Decaris symptoms. Decaris: an anthelmintic for children - a guide for moms

Decaris: instructions for use and reviews

Active substance

Levamisole (levamisole)

Release form, composition and packaging

Tablets light orange in color (may have darker blotches), round, flat, chamfered with quartering marks on one side, with a slight smell of apricot.

Excipients: corn starch, sodium saccharinate, K90, talc, apricot flavor, magnesium stearate, sunset yellow dye (E110).

2 pcs. - cellular contour packings (1) - packs of cardboard.

Tablets almost white, round, flat, chamfered and engraved with "DECARIS 150" on one side.

Excipients: corn starch, lactose monohydrate, sucrose, talc, povidone K90, magnesium stearate.

1 PC. - cellular contour packings (1) - packs of cardboard.

pharmachologic effect

The active substance of the drug Decaris - levamisole is an anthelmintic agent. Acting on ganglion-like formations of nematodes, Decaris causes depolarizing neuromuscular paralysis of the helminth muscle membrane, blocks succinate dehydrogenase, and inhibits fumarate dehydrogenase, disrupting the course of helminth bioenergetic processes. Thus, paralyzed nematodes are removed from the body by normal intestinal motility within 24 hours after taking the drug.

Pharmacokinetics

Suction

Levamisole, when taken orally at a dose of 50 mg, is rapidly absorbed from the gastrointestinal tract. C max in the blood is determined on average 1.5-2 hours after taking the drug.

Metabolism and excretion

Levamisole undergoes intensive metabolism in the liver, its main metabolites are p-hydroxy-levamisole and its glucuronide.

T1 / 2 from the body is 3-6 hours. Less than 5% is excreted unchanged by the kidneys, less than 0.2% of the administered dose is excreted through the intestines.

Indications

• infection with helminths Ascaris lumbricoides, Necator americanus and Ancylostoma duodenale.

Contraindications

• drug-induced agranulocytosis (history);
• lactation period;
• childhood up to 3 years;
• children's age (for tablets 150 mg);
• hypersensitivity to any of the components of the drug.

Carefully the drug is prescribed for renal and / or hepatic insufficiency, inhibition of bone marrow hematopoiesis.

Dosage

It is advisable to take the drug after meals with a small amount of water, in the evening.

Adults 1 tablet of 150 mg is prescribed once.

Children aged 3 to 6 years(10-20 kg) - 25-50 mg (0.5-1 tab. 50 mg each); children aged 6 to 10 years(20-30 kg) 50-75 mg (1-1.5 tablets of 50 mg), children aged 10 to 14(30-40 kg) - 75-100 mg (1.5-2 tablets of 50 mg) once.

There is no need for laxatives or a special diet.

If necessary, the drug can be repeated after 7-14 days.

Side effects

Headache, insomnia, dizziness, palpitations, convulsions, dyspepsia (nausea, vomiting, diarrhea).

There are development reports side effects from the side of the central nervous system (encephalopathy) 2-5 weeks after taking the drug, as well as about allergic reactions(skin rash), convulsions.

In most patients, these events were reversible, and early use of glucocorticosteroid therapy improved the prognosis.

The connection of these symptoms with the use of Decaris is not entirely convincing. When using large doses or with prolonged therapy, leukopenia, agranulocytosis, and tremor may occur.

Overdose

Symptoms: with the introduction of a large dose of levamisole (over 600 mg), the following signs of intoxication were described - nausea, vomiting, drowsiness, convulsions, diarrhea, headache, dizziness and confusion.

Treatment: in case of accidental overdose, if a lot of time has not passed after taking the drug, gastric lavage is performed. It is necessary to monitor the vital functions of the body and conduct symptomatic therapy. If there are signs of anticholinesterase action, you can enter.

drug interaction

With the simultaneous administration of the drug with alcoholic beverages, disulfiram-like phenomena are observed.

Caution is required when using Decaris with drugs that affect hematopoiesis.

While taking the drug with coumarin-like prothrombin time may increase, so it is necessary to adjust the dose of oral anticoagulant. Decaris increases the level of phenytoin in the blood, therefore, with their simultaneous use, it is necessary to control the level of phenytoin in the blood.

