Povidone iodine trade name. Povidone-iodine: instructions for use

Solution for external use 10% - 100 ml povidone-iodine - 10 g excipients: novoxinol 9 - 0.312 g; glycerin - 1.5 g; disodium hydrophosphate 12-hydrate - 0.32 g; citric acid - q.s.; sodium hydroxide - q.s.; demineralized water - up to 100 ml in a plastic bottle 100, 500 ml or in a 5 l canister. Vaginal suppositories - 1 supp. povidone-iodine - 200 mg excipients: macrogol 400 - 0.9 g; glycerin 85% - 0.9 g; macrogol 4000 - 1.0 g in a blister pack of 7 pcs.; in a pack of cardboard 2 packs.

Description of the dosage form

Solution for external use 10%: dark brown liquid with a characteristic odor of iodine. Foaming solution for external use 7.5%: dark brown liquid with a characteristic odor of iodine, foams when shaken. Concentrate for the preparation of a solution for external use: a dark brown liquid with a characteristic odor of iodine. Ointment 10%: dark brown ointment, homogeneous, with a characteristic odor of iodine. Suppositories: dark brown cone-shaped suppositories, homogeneous structure, with a characteristic odor of iodine.

Pharmacokinetics

When applied topically, there is practically no absorption of iodine from the skin, mucous membranes or wounds.

Pharmacodynamics

It has a wide spectrum of antimicrobial activity (gram-positive and gram-negative bacteria - with the exception of M. tuberculosis, fungi, viruses, protozoa). It has a longer effect than inorganic iodine solution. Suppositories are made on a water-soluble basis and do not irritate.

Indications for use Povidone-iodine

Solution for external use 10%: treatment and prevention of wound infections in surgery, traumatology, combustiology, dentistry; treatment of bacterial, fungal and viral infections skin, prevention of superinfection in dermatological practice; treatment of bedsores, trophic ulcers, diabetic foot; disinfection of the skin and mucous membranes of patients in preparation for surgery, invasive studies (punctures, biopsies, injections, etc.); disinfection of the skin around catheters, drains, probes; disinfection of the oral cavity during dental operations; disinfection of the birth canal during "small" gynecological operations (artificial termination of pregnancy, the introduction of an intrauterine device, coagulation of erosion or a polyp, etc.). Foaming solution for external use 7.5%: "disinfectant bath", for full or partial treatment of patients before surgery; disinfection of the skin of the hands of surgical personnel; hygienic treatment of patients; hygienic treatment of hands in contact with infected patients; processing of non-metallic instruments and patient care items. Concentrate for preparing a solution for local application: inflammatory processes in the mouth and throat; condition after surgical interventions in the mouth and throat; elimination of bad breath. Ointment: bacterial and fungal skin infections; burns; trophic ulcers, bedsores; infectious dermatitis; abrasions, wounds. Vaginal suppositories: treatment of vaginitis (mixed, non-specific); candidiasis; trichomoniasis; genital herpes; preoperative preparation.

Contraindications to the use of Povidone-iodine

hypersensitivity; adenoma thyroid gland; hyperthyroidism; dermatitis herpetiformis Dühring; CRF; simultaneous use of radioactive iodine; pregnancy; lactation; childhood(up to 8 years).

Povidone-iodine Use in pregnancy and children

Contraindicated. At the time of treatment should stop breastfeeding.

Povidone iodine side effects

When applied to a large wound surface and mucous membranes, systemic absorption of iodine may occur, which may affect tests of the functional activity of the thyroid gland, and also lead to the development of neutropenia. In some cases, with hypersensitivity to the drug, a local manifestation is possible. allergic reactions on iodine (hyperemia, burning, itching, swelling, pain), requiring discontinuation of the drug. Long-term use (more than 7-10 days) can cause the phenomenon of iodism (“metallic” taste in the mouth, increased salivation, swelling of the eyes or larynx, etc.), upon the appearance of which you should stop using the drug and consult a doctor.

drug interaction

Incompatible with other disinfectants and antiseptics, especially those containing alkalis, enzymes and mercury. Activity decreases in an acidic environment.

