Kromoheksal (eye drops): instructions for use, reviews, analogues, price, composition. Eye drops cromohexal Eye drops for allergies cromohexal instruction

Nasal spray Kromoheksal cromoglycic acid , as well as additional components: EDTA disodium salt, sodium dihydrogen phosphate, sodium monohydrogen phosphate, sodium chloride, water.

Eye drops Cromohexal contains the active ingredient - cromoglycic acid , as well as additional components: sodium chloride, disodium edetate, benzalkonium chloride, liquid sorbitol, disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate, water.

Kromoheksal for inhalation in the form of a solution contains the active component sodium cromoglycate and purified water as an additional component.

Release form

Several forms of this medicine are produced.

• Kromoheksal nasal spray 2% dosed- a colorless or yellowish solution that does not contain mechanical impurities. It is packaged in 15 ml or 30 ml polyethylene bottles equipped with a dosing device.
• Eye drops 2%- transparent, yellowish solution, not containing mechanical impurities. Contains in vials of 15 ml.
• Solution for inhalation– transparent, yellowish, not containing mechanical inclusions. It is contained in polyethylene ampoules of 2 ml, which are put into cardboard packs of 10 pcs.

pharmachologic effect

The medicine has an antiallergic effect.

The composition of all forms of Cromohexal includes the active ingredient disodium salt of cromoglycic acid. Active substance has a stabilizing effect on the membranes of basophilic granulocytes, also inhibits the entry of calcium ions into cells. Since the stabilization of mast cell membranes occurs under the influence of the drug, there is no degranulation and release of histamine, bradykinin and other mediators of allergy and inflammatory processes into the blood.

This remedy is most effective as a prevention of allergic manifestations. Clinical effect observed after a few days of use.

Pharmacokinetics and pharmacodynamics

After the drug has been applied intranasally, less than 7.5% of the dose received is absorbed into the systemic circulation. It binds to plasma proteins by 65%. The half-life is 1.5 hours. The active component is eliminated after a day with urine and bile in approximately equal amounts. Metabolism does not occur in the body.

When applied eye drops through the mucous membrane of the eye, the active component is absorbed slightly. The level of systemic bioavailability is less than 0.03%.

Indications for use

Kromoheksal spray nasal is indicated for occurring seasonally or throughout the year.

Eye drops Kromoheksal prescribed for both prevention and treatment keratoconjunctivitis , , allergic keratitis , as well as irritation of the mucous membrane of the eyes associated with allergic reactions (the action of factors environment, cosmetics, household chemicals, pets, plants, etc.).

Solution for inhalation appointed for the purpose preventive treatment manifestations allergic and non-allergic origin, as well as in endogenous forms asthma , which are associated with stress, the action of infection, high loads.

Contraindications

Kromoheksal in any form is contraindicated for use in case of hypersensitivity to any of the components of the drug.

Allergy eye drops and inhalation solution are not prescribed for children under 2 years old, nasal spray - for children under 5 years old. Also, the spray is not prescribed during pregnancy and breastfeeding.

With caution, Cromohexal spray is prescribed to people with hepatic or kidney failure, as well as patients with polyps in the nasal cavity.

Side effects

Nose drops Kromoheksal can cause the following negative effects:

• respiratory system: burning or symptoms of irritation of the nasal mucosa, coughing, sneezing, rhinorrhea , in rare cases - bleeding from the nose;
• allergic manifestations : itching and rash, , swelling of the lips, face or eyelids, difficulty swallowing or breathing;
• other manifestations: headaches, bad taste in the mouth.

Solution for inhalation can cause such unpleasant effects:

• irritation of the trachea and pharynx;
• slight cough, in very rare cases - reflex bronchospasm;
• skin rash;
• inflammation of the gastrointestinal tract.

All phenomena are short-lived, after discontinuation of the drug disappear.

Eye drops can provoke the development of such effects:

• deterioration in the clarity of vision;
• burning sensation in the eyes;
• manifestation of lacrimation;
• feeling foreign body;
• swelling of the conjunctiva;
• dry eyes;
• meibomite (barley);
• damage to the corneal epithelium is superficial.

Application instruction of Kromoheksal (Way and dosage)

Nasal spray instruction

The maximum allowable dosage is 6 times a day, 1 dose. After the effect has been achieved, you can reduce the number of applications per day. It is advisable in this case to use the spray in contact with allergens .

