Tsetrin: instructions, reviews, indications and analogues. Cetrin tablets: instructions for use and what it is for, price, reviews, analogues Interaction with other drugs and other forms of interaction

Tsetrin is antihistamine 3 generations, is prescribed for various allergic reactions in children and adults. Active substance- Cetirizine.

H1-histamine receptor blocker, antiallergic agent. Serotonin and cholinergic receptors does not block. It has an antiallergic effect, does not penetrate the BBB, if used as directed in therapeutic doses, the drug does not have a significant sedative effect.

The active substance of Cetrin tablets affects all stages of an allergic reaction - early and late, reduces the migration of neutrophils, eosinophils, basophils. The drug facilitates the course of existing allergic reactions and prevents their occurrence, has a pronounced antiexudative and antipruritic effect.

Reduces the permeability of capillaries, prevents the development of tissue edema, relieves spasm of smooth muscles.

Eliminates skin reaction to the introduction of histamine, specific allergens, as well as to cooling (with cold urticaria). Reduces histamine-induced bronchoconstriction bronchial asthma light flow.

The onset of the effect after a single dose of Cetrin 10 mg tablets is 20 minutes (in 50% of patients) and after 60 minutes (in 95% of patients), lasts more than 24 hours. Against the background of course treatment, tolerance to the antihistamine action does not develop. After stopping treatment, the effect of the tablets lasts up to 3 days.

What helps Cetrine?

According to the instructions, Cetrin tablets are prescribed to alleviate allergy symptoms with:

• seasonal and chronic allergic rhinitis;
• allergic conjunctivitis;
• itching of various etiologies;
• urticaria (including chronic idiopathic);
• angioedema (Quincke's edema).

Instructions for use Cetrin, dosage of tablets

Tablets are taken orally, regardless of the meal, washed down with clean water.

The standard dosage for adults and children over 6 years old, according to the instructions for use, is 1 tablet of Cetrin 10 mg once a day. Let's take 5 mg (half a tablet) \ 2 times a day.

Patients with reduced kidney function 5 mg once a day. At severe forms chronic kidney failure- 5 mg once every 48 hours.

Dosages:

• children 2-6 years old - 5 mg \ 1 time or 2.5 mg 2 times a day,
• children 1-2 years old - 2.5 mg (5 drops) 2 times a day.

special instructions

The instruction warns that if the dose of 10 mg per day (1 tablet of Tsetrin) is exceeded, the ability to react quickly may deteriorate.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Cetrin:

• Increased fatigue, asthenia, malaise, edema;
• From the side nervous system: paradoxical stimulation of the central nervous system, dizziness, headache, paresthesia, convulsions, dysgeusia, dyskinesia, dystonia, fainting, tremor;
• From the gastrointestinal tract: abdominal pain, dry mouth, nausea, diarrhea;
• Mental disorders: drowsiness, anxiety, aggressiveness, confusion, depression, hallucinations, insomnia, tic;
• From the side respiratory system: pharyngitis, rhinitis;
• survey data: weight gain;
• From the side of the heart: tachycardia;
• From the blood system and lymphatic system: thrombocytopenia;
• On the part of the organ of vision: disturbance of accommodation, blurred vision, involuntary movements of the eyeball;
• From the side of the kidneys and urinary system: dysuria, enuresis;
• From the skin and subcutaneous tissue: itching, rash, urticaria, angioedema, local drug rash;
• From the side immune system: hypersensitivity, anaphylactic shock;
• On the part of the liver and biliary system: impaired liver function (increased levels of transaminases, alkaline phosphatase, γ-glutamyl transferase and bilirubin).

Contraindications

It is contraindicated to prescribe Tsetrin tablets in the following cases:

• children's age up to 6 years;
• pregnancy and lactation;
• terminal stage of renal failure (CC less than 10 ml / min);
• hypersensitivity to cetirizine, hydroxyzine or piperazine derivatives, as well as to other components of the drug.

Carefully:

• in chronic renal failure (with CC> 10 ml / min, correction of the dosing regimen is required);
• patients with predisposing factors for urinary retention;
• with epilepsy and patients with increased convulsive readiness;
• elderly patients (with an age-related decrease in glomerular filtration);

Syrup is prescribed starting from 2 years, drops - from 6 months.

Overdose

Overdose symptoms are dry mouth, drowsiness, urinary retention, constipation, anxiety, irritability.

