What is better irifrin or bk. Eye drops "Irifrin bk" for children

In ophthalmology, Irifrin BK eye drops have established themselves as a highly effective remedy with a wide spectrum of action and a considerable list of contraindications with serious side effects. The medicine is designed to improve the outflow of fluid from the eye, narrow the vascular walls and dilate the pupils. But Irifirin BK will also be useful for children, because it helps them recover from myopia or hyperopia. The abbreviation "BK" indicates that there are no preservatives in the structure of the drops, and this, in turn, reduces the risk of developing allergic reactions and irritation.

Composition and medicinal properties

Manufacturers sell "Irifrin BK" in the form of a solution that is colorless or has a yellowish tint. It is poured into special bottles equipped with a dropper for more convenient drop-by-drop administration of the drug. The main component in the composition of "Irifrina BK" is phenylephrine, and it is supplemented by such auxiliary ingredients as:

• trilon B;
• injection water;
• food additive E223, E330;
• hypromellose;
• sodium salt of citric acid.

Irifrin BK has a strong vasoconstrictive effect and, when applied topically, acts on the vessels of the affected visual organ with virtually no systemic impact.

The drug helps fight high blood pressure inside the visual organ.

After instillation, the ophthalmic solution is quickly absorbed by the mucosa and in the first minutes provokes a narrowing vascular walls. As a result, a person ceases to feel overwork or irritation of the eye, redness disappears and the pupil expands. At the same time, the drug activates the process of fluid discharge, thereby reducing intraocular pressure.

Indications

"Irifrin BK" is designed to treat the following pathological conditions:

• inflammation of the iris and ciliary body eyeball;
• spasm of accommodation;
• red eye syndrome;
• glaucoma crisis;
• progressive muscle atrophy.

In addition, it is advisable to use eye preparation persons who are to surgical intervention or you need to test for angle-closure glaucoma. "Irifrin BK" is also needed for diagnostics, which allows to identify infections of the eyeball, and it is also used before a visual examination of the fundus.

Restrictions on use

Premature babies are not prescribed this drug.

Not everyone is allowed to drip "Irifirin BK". A drug for the eyes is contraindicated in premature babies and those under the age of 12, and it is also not recommended for people who have been diagnosed with pathologies such as:

• individual intolerance to the components of the medication;
• violation of the normal content of porphins in the liver;
• hyperfunction thyroid gland;
• congenital G6PD.

The drug will be dangerous for older people who have serious impairments in work of cardio-vascular system. You can not use it as an additional expansion of the pupil during operations for patients with impaired tear fluid production and the integrity of the eyeball. You can use "Irifrin BK" according to indications, but special care will be required for patients who have been diagnosed with type 2 diabetes mellitus or who are being treated with MAO inhibitors. One drop of the drug is enough to prepare the patient for ophthalmoscopy.

Thus, if ophthalmoscopy is to be carried out, then the solution is administered 1 drop half an hour before the start of the study. If necessary, the procedure is repeated twice with an interval of 1 hour. An ophthalmic preparation without preservatives is actively used to eliminate accommodation spasm by instilling the medicine 1 drop daily for a month. For the treatment of glaucoma crisis and iridocyclitis - in the same dosage, but three times a day.

