that the use of Mexidol is aimed only at cleansing and restoring already damaged tissues and cells, as well as at removing pain. The drug cannot provide the withdrawal of new portions of the toxin from the body.

Instructions for the use of tablets and injections

Despite the same active substance, tablets and solution has a different effect. In each individual case, the doctor himself decides in what form the medicine will enter the body, how long the effect should be, before or after meals it is necessary to drink tablets. These nuances depend on the characteristics of the disease, its severity and the stage of the treatment process. And it is also important to remember that adults and children require a different dose of the drug, which can only be correctly determined by a specialist.

When prescribing Mexidol in the form of injections, there are several general rules:

• The rate of entry of the drug into the vein should be a maximum of 40-60 drops per minute.
• It is also necessary to administer Mexidol intramuscularly slowly (within 5-7 minutes).
• The standard single dose is 200 mg, however, in case of exacerbation, 400 to 1200 mg are administered by injection.
• You can cancel the drug only after the restoration of all functions of the damaged organ.

For each of the diseases, the instructions for using the medicine differ from all other cases:

• In the treatment of brain disorders, the first 4 days are intravenously injected with Mexidol at a dosage of 200-300 mg. Then, for another 8 days, intramuscular injections are made - three times a day, 100 mg each.
• In the case of the treatment of a traumatic brain injury, pills are usually prescribed. You need to drink them 2 pieces 3 times a day. The duration of the course ranges from 5 days to 2 months, depending on the degree of damage and concomitant treatment.
• With attacks of vegetative-vascular dystonia, 200 mg per day intravenously is first prescribed for 10 days. This is followed by a course of taking 2-4 tablets twice or thrice a day. The duration of therapy is from 2 weeks to one and a half months. 3 days before the end of this period, you must begin to reduce the dose.
• In epilepsy, Mexidol in ampoules is used as an anticonvulsant. The first 2 weeks of injection are given intravenously. The maximum dose per day should not exceed 100 mg. Then another 2 weeks give injections intramuscularly in the same dosage.
• With local osteochondrosis, treatment begins with a 10-day course of intramuscular injections of 200-400 mg. After that, therapy is continued for another 2-6 weeks, taking 1 tablet three times a day. Relief occurs almost immediately, but if the cause is not eliminated, the pain will resume after the end of treatment.
• In case of poisoning with neuroleptics, Mexidol is prescribed in ampoules. It can be injected both intramuscularly and intravenously. The daily volume of the drug can vary from 300 to 500 mg, the course should be continued from 7 to 14 days.
• In case of a stroke, 400 mg of Mexidol solution must be administered in the first 4 hours. Treatment also continues in the form of injections (800–1200 mg per day), but already in a hospital and exclusively under the supervision of a doctor. After the condition improves, to consolidate the healing process, take 1-1.5 tablets 2-3 times a day for the entire period, which will be determined by the doctor.
• With atherosclerosis, injections intramuscularly have the most effective effect. The daily dosage can range from 100 to 300 mg.
• The drug is also used in case of occurrence purulent processes in abdominal cavity. A solution of Mexidol is administered three times a day, 200 mg each. With a mild course of the disease, injections are given in the buttock. In case of complications, intravenous injections are prescribed.

Despite the fact that Mexidol has an extremely small list of side effects, you should not engage in self-treatment. It is necessary to strictly follow all the recommendations of the attending physician.

Mexidol is a Russian drug with an antioxidant effect, used in cardiology and neurology. Available in the form of tablets and solution for injection. The use of the drug has some features, depending on the form of the drug, the age of the patient and his diagnosis. About all the nuances of the use of Mexidol - in this article.

The medicine was created on the basis of ethylmethylhydroxypyridine succinate. It is a membrane protector - a substance that protects body cells from various pathogenic effects (mainly from the destructive action of free radicals).

Belongs to the group of antioxidant drugs. INN (international generic name) – Ethylmethylhydroxypyridine succinate. The Latin name is Mexidolum.

Mechanism of action and properties

Ethylmethylhydroxypyridine succinate allows you to normalize the oxygen supply to tissues and the process of its absorption. It improves memory, reduces the harm of exposure to toxins (especially against the background of alcohol), increases the body's resistance to the occurrence of pathologies associated with oxygen deficiency.