Tsetrin analogues, price in pharmacies

If necessary, you can replace Tsetrin with an analogue according to active substance are the drugs:

1. cetirizine,
2. Allerza,
3. Zetrinal,
4. Zincet,
5. Letizen,
6. Parlazin.

When choosing analogues, it is important to understand that the instructions for use of Cetrin, the price and reviews for drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in pharmacies in Moscow and Russia: Cetrin tablets 10 mg 20 pcs. - from 153 to 178 rubles, the cost of 30 tablets - from 231 to 267 rubles, according to 574 pharmacies.

Keep out of the reach of children at a temperature not exceeding +25°C. The shelf life of tablets is 2 years, drops - 3 years.

Terms of dispensing from pharmacies - without a prescription.

The drug Cetrin instructions for use refers to antiallergic drugs from the group of histamine H1 receptor blockers. Tablets 10 mg, syrup or drops are prescribed for adults and children with allergic reactions of various nature. Patient reviews and doctors' recommendations indicate that this drug helps in the treatment of allergies.

Release form and composition

Cetrin is available in tablets, syrup and oral drops.

The syrup is an uncolored, transparent, homogeneous suspension that does not contain suspended particles. It has a fruity pleasant smell. It is sold in darkened bottles of 30 and 60 ml. A measuring spoon is included. Cetrin syrup contains the active substance at a concentration of 1 mg / ml.

Tablets are biconvex, film-coated. Available in blisters of 10, 20 and 30 pieces. Cetrin tablets contain 10 mg of cetirizine hydrochloride, as well as corn starch, lactose, povidone K30, magnesium stearate.

Drops are a clear, colorless liquid. Sold in bottles with a dropper dispenser. The volume of the bottle is 10-20 ml.

pharmachologic effect

Cetrine is a histamine antagonist that blocks H1 - histamine receptors. The active substance is cetirizine. The drug is shown as prophylactic against allergic reactions, as well as to facilitate their course. It has antipruritic and antiexudative effect.

Has an impact on allergic reactions at an early stage. In the stage of an allergic reaction that has begun, the drug limits the release of inflammatory mediators. Cetrin prevents tissue edema, relieves spasms of smooth muscles, and reduces capillary permeability.

Eliminates skin reactions to specific allergens. It does not have antiserotonin and anticholinergic effects. Subject to therapeutic doses, it practically does not have a sedative effect. After a single dose of the drug, the onset of the effect, in about half of the patients, is observed after 20 minutes, after 1 hour in 95% of patients.

The effect of the drug lasts more than 24 hours. At therapeutic treatment tolerance to the antihistamine action of the drug does not develop. After the end of treatment, the effect of the drug lasts up to 3 days.

What helps Cetrin? Indications for use

The drug Cetrin is prescribed to patients for the rapid removal of allergy attacks and the prevention of allergic reactions caused by such conditions:

• lacrimation and severe rhinorrhea;
• hay fever;
• angioedema;
• an allergic reaction to the stings of bees, mosquitoes, midges, horseflies;
• allergic reaction to UV radiation;
• urticaria, including idiopathic form;
• allergic conjunctivitis;
• allergic rhinitis, which often occurs during the flowering of grasses and ragweed;
• itching of the skin with dermatitis, eczema, neurodermatitis.

Tablets are often prescribed to patients prone to allergies as a preventive measure when taking certain medications or eating allergenic foods.

Instructions for use

Cetrin syrup is taken orally, regardless of the meal. Drinks water. Reception is best done in the evening.

• Adults and children over 6 years of age are prescribed 10 ml 1 time per day or 5 ml 2 times a day.
• Children from 2 to 6 years old are prescribed 5 ml 1 time per day or 2.5 ml 2 times a day.

The dosage is set taking into account the severity of the condition and the response of the patient. With reduced kidney function (CC 30-40 ml / min), take 5 ml of syrup 1 time per day. In severe chronic renal failure (CC 10-30 ml / min), 5 ml of syrup should be taken every other day.

Tablets are taken orally, without chewing and with a glass of water, regardless of the meal. Adults and children from 6 years old take 1 tablet 1 time per day or 0.5 tablet 2 times a day.

When taking the drug in the form of drops, the initial dose is 10 drops 1 time per day. According to indications, the dose is increased to 20 drops 1 time per day. It is recommended to take the minimum effective dose of the drug.

• Children from 6 months to 1 year are prescribed 5 drops 1 time per day.
• Children from 1 to 2 years old should take 5 drops 1-2 times a day.
• Children 2-6 years old take 5 drops 2 times a day or 10 drops 1 time a day.