Decaris cannot be used simultaneously with lipophilic drugs such as carbon tetrachloride, tetrachlorethylene, chenopodium oil, chloroform or ether, because. its toxicity may increase.

special instructions

During and after taking the drug for 24 hours, you can not drink alcohol.

There is insufficient evidence that levamisole, used as an anthelmintic agent, depresses the nervous system.

Levamisole is the main active ingredient of the drug Decaris (sometimes "Decoris" is used incorrectly).

On this page you will find all information about Decaris: complete instructions on application to this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Decaris. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Anthelmintic drug.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much is Decaris worth? The average price in pharmacies is at the level of 100 rubles.

Release form and composition

The medicine is produced in the form of tablets with a different dose:

• Decaris for adults - one tablet contains 150 mg active substance. It is flat, white, on one side there is an engraving of the name of the medicine. Additional components are determined by lactose, sucrose, talc, povdon, starch. Released in a cardboard box on a tablet.
• Decaris for children - each tablet contains 50 mg of levamisole. By appearance they are flat, round with an orange tint and a slight apricot scent. Have a risk for separation. As auxiliary ingredients there are talc, dyes, starch, nutritional supplements, fragrances. From the pharmacy it is released in a carton pack of 2 tablets.

The drug Decaris belongs to the group of synthetic anthelmintic drugs and has a pronounced immunomodulatory property. As active component the composition contains levamisole and other excipients.

Pharmacological effect

The high activity of such cells perfectly stimulates immune system organism.

Indications for use

1. (pathogens - ascaris);
2. (pathogens - pinworms);
3. Toxoplasmosis (causative agents - toxoplasma);
4. Strongyloidiasis (causative agents - intestinal acne);
5. Trichuriasis (causative agents - whipworm);
6. Hookworm infections (causative agents - hookworm);
7. Necatoroses (causative agents - necators);
8. Trichostrongylosis (pathogens - nematodes).

Contraindications

The drug Decaris can be taken only after consulting a doctor and determining the causative agent of invasion. Before starting therapy, the patient should carefully study the attached instructions, since the drug has a number of contraindications:

1. severe renal or hepatic insufficiency;
2. Pregnancy period in the 1st trimester;
3. Age of children up to 3 years;
4. Individual intolerance to the components of the drug;
5. Violations of cerebral circulation;
6. breastfeeding period.

Use during pregnancy and lactation

Only a specialist can prescribe Decaris during pregnancy - in emergency cases, when folk remedies ineffective - and only in the third (rarely - second) trimester.

Instructions for use

The instructions for use indicate that Decaris should be taken orally, after meals in the evening, with a small amount of water. There is no need for a special diet or laxatives.

• The drug is taken once. Adults are usually prescribed 1 tablet of 150 mg.

Children should take the drug based on age and weight:

• 3-6 years (from 10 to 20 kg) - 0.5-1 tablet of 50 mg (25-50 mg);
• 6-10 years (from 20 to 30 kg) - 1-1.5 tablets of 50 mg (50-75 mg);
• 10-14 years (from 30 to 40 kg) - 1.5-2 tablets of 50 mg (75-100 mg).

If necessary, after 1-2 weeks, the reception of Decaris can be repeated.

Side effects

As a rule, the use of anthelmintic agents is well tolerated by patients. But in some cases, if the instructions for using Decaris tablets were not followed or for a reason individual features organism, this drug may cause side effects:

1. Diarrhea, soreness in the abdomen.
2. Insomnia.
3. High body temperature.
4. Dizziness and headaches.
5. Weakness, malaise, fatigue.
6. Appetite disturbance.
7. Nausea and vomiting.
8. Changes in the composition of the cut.
9. Allergic manifestations in the form of itching, rashes, redness of the skin.

Taking Decaris can contribute to the development of such serious conditions as bleeding, leukopenia, myasthenia gravis, swelling in the periarbital part.

Overdose

In severe cases of overdose, side effects such as leg cramps, Quincke's edema, disorientation and possible hallucinations are noted. Often there is poor speech activity, a coma.

special instructions

During and after taking the drug for 24 hours, you can not drink alcohol. There is insufficient evidence that levamisole, used as an anthelmintic agent, depresses the nervous system.