Treatment lasts for 4 weeks, drug withdrawal is carried out gradually, over 1 week.

Before using the product, you need to remove the protective cap from the bottle and press the sprayer several times to achieve the optimal dosage. Before using the spray, be sure to thoroughly clean the nasal passages.

The instruction on Kromoheksal for inhalations

It is recommended to carry out inhalations 4 times a day, for one inhalation use one bottle of 2 ml. If possible, equal time intervals should pass between inhalations. If necessary, you can increase the frequency of application of the drug up to 6 times a day. After it has been reached therapeutic effect can be inhaled as needed.

With regular use, Kromohexal solution prevents the onset of asthma symptoms, but it does not relieve acute asthma attacks. The course of treatment should be at least 4 weeks, the dose should be reduced gradually, within one week. For inhalation, special inhalers are used.

Eye drops Kromoheksal, instructions for use

In each eye, it is necessary to instill 1-2 drops of the product, this must be done 4 times a day. You can increase the number of procedures up to 6-8 times a day. After the therapeutic effect has been achieved, the agent can only be used during contact with allergens. With chronic the duration of treatment is determined by the doctor individually.

Overdose

There is no information on an overdose of Cromohexal.

Interaction

When taken simultaneously, cromoglycic acid may enhance the action of H1-histamine blockers .

You can not inhale drugs at the same time and and Cromohexal solution.

Terms of sale

All forms of the remedy can be bought without a prescription.

Storage conditions

All forms of Cromohexal should be stored at temperatures up to 25 ° C. Keep away from children. Vials with solution for inhalation are intended for single use.

Best before date

You can store all forms of drugs for 3 years, after the package with drops or spray has been opened, you can store the product for 6 weeks. If stored incorrectly, the solution may turn yellow, in which case it should not be used.

special instructions

The product should not be used after the expiration date indicated on the package of the drug has expired.

With the manifestation of irritation, burning of the mucosa, which does not disappear or intensifies, treatment should be stopped.

Do not use inhalation solution to relieve acute attacks asthma .

When using any of the forms of the drug for a long time, it is required to monitor the condition of the patient's liver and kidneys.

When using Cromohexal eye drops, the need for taking ophthalmic agents, which contain glucocorticoids, is reduced.

The tip of the pipette should not touch the eye, you need to close the bottle after each use.

During treatment, you should carefully perform activities that require concentration.

Analogues

Analogues of the drug Kromoheksal, containing the same active ingredient, are the means: Vividrin , , Ifiral , Cromolyn , , Thaleum , Kuzikrom , Cromogen and etc.

Replacement of the drug can be only after prior approval by the attending physician.

children

The spray can not be used to treat children under 5 years of age, the solution and eye drops are not prescribed for children under 2 years of age. Cromohexal is carefully used for children under 4 years of age.

During pregnancy and lactation

Despite the fact that the use of Cromohexal for animals did not provoke a teratogenic effect, the drug is not prescribed for pregnant women. The active substance is able to penetrate into breast milk, so the drug is not used during lactation.

Active substance

Sodium cromoglycate (cromoglycic acid)

Release form, composition and packaging

◊ Eye drops 2% in the form of a clear, colorless to slightly yellowish solution without mechanical inclusions.

Metabolism and excretion

Not metabolized. It is excreted by the kidneys and through the intestines unchanged (in approximately equal amounts within 24 hours after application). T 1/2 - 5-10 minutes.

Indications

Prevention and treatment:

- allergic keratitis, keratoconjunctivitis;

- irritation of the mucous membrane of the eyes due to allergic reactions (environmental factors, occupational hazards, household chemicals, cosmetics, ophthalmic dosage forms, plants and domestic animals).

Contraindications

— childhood up to 2 years;

— hypersensitivity to sodium cromoglycate or to any other component of the drug.

FROM caution the drug should be used in children under the age of 4 years, with and during lactation.

Dosage

Adults and children over 2 years of age 1-2 drops are instilled into each conjunctival sac 4 times / day with an interval of 4-6 hours. If necessary, the dose can be increased to 6-8 instillations.

After achieving a therapeutic effect, the frequency of use of the drug can be reduced and used only in contact with allergens (house dust, fungal spores, pollen).

