Mifegin what kind of drug. How to take Mifegin tablets: instructions for use

Country of origin

Product group

Antiprogestogen drug Drug that increases the tone and contractile activity of the myometrium

Release forms

• 3 - blisters (1) - packs of cardboard.

Description of the dosage form

• Tablets light yellow, biconvex, with identification code "167B" on one side.

pharmachologic effect

Compound

• micronized mifepristone 200 mg Excipients: colloidal silicon dioxide, corn starch, povidone, microcrystalline cellulose, magnesium stearate.

Mifegin indications for use

• - Medical termination of uterine pregnancy early dates(up to 42 days of amenorrhea); - preparation and induction of labor in full-term pregnancy.

Mifegin contraindications

• - adrenal insufficiency; - acute or chronic renal and / or liver failure; - porphyria; - long-term use of glucocorticoids; - anemia; - violation of hemostasis (including previous treatment with anticoagulants); - the presence of severe extragenital pathology; - having a history hypersensitivity to mifepristone and / or auxiliary components. For medical abortion: - suspected ectopic pregnancy; - pregnancy not confirmed clinical research; - pregnancy for more than 42 days of amenorrhea; - pregnancy that occurred against the background of the use of intrauterine contraceptives or after cancellation hormonal contraception; - inflammatory diseases genital organs - smoking in women over 35 without prior consultation with a therapist. For the preparation and induction of labor - severe preeclampsia, preeclampsia, eclampsia;

Instructions for use:

Mifegin is a drug for medical termination of uterine pregnancy for up to 42 days and preparation and start of the delivery process of a full-term pregnancy in case of problems with the fetus.

Mifegin, active substance micronized mifepristone, is an antagonist of sex hormones, increases the contractility of the muscular component of the walls of the uterus and its tone.

Pharmacological action of Mifegin

Mifegin is a steroid synthetic antiprogestogen drug that blocks the action of the hormone progesterone at the receptor level, is gestagenically inert. Mifepristone counteracts glucocorticosteroids (GCS) at the receptor level.

Mifegin tablets increase the contractility of the muscular component of the uterine walls by stimulating the release of the main pro-inflammatory chemokine - interleukin 8 in the choriodecidual tissue. Mifepristone increases the sensitivity of the muscle tissues of the uterus to prostaglandins. To increase the effect, a course of synthetic prostaglandin analogs is prescribed simultaneously with Mifegin. As a result, scaly exfoliation of the amniotic membrane and prolapse (expulsion) of the ovum occurs.

Release form

Mifegin tablets are biconvex, light yellow, on one side the code "167B". The active ingredient is micronized mifepristone 200 mg per 1 tablet.

Mifegin's analogs

Analogues of Mifegin tablets for the active ingredient - tablets: Agesta, Ginepristone, Ginestril, Genale, Miropriston, Mifeprex, Mifepristone, Mifolian, Pencrofton

There are no analogues of Mifegin on the mechanism of action yet.

Indications for use Mifegin

Also, according to the instructions, Mifegin can be prescribed for the induction and preparation of labor in the event of intrauterine death of the fetus, when it is undesirable to use prostaglandin or oxytocin.

Contraindications

According to Mifegin's instructions for general indications not assigned if:

• adrenal insufficiency;
• Acute or chronic renal failure;
• Acute or chronic liver failure;
• Porfiria;
• anemia;
• Violations of hemostasis;
• Taking anticoagulants;
• Long-term use of glucocorticoids;
• The presence of complex extragenital pathology;
• Hypersensitivity to any components of the drug.

With medical abortion according to the instructions, Mifegin is not used in case of:

• Suspicion of an ectopic pregnancy;
• Pregnancy not confirmed by clinical studies;
• Absence of menstruation for more than 42 days;
• If pregnancy occurs after the abolition of hormonal contraceptives or during the use of intrauterine contraceptives;
• Inflammatory diseases of the genitourinary system;
• Smoking women over 35 years of age, without the permission of the supervising therapist.

When prescribing the drug to prepare and start the process of childbirth according to the instructions, Mifegin is not used in the case of:

• Severe preeclampsia, preeclampsia, eclampsia;
• Premature or overdue fetus;
• placenta previa;
• If the size of the fetal head does not match the size of the woman's pelvis;
• Abnormal presentation of the fetus;
• Bloody discharge of unknown etiology from the genital tract.

Chronic obstructive lung diseases, arterial hypertension, chronic heart failure, arrhythmia - diseases in which Mifegin tablets should be prescribed with caution.