Dosage Povidone-iodine

locally. Undiluted 10% solution is lubricated, washed infected skin and mucous membranes. For use in drainage systems, a 10% solution is diluted 10 or 100 times. Vaginal suppositories. Intravaginally (deep). After preliminary hygienic treatment, 1 supp. (previously moistened with water): in acute vaginitis 1-2 times a day for 7 days, in chronic and subacute vaginitis - 1 time a day at bedtime for 14 days (possibly longer).

Precautionary measures

Solution 10%, foaming solution 7.5%. It is necessary to ensure that no excess solution remains under the patient. Should not be heated before use. Concentrate 8.5% for the preparation of a solution for topical use. It has a deodorizing effect - it destroys bad breath that occurs after eating, alcoholic beverages, tobacco. Solutions 10, 7.5%; concentrate 8.5%; ointment 10%. The presence of pus and blood can reduce the antimicrobial effect of the drug. At the site of application, a colored film is formed, which persists until the entire amount of active iodine is released, which means the termination of the drug. Do not use for insect bites, domestic or wild animals. All dosage forms. Coloring on skin and fabrics is easily washed off with water. Avoid getting the drug in the eyes.

Compound

Each tube (20 g) contains: active substance : iodine povidone - 2 g; Excipients: macrogol 4000, sodium hydroxide, purified water, macrogol 400.
1 gram of ointment contains povidone iodized 100 mg/g.

Description

Brown ointment with a slight smell of iodine of a homogeneous consistency.

Pharmacotherapeutic group

Dermatotropic agents. Iodine-containing antiseptic preparations.
ATX code: D08AG02.

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Pharmacological properties

Pharmacodynamics
Povidone-iodine is a complex of iodine and a polymer of polyvinylpyrrolidone, from which iodine is released for some time after application of the drug and a constant concentration of active free iodine is provided. Free iodine (I2) has a strong bactericidal effect. In research in vitro quickly destroys bacteria, viruses, fungi and some simple organisms.
In vitro most microorganisms die within less than one minute, with the greatest bactericidal effect observed during the first 15-30 seconds. Drug resistance is unknown.
Pharmacokinetics
Suction
Systemic absorption of iodine after topical application to healthy subjects is negligible.
Povidone (PVP)
Absorption and even more so renal excretion of povidone depends on its molecular weight. Since its molecular weight is in the range of 35,000 - 50,000, a delay should be expected.
Iodine
Absorption of iodized povidone or iodides is similar to absorption of iodine from other sources. Excretion is predominantly by the kidneys.

Indications for use

For local treatment of wounds or small cuts and prevention of infection in small burns;
- in complex therapy fungal or bacterial infections of the skin, infected bedsores and trophic ulcers.

Contraindications

Hypersensitivity to iodine and other components of the drug;
- contraindicated in patients with thyroid diseases: nodular, colloid, endemic goiter, Hashimoto's thyroiditis, thyrotoxicosis, thyroid adenoma;
- Duhring's dermatitis herpetiformis;
- before and after radioactive iodine therapy or scintigraphy;
- neonatal period;
- children's age up to 2 years;
- pregnancy (II-III trimester) and lactation period.

Dosage and administration

For local use only.
Dosage
The drug is used externally and topically. The ointment is applied in a thin layer, without rubbing, on the lesion. Multiplicity of application of the ointment 1-2 times a day. The duration of therapy is 7-14 days.
The affected area must be cleaned and dried in advance, before applying the ointment, since its effectiveness in the presence of various organic substances, such as blood and pus, is reduced, since they oxidize and bind active iodine.
In the treatment of infected wounds, bedsores and trophic ulcers, after applying the ointment, if necessary, you can use a gauze bandage.