According to clinical data, the drug has positive influence on the vessels in the event of atherosclerotic changes, platelet aggregation and in the event of problems with cerebral hemodynamics.

The tool has the following effects on the body:

• antihypoxic: increases resistance to hypoxia, improves the utilization of oxygen circulating in the body;
• nootropic: affects the brain mental functionality;
• anxiolytic: reduces anxiety, nervousness, unreasonable feeling of fear, anxiety;
• stress-protective: protects life support systems from the harmful, negative effects of a psycho-emotional nature;
• antiepileptic: relieves tremor, muscle cramps of various origins.

How does Mexidol affect the blood?

Mexidol has antihypoxic, membrane-protective, nootropic, anticonvulsant, anxiolytic effects. Able to improve blood supply to the brain, brain metabolism, blood microcirculation and its rheological properties.

Allows to reduce platelet aggregation, stabilize work and improve the condition of membranes blood cells in case of hemolysis. It has a hypolipidemic effect, reduces the content of lipoproteins and cholesterol, endogenous intoxication, enzymatic toxemia (in the diagnosis of acute pancreatitis).

Mexidol helps to reduce the viscosity of the membrane and increase its fluidity. Thins the blood and strengthens vascular walls. On admission active ingredient The drug is absorbed into the patient's body within half an hour. Four hours later, ethylmethylhydroxypyridine succinate is determined in plasma. Excretion of the substance occurs naturally, with urine.

Prices, forms, components

There are two forms of drug production:

The approximate cost in Moscow and the Moscow region is presented in the table (Table 1).

Table 1 - The cost of Mexidol

In Moscow and the Moscow region, the highest cost for the drug was noted. In the regions you can buy it at a more attractive price.

Therapy Rules

Only a specialist can choose the right dosage. The daily number of tablets / ampoules and the duration of therapy depend on the patient's diagnosis. Therefore, it is categorically unacceptable to use Mexidol in self-medication. Even a minimal deviation from the permissible dose of the drug can lead to an overdose and dangerous consequences.

When is it used and what are the restrictions?

Indications for the appointment of the solution:

Mexidol in injectable form is also used for acute intoxication with neuroleptic drugs and for withdrawal of withdrawal symptoms in case of alcohol poisoning.

Indications for the use of tablets:

• TBI and their consequences;
• dyscircular, dysmetabolic, post-traumatic, mixed encephalopathy;
• vegetative dystonia;
• atherosclerotic cognitive impairment mild form;
• circulatory failures of the brain and their consequences;
• ischemia;
• asthenic condition;
• somatic diseases and their prevention;
• psychoemotional disorders;
• relief of abstinence on the background of alcohol dependence, with pronounced vegetative-vascular and neurosis-like disorders.

The tablet form can be used to eliminate the effects caused by intoxication with antipsychotic drugs.

Contraindications:

• liver disease;
• disorders in the work of the kidneys;
• intolerance to the components of the composition.

Experts say that at the moment there are no clinical data on the effect of the drug on the health of children, adolescents, pregnant and lactating women. Therefore, Mexidol therapy should be carried out with extreme caution and only as prescribed by a doctor.

Dosage of the tablet form of Mexidol (125 mg)

The optimal dosage is one to two tablets three times a day. The maximum permitted daily dose should not exceed 750 mg of the active ingredient. It is necessary to take the drug after a meal, drinking plenty of water.

It is recommended to start therapy with a minimum dose - no more than two tablets 1-2 times a day. Then the dosage is gradually increased, at the discretion of the doctor (depending on the reaction of the patient's body to the action of the drug, therapeutic effect).

The average duration of therapy is two weeks, the maximum is six. When Mexidol is used to relieve withdrawal symptoms based on alcoholism, treatment can last a maximum of 7 days. At coronary disease heart - long-term treatment, at least two months. It is forbidden to abruptly stop taking Mexidol. The dosage must be slowly reduced.

Intravenous jet and drip administration

The medicine is administered intramuscularly or intravenously. The dose is prescribed individually for each patient. However, the solution preparation technology is identical - the ampoule must be diluted in 200 ml of sodium chloride.

The initial stage of treatment is the minimum dosage of the drug. In most cases, 100 mg 2-3 times a day is prescribed. If the patient does not have a negative reaction to Mexidol, there are no adverse reactions, the dosage may be gradually increased. However, the maximum amount of the administered drug is not more than 800 mg per day.