How to use Mifegin

According to the instructions, Mifegin tablets are intended for oral administration. You can use the drug only in a hospital that has a license to provide medical services, appropriate medical equipment and specially trained medical personnel.

The regimen for the use of Mifegin tablets is determined by the attending physician.

Mifegin drug interaction

According to the instructions, Mifegin should not be taken simultaneously with non-steroidal anti-inflammatory drugs. You can start taking these drugs 8-12 days after taking mifepristone.

Side effects

According to reviews, Mifegin can cause not only systemic adverse reactions associated with taking mifepristone, but also undesirable effects directly from therapy.

Unwanted systemic side effects due to taking Mifegin tablets, according to reviews, they are manifested by general weakness, headache, dizziness, nausea, vomiting, diarrhea, elevated temperature, discomfort and pain in the lower abdomen.

Side effects from the treatment procedure when taking Mifegin, according to reviews, are usually manifested by bloody discharge from the genital tract, pain in the lower abdomen, inflammation of the uterus and appendages.

Storage conditions

Tablets Mifegin - a preparation of list A. Storage in a dry, dark place, out of the reach of children. Shelf life - 3 years from the date of manufacture.

There are a lot of drugs on the domestic pharmacological market that are intended for medical abortions.

One of them is Mifegin.

As part of the drug, the active substance is mifepristone.

It is an antiprogestogen that blocks progesterone at the receptor level.

It causes contraction of the uterus, softening of its cervix and, ultimately, the expulsion of the fetal egg.

• What happens after admission?
• When will the drug work?
• How long does it take for Mifegin to start working?
• What determines the effectiveness of abortion when applied?
• Pharmacokinetics
• The effect of Mifegin
• Recovery of the body after taking

Mifegin is today considered one of the most popular drugs that are used for medical abortion in the early stages.

The drug is used, as a rule, for periods up to 42 days, as well as at home as a means of emergency contraception within 72 hours after unprotected intercourse.

However, in order to understand how much Mefigin needs to be taken so that its effect on the body is gentle and at the same time leads to the desired result, it is worthwhile to better study the mechanism of its action.

What happens after admission?

If the patient is healthy and the examination has proved the possibility of using this drug, Mifegin is usually prescribed once at a dose of 600 mg (3 tablets) only with constant medical supervision.

When will the drug work?

It is difficult to answer unequivocally the question of how Mifegin works and how long after taking the fetal egg will be rejected.

It depends on the state of health and individual features female patients.

Maximum concentration active substance, according to research data, in the blood is reached 1.3 hours after ingestion.

Therefore, after a woman has taken the pills, it is recommended to stay in the clinic for 2 hours under the supervision of specialists. This will avoid the development of dangerous side effects.

How many hours does Mifegin work? Already 18 hours after ingestion, 50% of the dose of Mifegin that enters the body is excreted through the urinary system. The minimum concentration of the drug in the blood is determined on average after 72 hours, so that the active effect medicinal product on the body continues for 3 days.

What enhances or weakens the effect of the drug?

After a woman has taken the drug, the effect of Mifegin does not always lead to positive result. Since the drug can seriously affect the development of the fetus, doctors categorically do not recommend leaving the child.

In such cases, usually 36-48 hours after taking Mifegin, you must additionally drink the drug. female hormone prostaglandin, which will increase the contractility of the uterus, in the following doses:

• misoprostol - 400 micrograms, if no more than 49 days have passed since the last menstruation;
• gemiprost - 1 mg intravaginally, if no more than 63 days have passed since the last menstruation.

Most gynecologists prescribe prostaglandins according to the following scheme: the patient takes 2 tablets at a time, and after 3 hours - 2 more tablets. After that, 97% of medical abortion is successful.

Strengthen the effect of the drug and provoke the appearance of unwanted side effects - nausea, vomiting, headache, fever, pain in the abdomen, severe vaginal bleeding or exacerbation of chronic inflammatory diseases reproductive system- such concomitant diseases in a woman who wants to terminate a pregnancy can:

1. Obstructive diseases respiratory system, including bronchial asthma.
2. Arrhythmias.
3. Heart failure.
4. Arterial hypertension.

The abortive effect can be weakened by the simultaneous use of non-steroidal anti-inflammatory drugs with Mifegin or non-narcotic analgesics(the course of treatment with them should be prescribed no earlier than 8-10 days after taking drugs with the active substance mifepristone), as well as acetylsalicylic acid.

The effect of Mifegin on the body can be very strong in patients suffering from infectious endocarditis or those who have an artificial heart valve. For this reason, prophylactic antibiotic therapy is prescribed in such cases.