Side effect

Adverse reactions are listed according to the classification of unwanted side effects in accordance with the damage to organs and organ systems and the frequency of development: very often (≥ 1/10), often (≥ 1/100 to< 1/10), нечасто (≥ 1/1000 до < 1/100), редко (≥ 1/10000 до < 1/1000), очень редко (< 1/10000), частота не известна (не могут быть оценены по доступным данным).
Violations by immune system: rarely - hypersensitivity, very rarely - anaphylactic reactions.
Endocrine disorders: very rarely - hyperthyroidism (sometimes tachycardia or anxiety), the frequency is not known - hypothyroidism.
Metabolic and nutritional disorders: frequency not known - absorption of electrolytes, metabolic acidosis.
Skin and subcutaneous tissue disorders: rarely - contact dermatitis(for example, erythema, small blisters and itching), very rarely - angioedema.
Renal and urinary tract disorders: the frequency is not known - acute renal failure, impaired osmolarity.
Injuries, intoxications and complications of procedures: the frequency is not known - chemical burns of the skin.

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Interaction with other drugs

The combined use of Povidone-iodine ointment and enzyme preparations used in the treatment of wound surfaces leads to a decrease in the effectiveness of both drugs.
Simultaneous or sequential use of medicines containing iodinated povidone and antiseptics containing octenidine may cause temporary darkening of the skin at the site of use.
Attention!
The oxidative properties of iodinated povidone may interfere with some diagnostic tests, resulting in false positive results of tests to determine urinary or fecal hemoglobin, urinary glucose levels in patients using iodinated povidone preparations. Against the background of the use of preparations containing iodinated povidone, the absorption of thyroid iodine may be reduced, which may distort the results of diagnostic studies using radioactive iodine preparations and reduce the effectiveness of thyroid iodine therapy.
Thyroid scintigraphy may be recommended no earlier than 1-2 weeks after completion of treatment with drugs containing iodinated povidone.
Pharmaceutically incompatible with disinfectants containing mercury or oxidizing agents, alkali solutions (there is an accelerated destruction of the iodine-polyvinylpyrrolidone complex).
Weakens the effect of antitumor therapy with radioactive iodine, the effect of thyreostatic drugs from the group of thioamides (thiamazole, propyl-thiouracil).
When used simultaneously with potassium iodide and amiodarone, it increases the risk of developing iodism and thyroid dysfunction.
In the presence of blood, the bactericidal effect is reduced.
It should not be used simultaneously with drugs containing the following ingredients: chlorhexidine, tannic acid, silver.

Precautionary measures

Povidone-iodine ointment is intended for topical use.
Avoid contact with eyes.
Prolonged use may cause skin irritation, rarely serious skin reactions. If localized irritation or hypersensitivity treatment should be discontinued.
Do not reheat before use. Keep out of the reach of children.
When used on large areas of the skin and when long-term treatment- for example, when treating burns or wounds - a significant amount of iodine can be absorbed and cause hyperthyroidism.
It is recommended to avoid applying the ointment to skin areas whose total area exceeds 10 percent of the body surface area and / or apply the ointment for more than 14 days.
The patient's condition should be monitored for symptoms of iodism, hyperthyroidism, thyroid function, especially in cases of using Povidone-iodine ointment on large surfaces and / or for a long time.
Use in patients with impaired liver function, chronic renal failure requires increased caution.
Povidone-iodine ointment is not recommended for use in patients receiving lithium therapy.
Prescribing Caution should be observed in persons with impaired thyroid function. The use of the ointment in this group of patients should be as limited as possible and carried out only under conditions of careful monitoring of thyroid function.
Use in pediatrics. The use of ointment in newborns and children under 2 years of age is contraindicated.
Impact on laboratory parameters.
Against the background of treatment with ointment, it is possible to obtain false results when determining the level of thyroid hormones and protein-bound iodine in the blood plasma.

Use during pregnancy and lactation

Atomic iodine and iodide ion easily penetrate the placental barrier, are excreted in breast milk and can cause the development of goiter in a child. The use of ointment during pregnancy (from the 3rd month) is contraindicated. If necessary, its use during lactation should provide for the rejection of breastfeeding for the entire period of treatment and within 1 week after its completion.

Disinfection drugs are equally necessary both in the operating room and at home for every person. A tool such as Povidone-iodine has one big advantage in that it is available in several different forms, therefore it can be used in solving various health problems.

