Human leukocyte interferon - instructions for use. Interferon human leukocyte dry ampoule N10 Interferon dry instructions for use

Human leukocyte interferon (hereinafter referred to as Interferon) is an immunomodulating agent. The last two decades have been marked by the rapid development of clinical immunology and, in particular, such a direction as immunocorrection. The immune system in the human body performs the most important function of maintaining homeostasis. It has gained particular importance in last years marked by progressive deterioration of the environmental situation, an increase in the incidence of AIDS, the consequences of the Chernobyl accident and other man-made disasters. In this regard, the human immune system is under permanent extreme stress and needs external support. Moreover, the hectic pace of life in modern megacities has increased the influence of another negative factor - chronic stress, the impact of which on the immune system is no less detrimental than ionizing radiation and viral infections. One way to strengthen the immune status is to take immunomodulating agents. Representatives of this pharmacological group capable of influencing immune cells, thereby changing the nature, severity and direction of reactions immune system. The most well-known group of drugs in the class of immunomodulators are interferons. Interferons are protective proteins produced by cells as a response to the invasion of viruses and the aggressive effects of other synthetic or natural compounds. Interferons are a tool for non-specific (non-selective, acting on any foreign agents) body defense, which can also control the interaction between cells of the immune system, which allows these compounds to be called immunomodulators. Interferons realize their action by binding to a specific cell receptor, as a result of which about thirty proteins are synthesized that provide the immunomodulatory effects of interferon. Among them are regulatory peptides that do not let the virus through the cell membrane, preventing the synthesis of new viral cells that activate T-lymphocytes and phagocytes.

Human leukocyte interferon was created in the USSR in 1967 and immediately began to be actively used in the treatment and prevention of influenza and SARS. The drug has an immunomodulatory, antiviral, antiproliferative effect. Interferon fights viruses, increasing the resistance of healthy cells to the possible penetration of the virus. By interacting with specific receptors on the cell membrane, interferon changes the properties of the latter, acts as a trigger that activates specific enzymes, and acts on viral RNA, preventing the virus from multiplying. Stimulation of the activity of phagocytes and NK (the so-called natural killers from the English. Natural killer), i.e. cells directly involved in the immune response determines the immunomodulatory activity of the drug. Interferon is available in parenteral (ampoules), rectal (suppositories) and intranasal (spray) forms. The parenteral form is intended for the treatment of type B and C hepatitis, anogenital warts, multiple myeloma, cancer. lymphatic system(non-Hodgkin's lymphoma), granuloma fungoides, kidney cancer, malignant melanoma. Rectal form - for the treatment of hepatitis of all types. Intranasal - treatment and prevention of acute respiratory viral infections, incl. flu. The specific dose of the drug and the duration of the drug course are determined by the doctor, guided by the indications, the severity clinical picture, anamnesis, the degree of the patient's response to ongoing pharmacotherapy. Side effects of interferon are characteristic, first of all, of its parenteral form. These are signs of fever, dyspeptic disorders, decreased blood pressure, violations heart rate, drowsiness, rarely - dermatological reactions. The drug should be used with extreme caution by persons who have had a recent myocardial infarction. Hydration therapy is recommended at the initial stage of treatment.

Pharmacology

Interferon alfa is a mixture of various subtypes of natural alpha interferon from human blood leukocytes. It has antiviral, immunostimulating and antiproliferative effects. The antiviral effect of the drug is based mainly on increasing the resistance of body cells not yet infected with the virus to possible effects. By binding to specific receptors on the cell surface, interferon alpha changes the properties of the cell membrane, stimulates specific enzymes, acts on the RNA of the virus and prevents its replication. The immunomodulatory effect of interferon alpha is associated with stimulation of the activity of macrophages and NK (Natural killer) cells, which, in turn, are involved in the body's immune response to tumor cells.

Release form

1 dose - ampoules (10) - packs of cardboard.

Dosage

The dose, frequency and duration of use are set depending on the indications, the severity of the disease, the route of administration, and the individual response of the patient.

Interaction

Since interferons inhibit oxidative metabolism in the liver, there may be a violation of the biotransformation of drugs metabolized in this way.

When used simultaneously with ACE inhibitors possible synergism in relation to hematotoxic action; with zidovudine - synergism in relation to myelotoxic action; with paracetamol - it is possible to increase the activity of liver enzymes; with theophylline - a decrease in the clearance of theophylline.

Side effects

With parenteral use, side effects are observed much more often than with other routes of administration.