The completeness of abortion when taking this drug containing mifepristone depends on:

• the woman's health status (in particular, the cervix) and the presence of serious chronic diseases;
• the age of the pregnant woman;
• compliance with the rules of admission specified in the instructions;
• gestational age (it is optimal to terminate the pregnancy for a period of no more than 3-4 weeks).

Pharmacokinetics

Mifegin belongs to the group of steroid-type antiprogestogenic drugs that stop the synthesis of the "pregnancy hormone" progesterone at the receptor level.

This dramatically reduces the flow of this substance to the embryo and reduces the number of capillaries in the endometrium, which contributes to the contraction of this organ and the separation of the fetal egg from the walls of the uterus.

Mifegin improves the ability of the myometrium to contract, providing the release of a special substance - interleukin-8 - in cells of the choriodecidual type.

It is it that enhances the sensitivity of the myometrium to the effects of prostaglandins and provides an abortive effect.

Bleeding after using the drug usually begins within a day. The presence of clots in the discharge indicates an abortion that has begun.

On the 3-4th day after taking Mifegin, discharge of a yellowish or green tint may appear, indicating the development of a sexual infection.

Brown discharge, not accompanied severe pain, pungent odor, itching and burning, are considered the norm and can last up to 5-10 days.

A woman will be able to understand that an abortion has begun by the following symptoms:

1. Uterine bleeding of the menstrual type.
2. Pain in the abdomen, sometimes requiring pain medication.
3. Nausea and vomiting.
4. Diarrhea.
5. Increased fatigue and dizziness.

A couple of weeks after using Mifegin, it is recommended to undergo an ultrasound examination to check if there are any remnants of the fetal egg in the uterus.

If the pregnancy is more than 4 weeks or the drug was not taken in combination with prostaglandins, it may not work. Then you have to resort to surgical or mini-abortion.

Although most of Mifegin is excreted in just 72 hours, after termination of pregnancy with this drug, even the most enduring female body will recover for at least 3-4 weeks.

This period can be reduced by observing a few simple rules:

• exclusion of sexual activity for at least a month in order to avoid infection of the genital tract and increased bleeding;
• refusal of alcoholic beverages;
• a nutritious diet rich in vitamins;
• exclusion of intensive physical activity and training;
• compliance with the rules of personal hygiene.

And so, in our article, you learned how long Mifegin begins to act, how much to take and what effect it has.

The pharmacokinetics of Mifegin is quite simple, but its use requires consultation with a doctor. The consequence of home use of the drug may be its unpredictable effect on the body, so you should not joke with this.

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Source: http://sdelayusama.ru/kak-prinimat/kak-prinimat-mifegin.html

Mifegin (Mifegyn)

Name: Mifegin (Mifegyn)

Name

Mifegin (Mifegyn)

pharmachologic effect

Mifegin is a synthetic drug with a pronounced antiprogestogenic effect. Mifegin contains the active ingredient mifepristone, a substance that blocks the effects of progesterone at the receptor level.

The drug Mifegin is not characterized by gestagenic activity, there is some antagonism of mifepristone with glucocorticosteroid hormones (due to the competition of mifepristone and glucocorticosteroids at the level of binding to receptors).

When taking the drug Mifegin, there is an increase in the contractility of the myometrium due to an increase in the release of interleukin-8 in choriodecidual cells, as well as an increase in the sensitivity of the myometrium to the action of prostaglandins (Mifegin can be prescribed with synthetic analogues of prostaglandins to increase efficiency). Under the influence of the drug Mifegin, desquamation of the decidua occurs, as well as the excretion of the fetal egg.

After oral administration of 600 mg of mifepristone, the peak plasma concentration is reached within 1.3 hours and is 1.98 mg / l. The absolute bioavailability of the drug Mifegin reaches 69%.

About 98% of the accepted dosage of mifepristone binds to plasma proteins (mainly albumin and alpha-1-acid glycoprotein). After the distribution of mifepristone, excretion is slow, about half of the accepted dosage is excreted within 12-72 hours.

Half-life active component medication Mifegin reaches 18 hours.

Indications for use

Mifegin is used to terminate uterine pregnancy in the early stages (no more than 42 days of amenorrhea).
Mifegin can also be prescribed for the preparation and induction of labor in case of intrauterine fetal death (the use of mifepristone is offered mainly if the use of oxytocin or prostaglandins is undesirable).

