The drug furazolidone application. Medicinal reference book geotar

Furazolidone is an antibacterial agent with antimicrobial activity against Gram-negative and Gram-positive bacteria, Giardia and Trichomonas.

Synthetic derivative of 5-nitrofurforol. The drug is effective in the treatment inflammatory diseases caused by Gram-negative aerobic bacteria. Gram positive aerobic bacteria are less sensitive to it, as well as fungi and protozoa.

Anaerobic pathogens are insensitive to Furazolidone. Microbial resistance develops slowly.

It disrupts the processes of cellular respiration of microorganisms, inhibits the Krebs cycle, and also inhibits other biochemical processes of microorganisms, resulting in the destruction of their shell or cytoplasmic membrane.

As a result of the action of the drug, microorganisms release less toxins, and therefore an improvement general condition the patient is possible even before a pronounced suppression of the growth of microflora.

Unlike many other antimicrobial agents, Furazolidone not only does not inhibit, but even activates immune system organism (increase the complement titer and the ability of leukocytes to phagocytize microorganisms).

After ingestion, it is quickly and almost completely absorbed in the intestine. Therapeutically significant blood concentrations persist for 5 to 6 hours after taking a single dose. Furazolidone penetrates into the cerebrospinal fluid, where its concentration is the same as in the blood.

Indications for use

What is Furazolidone used for? According to the instructions, the drug is prescribed in the following cases:

The drug is used orally, after meals with plenty of water (except local application in surgery). Treatment should not last more than 10 days.

Standard dosages, according to the instructions for use Furazolidone, depending on the indications:

With dysentery, paratyphoid fever and food poisoning - 100-150 mg \ 4 times a day (but not more than 800 mg), for 5-10 days.
With giardiasis: adults - 100 mg \ 4 times a day, children - 10 mg / kg / day, distributing the daily dose into 3-4 doses.
The highest single dose for adults is 200 mg, the daily dose is 800 mg.

Additionally, it is used to treat burns and wound infections. In these cases, they are used topically in the form of wet-drying dressings, or irrigation with a solution of Furazolidone, in a ratio of 1:25000.

special instructions

During treatment with the drug, you should temporarily exclude from the diet or drastically limit foods - cottage cheese, cream, butter, hard cheese, coffee, strong tea, herring.

In order to prevent the development of polyneuritis, taking Furazolidone tablets should be combined with taking B vitamins.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Furazolidone:

decreased appetite, up to anorexia, nausea, vomiting;
allergic reactions- skin rash, hyperemia and itching of the skin, angioedema.

Contraindications

Furazolidone is contraindicated in the following cases:

severe chronic kidney failure;
pregnancy and breastfeeding period;
children under 3 years of age;
increased individual sensitivity or intolerance to the components of the drug;
cases of allergic reactions to drugs from the nitrofuran group.

Assign with caution:

chronic renal failure;
liver disease, accompanied by impaired organ function;
diseases of the central nervous system.

The drug is contraindicated during pregnancy. It can be prescribed only for vital necessity, taking into account the expected and the risk to the fetus. In animal studies, an adverse effect on the fetus was noted.

Overdose

Overdose symptoms are acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).

There are no specific antidotes.

Furazolidone analogues, price in pharmacies

If necessary, you can replace Furazolidone with an analogue in terms of therapeutic effect - these are drugs:

Nifuroxazide,
Entprofuril,
Rifaximin,
imipenem,
Azithromycin,
Fluoroquinolone,

When choosing analogues, it is important to understand that the instructions for use of Furazolidone, the price and reviews for drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Furazolidone 50mg 10 tablets - from 55 to 79 rubles, the cost of a pack of 20 tablets - from 87 to 108 rubles, according to 583 pharmacies.

Store at room temperature in a dry place out of the reach of children. Shelf life - 3 years.

Sale in pharmacies without a prescription.

Dysentery, paratyphoid, giardiasis, food poisoning.

Contraindications to the use of Furazolidone

Pregnancy, lactation. Increased individual sensitivity to the group of nitrofurans. End-stage chronic renal failure, glucose-6-dehydrogenase deficiency, children under 3 years of age (for this dosage form).
Carefully
Chronic renal failure, deficiency of glucose-6-phosphate dehydrogenase, diseases of the liver and nervous system.

