Ovestin drug: instructions and cheap Russian analogues. Ovestin cream - indications for use Candles Ovestin indications for use analogues

Having reached a certain age, a woman thinks: is there life after menopause, in particular, sexual life? Yes, but sometimes you have to take drugs like Ovestin to keep you sexually active. Consider its properties, analogues and their prices and try to find the safest and most effective option.

Rescue hormone: when is Ovestin's help needed?

This is a hormonal remedy that women who have entered the menopause need. It contains estriol - a natural female hormone. Its amount in the body sharply decreases with age, which leads to such unfortunate consequences as a violation of the pH environment of the vagina, manifested by dryness and itching, pain during intercourse. To eliminate such problems, as well as to save a woman from frequent and involuntary urination, this remedy is prescribed. There are several other indications for its use: infertility, the cause of which is the cervical factor, prevention inflammatory diseases urogenital tract. With the help of Ovestin, the vagina is prepared for diagnostic procedures and gynecological operations.

Candles, tablets, cream - what to choose?

The drug is produced in the Netherlands, available in three dosage forms. They make the same therapeutic effect: restore the epithelium of the vagina, optimize the microflora, increase local immunity, prevent the development of pathological flora, as they contain the same active substance. When using any of the forms, the agent must be applied once a day.

To conclude in what form it is better to use Ovestin, consider the instructions for use and the price of tablets, suppositories, cream, and also pay attention to its analogues:

• tablets. The average price in Russia is 914-1360 rubles. for 30 pcs. In addition to the main component (its content is 1-2 mg), they also contain several fillers: amylopectane, magnesium povidone, starch, lactose monohydrate, silicon dioxide, stearate. Ovestin in tablets instructions for use recommends taking this: the first month - from 2 to 4 pcs. (4-8 mg), then the dose is reduced to 1-2 tablets. (which is 1-2 mg per day). If the patient complains of urinary incontinence, the doctor may increase the daily "portion" to 8 mg. With infertility, provoked by a small percentage of sperm survival in the cervix, the tablets are taken from 6 to 15 days from the onset of menstruation;
• candles. Their cost is 1280-1540 rubles. for 15 pcs. Estriol (0.5 mg) is also present in them, and witepsol S is used as a stabilizer. Suppositories are used, for 30 days administering one suppository daily at night. If the woman's condition has improved, then after 2 weeks she is transferred to a maintenance dose - 2 suppositories per week;
• cream. Its price (15 g) is from 1497 rubles. The hormonal component (1 mg / g) is supplemented with a large number of auxiliary ingredients - polysorbate, cetyl palmitate, stearyl and cetyl alcohol, lactic acid, sorbitan stearate, sodium hydroxide, octyldodecanol, water. All of them are necessary in order to ensure comfortable and convenient use of the product - to give it a pleasant white tint and turn it into a homogeneous mass of the required consistency. The cream is injected into the vagina (for this it is equipped with a convenient applicator, which is filled to a special mark) once a day in the amount of 1 dose, which corresponds to 1 tablet. When the severity of symptoms decreases, the cream is used 2 p. in Week.

Important! Treatment with this drug in any form is prohibited for pregnant women, patients who have had breast cancer and those who are suspected of having a malignant neoplasm in the mammary gland. It cannot be prescribed to women with estrogen-dependent tumors, endometrial hyperplasia, vein thrombosis, vaginal bleeding. A contraindication to taking is a heart attack, exacerbation of chronic liver diseases, angina pectoris, individual intolerance.

Ovestin can cause very dangerous complications: neoplasia (both benign and malignant), stroke, venous thrombosis lower extremities, heart attack, cholelithiasis, chloasma, hemorrhagic purpura, erythema nodosum, baldness. External use of this drug can lead to the development of profuse bleeding, pain, a feeling of tension in the mammary glands.

Many prefer not pills, but topical agents. They are easy to use, they act directly in the problem area, and the improvement occurs already 30 minutes after the use of the drug. Suppositories are easier to use than creams, but take longer to absorb.