How does it work? What is it used against? In what forms is it produced and at what price can it be purchased? - let's talk today.

pharmachologic effect

medicinal product Povidone-iodine has an antiseptic and disinfectant effect.

It is active against Gram-positive and Gram-negative bacteria.

The mechanism of action of the drug Povidone-iodine does not apply to fungi, protozoa and viruses.

Its effect lasts much longer than the effect of inorganic iodine in solution. With local use of Povidone-iodine, absorption into tissues and blood practically does not occur.

Composition and form of release

The drug Povidone-iodine is produced in different forms:

• Solution for external use with concentration active ingredient at 10 o'clock%;
• A solution for external use with the possibility of foaming with a povidone iodine content of 7.5%;
• Concentrate for preparation of solutions;
• Ointment;
• Vaginal suppositories;
• Soap.

Photos of drug release forms:

Vaginal suppositories

Solution 7.5%

active substance The drug Povidone-iodine is the component of the same name.

In various forms of production, some auxiliary components are used:

1. Novoksinol;
2. Glycerol;
3. Disodium hydrophosphate 12-hydrate;
4. Sodium hydroxide;
5. Citric acid;
6. Macrogol;
7. Demineralized water.

Indications for use

different view The drug Povidone-iodine is used for various purposes.

Contraindications

The drug Povidone-iodine can not be used in all cases.

Some diseases and temporary conditions are contraindications:

1. Intolerance to the components of the agent;
2. Neoplasm of the thyroid gland in the form of an adenoma;
3. Dermatitis Dühring herpetiform type;
4. kidney failure chronic course;
5. Combination with radioactive iodine;
6. The period of bearing a child;
7. Breast-feeding;
8. Age, under 8 years old.

Photo gallery of contraindications:

Adenoma

Dermatitis Dühring

Breast-feeding

Side effects

The drug Povidone-iodine adverse reactions causes in rare cases. Basically, they manifest themselves in the form of allergic reactions with itching, hyperemia, swelling, burning and pain.

The use of Povidone-iodine for longer than 10 days can provoke the occurrence of iodism.

This phenomenon is determined by the presence of a metallic taste in the oral cavity, excessive salivation, swelling of the periocular soft tissues or larynx.

In any of these cases, therapy or prophylaxis with the drug Povidone-iodine is canceled.

drug interaction

The drug should not be combined with antiseptics and disinfectants. Especially the restriction applies to drugs containing alkali, enzymes, mercury.

It is forbidden to use Povidone-iodine with drugs based on chlorhexidine, tannic acid and silver.

Dosage and overdose

An overdose of the drug Povidone-iodine is not known, since it is used only externally and intravaginally.

Instructions for use

The drug Povidone-iodine is mainly produced in external forms of application.

Therefore, with their help, washing, dipping or lubricating are done.

If necessary, it is possible to apply an ointment bandage with iodine, called an application. The same manipulations are carried out with a solution in the form of lotions.

Candles are applied intravaginally and are intended for deep administration.

The doctor sets the features of their treatment, but the daily dosage cannot exceed 2 pieces. The course is 7 to 14 days.

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Shelf life and storage of the drug

At temperatures up to + 25 ̊ C, the drug Povidone-iodine is suitable for use within 3 year term since production.

special instructions

Vaginal suppositories Povidone-iodine can not use during menstruation.

The price of the drug in pharmacies

The cost of the drug varies greatly depending on the form of release and the volume of the drug. The average price is about 450 rubles.

Terms of dispensing from pharmacies

The drug Povidone-iodine is released only with a prescription in Latin.

Analogs substitutes

There are several complete analogues of Povidone-iodine, whose trade name is Povidone-Iodine:

• made on the basis of povidone iodine in the form vaginal suppositories, solution and ointment. Manufacturer: EGIS Pharmaceuticals PLC (Hungary).
• created with the addition of povidone iodine and potassium iodide in the form of a solution and powder. Producer: "YuzhPharm", "Troitsky iodine plant" (Russia).
• Polyiodin available in the form of suppositories and a solution based on povidone iodine. Producer: Gifrer-Barbezat (France).
• It is made in the form of a solution with iodine, potassium iodide and alcohol. Producer: "Yaroslavl pharmaceutical factory", "Aspharma", "Samarmedprom" and many others. (Russia).