Inside, after eating, drinking plenty of fluids.
With dysentery, paratyphoid, food poisoning appoint adults 100-150 mg 4 times a day, after meals, for 5-10 days. Doses for kids decrease according to age.
The duration of treatment depends on the nature and severity of the infection. You can prescribe the drug in the same doses in cycles of 3-6 days with an interval of 3-4 days. It is not recommended to take the drug for more than 10 days.
With trichomonas urethitis take orally 100 mg 4 times a day for 3 days.
With giardiasis appoint adults 100 mg 4 times a day. children at the rate of 10 mg / kg per day in 3-4 doses.
Maximum doses for adults: single - 200 mg, daily - 800 mg.

pharmachologic effect

Furazolidone is an antimicrobial agent, a derivative of nitrofurans. Active against gram-positive and gram-negative microbes, Trichomonas spp., Ciardia lamblia. The most sensitive to furazolidone are Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp. Salmonella typhi, Salmonella paratyphi. Weakly affects pathogens of purulent and anaerobic infections. Microbial resistance develops slowly. Blocks monoamine oxidase.

Nitrofurans disrupt the processes of cellular respiration of microorganisms, suppress the tricarboxylic acid cycle (Krebs cycle), and also inhibit the biosynthesis of nucleic acids of microorganisms, resulting in the destruction of their shell or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms release less toxins, and therefore an improvement in the general condition of the patient is possible even before a pronounced suppression of the growth of microflora. Unlike many other antimicrobial drugs, they not only do not inhibit, but even activate the body's immune system (increase the complement titer and the ability of leukocytes to phagocytize microorganisms).

Pharmacokinetics
Well absorbed in oral administration. Against the background of inflammation of the meninges in the cerebrospinal fluid, concentrations equal to those in plasma are created. It is rapidly and intensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). It is excreted mainly by the kidneys (65%), small amounts are found in the faeces, where therapeutic concentrations are reached against pathogens of intestinal infections.

Side effects of Furazolidone

Decreased appetite, up to anorexia; nausea, vomiting; allergic reactions (skin rash, flushing and itching of the skin, angioedema). With prolonged use - neuritis.

special instructions

Limited for use in chronic renal failure, diseases of the nervous system. For the prevention of neuritis with prolonged use, it must be combined with B vitamins.
Furozolidone has the ability to sensitize the body to the effects of alcohol and can be used to treat chronic alcoholism when other drugs are not effective enough or there are contraindications to their use.
It should be borne in mind that Furazolidone is an MAO inhibitor, therefore, when using it, the same precautions should be observed as when using classic MAO inhibitors.

Overdose

Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).
Treatment: drug withdrawal, admission a large number fluids, symptomatic therapy, antihistamines, B vitamins.

drug interaction

Means that alkalize urine reduce the effect (accelerate excretion in the urine), acidifying agents increase it. Aminoglycosides and tetracycline enhance antimicrobial properties.
Increases the inhibition of hematopoiesis against the background of chloramphenicol and ristomycin.

Pharmacological effect on the body

According to numerous reviews, this medicine is very helpful during treatment. inflammatory processes, which arise due to the development of gram-negative bacteria, namely aerobic.

The pharmacological effect directly depends on the dosage. If the dosage is high - bactericidal effect, and if low - bacteriostatic. The antibiotic produces an immunostimulating effect on the human body, as the activity of leukocytes in the blood increases significantly.

The drug increases the body's susceptibility to alcoholic beverages, so when they are used in parallel with the drug, vomiting and nausea will appear. Completely absorbed in the human intestine. One dose remains in the blood for six hours.

Furazolidone - what are these pills from? Indications for use

Furazolidone helps in the prevention and treatment of infectious, inflammatory diseases that occur on the patient's skin, in the gastrointestinal tract, and also in the genitourinary system. According to the instructions for use, the drug is intended for diseases such as:

dysentery;
the presence of giardiasis;
inflammation Bladder, as well as the urethra;
pyelitis;
cystitis;
diarrhea due to infection, such as food poisoning;
trichomonas infection;
wounds and burns skin.