Read also:

Ovestin's analogs: what is better for a woman's health?

AT pharmacy assortment you can find quite a few drugs whose action is due to the presence of the hormone estriol. Here is a list of suppositories that can be considered as an alternative to Ovestin:

• Ovipol clio (Moldova). The price of a package of 15 suppositories is 577 rubles. active ingredient estriol acts, it has a selective effect on the uterus, urethra, vagina, bladder, in particular, restores the epithelium during atrophy, prevents inflammatory processes;
• Estrokad (Germany). Price for 10 pcs. - from 717 rubles. Included in the pharmaceutical group of estrogens, contains 500 mcg of estriol. It is used as a replacement, pre- and postoperative therapy in menopausal women;
• Estrovagin. The cost of these suppositories does not exceed 700 rubles;
• Estriol (Germany). Candles for intravaginal use. Buy a pack of 30 possible for 1100-1300 rubles;
• Estrovagin is a domestic remedy with a similar composition (estriol 0.5 mg), which is almost impossible to find in pharmacies.

Ovestin vaginal cream has few analogues, the prices of which will please the patient more. Here's what you can replace an expensive drug with the permission of a doctor:

• Elvagin. An Indian remedy that also eliminates the symptoms of vaginal atrophy. Available in the form of both cream and suppositories. The price is more pleasant for customers - 500 rubles;
• Divigel (Finland). The cost is about 470 rubles. Produced in the form of a gel packaged in sachets. Used for estrogen deficiency. Helps to get rid of vaginal dryness, increases libido, increases the volume of cervical secretions.

Important! Any analogues of Ovestin with hormones, regardless of the manufacturer and price, should be used only on the recommendation of a specialist.

During menopause, a woman may experience a number of unpleasant sensations that are associated with a deficiency of sex hormones. Such symptoms are easy to eliminate if you start using Ovestin - with the appointment of a gynecologist.

Ovestin: description of the drug

Ovestin - a number of hormonal agents, estrogen derivatives. The series is represented by tablets, suppositories and vaginal cream, produced in Ireland by Aspen Health. The vaginal cream is sold in tubes of 15 g, packed in a cardboard box, inside the package there is a special applicator for ease of use. The cream has White color, homogeneous in structure.

The cream contains the main component - estriol. In the body of a woman, this hormone is produced naturally in the ovaries, refers to estrogens (steroid hormones). During menopause and in a number of other diseases, estrogen production drops sharply, and estriol is the least active, quickly excreted from the body and the safest hormone to make up for the existing deficiency.

Other components in the composition of the drug:

• chlorhexidine;
• water;
• sodium hydroxide;
• lactic acid;
• glycerol;
• alcohols, etc.

The drug can be used in conjunction with Ovestin tablets, but more often with its help local treatment is carried out. How much does the drug cost in pharmacies? The price is quite high - about 1400 rubles.

The action of the drug

As an analogue of a natural hormone female body(even men have minimal amounts of estriol - it is produced by the adrenal glands), the drug helps eliminate estrogen deficiency in postmenopausal women. This is necessary for the gradual adaptation of the body to new conditions and the elimination of unpleasant symptoms of menopause. The cream, when applied topically, has the following effects:

• improves the function of the epithelial layer of the genitourinary tract;
• optimizes the composition of local microflora and acid-base balance;
• enhances local immunity, increasing the immune defense of the genital area and making the mucous membrane less susceptible to infection;
• reduces major complaints in menopause- dryness, itching, discomfort with intimate contact;
• stops urination disorders, including urinary incontinence, urine output in small portions, increased urge.

The drug does not cause failures natural process hormonal changes in the body, since estriol is retained in the cells only for a short period of time. The drug, when used in short courses, does not affect the condition of the mammary glands.

When using Ovestin, there is no return of monthly bleeding - the woman's menstruation will not resume.