Instructions for use Irifrin BK
Buy Irifrin BK eye drops 2.5% 0.4ml
Dosage forms
eye drops 2.5%
Manufacturers
Promed Exports Pvt.Ltd (India)
Group
Drugs that stimulate alpha-adrenergic receptors
Compound
Active ingredient: phenylephrine hydrochloride - 25 mg.
International non-proprietary name
Phenylephrine
Synonyms
Irifrin, Mezaton, Nazol Baby, Nazol Kids, Neosynephrine-Pos
pharmachologic effect
Pharmacodynamics. Phenylephrine is a sympathomimetic. It has a pronounced alpha-adrenergic activity. At topical application in ophthalmology causes pupil dilation, improves the outflow of intraocular fluid and constricts the vessels of the conjunctiva. Phenylephrine has a pronounced stimulating effect on postsynaptic alpha-adrenergic receptors, has a very weak effect on beta-adrenergic receptors of the heart. The drug has a vasoconstrictor effect similar to the action of norepinephrine (norepinephrine), while it has practically no chronotropic and inotropic effects on the heart. The vasopressor effect of phenylephrine is weaker than that of norepinephrine, but is longer lasting. Causes vasoconstriction 30-90 seconds after instillation, duration 2-6 hours. After instillation, phenylephrine contracts the pupillary dilator and smooth muscle of the conjunctival arterioles, thereby causing pupillary dilation. Mydriasis occurs within 10-60 minutes after a single instillation. Continues after injection of a 2.5% solution and persists for 2 hours. Mydriasis caused by phenylephrine is not accompanied by cycloplegia. Pharmacokinetics. Phenylephrine easily penetrates into the tissues of the eye, the peak plasma concentration occurs 10-20 minutes after topical application. Phenylephrine is excreted by the kidneys unchanged ( Indications for use
Iridocyclitis (to prevent the occurrence of posterior synechia and reduce exudation from the iris). Pupil dilation during ophthalmoscopy and other diagnostic procedures necessary to control the state of the posterior segment of the eye, during laser interventions on the fundus and vitreoretinal surgery. Conducting a provocative test in patients with a narrow anterior chamber angle profile and suspected angle-closure glaucoma. Differential diagnosis of superficial and deep injection of the eyeball. Red eye syndrome (to reduce hyperemia and irritation of the mucous membrane of the eye). Prevention of asthenopia and spasm of accommodation in patients with high visual load. Treatment of false myopia (accommodation spasm) and prevention of the progression of true myopia in patients with high visual load.
Contraindications
Hypersensitivity to the components of the drug. Narrow-angle or closed-angle glaucoma. arterial hypertension in combination with ischemic heart disease, aortic aneurysm, atrioventricular block I-III degree, arrhythmia. Tachycardia. Type I diabetes mellitus in anamnesis. Constant use of monoamine oxidase inhibitors, tricyclic antidepressants, antihypertensive drugs. Additional expansion of the pupil during surgical operations in patients with violation of the integrity of the eyeball, as well as in violation of tear production. Reduced body weight in newborns. Hyperthyroidism. Hepatic porphyria. Congenital deficiency of glucose-6-phosphate dehydrogenase. breastfeeding period.
Side effect
Local. Conjunctivitis, keratitis, periorbital edema, eye pain, burning during instillation, lacrimation, blurred vision, irritation, discomfort, increased intraocular pressure, blockage of the anterior chamber angle (with narrowing of the angle), allergic reactions, reactive hyperemia. Phenylephrine may cause reactive miosis the day after application. Repeated instillations of the drug at this time may give less pronounced mydriasis than the day before. This effect is more common in older patients. Due to a significant reduction in the pupil dilator under the influence of phenylephrine, 30-45 minutes after instillation, particles of pigment from the pigment sheet of the iris can be detected in the moisture of the anterior chamber of the eye. Suspension in the chamber moisture must be differentiated with manifestations of anterior uveitis or with the ingress of blood cells into the moisture of the anterior chamber. Systemic. contact dermatitis. From the side of the cardiovascular system. Palpitations, tachycardia, arrhythmia, increased blood pressure, ventricular arrhythmia, reflex bradycardia, occlusion coronary arteries, embolism pulmonary artery.
Interaction
