What is sulfadimethoxin prescribed for? Sulfadimethoxine: what this antibiotic helps with, how often to use it, analogues

Sulfadimethoxine is a chemical analogue of para-aminobenzoic acid, a substance that is vital for bacteria and some protozoa (Toxoplasma) for the synthesis of their DNA.

Sulfadimethoxine is absorbed by bacteria, disrupts the formation of nucleic acids, as a result, the pathogen cell cannot multiply and function normally.

The drug is active against gram-positive and gram-negative microorganisms: streptococci, staphylococci, Proteus, Escherichia coli, Klebsiella, Shigella and Salmonella, Vibrio cholerae, gonococcus, Toxoplasma, the causative agent of trachoma.

Clinical and pharmacological group

Antibacterial agent, a derivative of sulfanilamide.

Terms of sale from pharmacies

Can buy by prescription.

Price

How much does Sulfadimetoksin cost in pharmacies? The average price is at the level of 35 rubles.

Composition and form of release

Dosage form of Sulfadimethoxine release - tablets: white or white with a creamy tint, flat-cylindrical, with a risk and a chamfer (in blister packs or cell-free packs of 10 pcs., in a cardboard bundle 1 or 2 packs; in polymer cans of 10 pcs., in 1 bank in a cardboard box; 15 pieces in a polyethylene case; 20 pieces in dark glass jars, 1 bank in a cardboard box).

Composition of 1 tablet:

• active substance: sulfadimethoxine - 0.2 or 0.5 g;
• auxiliary components (0.2 / 0.5 g of active ingredient): aerosil (colloidal silicon dioxide) - 0.000 44 / 0.001 1 g; potato starch of the "Extra" variety - 0.016 92 / 0.042 3 g; calcium stearate - 0.002 2 / 0.005 5 g; medical gelatin - 0.000 44 / 0.001 1 g.

pharmachologic effect

The drug is effective against bacterial infections. Its mechanism of action is to inhibit the enzyme glucose-6-dehydrogenase, which is responsible for the synthesis of dihydrofolic acid (a type of folic acid). It is necessary for bacteria to produce purines and pyrimidines, which are part of the DNA of the cell. Active substance The drug stops reproduction, and does not kill encapsulated bacteria that are dormant in the body, does not cause resistance.

The active ingredient is an analogue of para-aminobenzoic acid, disrupts the metabolism of bacteria and the production of phosphatase enzymes. Sulfadimetoksin inhibits the reproduction of gram-positive staphylococci, streptococci, gram-negative coli, Friedlander's sticks, Klebsiella, pneumococci, pathogens of dysentery and other shigellosis infections. The drug inhibits the growth of chlamydia, has little effect on proteas.

The drug is detected in the blood half an hour after ingestion, reaches a maximum concentration after 8-12 hours, does not penetrate the blood-brain barrier well, therefore it is ineffective against meningitis (caused by meningococcus) and inflammatory processes brain. The active substance of the composition shortly after absorption in the gastrointestinal tract is found in the articular and peritoneal fluid, pleural effusion, exudate of the middle ear. The metabolism of the component occurs in the liver, it is excreted in the urine and bile.

Indications for use

What helps? Sulfadimethoxine is used to treat infectious and inflammatory diseases (which are caused by microorganisms sensitive to sulfadimethoxine), such as:

• pyoderma,
• trachoma,
• sharp respiratory diseases,
• inflammatory diseases urinary and biliary tract,
• dysentery,
• drug-resistant forms of malaria (in combination with antimalarial drugs),
• inflammatory lesions of the central nervous system, wound infections.

Contraindications

According to the instructions, Sulfadimethoxine is contraindicated in the following cases:

• azotemia;
• porphyria;
• pregnancy and lactation (the appointment of Sulfadimethoxine is possible only in cases where the expected benefit exceeds the possible harm);
• age up to 3 months;
• thyroid disease;
• oppression of bone marrow hematopoiesis;
• congenital deficiency of glucose-6-phosphate dehydrogenase;
• liver / kidney failure;
• chronic heart failure;
• individual intolerance to the components of the drug.

Caution when using Sulfadimethoxine (relative contraindications) is required in the presence of the following diseases / conditions:

• anemia with a reduced color index;
• functional disorders of the liver / kidneys;
• folate deficiency.