Flu-like symptoms: fever, headache, myalgia, weakness.

From the side digestive system: loss of appetite, nausea, vomiting, diarrhea; rarely - abnormal liver function.

From the side of cardio-vascular system: arterial hypotension, arrhythmia.

From the side of the central nervous system: drowsiness, impaired consciousness, ataxia.

Dermatological reactions: rarely - slight alopecia, dry skin, erythema, skin rash.

Other: general weakness, granulocytopenia.

Indications

For parenteral use: hepatitis B and C, genital warts, hairy cell leukemia, multiple myeloma, non-Hodgkin's lymphomas, mycosis fungoides, Kaposi's sarcoma in patients with AIDS without a history acute infections; renal carcinoma; malignant melanoma.

For rectal application: treatment of acute and chronic viral hepatitis.

For intranasal use: prevention and treatment of influenza, SARS.

Contraindications

Severe organic heart disease, severe violations of the liver or kidneys; epilepsy and / or dysfunction of the central nervous system; chronic hepatitis and cirrhosis of the liver with symptoms of liver failure; chronic hepatitis in patients receiving or recently treated with immunosuppressants (with the exception of treatment with corticosteroids); autoimmune hepatitis; diseases thyroid gland resistant to traditional therapy; confirmed hypersensitivity to interferon alfa.

Application features

Use during pregnancy and lactation

The use of interferon alfa preparations during pregnancy is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, use in a nursing mother during lactation should decide on the termination of breastfeeding.

Patients of reproductive age during therapy should use reliable methods of contraception.

Application for violations of liver function

Application for violations of kidney function

Use in elderly patients

special instructions

Use with caution in patients with a history of recent myocardial infarction, as well as in cases of changes in blood clotting and myelodepression.

In thrombocytopenia with a platelet count of less than 50,000 / µl, s / c should be used.

With the development side effects from the side of the central nervous system in elderly patients receiving interferon alfa in high doses, a thorough examination should be carried out and, if necessary, treatment should be interrupted.

Patients should undergo hydration therapy, especially in the initial period of treatment.

Patients with hepatitis C receiving systemic interferon alfa therapy may experience thyroid dysfunction, manifested as hypo- or hyperthyroidism. Therefore, before starting a course of treatment, it is necessary to determine TSH level in the blood serum and start treatment only if the content of TSH in the blood is normal.

Use interferon alfa with caution simultaneously with hypnotics, sedatives, opioid analgesics.

Currently, pharmacology offers doctors and their patients a huge choice. medical preparations. Among them, the most popular are painkillers and antipyretics. Also in recent years, doctors often prescribe immunomodulatory compounds. "Human leukocyte interferon" is one of the subspecies of such drugs. It is about him that will be discussed in this article. You will learn how "Human Leukocyte Interferon" (dry) is applied. Also find out the cost of this tool.

The drug "Human leukocyte interferon": description and composition

This tool is immunomodulatory and immunostimulating. In addition, the drug has antitumor activity. The composition of the drug includes This is the so-called group of proteins that are produced by the donor's blood leukocytes. It is this substance that allows the body to fight many pathologies.

Indications: in what cases is the medicine used?

Who needs the drug "Human leukocyte interferon"? The remedy is prescribed to people of different sexes and ages with the following pathologies:

• malignant and benign tumors in the body;
• viral diseases;
• respiratory infections;
• bacterial pathologies of different departments and organs;
• liver and kidney disease (including hepatitis);
• state of immunodeficiency;
• diseases of the eyes and mucous membranes;
• fungal infections;
• as a prevention of various diseases.

In addition, the drug "Human leukocyte interferon" is used in complex therapy. In this case, the indications may not be described in the instructions. In this case, recommendations are given by a specialist individually to each patient.

Contraindications: when should you stop using the medicine?

Can everyone use Human Leukocyte Interferon? The instruction indicates the following contraindications:

• increased sensitivity and the possibility of developing an allergic reaction to interferon;
• exacerbation of pathologies of the liver and kidneys;
• severe heart and vascular disease;
• epilepsy and disorders of the nervous system;
• the period of pregnancy and subsequent breastfeeding (in some cases).

How does the drug affect the patient's body?

Means "Interferon human leukocyte" (liquid) begins its action immediately after entering the human body. The drug increases immune defense, affects the pathological cells of viruses and bacteria. In some cases, interferon alpha human contributes to a slight increase in body temperature. This is a completely normal reaction. Some pathological microorganisms die only when the thermometer crosses the mark of 37 degrees.