The components of Ovestin are quickly and completely absorbed, the maximum concentration in the blood is recorded after an hour, while it is higher than when taking tablets. The hormone is excreted by the kidneys, in a small form through the intestines.

Indications for therapy

The medicine is used in women in the presence of signs characterizing the lack of sex hormones in the body.

Since the cream is intended for intravaginal administration, its highest efficiency is manifested in relation to the organs of the genitourinary system. The drug is included in the complex of measures for HRT (hormone replacement therapy) during menopause. The main indications for the use of Ovestin cream are as follows:

• atrophic phenomena on the mucous membrane of the vagina, or atrophic colpitis;
• the appearance of dryness, itching, burning in the vagina;
• frequent urethritis, thinning of the urethra;
• pain when urinating;
• urinary incontinence in women.

Ovestin is also recommended before or after operations through the vagina, which are performed in postmenopausal women. Another important indication is the improvement of the condition of the mucous membrane for a more accurate diagnosis of oncological diseases.

The drug can also be used in women who are in the reproductive period. It helps to improve the condition of the cervix and cure infertility caused by cervical disorders. According to strict indications from the appointment of a specialist, the drug is used for synechia in children. It is used in girls to separate labial fusions when the vaginal opening is narrowed or absent.

Instructions for use

The drug is injected into the vagina using the attached applicator. It is enough to carry out therapy at night, once / day. Fill the applicator completely, which corresponds to 0.5 g of cream. The duration of therapy is no more than 28 days, but the dosage should be slowly reduced - not every day, but every other day, then twice / week. The indication for dose reduction is the elimination of symptoms.

Features of treatment in individual cases:

For maintenance therapy, the minimum effective dosage is used. After the end of the tablet intake, you can start using the cream on any day. The general course of therapy is determined by the doctor.

The risk of developing oncology increases after several years of using the drug, so you can’t abuse hormonal drugs!

During treatment, you need to be regularly examined by a gynecologist, and before starting therapy, undergo a colposcopy, a cytological examination of a smear, a diagnosis of the condition of the mammary glands, and a pelvic examination.

In a child, separation of adhesions with Ovestin is carried out only after consulting a pediatric gynecologist! The drug is applied to the girls on the adhesion area at bedtime, once / day, in severe cases - twice / day. It is necessary to apply the product clearly along the line of adhesions, without capturing the remaining areas. The duration of treatment is 14 days, then the doctor evaluates the results. If there is a positive trend, but adhesions persist, another course (14 days) is carried out after a 10-day break, and then the drug is replaced with a regular baby cream.

Side effects, contraindications

It is better to clarify contraindications before starting therapy, they are very serious. Prohibitions include:

The cream can cause allergic reactions, irritation, some women experience increased sensitivity, sore breasts. In this case, you need to reduce the dose of the drug. Also as side effects very rarely there are scanty discharge with blood, blood clotting and thrombosis, changes in libido, memory impairment.

Analogues and other information

There are drugs cheaper than Ovestin, therefore, with the permission of the doctor, you can replace the drug with a more economical one.

An overdose of the drug in topical application practically impossible if the excessive introduction is made once.

If large amounts of the drug enter the stomach, there is a risk of vomiting, bleeding. The drug may enhance the effect of taking medicines for high cholesterol.

International name

Group affiliation

Dosage form

pharmachologic effect

Estrogen synthesized in the human body. Once in the bloodstream, it forms a complex with specific receptors (in the uterus, vagina, urethra, mammary gland, liver, hypothalamus, pituitary gland), stimulates the synthesis of DNA and proteins. It has a selective effect, mainly on the cervix, vagina, vulva, causes increased proliferation of the epithelium of the vagina and cervix, stimulates its blood supply, helps to restore the epithelium during its atrophic changes during premenopause and menopause, normalizes the pH of the vaginal environment, the vaginal microflora, increases its resistance epithelium to infectious and inflammatory processes, affects the quality and quantity of cervical mucus. The effect on the endometrium is negligible (negligible risk of uterine bleeding).