Contraindications

• hypersensitivity (including to hydroxyzine);
• pregnancy, lactation;
• children's age up to 6 years (for this dosage form).

Side effects

Cetrin rarely causes side effects. Sometimes patients experience dry mouth and increased drowsiness. Less common are symptoms such as:

• hypersensitivity reactions (rash, itching, urticaria, angioedema);
• headache;
• migraine;
• dizziness;
• feeling of discomfort in the stomach / intestines.

Children, during pregnancy and lactation

During pregnancy and lactation, the use of the drug is contraindicated. If it is necessary to take Cetirizine during lactation, it is necessary to stop breastfeeding for the duration of treatment.

Taking the drug in the form of drops is contraindicated in children under 6 months. Children from 6 months to 1 year of age should use Cetrin drops with caution. The use of tablets is allowed for children over 6 years of age.

special instructions

When used in therapeutic doses, Cetrin does not potentiate the action of ethanol (alcohol), but the use of alcohol while using the drug is not recommended.

drug interaction

With the simultaneous appointment of Cetrin tablets with Theophylline, the clearance of Cetirizine decreases, which should be taken into account and this drug interaction should be avoided.

A competitive histamine antagonist, a metabolite of hydroxyzine, blocks H1-histamine receptors. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative action. Affects early stage allergic reactions, limits the release of inflammatory mediators at the "late" stage of an allergic reaction, reduces the migration of eosinophils, neutrophils and basophils. Reduces the permeability of capillaries, prevents the development of tissue edema, relieves spasm of smooth muscles. Eliminates skin reaction to the introduction of histamine, specific allergens, as well as to cooling (with cold urticaria). Reduces histamine-induced bronchoconstriction in mild bronchial asthma.

Virtually no anticholinergic and antiserotonin action. In therapeutic doses, it practically does not cause a sedative effect. The onset of the effect after a single dose of 10 mg of cetirizine is 20 minutes, lasts more than 24 hours. During the course of treatment, tolerance to the antihistamine effect of cetirizine does not develop. After the termination of treatment, the effect persists for up to 3 days.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract, the time to reach maximum concentration (TC max) after ingestion is about 1 hour. Food does not affect the completeness of absorption (AUC), but prolongs TC max by 1 hour and reduces the maximum concentration (C max) by 23%. When taken at a dose of 10 mg 1 time per day for 10 days, the equilibrium concentration of the drug (C ss) in plasma is 310 ng / ml and is observed 0.5-1.5 hours after administration. Communication with plasma proteins - 93% and does not change at a concentration of cetirizine in the range of 25-1000 ng / ml. The pharmacokinetic parameters of cetirizine change linearly when administered at a dose of 5-60 mg. The volume of distribution is 0.5 l / kg.

In small quantities, it is metabolized in the liver by O-dealkylation with the formation of a pharmacologically inactive metabolite (unlike other H1-histamine receptor blockers metabolized in the liver with the participation of the cytochrome P 450 system). Cytirizine does not accumulate. About 2/3 of the drug is excreted unchanged by the kidneys and about 10% - with stool. Systemic clearance - 53 ml / min. The half-life (T 1 / 2) in adults is 10 hours, in children 6-12 years old - 6 hours, 2-6 years old - 5 hours, 0.5-2 years old - 3.1 hours. In elderly patients, T 1 / 2 increases by 50 %, systemic clearance is reduced by 40% (decrease in kidney function).

In patients with impaired renal function (creatinine clearance below 40 ml / min), the clearance of the drug decreases, and T 1/2 lengthens (for example, in patients on hemodialysis, the total clearance is reduced by 70% and is 0.3 ml / min / kg, and T 1/2 is extended by 3 times), which requires a corresponding change in the dosing regimen.

Practically, it is not removed during hemodialysis.

In patients with chronic diseases liver (hepatocellular, cholestatic or biliary cirrhosis), there is a 50% T 1/2 lengthening and a 40% decrease in total clearance (dosing regimen adjustment is required only with a concomitant decrease in glomerular filtration rate). Penetrates into breast milk.

Release form

The syrup is colorless or slightly yellowish, transparent, with a pleasant fruity odor, free from visible particles; slight opalescence is allowed.