Depending on the form of the drug and its dosage, the effect of treatment may occur at different times. So, to speed up the action, it is recommended to use liquid types of medication.

"Human leukocyte interferon" (dry): instructions for use, dosage

How is the medicine used? Before using the drug, it must be prepared. To do this is quite simple. You won't need any special equipment. Be sure to read the instructions before use. The remedy can be applied intramuscular way, intravenously. Often, doctors recommend inhalation with a prepared solution. The medicine "Interferon human leukocyte" for children is used by the intranasal method.

For the treatment of colds, viral and bacterial infections of the respiratory tract

The medicine is dissolved in two milliliters clean water and injected into each nasal passage. On the first day of use, the recommended dose is one to three drops per nostril every two hours. On the following day, the solution is administered in a similar way, however, the intake is divided into three to five doses.

For the correction of eye diseases

The drug is diluted in one milliliter of water and instilled into the lower one up to 10 times a day. Treatment can last from two days to several weeks, respectively.

For malignant and benign tumors, immunodeficiency states

The medicine is administered intramuscularly or intravenously. For intramuscular injection, it is diluted with water for injection. The composition is injected into the muscle area or subcutaneously. In this case, an individual dosage and treatment regimen is selected depending on the symptoms. For intravenous administration the drug is diluted with a solution of sodium chloride.

Adverse reactions

In most cases, the drug "Interferon human leukocyte" reviews are positive. However, medicine is aware of cases of occurrence adverse reactions for such a correction. Most often they occur due to an incorrectly selected treatment regimen. This is exactly what happens in the case of self-administration of the drug. The reactions to the drug include the following:

• disorders of the digestive system (diarrhea, diarrhea, flatulence, nausea, and so on);
• malfunctions of the liver and circulatory system;
• drowsiness or overexcitation;
• rash and pruritus.

If at least one of the listed signs appears after using the medicine, you should stop taking the remedy as soon as possible and consult a doctor.

Medicine price

How much does this immunomodulatory agent cost? Much depends on the region in which the medicine is bought. Dry powder for the preparation of the composition is packaged in separate glass ampoules. One pack contains 10 such ampoules.

The price of a package of "Human leukocyte Interferon" ranges from 60 to 100 rubles. It is worth noting that the already prepared compositions are different trade names, and also have a higher cost, for example:

• "Grippferon" (drops in the nose): from 250 to 400 rubles;
• "Viferon" (rectal suppositories): from 150 to 300 rubles.

Special instructions for the use of the product

The liquid solution must be prepared immediately before each use. It is not recommended to store an open ampoule for more than eight hours. The drug in dry form must be kept in the refrigerator.

The tool goes well with other antiviral, antibacterial and antifungal medicines. That is why it is often used in the complex therapy of pathologies.

During the period of treatment, care should be taken when driving vehicles and engaging in other activities that require increased concentration.

Summarizing

You now know all about the drug called Human Leukocyte Interferon. Despite its safety, the drug is not recommended for independent use without consulting a doctor. The tool is an excellent cure for many ailments. It does not suppress your own immunity. That is why it is widely used in pediatrics.

The drug is sold without a doctor's prescription. In each pharmacy network you can find this medication or its analogues. Remember that you need to treat the disease on time and correctly. Use the services of doctors and be healthy!

human leukocyte interferon

International non-proprietary name

Interferonalfa

Dosage form

Lyophilizate for solution for intranasal administration 1000 IU

Compound

One ampoule contains

aactive substance - interferon human leukocyte α-type with antiviral activity of at least 1000 IU

Description

Porous amorphous mass or powder of white or light yellow to pink color. Hygroscopic.

Pharmacotherapeutic group

Immunomodulators. Immunostimulants. Interferons. Interferon alpha natural.

ATX code L03AB01

Pharmacological properties

Pharmacokinetic studies have not been conducted.

Pharmacodynamics

Human leukocyte interferon (Interferon alfa), lyophilisate for solution for intranasal administration, is a group of proteins synthesized by leukocytes of donor blood in response to exposure to the interferon inducer virus.

Interferon alpha has the ability to stimulate the phagocytic activity of macrophages, as well as the cytotoxic activity of T cells and "natural killers", has an indirect antiviral effect, inducing a state of resistance to viral infections in cells and modulating the immune system response aimed at neutralizing viruses or destroying those infected by them. cells.