It has a hypolipidemic effect, slightly increases the concentration of beta-lipoproteins in the blood, increases sensitivity to insulin action, improves glucose utilization, stimulates the production of globulins by the liver that bind sex hormones, renin, HDL and blood coagulation factors. Due to participation in the implementation of positive and negative feedback in the hypothalamic-pituitary-ovarian system, estradiol is able to cause moderately pronounced central effects; stimulates parasympathomimetic reactions.

Indications

Contraindications

Side effects

Soreness, sensitivity and enlargement of the mammary glands, amenorrhea, breakthrough bleeding, menorrhagia, intermenstrual "spotting" vaginal discharge, breast swelling, increased libido.

Peripheral edema, gallbladder obstruction, hepatitis, pancreatitis. Intestinal or biliary colic, flatulence, anorexia, nausea, diarrhea, dizziness, headache (including migraine), intolerance contact lenses, vomiting (mainly central genesis, mainly at high doses).

In the treatment of breast and prostate cancer (optional): thromboembolism, thrombosis.

Application and dosage

special instructions

Interaction

Enhances the effect of lipid-lowering drugs. Weakens the effects of male sex hormones, anticoagulants, antidepressants, diuretic, hypotensive, hypoglycemic drugs.

Barbiturates, antiepileptic drugs (carbamazepine, phenytoin) increase the metabolism of steroid hormones.

Antibiotics (ampicillin, rifampicin), drugs for general anesthesia, narcotic analgesics, anxiolytics, antiepileptic drugs, some antihypertensive drugs, ethanol reduce the effectiveness.

Folic acid and drugs thyroid gland enhance the action of estriol.

Reviews about the medicine Ovestin: 1

They prescribed a niece for synechia, they were worried that it was like a hormonal remedy for the child, albeit locally .... But in general they were satisfied, the synechia softened the cream, the doctor then completely divorced them.

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Ovestin - instructions for use, analogues, price, reviews - all information regarding Dutch-made products. The tool is intended to eliminate the symptoms of menopause caused by estrogen deficiency. Produced by Organon.

Composition, form, effect of the drug

Ovestin is available in several forms - suppositories or suppositories, tablets, cream. The active component of each of them is estriol. Natural hormone acts selectively on organs reproductive system. Stimulates the production of the hormone, improves the condition of the uterus, vagina. Especially effective for urogenital symptoms of menopause.

Unlike other estrogens, estriol acts quickly, but for a short time. As part of the cells of the endometrium, it lingers for a short time. Due to this, additional intake of progesterone is not required, the risk of developing diseases of the reproductive system, heart, and liver is reduced. Funds do not arise after cancellation bloody issues. Excretion of estriol from the body is carried out by the kidneys, 2% of the total amount by the intestines unchanged.

Indications for use

In most cases, the drug is used as hormone replacement therapy for insufficient estrogen levels caused by menopause.

The indication for the start of treatment is:

Ovestin with menopause is used to prevent infectious diseases vagina, urinary tract.

Contraindications

A hormonal remedy can not be taken in some cases. Be sure to take this fact into account when reading the instructions for use. Ignoring these points leads to serious negative consequences.

Under the supervision of a specialist, treatment is prescribed for women in the presence of diabetes, diseases of cardio-vascular system, pathologies of the gastrointestinal tract.

Side effects

In the first months of therapy, there are minor undesirable effects that disappear on their own, do not require discontinuation of the drug. These include:

• headache;
• diarrhea;
• nausea;
• pain in the mammary glands, an increase in breast size.

Individual intolerance to the components of the drug indicates allergic reaction on the skin. Ovestin should be canceled immediately in such cases:

When using Ovestin in the form of a suppository, itching, burning in the genitals may occur. If the discomfort does not go away for about 3 days, you need to raise the question of discontinuing the drug or reducing the dose.

