When vitamin B1 is prescribed in ampoules. Vitamin B1 (thiamine) - what does our body need and what products contain it most Vit in 1 ampoules instructions for use

Vitamin B1 is an important substance for ensuring the normal functioning of human organs and systems. It takes part in metabolism, synthesis of proteins and fats.

This vitamin plays the role of a catalyst for many chemical reactions, optimizes the work nervous system. Vitamin B1 (tablets) is a synthetic drug that is a safe and reliable source of the substance necessary for the body.

pharmachologic effect

The main thing active substance The drug is thiamine.

It penetrates well into various organs and tissues and is transported through the blood.

The highest concentration of the substance is observed in the skeleton, liver and muscles.

The half-life from the body is from 10 to 18 days.

Indications for the use of vitamin B1 tablets

Tablets must be taken when diagnosing hypovitaminosis or beriberi.

Symptoms of these disorders include:

• general weakness;
• severe muscle pain;
• frequent dizziness;
• headache;
• disorientation;
• vision problems;
• impaired coordination of movements;
• digestive problems;
• lack of appetite;
• hard breath.

In addition, B1 is prescribed for heart disease, nervous system disorders, diabetes, in the treatment of alcoholism, chronic diseases liver, ear pathologies (for example, otitis media).

As part of complex therapy B1 can also be used in the treatment of:

1. Burns.
2. Radiculitis.
3. Paralysis.
4. Ulcers of the stomach.
5. Metabolic disorders.
6. Ear diseases.

Dosing regimen of vitamin B1 tablets

The dosage of the drug is calculated individually depending on the disease and the characteristics of the prescribed treatment.

The course begins gradually with small doses. First you need to drink 1 tablet a day before meals.

Then, if there is such a need, the tablets are taken 2-3 times a day. The increase in dosage occurs under the condition of good tolerability of the drug.

The daily norm of the substance varies depending on age:

1. For an adult - up to 2 mg.
2. For an elderly person - up to 1.3 mg.
3. For children - up to 1.2 mg.

The average course of treatment is 30 days.

Side effect

Side effects from taking the drug can manifest themselves in various forms:

1. Increased heart rate, pain in the heart.
2. Severe headache, restlessness and nervous excitement.
3. Shortness of breath, heavy breathing.
4. Nausea, diarrhea.
5. Rash, urticaria, dermatitis.
6. Weakness, swelling, fever, profuse sweating.

These may be allergic reactions of the body to the drug, so before taking it, you need to consult your doctor.

Contraindications to the use of vitamin B1 tablets

special instructions

There are features of taking the drug during pregnancy, breastfeeding and kidney disease. There are also special conditions for children.

Use during pregnancy and lactation

Taking the drug is allowed with strict adherence to the dosage under the supervision of a physician. Permissible dosage - from 0.4 to 0.6 mg of the substance per day.

Application for violations of kidney function

In kidney diseases, vitamin B1 is best consumed with food, without using synthetic drugs. Vitamin is found in bread, various cereals, chicken and pork liver.

Taking tablets is possible in small quantities under the supervision of a physician.

Use in children

Children under 12 years of age should not take the drug.

After 12 years, you can give your child from 0.3 to 0.5 mg of vitamin per day.

Overdose

Ingestion of too much vitamin B1 can lead to consequences such as increased blood clotting and metabolic disorders.

To avoid subsequent health problems, in case of an overdose, it is necessary to stop taking the drug and eliminate the symptoms pointwise.

drug interaction

The drug has the best compatibility with vitamins B6 and B12. This vitamin complex has a strong analgesic effect, has a beneficial effect on the functioning of the nervous system and sensory organs.

B1 demonstrates conditional compatibility with the following substances:

1. caffeine.
2. Sulfur-containing drugs.
3. estrogen.
4. Anticonvulsants.

At the same time, you need to know what results such a combination will lead to. For example, the use of B1 along with caffeine will require an upward adjustment in the daily dose of the vitamin.

There is limited compatibility of the drug with barbiturates, carbonates, iodine and cuprum, so it is not recommended to combine it with these substances.

Terms and conditions of storage

The package with tablets should be kept out of the reach of children. The maximum allowed storage temperature is 25°C.

The shelf life of the drug is 3 years.

Terms of dispensing from pharmacies

Tablets are released without a prescription and age restrictions.

Price

The price of the drug varies from 50 to 300 rubles. depending on the number of tablets and the manufacturer.