Photo analogues:

Brown ointment with a slight smell of iodine, homogeneous consistency.

Pharmacotherapeutic group

Antiseptics and disinfectants. Iodine preparations.

Povidone-iodine

ATX code D08AG02

Pharmacological properties

Pharmacokinetics

Polyvinylpyrrolidone is an iodophor that binds iodine. Upon contact with the skin or mucous membranes, iodine is released gradually and slowly. When applied topically, less than 2% of the drug is absorbed. After absorption, it enters the liver, where elimination mainly occurs, associated with the slow release of iodide ion from the complex with polyvinylpyrrolidone. The elimination half-life, determined by the time of destruction of the polyvinylpyrrolidone-iodine complex, is about 7 hours and decreases in case of contact of Povidone-iodine with the protein of necrotic tissues or pus.

Pharmacodynamics

Povidone-iodine is a polyvinylpyrrolidone-iodine coordination complex, in which the concentration of active iodine is 0.1-1%. It has an antiseptic and disinfectant effect.

The mechanism of action is associated with the slow release of atomic iodine and iodide ions from the polyvinylpyrrolidone-iodine complex, which interact with the amino groups of transmembrane transport proteins of the bacterial wall and enzyme proteins, forming iodamines. This leads to the loss of its quaternary structure by the protein and the loss of structural, transport and catalytic functions.

Povidone-iodine has a wide spectrum of antimicrobial activity. Highly active against gram-positive bacteria Streptococcus spp. (including S. mutans, S. sanguis), Staphylococcus spp. (including S. aureus), Bacillus subtillis (vegetative forms and spores), Propionibacterium acne, Clostridium spp., Gram-negative bacteria Escherichia spp., Klostridium spp., Proteus spp., Pseudomonas spp., Schigella spp., Salmonella spp. , fungi Aspergillus spp., Candida spp., Microsporum spp., Penicillum spp., Nocardia spp., Trichophyton spp., Actinomyces spp. (including A. viscosus, A. naeslundii), viruses and some protozoa.

At the site of application of Povidone-iodine, a thin colored layer of tissue is formed, which remains until all the iodine is released. Due to the presence of polyvinylpyrrolidone, active iodine is released from the drug slowly and gradually, exerting a bacterial effect on microorganisms, without irritating and cauterizing effects on tissues. In the presence of blood proteins and pus, the antimicrobial activity of Povidone-iodine is somewhat reduced.

Indications for use

Small cuts and abrasions, small superficial burns, trophic and varicose ulcers, bedsores;

As part of a combination therapy for acute and chronic bacterial and candidal infections of the skin.

Dosage and administration

The drug is used externally and topically. The ointment is applied in a thin layer, without rubbing, on the lesion. Multiplicity of application of the ointment 1-2 times a day. The duration of therapy is 7-14 days.

The affected area must be cleaned and dried in advance, before applying the ointment, since its effectiveness in the presence of various organic substances, such as blood and pus, is reduced, since they oxidize and bind active iodine.

With purulent surgical wounds and infected burns, the ointment is applied under a gauze bandage, which should be changed after the gauze has completely discolored, but not earlier than after 4 hours.

With fresh thermal and chemical burns of I-II degree, the ointment is applied in a thin layer under a gauze bandage. After complete discoloration, the dressing impregnated with ointment is changed, but not earlier than after 4 hours. Before the formation of a scab, the bottom layer of the dressing is removed.

With trophic and varicose ulcers, Povidone-iodine is used in the form of ointment dressings. The skin around the wound is washed with warm water and soap, after which it is treated with zinc ointment. Povidone-iodine is applied to the wound with a layer of 2-3 mm, after which it is loosely covered with 3 layers of gauze napkins. Dressings are performed 1-2 times a day (after discoloration of gauze napkins soaked in Povidone-iodine), while the bottom layer of the napkin is not removed from the surface of the wound, and the ointment is applied over it. After 4-7 days, a general or local bath is prescribed, after which the treatment is continued.