Side effects

From the side of the organ of vision: violation of the clarity of visual perception, burning in the eye, swelling of the conjunctiva, sensation, dry eyes, lacrimation, meibomite (barley); superficial lesion of the corneal epithelium.

Overdose

There are no data on drug overdose.

drug interaction

To date, no interactions with other drugs have been identified.

special instructions

The use of the drug Cromohexal reduces the need for the use of ophthalmic preparations containing glucocorticoids.

When using Kromoheksal drops, due to the content of benzalkonium chloride, you should avoid wearing soft contact lenses; hard contact lenses must be removed 15 minutes before instillation and dressed after 15 minutes.

The bottle must be closed after each use. Do not touch the tip of the pipette to the eye.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially dangerous species activities that require increased concentration of attention and speed of psychomotor reactions.

Pregnancy and lactation

With caution, you should use the drug Kromoheksal during pregnancy and lactation.

Application in childhood

Contraindicated in children under 2 years of age, with caution in children under 4 years of age.

Terms of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored in a place protected from light, out of the reach of children, at a temperature not exceeding 25°C. Shelf life - 3 years.

Open vials should be used within 6 weeks.

Many patients often experience such symptoms: burning, increased lacrimation, redness.

These manifestations often indicate the development of an allergic reaction.

Also, such symptoms may be accompanied by inflammation of various etiologies. Eliminate manifestations will help special eye drops.

One of the most effective are Kromoheksal.

Indications for use

Doctors prescribe this drug for the development of such diseases:

• allergic keratitis.

It can be used to eliminate superficial injuries of the mucous membrane, its irritation during an allergic reaction and exposure to external factors. The drug can be prescribed by an ophthalmologist or an allergist. Effective for seasonal allergies to pollen and flowering. Basically, these factors cause irritation of the mucous membrane of the eyes. The only drawback of the drug can be considered a contraindication during pregnancy and lactation.

Price

Average cost - 100 rubles. It is worth noting that prices may vary depending on the pharmacy.

Compound

The composition of the drug is presented in the table:

Instructions for use

The drug is taken 1-2 drops 4 times in 24 hours. Use is only for local application. For people over 18 years of age, the dosage can be increased to 6 doses. In this case, it is necessary to adhere to the interval between doses of 4 hours. When the symptoms decrease, the interval is increased to 7 hours.

If there is no result from the treatment, then you need to consult a doctor. You may need to prescribe another medication. Usually, drops are used during an exacerbation of diseases until the symptoms disappear completely. For the purpose of prevention, you can only take it as directed by a doctor. With the development of hypersensitivity, you should immediately stop taking the medicine.

children

This drug should not be given to children under two years of age. Babies under 4 years old can be prescribed for the treatment of ophthalmic diseases with extreme caution. Treatment should be under the supervision of a physician. With the development of unwanted symptoms, therapy should be stopped. It is important to observe the body's response to medicinal product. For the treatment of very young children, it is necessary to choose a safer medicine.

special instructions

The use of any ophthalmic drops requires compliance with certain rules. After each use, the bottle must be tightly closed. It is possible to carry out instillations only with clean hands so that the vial does not touch the mucous membrane. This can lead to the development of a secondary infection. Take with caution simultaneously with glucocorticosteroids.

If therapy is to be prolonged, then monitoring of kidney and liver function will be required. Sometimes after instillation, visual acuity may decrease. Therefore, it is worth limiting driving vehicles. You should also refrain from activities that require heightened attention and visual acuity.

Interaction with other drugs

When using with other drugs, you should consult your doctor. Simultaneous use with antihistamine blockers (Diphenhydramine, Suprastin, Tavegil, Loratidine) may enhance their effect. Interaction with Ambroxol is not recommended due to the high risk of developing bronchospasm.

With simultaneous use with corticosteroids, the effect of hormonal drugs is enhanced. It should be borne in mind that patients who wear contact lenses should refuse them. Doctors recommend replacing them with glasses. When using hard lenses, they must be removed and put on at intervals of 15 minutes before and after the instillation of drops.

Pregnancy and lactation

This drug is not recommended during pregnancy and lactation. AT clinical practice there is no information on the effect of the drug on the fetus. The components in the composition are concentrated in breast milk. Therefore, the drug is prescribed in case of urgent need.

The effectiveness of the drug must exceed the harm to the fetus. The greatest risk to the baby is present in the first trimester of pregnancy. Much safer to prescribe in the second and third trimester.