Mode of application

Mifegin is intended for oral use. The use of Mifegin medicine is allowed only in hospitals and institutions licensed for this species activities, as well as suitably trained medical personnel and the necessary equipment. The scheme for the use of the drug Mifegin is determined by the doctor.

To terminate a uterine pregnancy (for a period of no more than 42 days of amenorrhea), they generally prescribe 600 mg of mifepristone (3 tablets of Mifegin) once under the supervision of a doctor.

After 36-48 hours, the appointment of prostaglandins is recommended: misoprostol at a dose of 400 mcg during pregnancy with a delay in menstruation up to 49 days or hemiprost at a dose of 1 mg intravaginally during pregnancy with a delay in menstruation up to 63 days.

After using medication, a woman should be under the supervision of a doctor for at least 2 hours. 36-48 hours after taking mifepristone, ultrasound diagnostics are recommended.

In addition, 8-14 days after taking the medicine Mifegin, a mandatory clinical, laboratory (determination of the level of beta-chorionic hormone) and ultrasound are carried out.

If after 14 days a high level of beta-chorionic hormone persists or during clinical and ultrasound examination it is revealed that the result of mifepristone is insufficient (incomplete abortion or continuation of the pregnancy), vacuum aspiration is indicated, followed by a histological examination of the aspirate. If, after taking mifepristone, the pregnancy has continued, abortion by other methods is necessary, since Mifegin can cause severe malformations. To induce labor, 200 mg of mifepristone (1 tablet of Mifegin) is often prescribed under medical supervision. After 24 hours, a second dose of 200 mg of mifepristone (1 tablet of Mifegin medication) is prescribed. 48-72 hours after taking the second dosage of the drug, a gynecological examination should be performed and, if necessary, oxytocin or prostaglandins should be prescribed.

The use of the drug Mifegin should be carried out simultaneously with the prevention of Rh-aloimmunization and common methods used during abortion.

Side effects

When using the drug Mifegin, the development of undesirable effects directly related to the therapy procedure, as well as systemic adverse reactions caused by mifepristone.

Undesirable effects associated with the treatment procedure often manifest themselves in the form spotting from the genital tract, as well as pain in the lower abdomen and exacerbations inflammatory processes uterus and appendages.

Systemic side effects of mifepristone may include weakness, headache, vomiting, nausea, fever, and abdominal discomfort and pain.

Contraindications

Mifegin is not prescribed to patients with a history of hypersensitivity reactions to mifepristone.

Mifegin is not used in patients suffering from adrenal insufficiency, acute and chronic form renal or hepatic insufficiency, porphyria, uterine myoma, anemia and hemostasis disorders, as well as patients who have been receiving glucocorticosteroids for a long time.

Mifegin is not used in women with uterine scars or severe extragenital pathology, as well as women suffering from inflammatory diseases of the reproductive system. Special care must be taken when prescribing Mifegin to smoking women over the age of 35. Mifegin is not prescribed for suspected intrauterine pregnancy.

In addition, it is not suggested to prescribe mifepristone during pregnancy, not confirmed by clinical studies, with amenorrhea for more than 42 days, which occurred while using an intrauterine contraceptive system or taking oral contraceptives.

For the induction of labor, mifepristone should not be prescribed to women with eclampsia, preeclampsia, severe gestosis, post-term or premature pregnancy. Caution is suggested when prescribing mifepristone to patients suffering from chronic obstructive pulmonary diseases (including bronchial asthma), severe arterial hypertension, heart failure and cardiac arrhythmias .

It is impossible to prescribe the drug Mifegin to patients under the age of 18 years.

Pregnancy

During lactation, if necessary, taking the medicine Mifegin should be temporarily interrupted breast-feeding. Restoring breastfeeding is possible no earlier than 2 weeks after taking the last dose of mifepristone.

Interaction with other drugs

Simultaneous administration of Mifegin with non-steroidal anti-inflammatory drugs is not suggested. Reception of non-narcotic analgesics is allowed no earlier than 8 days after taking the last dosage of mifepristone.

Overdose

When taking Mifegin at a dose of up to 2000 mg of the active substance, patients did not experience the development of undesirable effects.

With a significant increase in dosage (more than 2000 mg of mifepristone at a time), patients are likely to develop adrenal insufficiency.
There is no specific antidote. With the development of signs of overdose, symptomatic therapy is carried out.

It is necessary to monitor the patient's condition for at least 24 hours after an overdose of mifepristone.

Release form

Mifegin tablets, 3 pieces in blister packs made of PVC film and aluminum foil, in a carton box 1 blister pack.