Analogues

As analogues of vitamin B1 tablets can be used:

1. Thiamine chloride solution.
2. Thiamine-Vial.
3. Neuro-Ratiopharm.
4. Tiabene.

Vitamin is available both in tablets and in the form of a solution and capsules.

VITAMIN B1 - LEARN WHAT IS A LACK OF VITAMIN B1 IN THE BODY. SOURCES OF VITAMIN B1.

Vitamin B1 (thiamine) for the nervous system

The composition of the drug includes an active substance thiamine .

Water for injections can serve as an additional component.

Release form

Thiamine is available in the form of a powder, capsules, tablets or ready-made solution for injection. The substance is packaged in bags, vials or ampoules of 1 ml, 10 pieces per pack.

pharmachologic effect

The drug has an effect that can compensate for the deficiency .

Pharmacodynamics and pharmacokinetics

Thiamine is a synthetic analog of vitamin B1 with good water solubility. Inside the body, in the process of phosphorylation, the substance is converted into cocarboxylase - coenzyme of most enzymatic reactions.

According to the pharmacopeia, Thiamine Chloride, Thiamine Bromide, Thiamine Vial, Thiamine Hydrochloride- it's all trade names and analogues of vitamin B1. These preparations are offered in the form of a white crystalline powder, capsules, tablets or solution.

Usually they have a weak specific odor, dissolve well in water, show resistance to acidic solutions, but are easily destroyed under the influence of an alkaline and neutral environment.

Parenteral administration of drugs allows it to quickly penetrate into and evenly distributed throughout the body.

Phosphorylation of the substance occurs in the liver. The accumulation of the vitamin was noted in the heart, liver, kidneys, brain and spleen. The main substance is excreted with the help of the liver and kidneys.

Vitamin B1 or Thiamine is necessary for a complete carbohydrate, protein and fat metabolism, normal functioning of the nervous, digestive, endocrine and of cardio-vascular system.

Thiamine Mononitrate - what is it?

Thiamine Mononitrate has low hygroscopicity, but high resistance to external factors. Therefore, it is actively used in the process of fortification of various foods.

Indications for use

Thiamine is prescribed for:

• hypovitaminosis and avitaminosis B1;
• neuritis, radiculitis, peripheral paresis and paralysis, intestinal atony;
• fasting;
• chronic alcoholism;
• the expressed violations of functions of a liver;
• increased need for at .

Contraindications for use

The main contraindication to taking the drug is hypersensitivity.

Side effects

When taking Thiamin, side effects may develop in the form of: sweating, , allergic reactions – , skin, anaphylactic shock.

Thiamine, instructions for use (Method and dosage)

Instructions for use of Thiamine chloride informs that such a remedy can be prescribed for both internal and parenteral administration. The dosage is set by the doctor, but on average for adult patients it is 10 mg to be taken up to 5 times a day. For young patients under 3 years of age, the recommended dose is 5 mg to be taken every other day, for children 3-8 years old - 5 mg 3 times a day every other day, from 8 years old - 10 mg 1-3 times a day. The duration of treatment is about 30 days.

The instruction on Thiamine hydrochloride recommends using it for deep intramuscular injection. For adult patients and children from 7 years of age, a daily dosage of 25-50 mg is prescribed. Treatment begins with the introduction of a small amount of solution. If the drug is well tolerated by patients, then the daily dosage is increased by 25 mg. In this case, the daily dose should not exceed 300 mg. The therapeutic course is 10-30 injections. Children under 3 months are prescribed 12.5 mg, from 4 months to 7 years - 25 mg to be taken once a day.

Overdose

In cases of overdose, an increase in severity is possible. side effects. Therefore, the prescribed dose must be strictly observed.

Interaction

Simultaneous use with solutions containing sulfites , and also reduces their activity.

With simultaneous parenteral administration of thiamine and or cyanocobalamin perhaps a significant increase in its action. In addition, it can complicate the transformation of thiamine. It is forbidden to mix vitamin B1 with or, which can cause destruction , as well as with nicotinic acid capable of destroying vitamin B1.

Combination with suxamethonium iodide, Redergama, some sympatholytics, for example: or Oktadin - reduces them pharmachologic effect. The combination of Thiamine and hypnotics can reduce their hypnotic and hypotensive activity.

Terms of sale

Without recipe.

Storage conditions

To store vitamin B1, a dark, cool place is required, out of the reach of children.

Best before date

Special instructions

What foods contain vitamin B1?