Instructions for use

Dosage, duration of therapy is determined individually. What form of the drug to use, you need to discuss in advance with the gynecologist.

Instructions for use suppository

The use of Ovestin candles is carried out at the same time, or with a difference of no more than 1 hour.

How to use the cream

It is administered on the eve of sleep using a special applicator. It is filled up to a special mark. The dose corresponds to 1 tablet, suppository. Includes 500 micrograms of estriol.

in the treatment of mucosal atrophy Bladder, the vaginal remedy is applied daily for about 4 weeks. After reducing unpleasant symptoms, reduce the dosage to once every 2 weeks.

Before the operation, the remedy is used for 2 weeks daily. After surgery - twice a week.

Instructions for using the cream:

After use, the applicator is washed in warm water with soap, rinsed well. You can not boil it, put it in too hot water.

Use of tablets

Which is better, Ovestin cream or suppositories

There is no particular difference between them. To a large extent, it all depends on personal preferences.

Thus, everything is individual. The more convenient, the more they use. The effect of the application is similar.

The cost of the drug

The drug is sold in pharmacies, dispensed by prescription. The price varies, depending on the location of the pharmacy. You can buy the drug in Moscow at the following prices:

Some analogues are cheaper based on estriol. But the mechanism of action may differ. Therefore, the question of buying an analogue should be discussed in advance with your doctor.

Ovestin's analogs

Currently hormonal drugs for replacement therapy with menopause is more than enough. All of them normalize the hormonal background, eliminate the symptoms of menopause. Direct analogues of Ovestin can be considered drugs with an identical active ingredient.

• Ovipol Clio;
• Estrovagin;
• Elvagin;
• Estrocad;
• Estriol.

To evaluate the effectiveness of Ovestin, to choose an analogue, reviews of women help. To get truthful information about side effects, just visit the forum, or ask a question yourself.

In this article, you can read the instructions for the use of hormonal medicinal product Ovestin. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of doctors of specialists on the use of Ovestin in their practice. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ovestin in the presence of existing structural analogues. Use to treat itching, infertility, hot flashes and other menopausal disorders in adults, children, and pregnancy and lactation. Interaction of the drug with alcohol.

Ovestin- an estrogen drug. Estriol (the active ingredient in Ovestin) is a natural estrogen. In the pre-menopause and post-menopause (natural or surgical), estriol is used to treat symptoms caused by estrogen deficiency. Estriol has a selective effect mainly on the cervix, vagina, vulva and is especially effective for the treatment of urogenital symptoms caused by estrogen deficiency. In cases of atrophy of the vaginal mucosa, Ovestin causes increased proliferation of the epithelium of the vagina and cervix, stimulates its blood supply, helps to restore the epithelium, normal microflora and the physiological vaginal environment, affects the quality and quantity of cervical mucus. As a result, the resistance of epithelial cells to infection and inflammation increases.

Unlike other estrogens, estriol has a short-term effect, since it a short time lingers in the nuclei of endometrial cells, and if the recommended dosing regimen is observed, endometrial proliferation should not be expected. In this regard, the cyclic use of progestogens is not necessary, postmenopausal withdrawal bleeding does not occur.

Compound

Estriol + excipients.

Pharmacokinetics

When using the drug inside, as well as locally, estriol is rapidly and almost completely absorbed. Plasma albumin binding is 90%. Excretion of estriol (in bound form) is carried out mainly by the kidneys; about 2% is excreted through the intestines unchanged.

Indications

• substitution hormone therapy(HRT) for the treatment of atrophy of the mucous membrane of the lower urinary tract associated with estrogen deficiency, in particular for the treatment of symptoms such as dyspareunia, dryness and itching of the vagina, to prevent recurrent infections of the vagina and lower urinary tract; for the treatment of urinary disorders (eg, increased frequency, dysuria) and moderate urinary incontinence;
• pre- and postoperative treatment of postmenopausal women;
• menopausal disorders (hot flashes and night sweats);
• infertility caused by cervical factor;
• for diagnostic purposes with unclear results cytological examination cervix (suspicion of a tumor process) against the background of atrophic changes.