The introduction of Mexidon is possible in two ways:

1. Jet. The introduction of the solution is carried out slowly, the procedure should take about 7-8 minutes.
2. Drip. This method used in hospitals. The introduction of the drug through a dropper - 50 drops per minute.

The table shows dosage calculations medicinal product depending on the diagnosis (Table 2). The table provides information for general information. It should not be taken as instructions for use.

Table 2 - Dosage of Mexidol solution depending on the specific pathology

Some features of the treatment

The drug is used for many circulatory disorders of both cerebral and peripheral vessels, as well as for neurological and autonomic failures. Consider some of the features of the use of the drug.

With VSD, migraine and headache

Vegetative disorders are associated with hypoxic processes and affect the work of almost all human systems and organs. First of all, the brain and heart suffer, which leads to the development of symptoms characteristic of VVD.

Today, Mexidol is often used to stop these phenomena, aimed at supplying cells suffering from hypoxia with oxygen. As a result, blood flow normalizes, the work of cell membranes stabilizes, toxins are removed, stress resistance increases, negative manifestations of VVD, in particular migraine-type headaches, are removed.

It is worth remembering that not every form of VVD is an indication for taking the drug. It is of the greatest benefit in the cardiological type of pathology, as well as the presence of serious vascular and neurological disorders.

The dosage of the drug for VVD is calculated as follows:

1. With mild manifestations of VVD, migraines and headaches, a tablet form is prescribed, one or two tablets up to three times a day.
2. For severe symptoms, in particular panic attacks, a solution of the drug is prescribed intramuscularly up to three times a day, 0.05-0.1 g of the drug.

With osteochondrosis

The use of Mexidol is indicated for severe forms osteochondrosis, when blood flow disturbances, and hence metabolism, become critical. The drug has pronounced antioxidant properties, which allows you to remove toxins resulting from degenerative processes in the vertebrae.

The drug is prescribed intravenously up to 300-400 mg per day, depending on the patient's condition. As the severity of negative symptoms decreases, the dosage is reduced, and the drug is canceled. The duration of therapy is two weeks.

With pressure surges

Mexidol is not a special remedy for normalizing pressure, but it can affect its level. It is impossible to say unequivocally whether this drug lowers or increases blood pressure, rather, it is worth talking about its normalization, that is, the drug can change the pressure both up and down, stopping autonomic disorders.

Most often, the drug is taken with low blood pressure, but it can also be prescribed in the treatment of hypertension. The effect of the drug is explained by the fact that the level of dopamine in the brain rises, blood flow normalizes, thought processes improve, and hypoxic manifestations are removed.

It should be understood that with pressure surges after taking the drug, the patient may, in addition to a slight decrease or increase, experience emotional arousal, up to insomnia.

Treatment with drugs for violations of blood pressure should be carried out with extreme caution, since Mexidol can also cause a backlash in the body, in particular, an even greater increase in blood pressure, which will further aggravate the patient's condition.

Application in sports

Mexidol is actively taken in sports practice, as it normalizes metabolism and helps to eliminate toxins formed during the destruction of proteins and fats, and the deactivation of free radicals. The drug contributes to a better oxygen supply to tissues and regulates the work of the central nervous system, which helps to increase the endurance of the body, which is especially important for athletes.

The drug should be prescribed exclusively by a sports doctor. Restriction may be impaired kidney function. The standard dosage is one to two tablets up to 3 times a day. The duration of therapy depends on the condition of the athlete. The initial course of therapy is a week, but can be extended up to four weeks.

Side effects and precautions

The drug is well tolerated by the body, side effects rarely occur. They appear in the form of nausea, dry mouth, or an allergic reaction.

During the period of therapy with Mexidol, it is necessary to limit the driving of vehicles and work at hazardous facilities. Under the influence of the drug, the speed of psychomotor reactions and concentration of attention can be reduced.

With extreme caution, Mexidol is prescribed to patients with bronchial asthma. There is a high risk of more frequent attacks and the appearance of a severe allergic reaction.

Interaction with alcoholic beverages

As mentioned above, Mexidol is used to relieve withdrawal symptoms on the background of alcoholism. But this does not mean at all that it is allowed to take alcohol during therapy.

The medicine does not reduce the harmful, detrimental effect of alcohol on the human body when taken during therapy!