Storage conditions

The drug Mifegin should be stored and transported at a temperature of 15 to 25 degrees Celsius. Subject to storage conditions, the drug Mifegin is suitable for 3 years after release.
Mifegin tablets are supplied exclusively to specialized obstetric and gynecological institutions. The drug is used only in a hospital setting.

Synonyms

mifepristone.

Compound

1 tablet of medicine Mifegin contains: Mifepristone - 200 mg;

Additional ingredients.

Source: http://medprep.info/drug/medicament/mifegin

Mifegin - instructions for use, doses, side effects, contraindications - GEOTAR Medicinal Guide

Active substance MifepristoneMifepristoneSimilar drugsDisclose

Dosage form: Tablets. Composition: For one tablet:

Active substance: mifepristone micronized 200 mg (manufacturer's monograph) Excipients: colloidal silicon dioxide 3 mg, corn starch 102 mg, povidone 12 mg, microcrystalline cellulose 30 mg, magnesium stearate 3 mg.

Description: Light yellow, biconvex tablets, with an identification code on one side (167B). Pharmacotherapeutic group: AntigestagenATX: Pharmacodynamics: Mifepristone is a synthetic steroid antiprogestogenic agent (blocks the action of progesterone at the receptor level), does not have gestagenic activity.

Marked antagonism with glucocorticosteroids (GCS) (due to competition at the level of communication with receptors).

It increases the contractility of the myometrium by stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to prostaglandins (to enhance the effect, it is used in combination with a synthetic analogue of prostaglandin).

As a result of the action of the drug, desquamation of the decidua and expulsion of the fetal egg occur. Pharmacokinetics: After a single oral dose of 600 mg, the maximum concentration of 1.98 mg / l is reached after 1.3 hours. Absolute bioavailability is 69%.

In plasma, mifepristone is 98% protein bound: albumin and acid alpha1-glycoprotein.

After the distribution phase, the excretion is slow at first, the concentration decreases by 2 times between 12-72 hours, then more rapidly. The half-life is 18 hours. Indications: Medical termination of uterine pregnancy in the early stages (up to 42 days of amenorrhea). Preparation and induction of labor in full-term pregnancy.

Contraindications: A history of hypersensitivity to mifepristone and / or auxiliary components, adrenal insufficiency, acute or chronic renal and / or hepatic insufficiency, porphyria, long-term use of glucocorticoids, anemia, impaired hemostasis (including previous treatment with anticoagulants), the presence of severe extragenital pathology.

Suspicion of an ectopic pregnancy. Pregnancy not confirmed by clinical studies. Pregnancy for more than 42 days of amenorrhea.

Pregnancy that occurred against the background of the use of intrauterine contraceptives or after the abolition of hormonal contraception, inflammatory diseases of the genital organs, smoking in women over 35 without prior consultation with a therapist.

For the preparation and induction of childbirth: Severe preeclampsia, preeclampsia, eclampsia, premature or delayed pregnancy, placenta previa, mismatch in the size of the fetal head and the woman's pelvis, abnormal position of the fetus, bloody discharge from the genital tract of unclear etiology.

With caution: With caution prescribed for chronic obstructive pulmonary disease (including bronchial asthma), arterial hypertension, arrhythmias, chronic heart failure. Pregnancy and lactation: Breastfeeding should be stopped for 14 days after taking mifepristone.

Method of application and doses: The drug should be used only in medical institutions under the supervision of a physician.

For medical termination of pregnancy: Mifepristone 600 mg (3 tablets of 200 mg) is taken orally once in the presence of a physician.

The patient should be under the supervision of medical personnel for at least 2 hours after application. 36-48 hours after taking the drug Mifegin®, the patient should appear for ultrasound control. After 8-14 days, a clinical examination and ultrasound control are repeated, and the level of beta-chorionic hormone is also determined to confirm that a miscarriage has occurred. If there is no effect from the use of the drug on day 14 (incomplete abortion or ongoing pregnancy), vacuum aspiration is performed, followed by a histological examination of the aspirate.

For preparation and induction of labor: once a day, 200 mg mifepristone (1 tablet) by mouth in the presence of a doctor. After 24 hours, a second dose of 200 mg. After 48-72 hours, the state of the birth canal is assessed, and, if necessary, prostaglandins or oxytocin are prescribed.