Excipients: glycerol - 100 mg, sucrose - 450 mg, benzoic acid - 1.5 mg, disodium edetate - 1 mg, sorbitol solution 70% - 200 mg, sodium citrate - 1 mg, fruit flavor - 2.07 mg, purified water - q.s. 1 ml

30 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard.
60 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard.

Dosage

Inside, regardless of the meal, with a small amount of water, preferably in the evening.

Adults and children over 6 years old - 10 mg (10 ml of syrup) 1 time per day or 5 mg (5 ml of syrup) 2 times a day.

Children 2-6 years old - 5 mg (5 ml of syrup) 1 time per day or 2.5 mg (2.5 ml of syrup) 2 times a day, depending on the severity of the condition and response.

In patients with reduced kidney function (CC 30-40 ml / min), 5 mg / day (5 ml of syrup) is prescribed, with severe chronic renal failure (CC 10-30 ml / min) - 5 mg / day (5 ml of syrup) in one day.

Elderly patients with normal renal function do not require dose adjustment.

Overdose

Symptoms (occur when taking a single dose of 50 mg) - dry mouth, drowsiness, urinary retention, constipation, anxiety, irritability.

Treatment: gastric lavage, the appointment of symptomatic drugs. There is no specific antidote. Hemodialysis is ineffective.

Interaction

Pharmacokinetic interaction with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, diazepam and glipizide was not found.

Co-administration with theophylline (400 mg / day) leads to a decrease in the total clearance of cetirizine (the kinetics of theophylline does not change).

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Side effects

In some cases, possible: drowsiness, dry mouth; rarely - headache, dizziness, migraine, gastrointestinal discomfort (dyspepsia, abdominal pain, flatulence), allergic reactions (angioneurotic edema, rash, urticaria, itching).

Indications

• seasonal and year-round allergic rhinitis;
• allergic conjunctivitis;
• pollinosis (hay fever);
• urticaria, including chronic idiopathic urticaria;
• itchy allergic dermatoses (atopic dermatitis, neurodermatitis);
• angioedema (Quincke's edema).

Contraindications

• hypersensitivity (including to hydroxyzine);
• pregnancy, lactation;
• children's age up to 2 years.

Carefully

Chronic renal failure (with moderate and severe severity, correction of the dosing regimen is required), elderly age(possibly decreased glomerular filtration rate).

Application features

Use during pregnancy and lactation

Contraindicated in pregnancy.

Contraindicated in lactation, as the drug passes into breast milk.

Application for violations of liver function

Application for violations of kidney function

Use in children

Use in elderly patients

special instructions

If the dose of 10 mg / day is exceeded, the ability to react quickly may worsen. In recommended doses, it does not enhance the effect of ethanol (at a concentration of not more than 0.8 g / l), however, it is recommended to refrain from using it during treatment.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially dangerous species activities that require increased concentration of attention and speed of psychomotor reactions.

Instructions for use:

International name - Cetirizine

Pharmacological action and pharmacokinetics of Cetrin

Cetrine is a histamine antagonist that blocks H1 - histamine receptors. The active substance is cetirizine. Cetrin is indicated as a prophylactic against allergic reactions, as well as to facilitate their course. It has antipruritic and antiexudative effect. It has an effect on allergic reactions at an early stage. In the stage of an allergic reaction that has begun, the drug limits the release of inflammatory mediators. Cetrin prevents tissue edema, relieves spasms of smooth muscles, and reduces capillary permeability. Eliminates skin reactions to specific allergens. It does not have antiserotonin and anticholinergic effects. Subject to therapeutic doses, it practically does not have a sedative effect. After a single dose of the drug, the onset of the effect, in about half of the patients, is observed after 20 minutes, after 1 hour in 95% of patients. The effect of the drug lasts more than 24 hours. With therapeutic treatment, tolerance to the antihistamine action of the drug does not develop. After the end of treatment, the effect of the drug lasts up to 3 days.

Cetrin is well absorbed in the gastrointestinal tract. Taking the drug with food does not affect absorption. The maximum concentration of cetirizine in the blood occurs 1 hour after taking the drug and is 0.3 μg / ml. To a small extent, the drug is metabolized in the liver. The elimination half-life is approximately 10 hours, in elderly patients up to 12 hours, in children about 6 hours. The drug is excreted mainly in the urine.

Indications

• year-round and seasonal rhinitis and conjunctivitis of allergic origin;
• urticaria, including chronic urticaria;
• hay fever;
• allergic dermatitis;
• skin itching;
• angioedema;
• atopic bronchial asthma (in complex therapy).