Restrictions for use

Before drinking such a medication, it is advisable to carefully read the instructions in order to study the existing restrictions on use. Contraindications:

composition sensitivity;
the age of the baby who is less than one month old;
chronic renal failure;
deficiency of glucose, lactose.

As for girls and women in position, their condition should be assessed by the attending physician. The use of this medication during lactation and pregnancy is possible in a situation where there are no potential risks for the baby in the womb.

With extreme caution, the medicine is prescribed to those people who have problems with the liver, and there are also problems in the nervous system. It is forbidden to take patients whose work requires maximum attention and concentration.

Dosage and methods of application

These tablets are taken orally and do not need to be crushed or chewed. It is washed down with a glass of water, swallowing whole. According to the instructions for use, the drug is excellent for food poisoning, dysentery and paratyphoid. In this case, Furazolidone is drunk 4 times a day, 100 or 150 milligrams. The duration of the course is 8-10 days in a row.

To get rid of giardiasis, adults take 100 mg 4 times. Regarding young children, the required dosage of Furazolidone is calculated in the ratio of their total weight, namely 10 milligrams per kg of body weight baby body per day. The daily dosage should be divided into three doses, be sure to adhere to an equal period of time.

Suitable for quality and enough effective treatment trichomonas infection, as well as colpitis. In this case, Furazolidone must be consumed at least three times a day, 100 mg for 3 days. In addition, about five grams of powder, which consists of milk sugar (lactose) and Furazolidone, can be injected into the vagina once a day. A strict proportion is adhered to, namely 400 to 1, and the rectal suppositories of this drug are inserted into the rectum. If the patient has a diagnosis of trichamonas urethritis, then the drug is drunk 4 times a day for about three days, 100 milligrams each.

To get rid of a burn, a wound infection, you can make a special bandage, namely a wet-drying one. You can also use an irrigation solution, observing the proportion of 1 to 25,000.

Furazolidone - side effects

Although this antibiotic is low-toxic, it is necessary to strictly adhere to the instructions for use.

Possible side effects of the medication:

weakness and apathy;
violation of appetite, namely, a complete absence;
spasms, pain and discomfort that appear in the intestines and stomach;
bouts of vomiting and excruciating nausea.

In some cases, an allergic reaction may occur:

skin itching and rash;
redness;
swelling;
and puffiness;
Quincke's edema (the most dangerous).

To prevent development adverse reactions organism on Furazolidone, each dose of the drug is washed down with plenty of water. In addition, in parallel, you can drink vitamins belonging to group B, as well as antihistamines.

Long-term use of the drug, especially in infants, can provoke the following:

cough and shortness of breath;
neurotoxic reaction;
hemolytic anemia;
acute hyperthermia.

In order not to worsen the state of health, follow the instructions for use for this drug.

Drug interaction with other drugs

Before using Furazolidone, it is important to take into account the forms of its interaction with other medicines and alcoholic beverages.

There may be such reactions from alcohol and preparations containing ethanol:

panic;
a sharp drop in blood pressure;
fever and fever;
heart palpitations develop;
fear of death;
nausea with vomiting.

Interactions with amphetamine, various antidepressants, tyramine, and ephedrine may increase significantly arterial pressure, blood formation is inhibited.

Furazolidone - analogues and price

Price

Furazolidone is a fairly active antibiotic. There is a large list of medicines that can have a similar effect on the human body. Most often, patients prescribe more expensive drugs, not taking into account cheaper analogues.

Very often there are important circumstances that force a drug to be replaced with its analogue. The reasons may be different, for example: intolerance or too high sensitivity to the components of this tool.

The average price of Furazolidone in a pharmacy in Moscow and St. Petersburg is 65-75 rubles.

Analogues

Furazolidone analogs:

Syrup Finer- helps with constipation, problem skin. Outputs from human body toxins, bad cholesterol, perfectly cleanses the blood.
Suspension Befungin- prescribed for problems with the gastrointestinal tract: poisoning, gastritis and ulcers.
Tablets Compositum Gepar- an antioxidant that has a choleretic effect.
Capsules and tablets Negram- a good antibiotic, suitable for the treatment of pyelonephritis, urethritis, and cholecystitis.
Norbaktin tablets- a special complex that normalizes and restores the digestive system.