Side effects

These drops in rare cases can cause adverse reactions. Basically, local manifestations may appear in the form of burning, dryness, redness, increased lacrimation, impaired visual acuity. Barley, erosive changes in the mucosa and swelling may also occur.

With the development of any adverse reactions, you should immediately stop treatment and consult your doctor. You may need to choose a safer counterpart. Most patients tolerate this drug well.

Contraindications

These eye drops have a pronounced therapeutic effect, so there are certain contraindications for use:

• children under 2 years old;
• first trimester of pregnancy;
• the presence of erosive lesions of the mucosa;
• individual intolerance;
• hypersensitivity to the composition.

With extreme caution prescribed in the second and third trimester of pregnancy and while breastfeeding. It is forbidden to use in case of renal and hepatic insufficiency, since the active substance is excreted from the body through these organs.

Valeria, allergist: A large number of patients are allergic to pollen. Except respiratory organs eyes are severely affected. Therefore, protection is needed before the influence of allergens. I recommend such patients to use the drops before the onset of allergy symptoms. This will help reduce the risk of complications. In severe cases, simultaneous administration with antihistamine tablets. The drug has a good effect on the mucous membrane of the eye and rarely causes adverse reactions. I do not recommend self-medication, since a certain scheme will be required for an effective result. The doctor prescribes it on an individual basis.

Eye drops Cromohexal 2%- effective antihistamine for the prevention and treatment of acute and chronic allergic diseases eyes (conjunctivitis, keratoconjunctivitis). The drug is also used to relieve symptoms of irritation and dry eyes, with visual strain and eye fatigue.
Cromoglycic acid acts directly on the membranes of mast cells, blocking the entry of calcium ions into these cells and the subsequent release of biologically active substances responsible for the occurrence of allergic reactions: histamine, bradykinins, leukotrienes, prostaglandins. Thus, cromoglycic acid inhibits the occurrence of allergic reactions. immediate type and prevent their occurrence.
The drug has a local decongestant effect, eliminates the symptoms of eye irritation that occur when the mucous membrane of the eye is exposed to various contact allergens.
Kromoheksal can be used for visual fatigue, dry eye syndrome, to eliminate irritation and redness of the eyes caused by exposure to intense visual stress.
The most pronounced therapeutic effect is usually observed after one or two days from the start of the drug, therefore, for prevention seasonal allergies it is necessary to start treatment in advance.

Indications for use

Mode of application

Side effects

Contraindications

Pregnancy

Interaction with other drugs

Overdose

Storage conditions

Release form

Compound

Additionally

Allergies can manifest themselves in different ways, but more trouble is caused by an allergic reaction, which manifests itself before the eyes in the form of dryness, irritation and swelling. At this point, many come to the aid of various medications. Cromohexal eye drops is an ophthalmic drug used as an antihistamine to reduce allergy symptoms.

Pharmacological action and group

Kromoheksal belongs to the group of antiallergic drugs.

Ophthalmic drops help to cope with allergies due to their main substance - the disodium salt of cromoglycic acid. This substance prevents the release of hormonal components (histamine, bradykinin). This is achieved by the penetration of a trace element such as calcium into cell membranes. eyeball. Thanks to this, the shell of the eye remains not irritated due to contact with foreign objects from the outside world. To obtain the desired effect, it is recommended to use the drug for at least a week.

Release form and composition

Cromohexal is available in three forms. Its choice depends on the disease. Therefore, you should not self-medicate, it is better to consult a doctor so that he makes an accurate diagnosis.

Possible types of drugs:

• solution for inhalation;
• nasal spray aerosol;
• eye drops.

Kromoheksal eye drops are made in the form of a clear solution placed in a plastic bottle. The product is sold in a pharmacy in a box made of cardboard, along with instructions for use.

The active component of Cromohexal drops is the disodium salt of cromoglycic acid. It is she who ensures the effectiveness of the drug. In order to enhance the effectiveness of the drug, auxiliary substances are added to its composition, such as:

• benzalkonium chloride;
• disodium hydrogen phosphate dodecahydrate;
• distilled water;
• sorbitol;
• sodium chloride.

Together, all these components enhance the effect active ingredient, and also have an additional beneficial effect on the shell of the eyeball.