Contraindications

• hypersensitivity to cetirizine;
• pregnancy;
• lactation.

Caution should be exercised when Cetrin is used by persons with chronic renal failure, as well as by elderly patients and children. No feedback has been received on the treatment of children under one year of age with Cetrin.

Pregnancy and lactation

Side effects

Side effects of Cetrin can be expressed in the form of drowsiness, dry mouth, less often in the form of headache, dizziness, migraine, gastrointestinal disorders, allergic reactions.

Overdose of Tsetrin

Overdose symptoms may occur with single doses of 50 mg. Overdose is manifested by dry mouth, drowsiness, urinary retention, constipation, anxiety, increased irritability. It is treated with gastric lavage, symptomatic treatment. There is no antidote. The effectiveness of hemodialysis has not been confirmed.

Dosage of Tsetrin and instructions for use

Cetrin is taken orally, in the form of a tablet it is washed down with water, in the form of drops it dissolves in water.

Dosage for children over 6 years of age and adults - 10 mg of the drug 1 time per day, or 5 mg 2 times a day. Children from 2 to 6 years of age, half the adult dose. Children from one to two years old, 2 times a day, 2.5 mg (5 drops). Patients with reduced kidney function 5 mg once a day. In severe forms of chronic renal failure, Cetrin is indicated at 5 mg once every 48 hours.

special instructions

According to the feedback received, Cetrin, in doses above 10 mg per day, may have an effect on reducing the speed of the reaction. In connection with this instruction, Cetrin is recommended to take special care, during the period of therapy, for persons driving a car. Within the recommended doses, the drug does not enhance the effect of ethanol. However, the use of ethanol during therapy with Cetrin analogues is not recommended.

Interaction Cetrin

No significant pharmacokinetic interaction of Cetrin with cimetidine, pseudoephedrine, azithromycin, glipizide, ketoconazole, diazepam, erythromycin has been established.

Simultaneous use with theophylline leads to a decrease in the clearance of cetirizine without changing the kinetics of theophylline.

Storage conditions

Cetrin is stored in a dry, dark place out of the reach of children. The drug should be stored at room temperature not exceeding 25°C.

Active substance

Cetirizine dihydrochloride (cetirizine)

Release form, composition and packaging

◊ Film-coated tablets white or almost white color, round, biconvex, with a risk on one side.

Excipients: lactose, corn starch, povidone (K-30), magnesium stearate.

The composition of the film shell: hypromellose, macrogol 6000, titanium dioxide, talc, sorbic acid, polysorbate 80, dimethicone.

10 pieces. - blisters (2) - packs of cardboard.
10 pieces. - blisters (3) - packs of cardboard.

pharmachologic effect

A competitive histamine antagonist, a metabolite, blocks H1-histamine receptors. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative action. It affects the early stage of allergic reactions, limits the release of inflammatory mediators at the "late" stage of an allergic reaction, reduces the migration of eosinophils, neutrophils and basophils. Reduces the permeability of capillaries, prevents the development of tissue edema, relieves spasm of smooth muscles.

Eliminates the skin reaction to the introduction of histamine, specific, as well as to cooling (with cold urticaria). Reduces histamine-induced bronchoconstriction in mild bronchial asthma.

Virtually no anticholinergic and antiserotonin action.

In therapeutic doses, it practically does not have a sedative effect.

The onset of the effect after a single dose of 10 mg of cetirizine is 20 minutes, the duration of the effect is 24 hours. During the course of treatment, tolerance to the antihistamine effect of cetirizine does not develop. After stopping treatment, the effect persists for up to 3 days.

Pharmacokinetics

The pharmacokinetic parameters of cetirizine change linearly when administered at a dose of 5–60 mg.

Suction

After oral administration, it is rapidly absorbed from the gastrointestinal tract, Tmax after oral administration is about 1 hour. Food does not affect the completeness of absorption (AUC), but prolongs Tmax by 1 hour and reduces Cmax by 23%. When taken at a dose of 10 mg 1 time / day for 10 days C ss in plasma is 310 ng / ml and is observed 0.5-1.5 hours after administration.

Distribution

Protein binding is 93% and does not change at cetirizine concentrations in the range of 25-1000 ng/ml. V d - 0.5 l / kg.