Due to the fact that when taking the drug, transient, mild dizziness may occur, care should be taken when driving a car or when working with mechanisms during the entire course of treatment.

drug interaction

1. Caution is required when using Decaris with drugs that affect hematopoiesis.
2. With the simultaneous administration of the drug with alcoholic beverages, disulfiram-like phenomena are observed.
3. Decaris should not be used concomitantly with lipophilic drugs such as carbon tetrachloride, tetrachlorethylene, chenopodium oil, chloroform or ether, as its toxicity may increase.
4. With the simultaneous administration of the drug with coumarin-like anticoagulants, the prothrombin time may increase, so it is necessary to adjust the dose of the oral anticoagulant. Decaris increases the level of phenytoin in the blood, therefore, with their simultaneous use, it is necessary to control the level of phenytoin in the blood.

Reviews

We have selected real reviews of people about the drug Decaris:

Among the analogues of Decaris, which have a similar therapeutic effect, the following drugs can be mentioned:

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep away from children. Store between 15 and 30°C. Shelf life - 5 years.

Firstly, all antihelminthic drugs are toxic, giving them to children "for prevention" is not recommended. Besides, for effective treatment you need to know which helminths have settled in the body: Decaris is effective only against certain types of worms.

Decaris is a drug for the treatment of worms in children.

general characteristics

Decaris has antihelminthic and immunomodulatory effects. Today, there is a great choice of stronger and less toxic immunomodulators, and earlier the remedy was prescribed to treat and alleviate conditions such as:

• frequent acute respiratory infections and colds;
• herpes;
• acute leukemia;
• immunodeficiency states;
• some autoimmune diseases, etc.

Modern pediatricians use Decaris mainly for the treatment of identified helminthic invasions.

The manufacturer of the drug is the Hungarian company Gedeon-Richter. You can buy the medicine at the pharmacy without a prescription (but it’s better still as prescribed by the doctor). The second most important advantage of Decaris after its effectiveness, parents in the reviews call an acceptable price - only 60-80 rubles.

How does it work

Active active substance medication is levamisole. Quickly absorbed from the gastrointestinal tract, it immediately begins to act.

The immunomodulatory effect of the drug is manifested through the stimulation of blood cells responsible for immunity - T-lymphocytes, monocytes, neutrophils.

Indications

Today, Decaris for children is used as a highly effective antihelminthic drug. The agent acts on helminths with muscles:

• pinworms;
• roundworm;
• nematode;
• necator;
• whipworm;
• intestinal acne.

Against flukes and tapeworms, reliably sticking to the intestinal walls, Decaris is powerless.

Contraindications

The drug has an impressive list of contraindications. This is another reason to get a face-to-face consultation with a doctor before starting treatment. In particular, the use of Decaris is prohibited for children who:

• have not reached the age of 3;
• have hypersensitivity to the components of the drug;
• had cases of a decrease in the number of leukocytes in the blood after taking any drugs;
• have severe illness manifested through dysfunction of the liver and kidneys.

Do not prescribe medicine to children under the age of 3 years.

Unwanted Effects

Decaris tablets, according to parental reviews, rarely cause side effects if the instructions for use are followed. Undesirable effects may appear from:

• nervous system - irritability, migraine, dizziness;
• Gastrointestinal tract - stool disorder (/), nausea,;
• immune system - flu symptoms, allergic reactions in the form of rashes and itching;
• hematopoietic system - agranulocytosis (the rarest possible side effect).

Interaction with other drugs

If the child is treated with drugs that affect the process of hematopoiesis, Decaris is prescribed by a doctor with caution: doses of drugs are adjusted and the patient's performance is monitored. Decaris should not be taken with lipophilic agents (chloroform, carbon tetrachloride, chenopodium oil, etc.), as they increase its toxicity. In any case, before starting treatment, especially if the young patient is already taking any medications, it is necessary to consult a pediatrician.

Release forms

The drug is produced in the form of tablets. The option for children is Decaris 50, containing 50 mg of levamisole in each tablet. The composition of the product includes dyes and flavors, so the tablets have an apricot smell and a delicate orange color. For ease of dosing, risks are applied to their surface.

In no case do not confuse Decaris tablets for adults (150 mg) and for children (50 mg).