Combining the drug and alcoholic beverages can provoke dangerous side reactions. In this case, Mexidol will not reduce the harmful effects of alcohol, but will significantly increase it. The main blow will fall on the nervous, cardiovascular system and liver.

Many patients are convinced that taking alcohol occasionally, in minimal quantities during treatment with Mexidol is not dangerous. However, doctors argue that with such a regimen of therapy, one should not expect any positive therapeutic effect.

As a result, the patient is unable to receive vital succinate. This situation can lead to serious consequences not only for health, but also for life.

Can it be taken during pregnancy?

Doctors strongly do not recommend the use of the drug for pregnant women. At the moment, the positive / negative effect of Mexidol on the health of a pregnant woman and the development of the fetus has not been accurately determined. In order to avoid the negative impact of medicinal components, it is recommended to choose a safer therapy.

At breastfeeding the drug is undesirable. However, in case of emergency, when a woman's health is under serious threat, Mexidol is prescribed in the minimum dosage. At the time of the course of treatment, breastfeeding should be suspended.

Use in children

Despite warnings that the drug should be used with caution in patients of a younger age group, Mexidol is actively used in pediatrics. The effect of the drug on the children's body is still not well understood, however, experienced doctors take responsibility for the health of babies and include Mexidol in the therapeutic course.

Indications and dosage

For young patients, the drug is prescribed for circulatory disorders in the brain and for pathologies of the nervous system. According to statistics, the process of recovery of children after traumatic brain injuries is significantly accelerated. Also available positive reviews on the use of the drug in the treatment of psychoemotional disorders.

It is noted that in children aggression, nervousness decrease, cognitive abilities increase (memory improves, concentration of attention and learning ability increase).

The drug is used to eliminate hypoxia in newborns. Babies with this pathology are in dire need of the help of antioxidant drugs that help eliminate the problem associated with a lack of oxygen. In this case, Mexidol is very effective. Despite all the advantages, the use of Mexidol as prophylactic absolutely unacceptable!

For very young patients, it is allowed to add medicine to complementary foods (after crushing the tablet).

Parent feedback

And what do the parents who entrusted the health of their children to Mexidol think? Here are some reviews:

Tatyana, mother of Nastya (1 year old):“During a routine examination by a neurologist, the doctor revealed an increased tone in my daughter, which is uncharacteristic for this age. He prescribed a complex treatment - drugs Mexidol and. Mexidol was afraid to give the child, because the instructions clearly stated that the drug is undesirable for children.

But still decided to trust an experienced specialist. She gave me a crushed tablet 3 times a day. A month later, they again visited the doctor, who noted that the child had obvious improvements. I also want to note that there are no negative consequences during treatment, we did not observe.

Alena, mother of Christina (7 years old):“My girl received a severe head injury. The doctor prescribed us Mexidol. I warned the doctor in time that the baby was suffering from seizures. bronchial asthma. After that, the doctor performed a test. As it turned out, it is dangerous for us to take Mexidol. Prescribed alternative treatment.

When treating children, it is necessary to be extremely careful about the appointment of funds. It is important to notify the doctor about all the child's chronic diseases. You also need to strictly follow the treatment regimen prescribed by the specialist.

Similar drugs

Mexidol is a very expensive remedy, therefore it may not be available for many patients to purchase. In this case, generic drugs will help, which have a similar effect, but are more affordable. According to experts, in the Top 5 the best analogues includes Neurox, Mexicor, Cerecard, Mexifin and Ethoxydol.

Available only as a solution for injection. The basis of the drug is ethylmethylhydroxypyridine succinate. It is an antioxidant drug used for:

Prohibited for use during pregnancy and lactation, with pathologies of the kidneys and liver, hypersensitivity to components. Contraindicated in children and adolescents under 16 years of age.

It is administered intravenously or intramuscularly. Initial dosage - no more than 2 ampoules 1-2 times a day. Gradually, the dose can be increased, but should not exceed 800 mg per day. Depending on the patient's diagnosis, Neurox can be used from 5 to 14 days. The price is indicated in the table (Table 3).

Table 3 - Approximate cost of the drug

The table shows the average prices in Moscow. Depending on the region, the cost of the drug may vary slightly.