Release forms

Candles vaginal 0.5 mg.

Cream vaginal (sometimes erroneously called ointment).

Tablets 2 mg.

Instructions for use and dosage

Candles

Candles should be inserted into the vagina at night before going to bed.

In the treatment of atrophy of the mucous membrane of the lower urinary tract, 1 suppository per day is prescribed for the first weeks, followed by a gradual decrease in the dose, based on the relief of symptoms, until a maintenance dose is reached (i.e. 1 suppository 2 times a week).

In pre- and postoperative therapy of women in the postmenopausal period, with surgical interventions vaginal access appoint 1 suppository per day for 2 weeks before surgery; 1 suppository 2 times a week for 2 weeks after surgery.

For diagnostic purposes, with unclear results of a cytological examination of the cervix, 1 suppository is prescribed every other day for a week before taking the next smear.

If a dose is missed, the missed dose must be administered on the same day, as soon as the patient remembers about it (the dose should not be administered 2 times a day). Further applications are carried out in accordance with the usual dosing regimen.

At the beginning or during the continuation of the treatment of postmenopausal symptoms, the lowest effective dose should be used for the shortest possible period of time.

In women not receiving hormone replacement therapy (HRT) or women who are switching from continuous oral combination drug for HRT, treatment with Ovestin can be started on any day. Women who are switching from a cyclic HRT regimen should start treatment with Ovestin 1 week after stopping HRT.

Cream

The cream should be injected into the vagina with a calibrated applicator at night (before going to bed).

1 application (applicator filled to the ring mark) contains 500 mg of cream, which corresponds to 500 mcg of estriol.

In the treatment of atrophy of the mucous membrane of the lower urinary tract - 1 application per day during the first weeks (maximum 4 weeks), followed by a gradual decrease in dose, based on symptomatic relief, until a maintenance dose is reached (i.e. 1 application 2 times a week) .

With pre- and postoperative therapy of postmenopausal women, with surgical interventions by vaginal access - 1 application per day for 2 weeks before surgery; 1 application 2 times a week for 2 weeks after surgery.

For diagnostic purposes, with unclear results of a cytological examination of the cervix - 1 application every other day for a week before taking the next smear.

Instructions for use for patients

1. The cream is injected into the vagina at night (before going to bed).

2. Remove the cap from the tube, turn the cap over and use a sharp rod to open the tube.

3. Screw the applicator onto the tube.

4. Squeeze the tube to fill the applicator with cream until the piston stops.

5. Unscrew the applicator from the tube and close the tube with a cap.

6. In the prone position, the end of the applicator is inserted deep into the vagina and slowly pressed against the piston until it stops, introducing the cream.

After the injection of the drug, the piston is removed from the cylinder and the cylinder and piston are washed with warm soapy water. Do not use detergents. After that, the cylinder and piston are rinsed abundantly with clean water.

Do not immerse the applicator in hot or boiling water.

Tablets

The drug is applied inside. The daily dose should not exceed 8 mg.

With atrophy of the lower genitourinary tract caused by estrogen deficiency, 4-8 mg per day is prescribed for the first 4 weeks, followed by a gradual dose reduction in accordance with the symptoms until a maintenance dose of 1-2 mg per day is reached.

With pre- and postoperative treatment during operations on the vagina in the postmenopausal period - 4-8 mg per day for 2 weeks before surgery, 1-2 mg per day - for 2 weeks after surgery.

In the treatment of menopausal disorders (hot flashes, night sweats) - 4-8 mg during the week with a gradual dose reduction. For maintenance therapy, the lowest effective dose should be used.

In infertility due to cervical factor, as a rule, 1-2 mg per day is prescribed from the 6th to the 15th day menstrual cycle. However, in different patients, the daily dose may vary from 1 mg to 8 mg. The dose should be increased every month until the optimal effect on the cervical mucosa is achieved.