Specified medications able to perfectly replace Furazolidone. Before using any medicine, consult your doctor so as not to harm your health.

Furazolidone - a drug (tablets), belongs to the group of antiseptics and antimicrobials for the treatment of gynecological diseases. Important Features medicinal product from the instructions for use:

AT childhood: carefully
With impaired liver function: with caution
In case of impaired renal function: with caution

Package

Compound

In 1 tablet of furazolidone 0.05 g.

The composition also includes potato starch, calcium stearate, sucrose, polysorbate, lactose.

Release form

Plano-cylindrical tablets 0.05 g.

Granules for suspension preparation (for children).

pharmachologic effect

Antiprotozoal, antimicrobial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Furazolidone - is an antimicrobial agent, a derivative of nitrofuran. Salmonella, Shigella, Campylobacter, as well as protozoa (Labmlia, Trichomonas) and Vibrio cholerae are highly sensitive to it. Depending on the concentration, it has a bactericidal or bacteriostatic effect.

The mechanism of action consists in the blockade of many enzyme systems of the microorganism. Nitrofurans disrupt cellular respiration, inhibit the Krebs cycle and block the biosynthesis of nucleic acids. As a result, the shell of microorganisms or their cytoplasmic membrane is destroyed. Under the action of the drug, destroyed microbial cells release less toxins. Unlike other antimicrobial agents, they activate the immune system.

Works on strains resistant to some antibiotics. Does not affect anaerobes and Pseudomonas aeruginosa. Microbial resistance to the drug is rare.

What is Furazolidone used for? Since it is poorly absorbed in the gastrointestinal tract and high concentrations are created in the intestine, it is used for intestinal infections of bacterial and protozoal etiology. Unlike Furadonin, it has low toxicity.

Pharmacokinetics

Well absorbed when taken orally. Distributed in tissues and fluids. In cerebrospinal fluid with meningitis, the same concentrations are created as in plasma, and therapeutic concentrations are also achieved in the intestinal lumen. Intensively metabolized in the liver to an inactive metabolite. Excreted by the kidneys (up to 65%), small amounts are determined in the feces,

Indications for the use of Furazolidone

dysentery;
giardiasis;
cholera;
paratyphoid;
food poisoning;
trichomonas colpitis and urethritis;
pyelitis;
cystitis;
topical treatment of infected wounds and burns.

Contraindications

hypersensitivity;
pregnancy, breastfeeding;
renal failure (terminal stage);
severe liver failure;
age up to 3 years (tablets);
age up to 1 month (suspension).

It is prescribed with caution in diseases of the nervous system and deficiency of glucose-6-phosphate dehydrogenase.

Side effects

skin rash, skin itching, Quincke's edema;
loss of appetite;
pulmonary edema, bronchospasm (with prolonged use);
nausea, vomiting;
hepatotoxic action;
neuritis (with prolonged use).

The risk of peripheral neuropathy increases with diabetes, hypovitaminosis B and C, anemia.

Furazolidone tablets, instructions for use (Method and dosage)

The drug is taken orally, after meals, as it can cause dyspeptic disorders. The tablets should be taken with a glass of water. With prolonged use, in order to prevent neuritis, they are combined with the intake of B vitamins.

Instructions for use Furazolidone

The dose for adults with paratyphoid fever, dysentery and food poisoning is 0.1 g per day 4 times a day for 5-10 days. Single dose - 0.2 g, daily - 0.8 g.

With giardiasis - 0.1 g 4 times a day for up to 7 days, a week later the same course is repeated.

With trichomonas urethritis - 0.1 g 4 times for 3 days.

With trichomonas colpitis, the dosage and frequency of administration are the same and a powder containing furazolidone and milk sugar is simultaneously injected into the vagina, suppositories containing 4-5 mg of furazolidone are injected into the rectum.

For the treatment of burns locally in the form of dressings with a solution of the drug (1:25000).

Instructions for use for children

For children, the dose is calculated per kg of body weight. It is: one-time - 0.0025 g per kg, and daily 0.01 g per kg, distributed over 3-4 doses. The course of treatment is 5-7 days.

Application in veterinary medicine

The veterinary drug is a powder yellow color, insoluble in water.