The mydriatic effect of phenylephrine is enhanced when used in combination with topical atropine. Due to increased vasopressor action, tachycardia may develop. The use of the drug within 21 days after stopping the intake of patients with monoamine oxidase inhibitors and tricyclic antidepressants should be carried out with caution, since in this case there is the possibility of an uncontrolled rise in blood pressure. The vasopressor action of adrenergic agents can also be potentiated when used together with tricyclic antidepressants, beta-blockers, reserpine, guanethidine, methyldopa and m-anticholinergics. The drug can potentiate the oppression of cardiovascular activity during inhalation anesthesia as a result of an increase in the sensitivity of the myocardium to sympathomimetics and the occurrence of ventricular fibrillation. The use in conjunction with other sympathomimetics may increase the cardiovascular effects of phenylephrine. The use of phenylephrine can cause a weakening of concomitant antihypertensive therapy and lead to an increase in blood pressure, tachycardia. Pre-Installation local anesthetics may increase systemic absorption and prolong mydriasis.
Method of application and dosage
When conducting ophthalmoscopy, single instillations of a 2.5% solution of the drug are used. As a rule, to create mydriasis, it is enough to introduce 1 drop of a 2.5% solution of the drug into the conjunctival sac. The maximum mydriasis is reached in 15-30 minutes and remains at a sufficient level for 1-3 hours. If it is necessary to maintain mydriasis for a long time, after 1 hour it is possible to re-instill the drug. For diagnostic procedures: as a provocative test in patients with a narrow anterior chamber angle profile and suspected angle-closure glaucoma, 1 drop of the drug is instilled once. If the difference between the values ​​of intraocular pressure before instillation of the drug and after pupil dilation is from 3 to 5 mm Hg. Art., then the provocative test is considered positive; for differential diagnosis type of injection of the eyeball, 1 drop of the drug is instilled once: if 5 minutes after instillation, narrowing of the vessels of the eyeball is noted, then the injection is classified as superficial, while maintaining redness of the eye, it is necessary to carefully examine the patient for the presence of iridocyclitis or scleritis, as this indicates a deeper expansion lying vessels. In iridocyclitis, to prevent the development and rupture of already formed posterior synechiae and to reduce exudation into the anterior chamber of the eye, 1 drop of the drug is instilled into the conjunctival sac of the diseased eye 2-3 times a day for 5-10 days, depending on the severity of the disease. In schoolchildren with myopia low degree for the prevention of spasm of accommodation during a period of high visual load, 1 drop of the drug is instilled in the evening before bedtime, with progressive myopia medium degree 3 times a week in the evening before bedtime, with emmetropia - in the daytime, depending on the load. In case of hypermetropia with a tendency to spasm of accommodation with high visual load, the drug is instilled in the evening in combination with a 1% solution of cyclopentolate. With normal visual load, the drug is instilled 3 times a week in the evening before bedtime. In the treatment of false and true myopia, 1 drop of the drug is instilled in the evening before bedtime 2-3 times a week for a month.
Overdose
Overdose symptoms are restlessness, nervousness, dizziness, sweating, vomiting, rapid heartbeat, weak or shallow breathing. If a systemic effect of phenylephrine occurs, adverse effects can be stopped by using alpha-adrenergic blocking agents, for example, from 5 to 10 mg of phentolamine intravenously. If necessary, the injection can be repeated.
special instructions
Carefully. In patients with diabetes Type II - increased risk of high blood pressure. In elderly patients, an increased risk of reactive miosis. Exceeding the recommended dose of a 2.5% solution in patients with injuries, diseases of the eye or its appendages, in postoperative period, or with reduced tear production can lead to increased absorption of phenylephrine and the development of systemic side effects. Due to the fact that it causes conjunctival hypoxia - in patients with sickle cell anemia, when wearing contact lenses, after surgical interventions (decreased healing). With cerebral atherosclerosis, long-term bronchial asthma. Pregnancy and lactation. In animals on later dates Pregnancy phenylephrine caused fetal growth retardation and stimulated the early onset of labor. The effect of the drug in pregnant women has not been sufficiently studied, therefore, the drug should be used in this category of patients only if the expected benefit to the mother outweighs the risk of possible side effects for the fetus. If the drug is prescribed during lactation, breastfeeding should be discontinued.
Storage conditions
Do not freeze. Store in a place protected from light, out of the reach of children, at a temperature not exceeding 25 C.