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Side effects

Itching, hyperemia at the application site

allergic reactions

Contact dermatitis with the formation of psoriasis-like red small bullous elements

In isolated cases:

When applied to large areas of the skin (exceeding 10% of the body area) and with a duration of treatment of more than 14 days, iodine absorption in significant quantities and the development of iodism and hyperthyroidism are possible

After the use of Povidone-iodine over large areas (for example, in the treatment of burns), cases of electrolyte imbalance (hypernatremia, impaired osmolarity and metabolic acidosis up to kidney failure in isolated cases).

Contraindications

Hypersensitivity to iodine and other components of the drug

Thyroid diseases (nodular, colloid, endemic goiter, Hashimoto's thyroiditis, thyrotoxicosis, thyroid adenoma)

Duhring's dermatitis herpetiformis

Simultaneous therapy with radioactive iodine

Children's age up to 2 years

Pregnancy (II-III trimester) and lactation.

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Drug Interactions

With simultaneous use enhances the effect of systemic antibiotic therapy.

Pharmaceutically incompatible with disinfectants containing mercury or oxidizing agents, alkali solutions (there is an accelerated destruction of the iodine-polyvinylpyrrolidone complex).

Weakens the effect of antitumor therapy with radioactive iodine, the effect of thyreostatic drugs from the group of thioamides (thiamazole, propylthiouracil).

When used simultaneously with potassium iodide and amiodarone, it increases the risk of developing iodism and thyroid dysfunction.

In the presence of blood, the bactericidal effect is reduced.

Do not use simultaneously with drugs containing the following ingredients: chlorhexidine, tannic acid, silver.

The povidone-iodine complex has antimicrobial activity in the pH range of 2-7. Interaction with proteins and other unsaturated organic substances reduces its effectiveness.

The simultaneous use of povidone-iodine ointment and enzyme ointments for the treatment of wounds reduces the effectiveness of both drugs.

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special instructions

The drug is intended exclusively for topical use. The use of the drug for a long time can cause irritation, in rare cases, severe reactions on the skin. If signs of irritation or hypersensitivity appear, the application of the drug should be discontinued. Avoid getting the drug in the eyes.

Caution in prescribing. Should be observed in persons with impaired thyroid function. The use of Povidone-iodine in this group of patients should be as limited as possible and carried out only under conditions of careful monitoring of thyroid function. Particular caution should be observed with regular use of the drug in patients with impaired liver and kidney function (previously diagnosed chronic renal failure).

In persons with impaired liver function, also use with caution. Regular use of the ointment should be avoided in patients receiving lithium preparations.

Impact on laboratory parameters. Due to the oxidizing properties of povidone-iodine, its traces in certain types of studies to detect hidden blood in the feces, as well as blood or glucose in the urine, can lead to false positive results. During the use of povidone-iodine, the uptake of iodine by the thyroid gland may decrease, which may affect the results of some diagnostic tests (for example, thyroid scintigraphy, protein-bound iodine determination, radioactive iodine measurements), and may also interact with iodine preparations used for the treatment of thyroid diseases. To obtain undistorted research results after prolonged therapy with Povidone-iodine, it is recommended to withstand a sufficiently long period of time without this drug.

Use in pediatrics. The use of Povidone-iodine in newborns and children under 2 years of age is contraindicated, because. their skin is more permeable and they are more likely to have a high sensitivity to iodine, which increases the risk of developing hyperthyroidism. Avoid accidental ingestion of the drug into the mouth and gastrointestinal tract in children.

Pregnancy and lactation. Atomic iodine and iodide ion easily cross the placental barrier, are excreted into breast milk and can cause the development of goiter in a child. The use of Povidone-iodine during pregnancy (from the 3rd month) is contraindicated. If necessary, its use during lactation should provide for the rejection of breastfeeding for the entire period of treatment and within 1 week after its completion.