If a woman missed taking the next dose, and the delay was no more than 12 hours, it is necessary to take the pill as soon as possible. If the delay was more than 12 hours, you should skip one dose and continue to take the drug at the usual time.

Tablets are taken with water, preferably at the same time of day.

The daily dose should be taken in 1 dose.

Side effect

• intermenstrual bloody spotting from the vagina;
• cervical hypersecretion;
• soreness and tension of the mammary glands;
• jaundice;
• nausea;
• skin rash;
• increase in blood pressure;
• headache.

Contraindications

• identified or suspected estrogen-dependent tumors (breast cancer, endometrial cancer);
• vaginal bleeding of unknown etiology;
• confirmed venous thromboembolism (deep vein thrombosis, pulmonary thromboembolism) within the last 2 years;
• a history of venous thromboembolism or thrombosis if anticoagulant therapy is not performed;
• diabetes mellitus with angiopathy;
• sickle cell anemia;
• Dubin-Johnson syndrome;
• Rotor syndrome;
• violation of cerebral circulation;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to the active and / or excipients of the drug.

The drug should be prescribed with caution in the following conditions:

• familial hyperlipoproteinemia;
• increased risk of thromboembolic complications;
• systemic lupus erythematosus;
• prolonged immobilization, serious surgical interventions;
• severe liver disease;
• history of gallbladder disease (especially cholelithiasis);
• hepatic porphyria;
• severe itching or cholestatic jaundice (including history during a previous pregnancy);
• pancreatitis;
• endometriosis;
• leiomyoma;
• bronchial asthma;
• arterial hypertension;
• hypercalcemia due to bone metastases of breast cancer;
• herpes of pregnant women;
• epilepsy;
• otosclerosis.

Use during pregnancy and lactation

Ovestin is contraindicated for use during pregnancy and lactation (breastfeeding).

special instructions

Before starting hormone replacement therapy, it is necessary to conduct a complete medical examination.

During treatment, every 6 months should be carried out regular examinations(including breast examination, mammography) according to accepted medical practice.

It is necessary to exclude the presence of a history of thromboembolism, repeated spontaneous abortions, which indicates thrombophilia. The risk of thromboembolism increases with prolonged immobilization, severe trauma and surgical interventions. In these cases, it is necessary to temporarily interrupt hormone replacement therapy (4-6 weeks before surgery)

The use of estriol does not lead to an increase in the density of the mammary gland. And perhaps the use of estriol does not increase the risk of developing breast cancer.

Cases of venous thromboembolism (deep vein thrombosis of the lower leg, pelvic vein thrombosis and pulmonary thromboembolism) are observed more often in women receiving hormone replacement therapy.

drug interaction

There were no cases of interaction of the drug Ovestin with other drugs.

Known data on the enhancement of the pharmacological effect of glucocorticosteroids (GCS), lipid-lowering agents when used together with estrogens. If necessary, the dose of GCS can be reduced.

It is possible to weaken the effects of drugs of male sex hormones, anticoagulants, antidepressants, diuretics, hypotensive and hypoglycemic agents.

Barbiturates, antiepileptic drugs (carbamazepine, phenytoin) increase the metabolism of steroid hormones.

Antibiotics (ampicillin, rifampicin), general anesthetics, opioid analgesics, anxiolytics, antiepileptics, some antihypertensives, ethanol (alcohol) reduce the effectiveness of estrogens.

Folic acid and thyroid hormone preparations increase the effect of estriol.

Ovestin may alter the effectiveness of oral anticoagulants.

Estriol may increase pharmacological effect succinlycholine, theophylline, foleandomycin.

Analogues of the drug Ovestin

Structural analogues according to active substance:

• Ovipol Clio;
• Elvagin;
• Estriol;
• Estrovagin;
• Estrocad.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.