The drug is used for salmonellosis, coccidiosis, colibacillosis, enteritis, balantidiasis in animals and birds. Can also be used pharmacy drug in tablets (in one tablet 50 mg).

The dosage for these diseases is the same for chickens, for turkeys and for broilers - the drug is added to the feed at the rate of 3 mg per head 2 times a day, the treatment is carried out for 8 days. If necessary, the course of treatment is repeated, but after a break of 10 days. Prophylactically, young animals up to 10 days of age are given daily 2 mg per head once a day.

An overdose is unacceptable, because the bird develops drowsiness, lethargy, and death may occur. How to give to chickens? Better with food. Another option is to dissolve in water and give as a drink. But you need to know that the drug dissolves poorly and loses its properties when exposed to sunlight.

Overdose

Manifested by toxic hepatitis, polyneuritis and changes in the blood.

Treatment consists of discontinuing the drug, prescribing antihistamines and B vitamins, drink plenty of water.

Interaction

Aminoglycosides and tetracycline enhance its antimicrobial action.

Antidepressants, Phenylephrine, Ephedrine, MAO inhibitors, Tyramine, Amphetamine in combination with furadonin cause a significant increase in blood pressure.

Means that alkalinize urine reduce the effect of the drug.

Inhibition of hematopoiesis is enhanced when used with Chloramphenicol and Ristomycin.

Incompatible with alcohol, since this combination causes disulfiram-like reactions.

Terms of sale

Without recipe.

Storage conditions

At a temperature not exceeding 25C.

Best before date

Furazolidone for children

The instruction for children provides for the following indications for use: amoebic dysentery, salmonellosis, giardiasis.

How to give Furazolidone to children?

For children, a convenient form of release is in the form of granules, from which a suspension is prepared by adding 100 ml of water. When properly prepared, 1 ml of the suspension will contain 0.0003 g of the drug. The suspension is used 4 times a day, measuring with a measuring cup and used up to 7 years of age. A single dose is: at 1-2 years, 4-5 ml, 3-4 years, 6-7 ml, 4-5 years, 7.5-8.5 ml.

From the age of 7, children can already take pills. The dosage of tablets for children is correspondingly less than for adults. At the age of 7-14 years, a single dose of 0.03-0.05 g is recommended, daily - 0.12 g -0.15 g.

Reviews of parents testify to its effectiveness in intestinal infections.

“They took bifiform and enterofuril - nothing helped. I had diarrhea for a week, until the doctor prescribed furazolidone + linex.

“Smecta didn’t help, enterofuril did the same, in the end furazolidone helped.”

Usually, no adverse reactions were noted for a 5-day period of administration.

Furazolidone during pregnancy

The drug belongs to category C. This means that in the study of the drug in animals, an adverse effect on the fetus was noted, but there are no data on the effect on the human fetus. According to the instructions, the drug is contraindicated during pregnancy. It can be prescribed only for vital necessity, taking into account the expected and the risk to the fetus.

Furazolidone for cystitis

How effective is this drug for cystitis? Based on pharmacokinetics, its highest concentration is determined in the intestinal lumen, and hence it follows that the drug will be most effective in intestinal infections. From the group of nitrofurans, it is better to use Furadonin in the treatment of urinary tract infections, but it is more toxic.

If Furazolidone can be used as monotherapy for cystitis, then for pyelitis and pyelonephritis it is prescribed in combination with antibiotics. Derivatives of the nitrofuran series do not create therapeutic concentrations in the kidney parenchyma, so they are used only for cystitis.

Furazolidone tablets from cystitis in the usual dosages, which were mentioned above, are used in the uncomplicated course of the disease. With hemorrhagic or purulent cystitis, more serious treatment is required.

Furazolidone for diarrhea

Is this drug always indicated? And is it possible to take it immediately with any disorder of the stool? There are clear indications - shigellosis, amoebic dysentery, salmonellosis. The drugs of choice for the treatment of salmonellosis and shigellosis are fluoroquinolone drugs and furazolidone. Sometimes even with an acute intestinal infection (AII) of mild and moderate form, especially in children, treatment begins with probiotics (Bifiform, Probifor, Enterol, Bifistim) and enterosorbents (Filtrum, Neosmectin, Enterosgel). Only when severe forms or the absence of the effect of the previous treatment within 2-3 days, tablets for diarrhea Furazolidone are prescribed.