Side effects: Bloody discharge from the genital tract, discomfort and pain in the lower abdomen, exacerbation of inflammation of the uterus and appendages, weakness, headache, nausea, vomiting, diarrhea, dizziness, hyperthermia, urticaria; on the background combined treatment with misoprostol (optional): vaginitis, dyspepsia, insomnia, asthenia, leg pain, restlessness, anemia, decrease in Hb (more than 2g / dl), fainting, leucorrhea. Overdose: Mifepristone in doses up to 2 g does not cause unwanted reactions. In cases of overdose of the drug, adrenal insufficiency may occur. Interaction: The use of non-steroidal anti-inflammatory drugs should be avoided for 8-12 days after the use of mifepristone. or ongoing pregnancy), the pregnancy must be terminated in another way, since the formation of congenital malformations in the fetus is possible. The use of the drug requires the prevention of Rh alloimmunization and other general measures associated with abortion. Patients with artificial heart valves or infective endocarditis should be treated prophylactically with antibiotics when using mifepristone. The drug should be used in obstetric and gynecological medical institutions that have the appropriate license, trained medical personnel and the necessary equipment. Release form / dosage Packing: Packing: 3 tablets in a PVC/aluminum foil blister.

One blister with instructions for use in a cardboard pack.

Storage conditions: Keep out of the reach of children. In a place protected from light, at a temperature not exceeding 25 ° C. Shelf life: 4 years. Do not use after the expiration date indicated on the package. Conditions for dispensing from pharmacies: For hospitals Registration number: P N015925/01 Registration date: 10/06/2009 / 02/26/2015 IZVARINO PHARMA LLC Russia Date of information update: 2016-09-19Illustrated instructionsInstructions Top

Source: http://www.lsgeotar.ru/mifegin-5809.html

Mifegin

Mifegin is a synthetic antiprogestogen medication used for medical abortion in the early stages, as well as to increase the tone and contractile activity of the myometrium.

Pharmacological action of Mifegin

The active component of Mifegin, without showing gestagenic activity, blocks the action of progesterone at the receptor level. Its antagonism with glucocorticosteroids is noted, which is associated with emerging competition at the level of communication with receptors.

As a result of the action of Mifegin, desquamation of the decidua and expulsion of the fetal egg are observed.

The use of Mifegin is possible only in medical institutions and centers of obstetrics and gynecology with the appropriate license, equipped with the necessary equipment.

Release form

Medication Mifegin is produced in the form of light yellow tablets containing the active substance (mifepristone) in an amount of 200 mg. In blisters of 3 tablets.

Analogues

Mifegin analogues are also produced with the content of mifepristone as an active component: Pencrofton, Agesta, Ginestril, Ginepristone, Miropristone, Genale, Mifepristone, Mifeprex and Mifolian.

Indications for use Mifegin

Medication Mifegin is used:

• For drug interruption of uterine pregnancy (only in the early stages);
• During the preparation and induction of labor (if the pregnancy is full-term).

Contraindications

According to the instructions of Mifegin, it is contraindicated to use:

• Against the background of acute or chronic renal and hepatic insufficiency;
• With adrenal insufficiency;
• With severe extragenital pathology;
• Against the background of long-term use of glucocorticoids;
• With porphyria;
• In violation of hemostasis;
• Against the background of anemia;
• Against the background of hypersensitivity to the active (mifepristone) or auxiliary components in history.

Mifegin tablets for abortion are not used:

• In cases where pregnancy is not confirmed by the necessary clinical studies;
• If there is a suspicion of an ectopic pregnancy;
• In cases where pregnancy has occurred after the abolition of hormonal contraceptive medications or against the background of the use of intrauterine contraceptives;
• In diseases of the genital organs, which are inflammatory in nature;
• For more than 42 days of amenorrhea.

In addition, additional consultation with a therapist when using Mifegin is required if a woman over the age of 35 smokes.

Mifegin is not used for induction and preparation of childbirth with:

• Abnormal position of the fetus;
• Preeclampsia, severe preeclampsia and eclampsia;
• Both premature and post-term pregnancy;
• placenta previa;
• Mismatch between the size of the pelvis of the woman and the head of the fetus;
• The presence of bloody discharge from the genital tract, the etiology of which is unclear.

Particular caution requires the use of Mifegin against the background of chronic obstructive pulmonary diseases, including bronchial asthma, arrhythmias, arterial hypertension and chronic heart failure.

Against the background of infective endocarditis and women with artificial heart valves, when using Mifegin, it is necessary to carry out prophylactic antibiotic treatment.

Method of application and dosage

Mifegin according to the instructions is used only under medical supervision in medical centers or other licensed institutions.

When using a medication for abortion, take 3 tablets of Mifegin once in the presence of a doctor. At the same time, it is necessary to remain under the supervision of a doctor for at least another 2 hours.