It is sold in the form of capsules for oral administration and solution for injection. The basis of the drug is succinate. Antioxidant agent used in the treatment of ischemia, stroke, encephalopathy, cognitive disorders. Contraindications - diseases of the liver and kidneys, pregnancy and lactation, children and adolescence(up to 18 years old), hypersensitivity to the components of the composition.

Treatment with capsules begins with a minimum dose of 100 mg three times a day. Gradually, the dosage may increase, at the discretion of the attending physician. But the daily dose should not exceed 800 mg.

Solution therapy requires careful individual approach. The duration of treatment should not exceed 7-10 days. The optimal dosage is 200 mg twice or thrice a day. The cost of the drug: 140 rubles for 20 tablets of 100 mg, 350 rubles for 10 ampoules (2 ml).

- another analogue drug based on the substance ethylmethylhydroxypyridine succinate. Available in the form of a solution for intravenous / intramuscular injection.

It is prescribed for anxiety conditions against the background of a neurosis-like disorder, vegetative-vascular dystonia, encephalopathy, mild cognitive disorders, acute pathologies cerebral circulation, ischemia, infarction.

The drug is contraindicated in liver failure, impaired renal function, a tendency to develop allergic reactions, pregnancy, lactation. There are age restrictions (not recommended for the treatment of patients under 18 years of age).

Doctors insist that Cerecard cannot be used alone at home! The introduction of a medicinal substance should be carried out by an experienced specialist. The drug must be diluted in sodium chloride solution before use. The recommended dosage is one ampoule three times a day. Approximate cost: for 10 ampoules of 2 ml - 350 rubles, for 5 ampoules of 5 ml - about 220 rubles.

- a membrane-protective drug, the active ingredient is ethylmethylhydroxypyridine succinate.

Indications for appointment:

• neurosis-like state;
• vegetovascular dystonia;
• ischemia;
• heart attack;
• circulatory disorders of the brain;
• abstinence on the background of dependence on alcohol.

The drug is contraindicated in case of hypersensitivity to the composition, severe violations kidneys and liver, lactation, pregnancy. Not recommended for use in patients under the age of sixteen.

Produced in the form of a solution, it goes on sale in ampoules. One ampoule is prescribed from 1 to 3 times a day. The duration of treatment is a maximum of 14 days. You can buy 10 ampoules (2 ml) for about 290 rubles, 5 ampoules (5 ml) - for 280 rubles.

Refers to the inhibitors of the free radical process, which is based on the substance ethoxydol (malate) of ethylmethylhydroxypyridine. It is prescribed for the treatment of cognitive disorders, encephalopathy, ischemia and stroke.

Contraindicated in:

It is prescribed with caution to children and elderly patients. Produced in the form chewable tablets. The tablet must be thoroughly chewed, then washed down with plenty of water. The optimal dosage is one tablet three times a day.

The price of Ethoxydol: 20 tablets of 100 mg can be purchased for about 650 rubles, 50 tablets of 100 mg - for 1450 rubles.

Mexidol or Cereton: which is better?

Experts identify another drug that belongs to the group of nootropic drugs. We are talking about Cereton. The active ingredient is choline alfoscerate.

Indications for use:

• degenerative, involutional disorders of the brain;
• cognitive disorders;
• pseudomelancholic condition in elderly patients;
• psychoorganic syndrome.

Many argue that Cereton is a powerful competitor to Mexidol. However, if you pay attention to the indications for the appointment of Cereton, you can note a narrower scope of application of this drug.

It belongs to the group of nootropic drugs, has a slightly different effect on the body. Also, the basis of the composition of the two drugs is different. Therefore, it is not entirely advisable to compare Cereton and Mexidol.

Antioxidant drug

Active substance

Release form, composition and packaging

Film-coated tablets from white to white with a creamy tint, round, biconvex.

Excipients: lactose monohydrate - 97.5 mg, - 25 mg, magnesium stearate - 2.5 mg.

The composition of the film shell: Opadry II white 33G28435 - 7.5 mg (hypromellose - 3 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg).

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (4) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.

pharmachologic effect

Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics / neuroleptics /).

The mechanism of action of the drug Mexidol is due to its antioxidant, antihypoxant and membrane-protective action. The drug inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces the viscosity of the membrane, increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission. Mexidol increases the content in the brain. It causes an increase in the compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, and stabilization of cell membranes.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the content of total cholesterol and LDL.