Appointment during pregnancy and lactation

Sulfadimethoxine is highly undesirable to use during pregnancy and during breastfeeding, since it penetrates well through the placenta and into breast milk, and can cause dyspepsia, liver and kidney disorders, kernicterus, or hemolytic anemia in a child.

Dosage and method of application

As indicated in the instructions for use, before taking it, it is necessary to check the sensitivity of pathogenic microflora to this drug. It does not make sense to use sulfadimethoxine in the absence of sensitivity, since the harm caused active substance the body outweighs the benefits of fighting pathogenic bacteria.

• Adults are prescribed a dose of 1000 mg on the first day, then 500 mg per day. In the case of a severe infection, it is possible to increase the starting dose to 2 mg, and the daily dose to 1 mg. Take the medicine once a day, after meals. The duration of treatment is 7-10 days.
• For children, the drug is prescribed at a dose of 25 mg / kg of body weight on the first day, and 12.5 mg / kg per day on the following days.
• Reception of the drug must necessarily take another 2-3 days after the decrease in body temperature. During the use of the drug, it is necessary to limit the patient's exposure to the sun, or his exposure to ultraviolet radiation.

It is necessary to strictly observe the time interval for taking the tablets. Do not take a double dose if the drug was not taken on time. In this case, you should drink it as quickly as possible, and not move the dose too close to the next one in order to avoid overdose.

In the veterinary medicine of small animals, children's dosages of the drug are used.

Side effect

The use of Sulfadimethoxine can cause the following side effects:

• Central Nervous System: Possible headache.
• Hematopoietic system: rarely - agranulocytosis, leukopenia.
• Digestive system: cholestatic hepatitis, nausea, dyspeptic symptoms, vomiting.
• Allergic manifestations: drug fever, skin rashes

Overdose

The state of oversaturation of the body with the drug is clinically manifested in intense thirst, severe dryness in the mouth, a small amount of rich yellow-brown urine, pain in the right hypochondrium (projection of the liver) and lower back (renal localization). Biochemical analysis will reveal a significant increase in enzymes such as AST, ALT and acid phosphatase.

Therapeutic measures for overdose:

1. Reflexogenic initiation of vomiting.
2. Gastric lavage or high cleansing enema.
3. Astringents and adsorbents orally.
4. Salt laxatives.
5. Forced diuresis, if the drug has been completely absorbed from the gastrointestinal tract.

special instructions

It is used externally as part of combined preparations.

Interaction with other drugs

Sulfadimetoksin reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins).

Gross formula

Pharmacological group of the substance Sulfadimetoksin

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Sulfadimethoxine

White or white with a creamy tinge, odorless crystalline powder. Practically insoluble in water, slightly soluble in ethanol, soluble in acetone, easily in dilute hydrochloric acid and caustic alkali solutions.

Pharmacology

It blocks the absorption of para-aminobenzoic acid by microorganisms and the synthesis of folate (sulfonamides, similar in chemical structure to para-aminobenzoic acid, are captured by the microbial cell instead of para-aminobenzoic acid and disrupt the course of metabolic processes in it). Effective against gram-positive and gram-negative microorganisms, including Staphylococcus spp., Streptococcus spp.(incl. Streptococcus pneumoniae), Klebsiella pneumoniae, Escherichia coli, Shigella spp., Chlamydophila (Chlamydia) trachomatis. Relatively slowly absorbed from the gastrointestinal tract. After oral administration, it is found in the blood after 30 minutes, C max is reached after 8-12 hours. The required therapeutic concentration in the blood (in adults) is noted when taking 1-2 g on the 1st day and 0.5-1 g on the following days.

Application of the substance Sulfadimethoxine

Tonsillitis, sinusitis, otitis media, inflammatory diseases of the biliary and urinary tract (uncomplicated), wound infection, trachoma, erysipelas, dysentery.

Contraindications

Hypersensitivity.

Application restrictions

Diseases of the hematopoietic system, dysfunction of the kidneys and liver, chronic heart failure.

Side effects of the substance Sulfadimethoxine

Headache, dyspepsia, fever, leukopenia, agranulocytosis, nausea, vomiting, allergic reactions, cholestatic hepatitis.

Interaction

Reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins).