Indications for use

Specialists prescribe Cromohexal eye drops for several eye diseases:

• conjunctivitis caused by allergies;
• keratoconjunctivitis;
• allergic keratitis.

It is worth noting that the drug is used not only in the presence of these diseases, but is also used if the patient has a superficial lesion of the corneal epithelium and irritation of the mucous membrane of the eyes caused by an allergic reaction or external factors.

Instructions for use

When buying eye drops, you must carefully study the instructions for use, which contains a description of the drug and the dosage required for admission. The exact dose of the drug will be prescribed by a doctor who will get acquainted with the disease and the characteristics of the patient's body.

General instructions for use are as follows:

• as before any procedure, you need to wash your hands with soap so that the infection does not get into the eye and into the solution;
• unscrew the protective cap from the dropper bottle;
• tilt your head back and pull the lower eyelid;
• apply 1-2 drops of the drug under the lower eyelid;
• screw on the cap;
• do not strain your eyes for 10-15 minutes.

If the patient has a severe ophthalmic disease, then the specialist can increase the number of daily procedures to 6-8, but the patient must be under his control.

After the desired effect has been obtained, the number of medications is reduced.

Before instilling Cromohexal, you should first remove the lenses and put them on only 15-20 minutes after the procedure.

Side effects and contraindications

As with most drugs, the use of Cromohexal medication can cause a number of side effects:

• barley formation (meibomite);
• the appearance of a burning sensation;
• increased secretion of tear fluid;
• dryness in the eyes;
• swelling of the lower eyelid;
• deterioration of vision.

If a this symptomatology was found, you should abandon the drug and contact a competent specialist to prescribe a new one.

In order to avoid health complications in the future, the patient is advised to familiarize himself with a number of contraindications for use. Among them are:

• hypersensitivity to the components of the drug;
• the age of the patient has not reached two years;
• period of pregnancy and breastfeeding.

Although the drug is approved for children under two years of age, it should be used with caution at this age.

Interaction with other drugs

Cromohexal is allowed to be used with other drugs. The only condition is that at least 15 minutes must pass between the receptions of funds, and preferably more.

Use in children

Kromoheksal eye drops are strictly forbidden to be used as a treatment for ophthalmic diseases in children under the age of two. If the age of the child is from 2 to 4 years, then the solution should be dripped into their eyes with caution. Further observation by a doctor is recommended to study the body's reaction to the active ingredient of the drug.

If the infant is less than two years old, then the specialist should prescribe him another drug that is suitable for his age, for the treatment of ophthalmic diseases.

Use in pregnancy

Studies conducted on representatives of the fauna did not reveal any negative effect on the fetus of the pregnant woman themselves. Despite this, Cromohexal is not recommended for use by women during pregnancy and lactation, since the active substance easily passes into breast milk.

Storage conditions and shelf life

Immediately after manufacture, ophthalmic drops are suitable for use for three years. However, immediately after the bottle has been opened, the shelf life of the solution is reduced to 1.5 months.

When choosing a place to store the drug, you need to pay attention to several factors:

• it must be inaccessible to children;
• the temperature in it should not be higher than room temperature (25 degrees);
• the medicine will not be exposed to direct sunlight.

The ophthalmic remedy should not be used after it has expired.

Analogues

If there is no Cromohexal in the pharmacy, then you can buy its substitutes. Despite the fact that the drug itself is inexpensive, it is possible to buy an analogue even cheaper.

The main substitutes are:

• "Lecrolin". Also, like Cromohexal, this drug contains sodium cromoglycate in solution. It is used as an antihistamine. It interacts well with other drugs.
• "Kromoglin". The active substance is the disodium salt of cromoglycic acid. Discharged for diseases bronchial asthma and chronic bronchitis. Produced in the form of a solution for inhalation and tablets.
• "Allergodil". It is produced in two forms: nasal spray and eye drops. It is used when the patient has allergic rhinitis and rhinoconjunctivitis, nasal congestion and sneezing.

Price and reviews

The average price in Russia of Cromohexal eye drops does not exceed 100 rubles. It is impossible to name the exact amount, since each region has its own.

After reading the user reviews, you can see that the majority are positive. This is due to the fact that drops, due to their low cost, are available to everyone, and, despite the low price, they do an excellent job of preventing the release of histamine.

Only a few reviews are negative. They say that Cromohexal eye drops caused side effects in humans.