To prevent deficiency of Vitamin B1, it is necessary to include in your diet foods that contain this substance. Most of this component is found in buckwheat, oatmeal, peas, nuts and fatty pork. Thiamine is also part of the bread made from coarse flour, sprouted wheat, rice bran, green vegetables, some berries and fruits.

A sufficient amount of the vitamin is present in wild and garden greens, algae, brewer's yeast, poultry, beef, liver, eggs and fish.

Application for hair Thiamine chloride and its analogues

Thiamine Vial in ampoules is intended to strengthen hair, which is not recommended to be used in its pure form, due to the possibility of development .

Thiamine Vial - what is it?

It should be noted that this drug is an analogue of vitamin B1. You can noticeably improve the condition of your hair if you use this product with shampoo. Before each hair wash, you need to add just a few drops of vitamin to the shampoo. The result is beautiful and manageable hair.

In addition, you can add thiamine to masks or hair balms, which greatly enhances them. positive influence on quality and structure. A great way to strengthen hair is wrapping, which makes them healthier, more beautiful and shiny.

To do this, make a mixture of two teaspoons of castor or burdock oil, thiamine ampoules, ampoules , solution and lemon juice.

All this must be mixed well and rubbed into the hair roots. The rest of the remedy is to distribute along the length of the hair. Wrap your head in a towel and soak for at least two hours. Then wash your hair well with shampoo. The procedure is recommended to be performed every other day for three weeks.

Analogues

The main analogues of this drug: Vitamin B, Anevril, Anevrin, Benerva, Berin, Betabion, Benevrin, Betamine, Betanevrin, Betaxin, Betiamin, Bevital, Bevitin, Christovibex, Orizanin, Vitaplex Bi.

Also have a similar effect: , .

Alcohol

The simultaneous use of alcohol can significantly weaken the effect of vitamin B1 and accelerate its excretion from the body.

Thiamine - what is it? This is the second name of vitamin B1. Vitamin B1 is one of the water-soluble B vitamins. It plays an important role in the metabolism of fats, carbohydrates and other components that ensure the normal functioning of the body.

Each vitamin performs its own functions, which are aimed at ensuring that the body functions properly and smoothly. Let's get acquainted with the role of vitamin B1.

Ensuring metabolic processes

Vitamin B1 is involved in the production of adenosine triphosphate (ATP), which is the main component for the body's energy production. Thiamine is necessary for protein and fat to be well absorbed, it helps to convert carbohydrates into glucose, without it the process of formation of red blood cells does not go through. Also, vitamin B1 maintains the tone of the muscles of the digestive system, normalizes appetite, removes the symptoms of motion sickness and eliminates motion sickness.

Maintenance of the nervous system

The energy produced by the body is primarily used for the normal functioning of the brain and nervous system. If it is not enough, then with a high degree of probability negative changes begin in the work of these organs. And this can provoke violations of coordination of movements, deterioration in the process of memorization and learning.

Thiamine is also considered an anti-stress vitamin. That is why its insufficient amount causes the development depression, apathy, bad mood, lack of motivation. To make quick decisions and be in a good mood, you need vitamin B1.

Maintaining the activity of the cardiovascular system

Thiamine is a good prevention of pathologies of the heart and blood vessels. It helps to maintain the activity of the ventricles and is used in the treatment of heart failure, improves microcirculation and blood formation processes, and contributes to the normal activity of the myocardium.

Immunity Boost

A healthy digestive system is of great importance for maintaining the body's defenses in good condition. And vitamin B1 plays the role of an assistant in the secretion of hydrochloric acid - a component necessary for the full digestion of incoming food and the allocation of all useful substances necessary to strengthen the immune system.

Keeping the brain working

Thiamine prevents the occurrence of cerebellar syndrome, prevents the development of memory problems (improves attention, thought processes, brain activity, learning ability, etc.). An increased dosage of vitamin B1 is used for alcohol intoxication, when leaving a coma.

Prevention of vision problems

Research results suggest that vitamin B1, supplied in sufficient quantities, can protect against glaucoma and cataracts. This is due to its ability to positively influence nerve and muscle signals, which has great importance in the transmission of information from the eyes to the brain.

Help in the treatment of alcoholism

The vast majority of alcoholics are deficient in thiamine. This is especially true for those who consume alcohol in in large numbers and eats little. With the appointment of additional doses of vitamin B1, the symptoms caused by alcoholism are reduced, since thiamine smooths out the negative effects of alcoholic beverages and tobacco.