Instructions for use Povidone-Iodine
Buy Povidone-Iodine solution 10% 10ml
Dosage forms
solution for external use 10%
Manufacturers
Iodine technologies and marketing (Russia)
Group
Antiseptics - halogens and halogenated
Compound
The active substance is povidone-iodine.
International generic name
Povidone-Iodine
Synonyms
Aquazan, Betadine, Brownodine B.Brown, Iodine-Ka, Iodovidone, Iodoxide, Iodosept, Polyiodine
pharmachologic effect
Antiseptic, disinfectant. It has a wide spectrum of antimicrobial activity (gram-positive and gram-negative bacteria - with the exception of M / tuberculosis, fungi, viruses, protozoa). It has a longer effect than inorganic iodine solution. Suppositories are made on a water-soluble basis and do not irritate. When applied topically, there is practically no absorption of iodine from the skin, mucous membranes or wounds.
Indications for use
Solution for external use 10%. Treatment and prevention of wound infections in surgery, traumatology, combustiology, dentistry. Treatment of bacterial, fungal and viral infections of the skin, prevention of superinfection in dermatological practice. Treatment of bedsores, trophic ulcers, diabetic foot. Disinfection of the skin and mucous membranes of patients in preparation for surgery, invasive studies (punctures, biopsies, injections, etc.). Disinfection of the skin around catheters, drains, probes. Disinfection of the oral cavity during dental operations. Disinfection of the birth canal during "small" gynecological operations (artificial termination of pregnancy, the introduction of an intrauterine device, coagulation of erosion or a polyp, etc.). Solution 7.5% for external use foaming. "Disinfectant bath", for complete or partial treatment of patients before surgery. Disinfection of the skin of the hands of surgical personnel. Hygienic treatment of patients. Hygienic treatment of hands in contact with infected patients. Treatment of non-metallic instruments and patient care items. Concentrate for preparing a solution for local use . Inflammatory processes in the mouth and throat. Condition after surgical interventions in the mouth and throat. Eliminate bad breath. Ointment: bacterial and fungal infections of the skin, burns, trophic ulcers, bedsores, infectious dermatitis, abrasions, wounds. Vaginal suppositories: treatment of vaginitis (mixed, non-specific), candidiasis, trichomoniasis, genital herpes; preoperative preparation.
Contraindications
Hypersensitivity, thyroid adenoma, hyperthyroidism, Duhring's dermatitis herpetiformis, chronic renal failure, simultaneous use of radioactive iodine, pregnancy, lactation, children under 8 years of age.
Side effect
When applied to a large wound surface and mucous membranes, systemic reabsorption of iodine may occur, which may affect tests of the functional activity of the thyroid gland, and also lead to the development of neutropenia. In some cases, with hypersensitivity to the drug, local manifestations of allergic reactions to iodine (hyperemia, burning, itching, swelling, pain) may occur, requiring drug withdrawal. Long-term use (more than 7-10 days) can cause the phenomenon of iodism ("metallic" taste in the mouth, increased salivation, swelling of the eyes or larynx, etc.), upon the appearance of which you should stop using the drug and consult a doctor.
Interaction
Incompatible with other disinfectants and antiseptics, especially those containing alkalis, enzymes and mercury. Activity decreases in an acidic environment.
Method of application and dosage
locally. Undiluted 10% solution is lubricated, washed with infected skin and mucous membranes. For use in drainage systems, a 10% solution is diluted 10 or 100 times.
Overdose
No information.
special instructions
Povidone-iodine solution should not be used in combination with other antiseptic agents, enzymatic ointments. Trial use is advisable before the systematic use of povidone-iodine preparations. In the presence of blood, the bactericidal effect of povidone-iodine may decrease. Avoid getting povidone-iodine preparations in the eyes. At the site of application, a colored film is formed, which persists until the entire amount of active iodine is released, which means the termination of the drug. Do not use for insect bites, domestic or wild animals.
Storage conditions
At a temperature of 0-25 ° C, in a place protected from light.