Name:

Sulfadimethoxine (Sulfadimethoxine)

Pharmacological
action:

Antibacterial agent, a sulfanilamide derivative.
It has a long-term effect when taken orally. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines.
Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae); gram-negative bacteria: Klebsiella pneumoniae, Escherichia coli, Shigella spp.
Active against Chlamydia trachomatis.
Pharmacokinetics
After ingestion, after 30 minutes it is found in the blood, Cmax is reached within 8-12 hours. It penetrates poorly through the BBB. Therapeutic concentration in adults is noted when taking 1-2 g on the first day and 0.5-1 g on the following days.
Unlike other sulfonamides, the predominant metabolism is carried out along the path of microsomal glucuronidation associated with CYP450 isoenzymes and NADPH-dependent.

Indications for
application:

Pneumonia (inflammation of the lungs);
- acute respiratory diseases (diseases respiratory tract);
- bronchitis (inflammation of the bronchi);
- angina, sinusitis (inflammation maxillary sinus);
- otitis media (inflammation of the ear cavity);
- inflammatory lesions of the central nervous system;
- dysentery;
- inflammatory diseases of the urinary and biliary tract;
- erysipelas;
- pyoderma (purulent inflammation of the skin);
- wound infection, trachoma;
- drug-resistant forms of malaria (together with antimalarial drugs).

Mode of application:

Before prescribing a drug to a patient, it is desirable to determine the sensitivity of the microflora to it that caused the disease in this patient.
Apply inside (in tablets).
The daily dose is given in one dose.
The intervals between doses are 24 hours. In mild forms of the disease, 1 g is prescribed on the first day, and 0.5 g each on subsequent days; with moderate forms - respectively, 2 g and 1 g each.
Children are prescribed 25 mg / kg on the 1st day and 12.5 mg / kg on subsequent days.

Side effects:

From the CNS: possible headache.
From the side digestive system : dyspeptic symptoms, nausea, vomiting, cholestatic hepatitis.
allergic reactions : skin rash, drug fever.
From the hematopoietic system: rarely - leukopenia, agranulocytosis.

Contraindications:

Hypersensitivity to sulfonamides;
- inhibition of bone marrow hematopoiesis;
- renal and / or liver failure;
- chronic heart failure;
- congenital deficiency of glucose-6-phosphate dehydrogenase;
- porphyria, azotemia;
- pregnancy and lactation;
- childhood up to 3 years old.

Carefully prescribed to patients with impaired hematopoiesis, heart failure, liver disease and impaired renal function.
During treatment, a plentiful alkaline drink, monitoring of blood and urine parameters is recommended.
It is used externally as part of combined preparations.

Interaction
other medicinal
by other means:

Sulfadimetoksin reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins).

Attention! The information is provided for informational purposes only. This manual should not be used as a guide to self-medication. The need for appointment, methods and doses of the drug are determined solely by the attending physician.

general characteristics

international and chemical names: sulfadimethoxine; 4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;

basic physical and chemical properties: tablets of white or white color with a creamy tinge, flat-cylindrical shape, with a chamfer and risk;

compound: 1 tablet contains sulfadimethoxine 0.5 g;

Excipients: sodium starch glycolate, pregelatinized starch, calcium stearate.

Release form. Tablets.

Pharmacotherapeutic group

Antimicrobial agents for systemic use. Sulfonamides (Sulfonamides- a group of antimicrobial medicines, derivatives of sulfanilic acid. Used mainly in the treatment of infectious diseases) long action. ATC code J01E D01.

Pharmacological properties

Broad spectrum antibacterial agent with bacteriostatic (Bacteriostatic- the effect of antibiotics, causing inhibition of the processes of reproduction of bacterial cells) effect.

Pharmacodynamics. Sulfadimethoxine, being an analogue of para-aminobenzoic acid in chemical structure, prevents its absorption and disrupts biosynthetic processes in cells bacteria (bacteria- a group of microscopic, predominantly unicellular organisms. Many bacteria are causative agents of diseases in animals and humans. There are also bacteria necessary for the normal process of life). Inhibits the growth and reproduction of gram-positive and gram-negative bacteria, including anaerobes (Anaerobes(anaerobic organisms) - some types of bacteria, yeast, protozoa, capable of living in the absence of atmospheric oxygen. Widely distributed in soil, water, and bottom sediments). Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae); gram-negative bacteria: Klebsiella pneumoniae, Escherichia coli, Shigella spp. Active against Chlamydia trachomatis.
The antimicrobial effect of sulfadimethoxine is significantly weakened in the presence of pus and tissue decay products.