1.5-2 days after taking the tablets, it is necessary to conduct a control ultrasound examination. To confirm the miscarriage, an ultrasound scan is repeated 1-2 weeks later, simultaneously with tests to determine the level of beta-chorionic hormone.

If a miscarriage has not occurred (usually with an incomplete abortion or an ongoing pregnancy), on the 14th day do vacuum aspiration, after which they carry out histological examination aspirate.

For the induction and preparation of childbirth, take 1 tablet of mifepristone once in the presence of a doctor. Repeated reception is possible in a day in the same dose. An assessment of the state of the birth canal is carried out after 2-3 days, and if necessary, the doctor may prescribe oxytocin or prostaglandins.

Mifegin, according to reviews, does not cause adverse reactions when taken in a dose of up to 2 g. In some cases, an overdose can lead to the development of adrenal insufficiency.

drug interaction

Use during pregnancy and lactation

After taking Mifegin, according to the instructions, breastfeeding is recommended to be interrupted for two weeks.

Side effects

When using Mifegin, according to reviews, various disorders can be observed, manifested as:

• Hives;
• Pain and discomfort in the lower abdomen;
• Nausea;
• Exacerbation of chronic inflammatory processes of the appendages and uterus;
• Diarrhea;
• Headache;
• Weakness;
• Bloody discharge from the genital tract;
• Vomit;
• Hyperthermia;
• Dizziness.

When conducting combination therapy simultaneously with misoprostol, Mifegin, according to reviews, can lead to the development of:

• Dyspepsia;
• vaginitis;
• Asthenia;
• insomnia;
• Anxiety;
• Pain in the legs;
• Decrease in hemoglobin;
• anemia;
• Beley;
• Fainting states.

Terms and conditions of storage

The Mifegin medication is not distributed through the pharmacy network (list A), but is sold exclusively to obstetric and gynecological centers and institutions with an appropriate license for this type of activity.

The shelf life of Mifegin tablets is 3 years, provided they are stored in compliance with the recommended temperature regime (up to 25 degrees Celsius).

Every person from the very early childhood faced with medication. Some drugs help relieve pain and improve well-being, while others are aimed at treating viral, inflammatory and bacterial diseases. Women quite often have to take hormonal drugs. This article will focus on the drug "Mifegin". Reviews of the medicine are quite diverse. Women who take the remedy on their own, in many cases, succeed and effective action medicines. Physicians do not welcome such tactics. Let's try to find out in detail what the medicine "Mifegin" has reviews.

What does the manufacturer say?

Tablets "Mifegin" reviews from manufacturers and pharmacists have the following. The medicine is an antiprogestogen drug that blocks the production of the natural hormone of the second phase and pregnancy. At the same time, the drug also increases the contractile function of smooth muscles (in particular, the reproductive organ).

The manufacturer claims that after taking the drug, after a few hours it comes active action. First, detachment from the wall of the uterus occurs. After that, the drug actively affects the ovaries and adrenal glands, stopping the release of progesterone. Next, the endometrium and myometrium begin to move away from the walls of the uterine muscle.

Are there any contraindications to taking the drug?

Recommendations for taking the drug "Mifegin" are as follows. It is strictly forbidden to use tablets for diseases of the adrenal glands and pituitary gland. Otherwise, an unexpected reaction may occur. It is also necessary to use the drug very carefully for diseases of the liver, kidneys and urinary tract.

The manufacturer says that for an abortive effect, the composition cannot be used if there is a suspicion of an ectopic pregnancy. It is also worth choosing an alternative method when the developmental period of the fetal egg is more than six weeks. If conception occurred during the use of oral or intrauterine contraceptives, then the pills are strictly prohibited. With extreme caution, you need to approach such a correction for diseases of the genital organs, inflammation and bad habits among women.

The annotation states that the agent cannot be used to start labor in the following cases: with presentation or before a planned operation caesarean section when the fetus is not positioned correctly, with multiple pregnancy and bleeding.

What do the doctors say?

What is the drug "Mifegin" reviews of doctors? Gynecologists and obstetricians say that the medicine is strictly forbidden to use on its own. Before starting therapy, you must definitely contact and undergo an examination. So, for starters, gynecologists prescribe an ultrasound examination and analysis of the microflora. Only after receiving the results and certain data on ultrasound, you can start using the tool.

Experts say that the drug should be taken only within the walls of a medical institution. Otherwise, an unexpected reaction to the active substance may occur and a complication may develop. Doctors say that sometimes there is severe bleeding that requires urgent surgical intervention. If a woman is at home at this moment, then taking the drug can even lead to death.