Only a doctor can prescribe how to take it for diarrhea, and in the absence of positive dynamics, it is possible to switch to “reserve” antibiotics (Imipenem, Azithromycin, Amikacin, etc.). Do not forget to take a course of probiotics after treatment.

Furazolidone's analogs

There are no analogues for the active substance. Nifuroxazide and Entprofuril nirofuran derivatives, antibiotics Rifaximin, Imipenem, Azithromycin, Amikacin, Fluoroquinolone, Ciprofloxacin have a similar effect.

Reviews about Furazolidone

The question is often asked about this drug - is it an antibiotic or not? This is not an antibiotic, but a synthetic antibacterial agent, which differs from true antibiotics by the mechanism of action on microorganisms and the effect on the human body.

What is Furazolidone tablets for? Is this drug prescribed only for diarrhea? Intestinal infections- this is the main indication for the use of the drug. In addition to Furazolidone, other intestinal antiseptics (Nifuroxazid, Rifaximin) can be prescribed for the correction of microflora, followed by the use of probiotics.

There are other indications for the use of Furazolidone, which the annotation does not indicate. For example, anti-Helicobacter therapy, including Furazolidone, is effective in the treatment of erosive and ulcerative diseases in adults. The same treatment regimen is used for children infected with Helicobacter pylori (HP). It includes De-nol, Furazolidone, Amoxicillin, Ranitidine and after treatment 100% HP eradication is achieved.

Reviews often point to side effects drug - nausea and sometimes vomiting. When taking the drug without a doctor's prescription, carefully study all contraindications and follow the recommended doses.

Furazolidone price, where to buy

The drug is available in all pharmacies in Moscow and other cities of Russia, so you do not need a prescription in Latin to purchase the drug.

The price of Furazolidone tablets 50 mg No. 20 is 119-150 rubles.

Europharm* 4% discount with promo code medside11

The drug from my drink, Furazolidone "// Explanatory video.

Furazolidone | instructions for use

Furazolidone tablets description and instructions - CLOSE-UP *

★ Furazolidone for giardiasis. Also effective against a number of bacteria and dysentery

The medicine Furazolidone is a derivative of 5-nitrofurforol of synthetic origin. Its maximum effectiveness is observed in the treatment of inflammatory diseases caused by gram-negative rods. Gram-positive cocci, protozoa and fungi are less sensitive to this agent. Anaerobic pathogens are not sensitive to the drug.

Reviews about the drug say that it also has minor immunostimulating properties, which are due to the ability of this drug to increase the phagocytic activity of leukocytes. Furazolidone causes hypersensitivity human body in relation to ethyl alcohol. For this reason, when the patient simultaneously consumes these tablets and drinks alcohol, side effects such as nausea and vomiting occur. Furazolidone and alcohol are incompatible, therefore, at the time of therapy, it is necessary to completely exclude the use of alcoholic beverages.

The development of resistance to the active substance of the drug is rather slow.

When taken internally, Furazolin quickly and almost completely dissolves in the intestine. Substance level sufficient for therapeutic effect, persists for about six hours after the dose. The agent enters the cerebrospinal fluid and there its content will be the same as in the plasma. An increased concentration of the active substance will also be observed in the intestine.

Excretion of the drug from the body is carried out by the kidneys, in most cases in its original state, sometimes in the form of metabolites.

Furazolidone: an antibiotic or not?

Most patients consider furazolidone to be an antibiotic. However, this opinion is erroneous. The medicine does not belong to antibiotics, it has a completely different effect on the body and harmful bacteria. The drug is included in the group of synthetic antibacterial drugs, resistance is not formed in relation to it.

The composition of Furazolidone and the release form

The active substance of the drug is Furazolidone. In addition, the medicine contains additional components - potato starch, sucrose, lactose and polysorbate.

The release form of the drug is tablets containing 50 mg of the active substance. This photo shows what the packaging looks like. It contains 10 tablets packed in cells. In addition, in pharmacies you can find cans of polymeric material that contain 50 tablets of furazolidone.