Pharmacokinetics. When taken orally, it is relatively slowly absorbed from the gastrointestinal tract; in the blood is detected after 30 minutes. The maximum concentration in the blood is reached after 8-12 hours. The required therapeutic concentration in the blood (in adults) when taking 1-2 g is noted on the first day, maintenance doses (0.5-1 g) provide a therapeutic level in the blood throughout the course of treatment .
It penetrates well into tissues and body fluids, including pleural effusion, peritoneal and synovial fluid, medium exudate ear (Ear- the organ of hearing and balance. Consists of the outer and middle ear, which conduct sound, and inner ear that perceives it. sound waves captured auricle cause vibration eardrum and then through the system of auditory ossicles, liquids, and other formations are transmitted to the perceiving receptor cells), chamber moisture, tissues of the genitourinary tract. Penetrates through placenta (Placenta- an organ that communicates and exchanges substances between the mother's body and the fetus during fetal development. It also performs a hormonal and protective function. After the birth of the fetus, the placenta, along with the membranes and the umbilical cord, are released from the uterus) and into breast milk. Weakly penetrates through blood-brain barrier (Blood-brain barrier- a barrier formed by the endothelium of the cerebral vessels: there are no intercellular spaces characteristic of other vessels between the endothelial cells. As a result, water-soluble polar substances do not enter the brain from the blood).
Metabolism (Metabolism- the totality of all types of transformations of substances and energy in the body, ensuring its development, vital activity and self-reproduction, as well as its connection with environment and adaptation to changes in external conditions) carried out mainly in the liver by microsomal glucuronidation. It is excreted in the form of metabolites, mainly by the kidneys, and also with bile.

Indications for use

Infectious and inflammatory diseases caused by sensitive to sulfadimethoxine microorganisms (Microorganisms- the smallest, predominantly unicellular organisms that are visible only through a microscope: bacteria, microscopic fungi, protozoa, sometimes they include viruses): respiratory tract and ENT organs (tonsillitis, bronchitis, pneumonia, otitis (Otitis- ear infection), sinusitis (Sinusitis- inflammation of the mucous membrane, sometimes of the bone walls maxillary sinus often occurs as a complication of the flu)), biliary and urinary tract, meningitis, shigellosis, wound infection, pyoderma (pyoderma- These are skin diseases, the main symptom of which is suppuration), gonorrhea (Gonorrhea- a sexually transmitted disease caused by gonococcus. 3-5 days after infection, pain and suppuration from the urethra appear. Possible inflammatory complications of the genital organs, Bladder, joints, etc.), trachoma, erysipelas, toxoplasmosis; resistant forms malaria (Malaria- a group of acute protozoans vector-borne diseases humans and animals whose pathogens are transmitted by mosquitoes of the genus Anopheles. Accompanied by fever, chills, splenomegaly (enlargement of the spleen), hepatomegaly (enlargement of the liver), anemia)(in combination with antimalarial drugs).

Dosage and administration

Assign inside after meals, 1 time per day with an interval between doses of 24 hours.
Adults are prescribed:
for mild infections - on the first day, 1 g (2 tablets), on subsequent days -
0.5 g (1 tablet);
with moderate and severe infections - on the first day, 2 g (4 tablets), on subsequent days - 1 g (2 tablets). If necessary, the dose may be increased.
Children under 12 years of age are prescribed: on the first day, 25 mg / kg, on subsequent days, 12.5 mg / kg; children over 12 years old - on the 1st day, 1 g (2 tablets), on the following days - 0.5 g each
(1 tablet).
The duration of the course of treatment depends on the severity of the disease and is 7-10 days.
Treatment must necessarily continue for 2-3 days after normalization of body temperature.

Side effect

From the side nervous system (Nervous system - a set of formations: receptors, nerves, ganglia, brain. Carries out the perception of stimuli acting on the body, the conduction and processing of the resulting excitation, the formation of response adaptive reactions. Regulates and coordinates all body functions in its interaction with the external environment): headache. From the digestive system: dyspepsia (Dyspepsia- indigestion resulting from a lack of enzymes or as a result of poor nutrition), nausea, vomiting, cholestatic hepatitis. Allergic reactions: skin rash, drug fever (Fever- a special reaction of the body that accompanies many diseases and is manifested by an increase in body temperature. The febrile reaction most often occurs when infectious diseases, with the introduction of therapeutic sera and vaccines, with traumatic injuries, crushing of tissues, etc.). From the hemopoietic system: rarely - leukopenia (Leukopenia- the content of leukocytes in peripheral blood is less than 4000 per 1 μl, due to the impact on the body of various damaging factors), agranulocytosis.