Irifrin BK: instructions for use and reviews

Latin name: Irifrin
ATX code: S01FB01
Active substance: Phenylephrine
Manufacturer: Promed Exports, India
Vacation from the pharmacy: On prescription
Storage conditions: t up to 25 C
Best before date: 2 years.

Eye drops Irifrin - a drug with α-adrenomimetic activity, is prescribed for the treatment and prevention of ophthalmic pathologies.

Indications for use

Not everyone knows what these eye drops are used for. The use of Irifrin is indicated for:

• The rapid development of iridocyclitis (in order to prevent the formation of posterior blues, as well as reduce exudation directly from the iris)
• Diagnosis of ophthalmic pathologies, in which there is a need for a pupil dilation procedure, for complete examination posterior part of the eye
• Provacation test with a narrow angle of the anterior eye chamber and in the case of diagnosing angle-closure glaucoma
• Conducting a comprehensive differential examination and deep injection
• Pupil dilation during eye fundus surgery using a laser
• Elimination of glaucoma-cyclic crises
• Surgical treatment of pathologies of the retina and vitreous body
• Relief of the so-called red eye syndrome ( medical therapy aimed at eliminating redness and irritation).

It is possible to prescribe Irifrin to children from the age of twelve.

Composition and forms of release

Irifrin eye drops differ in dosage.

Irifrin BK drops (1 ml) include the only component represented by phenylephrine in the form of hydrochloride, its amount in the ophthalmic agent is 25 mg. Also as part of Irifirin BK eye drops includes:

• Hypromellose
• Edetate disodium
• Citric acid
• Prepared water.

The drug Irifrin contains the same active ingredient as in Irifrin BK, its amount in drops is 100 mg.

List of other components:

• Sodium Hydroxide and Hydrophosphate Dihydrate
• Anhydrous sodium dihydrogen phosphate
• Edetate disodium
• Metabisulphite and sodium citrate dihydrate
• Benzalkonium chloride
• citric acid hydrate
• Purified water.

Irifrin 2.5%, as well as 10% is represented by a transparent yellowish homogeneous liquid. Irifrin eye drops (2.5%) are available in a bottle - a dropper, the volume of which is 5 ml. The second drug - Irifrin BK (10% solution) is sold in a small tube-dropper with a volume of 0.4 ml.

Medicinal properties

Price for Irifrin: from 487 to 695 rubles.

Phenylephrine is a special substance from the group of selective α-adrenergic agonists, which has a predominant effect on the α1-adrenergic receptors themselves.

Under the influence of the drug, active stimulation of α1-adrenergic receptors is observed, which are located inside the postsynaptic vascular membranes, as well as the radial muscle localized in the iris. There is no pronounced effect on accommodation itself, intraocular pressure normalizes.

The drug has a specific effect on the formation of peripheral vasoconstriction of arterioles, stimulates the process of narrowing of the conjunctival vessels.

Phenylephrine is not one of the catecholamines; therefore, it is practically not affected by COMT, which is involved in the biotransformation of the catecholamines themselves. Due to this, a persistent and long-lasting effect of the droplet component is manifested. It should be noted that the vasomotor effect of the drug persists for a long time, and the severity of the therapeutic effect is significantly lower, in contrast to drugs based on norepinephrine.

Phenylephrine promotes minimal contraction of the ciliary muscle, cycloplegia does not appear.

With an active influence on α1-adrenergic receptors, an insignificant effect on cardiac β-receptors is observed, therefore, during treatment, no pronounced negative effect on the cardiovascular system is recorded.

The active ingredient is rapidly absorbed and penetrates through the conjunctiva of the eye, therapeutic effect registered after 10 minutes. from the moment of installation. The maximum effect is achieved after 1 hour. The duration of midraz will depend on the dosage of drugs used. Mydriasis is observed for the next 2-6 hours. At the same time, the impact on the activities of the National Assembly was not diagnosed. Breeding process active ingredient carried out by the kidneys in its original form.

Irifrin drops: instruction

Usually, ophthalmoscopy takes place using 2.5% eye drops, it is recommended to drip them at a dosage of 1 cap. The expected dilation of the pupil is observed after a short period of time - 15-30 minutes, its severity is recorded over the next three hours. If there is a need to extend mydriasis, the next installation is allowed after 1 hour.

In adults or children from 12 years of age, in case of detection of incomplete pupillary dilation and with a rigid iris, the use of Irifirin 10% in the same dosing regimen may be prescribed.

To carry out the diagnosis, a one-time instillation of a 2.5% drug is carried out:

• With a provacation test, when a narrow profile of the angle of the anterior chamber is recorded, or the development of angle-closure glaucoma is possible. If the difference between the obtained indicators of the measured IOP before the installation and after the onset of the expansion of the eye is 3-5 mm Hg. Art., the test is classified as positive.
• With differential diagnosis of the type of injection of the eyeball: in case of vasoconstriction after 5 minutes. after installation, a superficial injection is recorded; with the severity of redness of the mucous membranes, it is necessary to conduct an additional examination for the timely detection of scleritis or iridocyclitis.