The preparation does not contain antibodies to human immunodeficiency viruses (HIV-1, HIV-2), hepatitis C virus and hepatitis B surface antigen (HBsAg).

Indications for use

Prevention and treatment of influenza and other acute respiratory viral infections

Dosage and administration

For the purpose of prevention

The introduction of the drug should begin with an immediate threat of infection and continue as long as the risk of infection persists. The drug is administered to adults and children from birth in the same dose by spraying or instilling an aqueous solution into the nose.

The ampoule with the drug is opened immediately before use. Sterile distilled or cooled boiled water is added to the ampoule up to the line corresponding to 2 ml, gently shaken until the contents are completely dissolved. The dissolved drug is a clear or slightly opalescent liquid, colorless or from light yellow to pink. The dissolved drug can be stored during the day at a temperature of 2 ° C to 8 ° C.

Spraying can be done with sprayers of any system in accordance with the instructions attached to them. In each nasal passage, 0.25 ml of the solution should be injected twice a day with an interval of at least 6 hours. When instilled, the drug is administered 5 drops into each nasal passage 2 times a day with an interval of at least 6 hours.

FROMgoal of treatment

The drug is used in the same dose for adults and children from birth by spraying or instillation into the nose.

When sprayed or instilled, the drug is dissolved in 2 ml of water and injected 0.25 ml (5 drops) into each nasal passage after 1-2 hours at least 5 times a day for 2-3 days.

Side effects

During the use of the drug side effects are not registered.

Contraindications

Hypersensitivity to interferon preparations

Drug Interactions

Can be used simultaneously with other antiviral preparations local application and congestants.

special instructions

The introduction of the drug by injection is strictly prohibited!

Use with caution in people with allergic diseases.

At allergic reactions immediate type carry out symptomatic therapy.

Application in pediatrics

For children from the neonatal period (from birth), the drug is used by spraying or instillation.

Pregnancy and lactation

AT modern world a person is susceptible to many diseases. Especially often a person is sick with a cold or flu. Specialized drops allow them to be cured easily and effectively.

However, with more serious illnesses, such as warty formations on the skin, malignant blood diseases, herpes diseases in AIDS patients, really serious drug treatment is necessary.

One of the effective drug, designed to fight various kinds of viruses and strengthen the immune system of immunity - "Interferon". The drug has a wide range of effects, which allows it to be used both for the prevention of diseases and for the treatment of a large number of diseases.

"Interferon" dry in ampoules was first released in 1957. Then the professors found out that this medicine eliminates foci of the virus and does not allow influenza infections to multiply.

Today, dry "Interferon" is sold in white or yellow ampoules. AT compound medicines include donated leukocytes, presented as a mixture of proteins.

Using the drug, the body instantly assimilates the necessary elements. After that, the elimination of viruses begins.

Among side effects note:

• skin diseases;
• nausea;
• headache;
• shiver.

Among contraindications note:

• individual intolerance;
• violation of the functioning of the human immune system;
• the agent can begin to be perceived as the body's own tissues;
• acute form coronary disease hearts;
• partial loss of kidney function.

If you take the medicine for a long time, monitor the composition of the blood and the functioning of the liver.

In what cases is it possible to use "Interferon"

For prevention:

• flu and colds;
• chronic hepatitis C;
• chronic hepatitis B;
• at viral infection in which a person is affected by fever and intoxication;
• oncopathologies, including AIDS patients.

In the following diseases, the medicine should be used during treatment:

• wart-like formations on the mucous membranes and skin in the genital area;
• plasma cell cancer;
• with skin cancer;
• Kaposi's sarcoma (in patients with AIDS);
• leukemia with leukocytes with hair-like outgrowths;
• defeat bone marrow person;
• tumors in the kidneys and bladder;
• the formation of multiple papillomas on the mucous membrane of the larynx;
• a significant increase in platelets in the blood;
• malignant tumor of the reticular tissue.

It should be noted that Interferon should start using at the first appearance of the threat of the disease. Thus, you will more effectively destroy the source of inflammation and recover faster.

"Interferon" dry - instructions for use

Usually "Interferon" is prescribed for the most early stages diseases. If you notice the first symptoms of a cold or flu, get this medicine.

The dosage of the drug for children and adults is identical.

It should be applied by instillation into the nose by inhalation or spraying. When spraying, inject 0.25 ml solution.

Open the ampoule a second before use!