Reception scheme

The dosage of the drug in accordance with the age of the patient is described in the instructions:

• 3-6 years old - 0.5-1 tab.;
• 6-10 years old - 1-1.5 tablets;
• 10-14 years old - 1.5-2 tab.

These doses are derived taking into account the norms of body weight of children belonging to certain age groups. Still, it is more correct to focus on the weight of a particular child from the calculation 2.5 mg levamisole per 1 kg.

If a seven-year-old child weighs only 17 kg, the recommended dose for him is 42.5 mg of the active substance, i.e. a little more than 3/4 tablets of Decaris 50 (but not 1-1.5 tablets in any way - the norm indicated in the instructions for children 6-10 years old).

Usually Decaris accepted once. In some cases, the doctor may adjust the regimen by adding a second appointment after 1-2 weeks.

The drug is best given to children in the evening, immediately after meals. The tablet should be taken with a small amount of water.

Often, Enterosgel and Borjomi are prescribed together with Decaris to minimize harm to the liver.

Only a doctor can choose the right dosage for your child!

Analogues

An analogue of Decaris - Pirantel - an antihelminthic that can be given to children from 6 months.

Country of origin

Product group

Anthelmintic drug

Release forms

• Tablets 50mg - 2 pcs. Tablets 150mg - 1 pc.

Description of the dosage form

• Tablets are round, flat, light orange, chamfered, marked "+" on one side, with a slight apricot odor. Tablets are round, flat, light orange, chamfered, marked "+" on one side, with a slight apricot odor. Tablets are flat, almost white, chamfered, engraved with "DECARIS 150" on one side.

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• levamisole hydrochloride 177 mg, which corresponds to the content of levamisole 150 mg Excipients: corn starch, lactose monohydrate, sucrose, talc, povidone, magnesium stearate. levamisole hydrochloride 59 mg, which corresponds to the content of levamisole 50 mg Excipients: corn starch, sodium saccharinate, talc, povidone, apricot flavor, magnesium stearate, dye sunset yellow (E110). levamisole hydrochloride 59 mg, which corresponds to the content of levamisole 50 mg Excipients: corn starch, sodium saccharinate, talc, povidone, apricot flavor, magnesium stearate, sunset yellow dye (E110 levamisole hydrochloride 59 mg, which corresponds to the content of levamisole 50 mg Excipients: corn starch, sodium saccharinate, talc, povidone, apricot flavor, magnesium stearate, sunset yellow dye (E110).

Decaris indications for use

• As an antihelminthic agent: - ascariasis; - ankylostomiasis. As an immunomodulator: - infectious diseases(recurrent herpes simplex caused by Herpes simplex viruses types 1 and 2, herpes zoster, warts, often recurrent infectious and inflammatory diseases of the upper sections respiratory tract in children, recurrent sinusitis, chronic active hepatitis B, persistent viral hepatitis, in which the Australian antigen (HBsAg) is detected in the blood for more than 3 months); - immunodeficiency states and autoimmune diseases ( rheumatoid arthritis, Crohn's disease, recurrent aphthous stomatitis, Reiter's disease, to maintain remission achieved by other means in SLE); - malignant neoplasms lungs, colon, breast (after surgical, radiation or chemotherapy treatment); - lymphogranulomatosis and leukemia (during remission in the intervals between courses of chemotherapy).

Decaris contraindications

• - drug-induced agranulocytosis (history); - children's age up to 3 years; - period of breastfeeding. 150 mg tablets are not prescribed for children! With caution: patients with renal and / or hepatic insufficiency, with oppression of bone marrow hematopoiesis.

Decaris dosage

• 150 mg 50 mg

Decaris side effects

• Headache, insomnia, dizziness, palpitations, convulsions, dyspepsia (nausea, vomiting, abdominal pain, diarrhea). There are reports of the development of side effects from the central nervous system (encephalopathy) 2-5 weeks after taking the drug, as well as allergic reactions (skin rash), convulsions. In most patients, these events were reversible, and early use of glucocorticosteroid therapy improved the prognosis. The connection of these symptoms with the use of Decaris is not entirely convincing. When using large doses or with prolonged therapy, leukopenia, agranulocytosis, and tremor may occur.

drug interaction

Storage conditions

• keep away from children