Contraindications

Hypersensitivity to sulfonamides and other components of the drug, inhibition of bone marrow hematopoiesis, renal and / or liver failure, congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azotemia, pregnancy, lactation, children under 2 months of age.

Overdose

Possible aggravation side effects. Treatment is symptomatic.

Application features

The drug is contraindicated in pregnancy. Stop during treatment breast-feeding because the drug passes into breast milk and may cause nuclear jaundice (Jaundice- a painful condition characterized by the accumulation of bilirubin in the blood and its deposition in tissues with staining in yellow skin, mucous membranes, sclera of the eyes. Occurs with increased breakdown of red blood cells (eg, neonatal jaundice, jaundice in hemolytic anemia), viral hepatitis and other diseases of the liver, obstruction of the outflow of bile), as well as hemolytic anemia (Hemolytic anemia - anemia due to increased hemolysis (destruction of red blood cells), which occurs due to a defect in the structure of red blood cell membranes) in children with glucose-6-phosphate dehydrogenase deficiency.
The use of the drug in children under the age of 2 months is possible only for the treatment of congenital toxoplasmosis for health reasons.
Restriction to medical use drug is chronic (Chronic- a long, ongoing, protracted process, occurring either constantly or with periodic improvements in condition) heart failure.
The drug should be avoided in patients over 65 years of age due to an increased risk of severe side effects.
During the course of treatment, it is necessary to systematically monitor the state of kidney function and the picture of peripheral blood.
During therapy (Therapy- 1. The field of medicine that studies internal diseases, one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate a type of treatment (oxygen therapy\; hemotherapy - treatment with blood products)) recommended a large number of alkaline drink sufficient to maintain diuresis (Diuresis- the amount of urine excreted in a certain time. In humans, daily diuresis averages 1200-1600 ml) at a level of at least 1.2 l / day for adults.
During treatment with the drug, it is necessary to follow the dosing regimen, take the prescribed dose after 24 hours, do not skip the dose. If you miss a dose, take it as soon as possible; do not take if it is almost time for the next dose; do not double the dose. It is recommended to avoid exposure to direct sunlight and ultraviolet radiation.
Data on the effect of the drug on the ability to drive Vehicle and to fulfill potentially dangerous species activities are missing.

Interaction with other drugs

Reduces the effectiveness of bactericidal antibiotics (Antibiotics- substances that have the ability to kill microbes (or prevent their growth). Used as medications, suppressing bacteria, microscopic fungi, some viruses and protozoa, there are also antitumor antibiotics) acting only on dividing microorganisms (including penicillins, cephalosporins). Antibacterial activity is reduced by procaine, benzocaine and tetracaine, and enhanced by barbiturates and para-aminosalicylic acid. Methotrexate and phenytoin increase toxicity (Toxicity- the ability of some chemical compounds and substances of biological nature to have a harmful effect on the human body, animals and plants) sulfadimethoxine; non-steroidal anti-inflammatory drugs, thioacetazone, chloramphenicol, myelotoxic drugs increase toxic (Toxic- poisonous, harmful to the body) action on the blood. Sulfadimetoksin enhances the effect anticoagulants (Anticoagulants- drugs that reduce blood clotting) indirect action, phenytoin, sulfonamides with hypoglycemic action; reduces efficiency oral (oral- the route of administration of the drug through the mouth (per os)) contraceptives. Pyrazolone derivatives, indomethacin and salicylates increase the free fraction of sulfadimethoxine in the blood.

Product General Information

Terms and conditions of storage. To store in the place protected from light at a temperature from 8 °C to 25 °C. Keep out of the reach of children.
Shelf life - 5 years.

Holiday conditions. On prescription.

Package. 10 tablets in a blister pack and in a pack; 10 tablets in a blister pack.

Manufacturer.LLC "Pharmaceutical company "Health".

Location. 61013, Ukraine, Kharkov, st. Shevchenko, 22.

Website. www.zt.com.ua

Preparations with the same active ingredient

• Sulfadimetoksin - "Darnitsa"

This material is presented in free form on the basis of the official instructions for the medical use of the drug.