The anti-stress effect is manifested in the normalization of post-stress behavior, somato-vegetative disorders, the restoration of sleep-wake cycles, impaired learning and memory processes, and the reduction of dystrophic and morphological changes in various brain structures.

Mexidol has a pronounced antitoxic effect in withdrawal symptoms. Eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, vegetative functions, and is also able to relieve cognitive impairment caused by prolonged use of ethanol and its withdrawal. Under the influence of Mexidol, the action of tranquilizers, neuroleptics, antidepressants, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Mexidol improves the functional state of ischemic myocardium. In conditions of coronary insufficiency, it increases the collateral blood supply to the ischemic myocardium, helps to preserve the integrity of cardiomyocytes and maintain their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction.

Pharmacokinetics

Suction and distribution

Rapidly absorbed when taken orally. C max at doses of 400-500 mg is 3.5-4.0 μg / ml.

It is rapidly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9-5.2 hours.

Metabolism

Metabolized in the liver by glucuronconjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - is formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and found in the urine for 1-2 days after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuronconjugates.

breeding

T 1 / 2 when taken orally - 2-2.6 hours. Rapidly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. Most intensively excreted during the first 4 hours after taking the drug. Urinary excretion rates of unchanged drug and metabolites are subject to individual variability.

Indications

• consequences of acute disorders of cerebral circulation, incl. after transient ischemic attacks, in the phase of subcompensation (as preventive courses);
• mild traumatic brain injury, consequences of traumatic brain injury;
• encephalopathy various genesis(dyscirculatory, dysmetabolic, post-traumatic, mixed);
• syndrome of vegetative dystonia;
• mild cognitive disorders of atherosclerotic genesis;
• anxiety disorders in neurotic and neurosis-like conditions;
• IHD (as part of complex therapy);
• relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-abstinence disorders;
• conditions after acute intoxication with antipsychotics;
• asthenic conditions, as well as to prevent the development somatic diseases under the influence of extreme factors and loads;
• exposure to extreme (stress) factors.

Contraindications

• acute hepatic and / or;
• increased individual sensitivity to the drug.

Due to insufficient knowledge of the action of the drug - childhood, pregnancy, breastfeeding.

Dosage

Inside, 125-250 mg 3 times / day; the maximum daily dose is 800 mg (6 tablets). Duration of treatment - 2-6 weeks; for relief of alcohol withdrawal- 5-7 days. Treatment is stopped gradually, reducing the dose within 2-3 days.

Initial dose - 125-250 mg (1-2 tablets) 1-2 times / day with a gradual increase until a therapeutic effect is obtained; the maximum daily dose is 800 mg (6 tablets).

The duration of the course of therapy in patients with IHD is at least 1.5-2 months. Repeated courses (on the recommendation of a doctor) are preferably carried out in the spring and autumn periods.

Side effects

It is possible that individual adverse reactions: dyspeptic nature, allergic reactions.

One Mexidol tablet contains 125 mg of active ingredient ethylmethylhydroxypyridine succinate , as well as a number of auxiliary components:

• lactose monohydrate;
• sodium carboxymethylcellulose (sodium carmellose);
• magnesium stearate.

Each tablet is coated with a white or creamy white coating, consisting of:

• opadra II white (macrogol polyethylene glycol);
• polyvinyl alcohol;
• talc;
• titanium dioxide.

Release form

The drug Mexidol has two forms of release: in ampoules and in tablets .

Mexidol in ampoules created for infusions and intramuscular injections . The solution is available in colorless or light-protected glass ampoules, on which the breaking point is indicated in blue or white and with three marking rings, the top of which yellow color, middle - white, bottom - red.

Ampoules have a capacity of 2 or 5 ml and are packed in 5 pieces in blisters. The carton package is completed with 1 or 2 contour packs, as well as instructions for medical use drug.

For hospitals, Mexidol solution is packed in 4, 10 or 20 blisters.

One tablet of the drug Mexidol has a mass of 125 mg and is intended for oral administration. Tablets are available in packs of 10 pieces in blister packs made of PVC film and aluminum foil, or 90 pieces in plastic jars made of food-grade plastic.

For hospitals medical institutions tablets are produced in plastic jars made of food-grade plastic, 450 or 900 pieces each.