How to use the medicine at home?

If you decide to use the drug "Mifegin" at home, you must first read the annotation. It is worth remembering that doctors categorically do not welcome such tactics. However, many women prefer to do everything on their own. The instruction says that the pills can be used for an abortive effect or to induce labor. In both cases, the dosage and method of application is completely different.

To terminate a pregnancy

The drug "Mifegin" at home is used in the following way. A woman needs to drink three tablets of the drug (600 milligrams). After this, bleeding should begin, which leads to spontaneous miscarriage. You should definitely see a doctor two days after using the product and undergo an ultrasound scan.

Most often, the drug causes a complete abortion. However, there are cases when the fetal membranes linger in the uterine cavity. In this case, scraping or

To start labor

The drug "Mifegin" at home can be used to approximate labor. Many expectant mothers can't wait to meet their baby, and they use this method. Doctors strongly do not recommend doing this. Since taking the remedy can lead to an unexpected reaction and the occurrence of complications.

To start labor, one tablet of the drug is taken at a dose of 200 milligrams. After that, the process may begin immediately or the effect will be absent altogether. In the second case, it is worth reusing the same dosage of the drug after one day.

The drug "Mifegin": reviews of women

What do the fair sex say, who happened to use this remedy on their own? The drug "Mifegin" reviews is very controversial. Some women were completely satisfied with this medicine. Others talk about the inefficiency and harm of the drug. Consider the main reviews of women.

The drug fully fulfills its task (interrupts the pregnancy)

Women who used Mifegin tablets on their own give the following reviews. The tool did a great job. Already one hour after the use of the drug, its active effect began. The contractile function of the uterine muscle increased and discharge from the genital tract began.

Also, representatives of the weaker sex say that after using the pills, pulling pains appeared in the lower abdomen. However, this is a completely normal reaction. All due to the fact that the uterus does not just contract, but tries to push it out along with the endometrium.

The remedy proved to be ineffective

Some women say that after using the pills, the pregnancy did not stop at all or there was a partial detachment of the membranes. Doctors say that the reason for this may be the wrong intake of the drug or a long time.

After such therapy, such women were forced to go to a medical institution for curettage. Some representatives of the weaker sex changed their minds about terminating the pregnancy, but it was already too late. Doctors say that after taking the drug "Mifegin" there is no way back. The medicine affects the fetus and causes irreparable harm to it. Even if the pregnancy persists, there is a high risk of having a baby with serious abnormalities.

What do women say about taking the drug to start labor?

Most women were satisfied with this medicine. According to them, after taking two tablets with a break of 24 hours, the cervix softened and leveled. The birth canal became completely ready for further manipulations.

Also, some women were dissatisfied with such therapy. According to them, after giving birth, the opportunity to establish breastfeeding disappeared. The drug not only affects the production of prolactin and oxytocin, but is also absorbed into breast milk. Such a substance may not be very good influence to the fruit.

Analogues of "Mifegin"

Like any other drug, this medicine There are similar in composition and action means. All of them have the same effect on the body and, however, not every drug can be used to induce labor.

Analogues of "Mifegin" can be distinguished as follows:

• tablets "Mifepristone" (they are a complete analogue and can be used during the absence of timely labor activity);
• the drug "Mifepristone-72" (they have a different dosage and the need for an additional calculation of the number of tablets for a single dose);
• means "Mifepreks", "Mifolian" and many others.

Price category of the drug

The tool may have a different value. It all depends on the number of tablets in the package and the region in which the drug is purchased. A standard pack contains three pills with a dosage of 200 milligrams each. The cost of such a medicine is from 2800 to 3500 rubles.

Many women ask pharmacists: “What is cheaper? "Mifegin"? "Mifepristone"? Reviews of pharmacists say the following. One pack of Mifepristone, which includes three capsules with a dosage of 200 milligrams, costs about 1,300 rubles. This suggests that the analogue of the original drug is much cheaper.

It should be noted that when performing manipulations in medical institution The drug can cost you absolutely free. To do this, you only need to have a passport and an insurance policy. This option, given the possible risks, is preferable.

Summarizing

Now you know what reviews the drug "Mifegin" has. Remember that there are many factors to consider before using it. Be sure to seek help from specialists! After all, it is not in vain that the manufacturer says that the drug should be taken only under the supervision of a doctor.

Be responsible for your health. Especially when it comes to inducing labor with this remedy. Do not self-appoint and always be healthy!