For instillation into the nostrils, you must add purified water up to symbolism in 2 ml to the powder in the ampoule.

Use the medicine six drops in each nostril. It is worth knowing that the interval between uses should be approx. seven o'clock.

The duration of the course should not exceed five days.

The use of the drug is prohibited in diseases of the thyroid gland. If you have impaired liver and kidney function, the use of the drug is dangerous to health.

The use of medicine for children under two years of age is allowed only after consulting a doctor.

Conclusion

In the cold season, a person is prone to colds much more often than in summer. According to experts, the best treatment diseases is the maintenance of immunity throughout the year.

In cases of a weakened immune system and for prevention, use Interferon. It is like a barrier to protect you from viruses and various infections.

Use the drug only with the permission of your doctor. Keep track of the expiration date of the medication.

Do not use the medicine if the package seal is broken.

Human leukocyte interferon is an immunomodulatory drug with antiviral, antitumor and antiproliferative effects.

Release form and composition

Dosage forms of Interferon:

• Solution for local and inhalation use 1000 IU / 1 ml (2 ml in ampoules, 5 and 10 ampoules in a carton box; 2 ml in vials, 1, 5 or 10 vials in a package; in 5 ml dropper bottles , 1 per pack);
• Lyophilizate for the preparation of a solution for intranasal and inhalation use 1000 IU (1 dose in an ampoule, 5 or 10 ampoules in a carton box);
• Lyophilisate for solution for intramuscular injection 10,000 IU / 1 dose (in ampoules, 5 or 10 ampoules in a box, complete with a solvent);
• Rectal suppositories 40,000 ME (10 per pack).

The active substance of the drug is interferon alfa.

Indications for use

Parenterally Interferon human leukocyte is prescribed for:

• Hepatitis B and C;
• multiple myeloma;
• Genital warts;
• Fungal mycosis;
• hairy cell leukemia;
• non-Hodgkin's lymphomas;
• malignant melanoma;
• renal carcinoma;
• Kaposi's sarcoma in AIDS patients without a history of acute infections.

Rectally Interferon is used for acute and chronic viral hepatitis.

Intranasal and inhalation drug is prescribed for the prevention and treatment of acute respiratory viral infections and influenza.

Contraindications

Human leukocyte interferon is contraindicated in:

• Severe impaired renal / liver function;
• Severe organic heart disease;
• Chronic hepatitis and cirrhosis of the liver with symptoms of liver failure;
• Epilepsy and dysfunction of the central nervous system;
• autoimmune hepatitis;
• Thyroid diseases that are not amenable to traditional methods of therapy;
• Chronic hepatitis in patients who have recently received or are currently receiving immunosuppressants (with the exception of GCS);
• Known hypersensitivity to interferon alfa.

During pregnancy, the drug can be used only if the benefit to the woman outweighs the possible risks to the fetus.

If necessary, treatment during lactation breast-feeding should be stopped.

Special observation during the period of Interferon use is necessary for the elderly, patients with a history of myocardial infarction, as well as for myelodepression and changes in blood clotting.

With caution, the drug is used simultaneously with opioid analgesics, sedatives and hypnotics.

Method of application and dosage

Doses and duration of treatment, especially with parenteral administration, are set by the doctor individually for each patient, taking into account the indications, the severity of the course of the disease, the method of application and the reaction of the body.

Average daily doses for i / m administration, depending on the indications:

• Hairy cell leukemia: 3 million IU for 16-24 weeks, then 3 million IU three times a week;
• Cutaneous T-cell lymphoma: the first 3 days - 3 million IU, the next 3 days - 9 million IU, from 7 to 84 days - 18 million IU. With maintenance therapy, the maximum tolerated dose is prescribed, but not more than 18 million IU three times a week;
• Kaposi's sarcoma in patients with AIDS: the first 3 days - 3 million IU, the next 3 days - 9 million IU, from 7 to 9 days - 18 million IU, with good tolerance from 10 to 84 days - 36 million .ME. With maintenance therapy, the maximum tolerated dose is prescribed, but not more than 36 million IU three times a week;
• Renal cell carcinoma: in the case of monotherapy - 36 million IU, in combination with vinblastine - 18 million IU three times a week. The dose is increased gradually, treatment begins with 3 million IU. The course of treatment - 84 days;
• Melanoma: 18 million IU three times a week for 8-12 weeks;
• Chronic myeloid leukemia and thrombocytosis in chronic myeloid leukemia: the first 3 days - 3 million IU each, the next 3 days - 6 million IU each, from 7 to 84 days - 9 million IU each. The general course of treatment is 8-12 weeks;
• Thrombocytosis in myeloproliferative diseases (with the exception of chronic myeloid leukemia): the first 3 days - 3 million IU each, from day 4 to 30 - 6 million IU each;
• Chronic hepatitis C: for 3 months - 6 million IU three times a week, for another 3 months - 3 million IU three times a week;
• Chronic active hepatitis B: 4.5 million IU three times a week. Duration of treatment - 6 months;
• Primary and secondary thrombocytosis: 2 million IU 5 times a week for 4-5 weeks. If after 2 weeks the number of platelets does not decrease, the daily dose is increased to 3 million IU, if there is no effect by the end of the third week of treatment - up to 6 million IU;
• Initial thrombocytopenia (less than 15 G/l): 0.5 million IU;
• Transitional phase of chronic granulocytic leukemia and myelofibrosis: 1-3 million IU;
• Multiple myeloma: 1 million IU every other day in combination with corticosteroids and cytostatics. The minimum course of treatment is 2 months.

In acute and chronic viral hepatitis, as a rule, 1 suppository per day is prescribed. The course of treatment is 10 days.

For influenza and SARS, a solution is prepared from the lyophilisate using distilled or boiled water at room temperature: it is poured directly into the ampoule to the mark corresponding to 2 ml, then shaken well until the powder is completely dissolved. The contents of the ampoule with the finished solution is also diluted with 2 ml of water.

For the prevention of influenza and SARS, it is recommended to start using Interferon when there is a threat of infection and continue therapy until the risk of infection persists. The drug is instilled into each nasal passage 5 drops (or sprayed 0.25 ml) twice a day with a minimum interval of 6 hours.

FROM therapeutic purpose Human leukocyte interferon should be started when the first signs of a "cold" appear. The solution is instilled 5 drops into each nasal passage at least 5 times a day at intervals of 1-2 hours for 2-3 days.

Another effective method application - inhalation (through the mouth or nose). For one inhalation, the contents of 3 ampoules are dissolved in 10 ml of water, slightly warmed up (to a maximum temperature of 37 ºС), procedures are carried out 2 times a day.

Side effects

Possible side effects of human leukocyte Interferon:

• Flu-like symptoms: weakness, headache, fever, myalgia;
• From the side of the central nervous system: ataxia, impaired consciousness, drowsiness, nervousness, depression, sleep disturbances;
• From the side of the cardiovascular system: arrhythmia, arterial hypotension;
• From the gastrointestinal tract: loss of appetite, heartburn, diarrhea, nausea, vomiting, abnormal liver function;
• Dermatological reactions: dry skin, skin rash, slight alopecia, erythema;
• On the part of the hematopoietic organs: granulocytopenia;
• Other: joint pain, sweating, weight loss, visual disturbances.

Most often, adverse reactions are observed with parenteral use.

special instructions

The earlier the use of Interferon for influenza and SARS, the higher the effectiveness of the drug.

If the number of platelets in thrombocytopenia is less than 50 thousand / μl, the drug is administered subcutaneously.

With the development of side effects from the central nervous system in elderly people receiving high doses of interferon alfa, an additional examination is carried out. In some cases, treatment has to be interrupted.

During the period of use of the drug, it is necessary to ensure sufficient fluid intake into the body, especially at the beginning of treatment, to control liver function and the content of blood cells. Patients of childbearing age are advised to use reliable methods of contraception.

Before treating hepatitis C, the level of TSH in the blood serum should be determined, Interferon can be prescribed only in the case of a normal indicator.

In case of flu-like symptoms, paracetamol is prescribed.

Interferons inhibit oxidative metabolism in the liver, therefore, the biotransformation of drugs metabolized in this way may be impaired.

With the simultaneous use medicinal product with zidovudine, synergism is possible in relation to myelotoxic action, with ACE inhibitors - synergism of hematotoxic action, with theophylline - a decrease in its clearance, with paracetamol - an increase in the activity of liver enzymes.

Analogues

Alfaferon, Wellferon, Interferon alfa-2b human recombinant, Interferon alfa-2 recombinant hydrogel-based ointment, Inferon, Lokferon.

Terms and conditions of storage

Store at 2-10 ºC. Keep away from children!

Shelf life - 2 years. The solution prepared from the lyophilisate can be stored for no more than 2 days in the refrigerator.

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