With iridocyclitis, Irifrin and Irifrin BK can be used. Installations are carried out twice or thrice a day at a dosage of 1 cap. How long the treatment will last is determined individually.

For Irifrin BK, the instructions for use are not so extended, these eye drops do not have a pronounced vasoconstrictor effect, this is what the drug differs from the usual Irifrin. It will be possible to stop the glaucoma-cyclitic crisis by instilling a 10% solution from 2 to 3 r. during the day.

During preparation for the operation in about 30-60 minutes. installation with a 10% solution is recommended. Not everyone knows why the medicine is used, thanks to this, mydriasis will be achieved. After the opening of the eyeball, the subsequent installation is not carried out.

Irifrin is prescribed for myopia, myopia. It is preferable to use Irifrin BK, it is necessary to instill eye drops at a dosage of 1 cap. If the disease worsens, dose adjustment will be required.

Contraindications and precautions

Price for Irifrin BK: from 576 to 798 rubles.

You should not instill the drug when:

• Susceptibility to components
• Diagnosing glaucoma
• Pathologies of the cardiovascular system, in which tachycardia is observed, increased blood pressure
• SD of the first type
• Development of hepatic porphyria
• Thyroid ailments, accompanied by increased production of hormones
• Pregnancy, HB (may have a negative effect on the child).

Before use, you should carefully study the instructions for use of drugs. The duration of the process of pupil dilation can be from 1 to 3 hours, during this period of time photophobia may develop. Until the vision is fully restored, it is worth excluding stay in heavily lit rooms, visual overstrain is not recommended (reading, working at a computer, watching TV).

In elderly patients, reactive miosis may occur, with repeated use of eye drops, their therapeutic effect is weakened.

Benzalkonium chloride, contained in drops, can contribute to discoloration of the surface of contact lenses, therefore, lenses must be removed before installation, they can be used after 15 minutes. from the moment of installation.

Open drops are stored for 1 month.

Cross-drug interactions

With the additional use of drugs based on phenylephrine, as well as atropine, the effect of the drops is enhanced.

At combined application drugs containing MAO inhibitors, and for 3 weeks. after the end of the use of drops, a sharp jump in blood pressure may be observed.

The use of a 10% solution with β-blockers can provoke the onset of acute arterial hypertension.

Reception of sympathomimetics can increase the severity of the cardiovascular effect of the drug.

Side effects and overdose

Possible manifestation of local reactions:

• The occurrence of an inflammatory process
• Incoming hyperemia of the conjunctiva
• Local swelling and pain
• Feeling of intense burning
• Increased lacrimation
• Ophthalmotonus
• Miosis (one day after installation).

With a significant reduction in the sphincter of the pupil, provoked by the influence of the active component of the drug, after 35 minutes. after installation in the moisture of the anterior eye chamber, pigment grains may appear directly from the iris leaf. In this regard, differentiation with anterior uveitis or with the penetration of blood cells will be required.

Allergy symptoms can be recorded - dermatitis.

CVS manifestations: a sharp increase in heart rate, various vascular pathologies, circulatory disorders, blockage of the pulmonary artery itself. This increases the risk of myocardial infarction in the elderly.

With the described side symptoms, the replacement of Irifrin with analogues is not excluded.

Possible enhancement of systemic adverse reactions. In this case, you will need to take funds based on α-blockers.

Analogues

Sentiss Pharma, India

Price from 501 to 698 rubles.

Midrimaks - a drug that belongs to mydriatic drugs, is prescribed for examination and before an ophthalmic operation in order to dilate the pupil. The action of the drug is due to the presence of phenylephrine, as well as tropicamide.

Pros:

• Fast acting
• Can be used for dry keratoconjunctivitis
• Can be stored after opening, the shelf life of an open bottle is 1 month.

Minuses:

• As a result of the use of eye drops, ophthalmotonus may occur (as the abstract describes)
• May cause allergic reactions
• Should not be combined with local anesthetics.