Metabolism

It is metabolized in small amounts in the liver by O-dealkylation with the formation of a pharmacologically inactive metabolite (unlike other blockers of histamine H 1 receptors metabolized in the liver with the participation of isoenzymes of the cytochrome P 450 system. Cetirizine does not accumulate.

breeding

About 2/3 of the drug is excreted unchanged by the kidneys and about 10% - with feces.

Systemic clearance - 53 ml / min. T 1/2 in adults - 10 hours, in children 6–12 years old - 6 hours, 2–6 years old - 5 hours, 0.5–2 years old - 3.1 hours. In elderly patients, T 1/2 increases by 50 %, systemic clearance is reduced by 40% (decrease in kidney function).

Pharmacokinetics in special clinical situations

In patients with impaired renal function (CC below 40 ml / min), the clearance of the drug decreases, and T 1/2 lengthens (for example, in patients on hemodialysis, the total clearance is reduced by 70% and is 0.3 ml / min / kg, and T 1/2 lengthens 3 times), which requires a corresponding change in dosing regimen. Practically not removed during hemodialysis.

In patients with chronic liver diseases (hepatocellular, cholestatic or biliary cirrhosis), there is a 50% prolongation of T 1/2 and a decrease in total clearance by 40% (correction of the dosing regimen is required only with a concomitant decrease in glomerular filtration rate). Penetrates into breast milk.

Indications

• seasonal and year-round allergic rhinitis;
• allergic conjunctivitis;
• pollinosis (hay fever);
• urticaria (including chronic idiopathic urticaria);
• itchy allergic dermatoses (atopic dermatitis, neurodermatitis);
• angioedema (Quincke's edema).

Contraindications

• hypersensitivity (including to hydroxyzine);
• pregnancy;
• period breastfeeding;
• children's age up to 6 years (for this dosage form).

Carefully

Chronic renal failure (moderate and severe - dosage adjustment is required), old age (glomerular filtration rate may decrease).

Dosage

Inside, regardless of the meal, without chewing, the tablets are washed down with 200 ml of water.

Adults- 10 mg (1 tab.) 1 time / day or 5 mg (1/2 tab.) 2 times / day.

Children over 6 years old- 5 mg (1/2 tab.) 2 times / day or 10 mg (1 tab.) 1 time / day.

At patients with reduced renal function (CC 30-49 ml / min) prescribe 5 mg / day (1/2 tab.), with severe chronic renal failure (CC 10-30 ml / min)- 5 mg / day (1/2 tab.) every other day.

Side effects

Usually Cetrin is well tolerated.

In some cases: drowsiness, dry mouth.

Rarely: headache, dizziness, migraine, gastrointestinal discomfort (dyspepsia, abdominal pain, flatulence), allergic reactions (angioedema, rash, urticaria, itching).

Overdose

Symptoms(occur when taking a single dose of 50 mg): dry mouth, drowsiness, urinary retention, constipation, anxiety, irritability.

Treatment: gastric lavage, the appointment of symptomatic drugs. There is no specific antidote. Hemodialysis is ineffective.

drug interaction

Pharmacokinetic interaction with pseudoephedrine, ketoconazole, erythromycin, azithromycin, diazepam and glipizide was not found.

Co-administration with theophylline (400 mg / day) leads to a decrease in the total clearance of cetirizine (the kinetics of theophylline does not change).

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

special instructions

If the dose of 10 mg / day is exceeded, the ability to react quickly may worsen.

Pediatric use

For children aged 2 years and older Cetrin is used in the form of a syrup.

Influence on the ability to manage vehicles and mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Pregnancy and lactation

Pregnancy

When analyzing prospective data on pregnancy outcomes, there were no cases of malformations, embryonic and neonatal toxicity with a clear causal relationship.

Animal studies have not revealed any direct or indirect adverse effects of cetirizine on the developing fetus (including in the postnatal period), the course of pregnancy and childbirth.

Controlled clinical research on the safety of the drug during pregnancy has not been conducted, so cetirizine should not be used during pregnancy.

Breast-feeding

Cetirizine is excreted from breast milk in a concentration representing from 25% to 90% of the concentration of the drug in plasma, depending on the time of appointment. During breastfeeding, the drug is used after consulting a doctor if the intended benefit to the mother outweighs the potential risk to the child.

Fertility

Available data on the effect on human fertility is limited, but no negative effect on fertility has been identified.

Carefully the drug should be prescribed to elderly patients (with an age-related decrease in glomerular filtration).

Terms of dispensing from pharmacies

The drug is released without a prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 2 years.