You do not need a prescription from a doctor to buy this medicine.

Furazolidone: what helps, indications for use

Furazolidone tablets are used for the treatment of infectious and inflammatory diseases of the skin, gastrointestinal tract, and genitourinary tract. Instructions for use, which can also be found on the official website of the manufacturer, says that the drug is prescribed if the patient has lamblia. In addition, indications for use include diseases such as enterocolitis, typhoid, bacillary dysentery, urethritis, cystitis, trichomoniasis, skin lesions and burns, stool disorder caused by infectious causes, including food poisoning.

Furazolidone: instructions for use

The attending physician will calculate the dosage and tell you how to take furazolidone.

Method of application - internal. In this case, the tablet cannot be crushed, it must be swallowed as a whole, and then washed down with plenty of water.

For the treatment of food toxic infectious diseases(dysentery, paratyphoid) daily dosage should be from 100 to 150 mg. Tablets are taken depending on the severity of the disease from 7 to 10 days.

For the treatment of Trichomonas urethritis, it is necessary to drink two tablets four times a day. The course of therapy lasts three days. The drug is taken after meals.

Furazolidone is often used for giardiasis. Experts believe that this drug helps to quickly get rid of Giardia. Adults are advised to drink two tablets of furazolidone 50 mg four times a day. For the treatment of this disease in children, the dosage of the prescribed drug will depend on body weight. It is calculated in this way: 10 mg per kilogram of weight. The daily dosage is divided into equal three parts.

For burns and infected wounds, this remedy is also prescribed. Only in this case, the application will be local, for which the affected area is either irrigated with a solution of the drug, or a wet bandage is applied.

Side effects

Such tablets belong to the category of drugs with low toxicity, but in some cases side effects are still observed, manifested in the form of a deterioration in appetite, abdominal pain, nausea and vomiting. The instructions for use indicate such possible negative effects after using the drug, such as skin rashes, allergic reactions, itching, urticaria, angioedema. To prevent undesirable consequences, the tablets used must be washed down with a sufficient amount of water. In addition, it is recommended to drink antihistamines and B vitamins during therapy.

With prolonged therapy with this drug, especially in children under 12 months, conditions such as hyperthermia, hemolytic anemia, shortness of breath, cough, neurotoxic reactions.

Furazolidone: contraindications

This drug should not be taken in the following cases:

Individual intolerance to one or more components of the drug.
Chronic renal failure in the terminal stage.
Lack of lactose.

If we consider the question of at what age furazolin can be used, then it should be noted that this is possible after the child is one month old.

During pregnancy, any medications should be used with extreme caution, be sure to evaluate such therapy on a “benefit-harm” basis. The doctor can prescribe furazolin only in situations where the benefit of the drug significantly outweighs the potential danger to the child.

The use of this medicinal product must be carried out very carefully if there is any disease of the liver or nervous system. The drug is not recommended for people whose activities require increased attention and concentration.

Interaction with other drugs

Before using any medicine, you need to find out how it interacts with other drugs in order to avoid complications. If we talk about the compatibility of furazolidone with other medicines, the following should be noted:

With the simultaneous use of furazolidone with sedative drugs, tyramines, amphetamines, as well as sleep-improving agents, an increase in blood pressure may be observed.
With alcohol-containing tinctures, blood pressure can be lowered, there is a risk of fever, as well as mental disorders.
When used in conjunction with medicines with a saturated alkaline composition, a decrease in the effectiveness of furazolidone is possible. Conversely, products containing saturated acids increase the effectiveness of this medication.

In order to prevent the occurrence side effects due to the simultaneous use of incompatible drugs, it is worth consulting a doctor before starting treatment.

Overdose

If furazolin is used in doses exceeding the dosage recommended by the instructions for use, a person may experience severe liver damage, sometimes acute hepatitis.

There are no specific antidotes. In case of an overdose, you will need to rinse the stomach and drink a sorbent or a laxative based on salt. If necessary, infusion treatment is prescribed to help restore fluid and electrolyte balance. When intoxication is very severe, hemodialysis is performed - a procedure during which toxic substances are eliminated from the body.

Furazolidone: analogues

Similar drugs that would have a similar active substance, are not currently in production.