Registration number: РN003805/01

Trade name of the drug: Sulfadimethoxine

international generic name(INN): Sulfadimethoxine

Dosage form: tablets

Compound:
One tablet contains: sulfadimethoxine 0.2 g or 0.5 g; excipients (potato starch; colloidal silicon dioxide (aerosil); calcium stearate, food gelatin) in an amount sufficient to obtain a tablet weighing 0.22 or 0.55 g.

Description: Tablets white or white with a creamy tinge, flat-cylindrical shape.

Pharmacotherapeutic group: antimicrobial agent, sulfanilamide
ATX code J01ED01

Pharmacological properties
Antimicrobial bacteriostatic agent, long-acting sulfanilamide. The mechanism of action is due to competitive antagonism with para-aminobenzoic acid, inhibition of dihydropteroate synthetase, impaired synthesis of tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines. Active against gram-positive and gram-negative microorganisms: Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae, Friedlander's bacillus, Escherichia coli, Shigella spp., Chlamydia trachomatis.

Pharmacokinetics
After ingestion, after 30 minutes it is found in the blood, the time to reach the maximum concentration is 8-12 hours. It penetrates poorly through the blood-brain barrier. Therapeutic concentration in adults is noted when taking 1-2 g on day 1 and 0.5-1 g on the following days. The drug accumulates in the blood, primarily due to the high degree of binding to plasma proteins (90-99%). It is well distributed among organs and systems. But unlike other representatives of long-acting sulfonamides, it penetrates poorly through the blood-brain barrier and its concentration in the cerebrospinal fluid is low (with inflammation of the meningeal membranes, the permeability of the blood-brain barrier increases dramatically). It penetrates well into the pleural fluid (60-90% of the concentration in the blood), into the biliary system, where its concentration is 1.5-4 times higher than in the blood. Unlike other sulfonamides, the predominant metabolism is carried out along the path of microsomal glucuronidation associated with cytochrome P450 and NADPH-dependent. It is excreted slowly, primarily due to retention in the blood by plasma proteins and due to a high degree of reabsorption in the tubules of the kidneys (93-97.5%). The blood contains 5-15% acetylated metabolites, the urine contains 10-25% acetyl derivatives and 75-90% sulfadimethoxine glucuronide; the latter is highly soluble and does not provoke the development of crystalluria. The acetylated derivative is not reabsorbed and is completely excreted by the kidneys. After 24 hours, 20-44% of the dose taken is excreted, after 48 hours - up to 56%, after 96 hours - up to 83.3%.

Indications for use
Infectious and inflammatory diseases caused by sensitive microflora: tonsillitis, bronchitis, pneumonia, sinusitis, otitis, dysentery, inflammatory diseases of the biliary and urinary tract, erysipelas, wound infection, trachoma.

Contraindications
Hypersensitivity, depression of bone marrow hematopoiesis, renal / hepatic failure, chronic heart failure, congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azotemia, pregnancy. This dosage form not intended for use in children under 2 years of age.

Carefully- lactation period.

Dosage and administration
Inside, 1 time per day, on day 1 - 1-2 g, then - 0.5-1 g / day.
Children (from 2 years old) on the 1st day - 25 mg / kg / day, then - 12.5 mg / kg / day. The course of treatment is 7-10 days.

Interaction
Reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins).
Procaine, benzocaine and tetracaine reduce antibacterial activity.
Para-aminosalicylic acid and barbiturates enhance the antimicrobial effect.
Salicylates, methotrexate and phenytoin increase the toxicity of sulfadimethoxine.
Non-steroidal anti-inflammatory drugs, thioacetazone, chloramphenicol increase the toxic effect on the blood (leukopenia, agranulocytosis).
Enhances the effect of indirect anticoagulants, phenytoin, sulfonamides with hypoglycemic action.
Pyrazolone derivatives, indomethacin and salicylates increase the free fraction of the drug in the blood.
Reduces the effectiveness of oral contraceptives. Enhances the metabolism of cyclosporine.

special instructions
During therapy, a plentiful alkaline drink, monitoring of blood and urine parameters is recommended.

Release form
Sulfodimetoksin tablets 0.2 g and 0.5 g then 10 tablets in a blister pack. Two blister packs together with instructions for medical use in a cardboard box.

Best before date
3 years. Do not use the drug after the expiration date.

Storage conditions
List B. In a place protected from light and out of the reach of children.

Terms of dispensing from pharmacies
By prescription.

Manufacturer
JSC "NIZHFARM"
Russia 603950, Nizhny Novgorod GSP-459, Salganskaya st., 7