Description of the drug in the form of a solution for injection

Mexidol in ampoules has the appearance of a clear liquid, which can be either colorless or slightly yellowish.

Description of the tablet form of Mexidol

Tablets are biconvex, round, film-coated, the color of which can vary from white to white with a slightly creamy tint.

pharmachologic effect

The medicine Mexidol belongs to pharmacological group drugs that affect the nervous system.

The drug is characterized by:

• antioxidant ;
• antihypoxic ;
• membrane stabilizing ;
• nootropic ;
• anxiolytic properties.

In addition, it has a pronounced stress-protective effect (that is, it increases the body's resistance to stress ), promotes memory improvement , has the ability to prevent or stop seizures convulsions , and also reduces the concentration of individual fractions lipids (in particular, low density lipoproteins ) in various tissues and body fluids.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The pharmacological properties of Mexidol are due to the activity of ethylmethylhydroxypyridine succinate, which is part of it.

According to Wikipedia, this substance belongs to the category medicines, preventing or slowing down the processes of peroxidation membrane lipids in cells.

Ethylmethylhydroxypyridine succinate belongs to the class of 3-hydroxypyridines and is a pyridine derivative of the general formula C5H4_nN(OH)n.

The substance has the form of colorless crystals, which are characterized by the ability to easily dissolve in ethanol and acetone , moderately soluble in water and limited - in diethyl ether , benzene and naphtha .

The mechanism of action of ethylmethylhydroxypyridine succinate is determined by its antioxidant and membrane-protective properties.

At the same time, patients have a significant increase in functional activity retina of the eye and optic nerve improves visual acuity.

The anti-stress effect of treatment with Mexidol tablets is expressed as:

• normalization of behavior after suffering stress ;
• disappearance of symptoms somatovegetative disorders ;
• normalization of sleep and wake cycles;
• restoration (partial or complete) of impaired learning abilities;
• memory recovery;
• reducing the severity of dystrophic and morphological changes in various parts of the brain.

Mexidol is also a remedy that effectively eliminates the symptoms that occur when withdrawal states .

The drug belongs to the group metabolic cardiocytoprotectors . The mechanism of its action is due to the fusion in its composition of the antihypoxant succinate and the antioxidant emoxipin, which is characterized by a wide spectrum of action.

In combination with other therapeutic measures, Mexicor is indicated for the treatment myocardial ischemia and ischemic stroke . It is also recommended to prescribe it in the treatment of mild and moderate cognitive disorders and for symptomatic relief dyscirculatory encephalopathy .

Mexiprim and Mexidol - which is better?

Mexiprim is the German analogue of Mexidol. Its manufacturer is the concern STADA Arzneimittel AG. The main difference between the drugs is the composition of the auxiliary components of the core and shell of the tablets. The mechanism of action and indications for use are similar.

Mexidol or Mildronate - which is better?

Belongs to a group of drugs that improve metabolism and energy supply of tissues. It is available in the form of gelatin capsules, solution for injection and syrup for oral administration.

The active substance of the drug - meldonium (trimethylhydrazinium propionate), which is similar in structure to gamma-butyrobetaine (a substance present in every cell of a living organism).

Mildronate used as a vasodilator. In addition, the drug improves the supply of organs and tissues with oxygen, improves humoral and tissue levels, reduces blood pressure.

Mexidol and Mildronate according to the decision of the doctor, they can be prescribed as part of combination therapy for the treatment of patients with:

• consequences alcohol withdrawal syndrome ;
• violations circulation in the brain ;
• coronary disease .

Synonyms

Synonyms of Mexidol:

• film-coated tablets and solution for intravenous and intramuscular administration Medomexy ;
• solution for intravenous and intramuscular administration Meksidant ;
• film-coated tablets and solution for intravenous and intramuscular administration;
• mexifin ;
• solution for intravenous and intramuscular administration;
• injection solution and tablets Mexipridor ;
• solution for intravenous and intramuscular administration and capsules.

Prescribing the drug Mexidol to children

The drug is not prescribed for children and adolescents due to insufficient knowledge of the effect of ethylmethylhydroxypyridine succinate on the children's body.

Mexidol and alcohol

Mexidol is a drug with a powerful antioxidant action. For this reason, it is widely used in a wide variety of medical fields, including surgery ,psychiatry , neurology etc.