Can Vitamin B1 Be Harmful?

Thiamine is useful for organs and systems, it affects them positive impact and is generally well tolerated by patients. However, some negative manifestations after the use of thiamine occur:

• allergies in the form of skin itching, urticaria, Quincke's edema;
• soreness with subcutaneous injection of the drug.

Daily rate B1

The need for vitamin B1 for each category of people is different. Let's get acquainted with the dosage in more detail:

• for children from birth to 6 months - 0.2 mg;
• from 7 months to 1 year - 0.3 mg;
• from 1 year to 3 years - 0.5 mg;
• from 4 to 8 years - 0.6 mg;
• from 9 years to 13 years - 0.9 mg;
• for young men and adult men - 1.2 mg;
• for girls and adult women - 1.1 mg;
• for pregnant and lactating women - 1.4-1.5 mg.

Foods rich in vitamin B1

The highest amount of thiamine is found in nuts, grains, meat products. A lot of vitamin B1 is determined in the products shown in the table.

Many vegetables contain thiamine in moderate amounts. These are broccoli, onions, beans, pumpkin, carrots, tomatoes, green pea, beets, Brussels sprouts, spinach and eggplant. If these vegetables are consumed with cereals and bread, then enough vitamin B1 will enter the body.

Features of the absorption of B1 by the body

Thiamine, getting into the body, is absorbed with some nuances.

1. If a person suffers from alcohol addiction, liver disease, or other serious health problems, then vitamin B1 is not fully absorbed.
2. Foods consumed in large quantities, which contain tannins and caffeine (tea, coffee), do not allow the body to fully absorb vitamin B1.
3. Freshwater fish and shellfish eaten raw prevent the body from fully absorbing thiamine. If these products are subjected to heat treatment, this quality disappears.

Why is B1 deficiency dangerous?

Insufficient intake of vitamin B1 in the body can provoke the following disorders:

• negative changes in the activity of the heart and blood vessels, brain, nervous system;
• headache, fatigue;
• irritability, apathy and depression;
• nausea, loss of appetite, abdominal discomfort, indigestion, colitis;
• muscle weakness;
• rapid weight loss, anorexia, aging of the body;
• neuritis;
• confusion of thoughts and decrease in short-term memory;
• accumulation of pyruvic acid in the body, which is caused by problems with the digestion of carbohydrates due to a deficiency of vitamin B1. And an excess of acid leads to shortness of breath, loss of mental activity and disturbances in cardiac activity;
• development of beriberi;
• the appearance of Wernicke-Korsakoff syndrome, which is characterized by a decrease in mental abilities and memory impairment.

Excess vitamin B1

Both deficiency and excess of thiamine negatively affect the activity of organs and systems of the body. Let us consider in more detail what disorders can occur with excessive intake of vitamin B1:

• allergic reactions arising from the increased activity of acetylcholine, which plays a primary role in the occurrence of allergies;
• discoordination of enzyme systems of the liver and its fatty degeneration;
• violation of renal activity;
• most dangerous complication, which in 10 - 20% of cases ends in death, is anaphylactic shock(anaphylaxis).

After reviewing this material, you can conclude why the body needs vitamin B1, what threatens the deficiency and excess of thiamine for health. Be healthy!

Vitamin B1:: Dosage form

capsules, solution for intramuscular injection, tablets, coated tablets

Vitamin B1:: Pharmacological action

Vitamin B1. In the body, as a result of phosphorylation processes, it turns into cocarboxylase, which is a coenzyme of many enzymatic reactions. It plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of nerve excitation in synapses. Protects cell membranes from the toxic effects of peroxidation products.

Vitamin B1:: Indications

Hypovitaminosis and avitaminosis B1, incl. in patients on tube feeding, hemodialysis, with malabsorption syndrome. As part of complex therapy - burns, prolonged fever, neuritis and polyneuritis, sciatica, neuralgia, peripheral paresis and paralysis, Wernicke's encephalopathy, Korsakov's psychosis, chronic liver damage, various intoxications, myocardial dystrophy, coronary circulation disorders, peptic ulcer stomach and duodenum, atonic constipation, intestinal atony, sprue, thyrotoxicosis, diabetes, endarteritis; dermatoses (eczema, atopic dermatitis, psoriasis, red lichen planus) with neurotrophic changes and metabolic disorders; hemodialysis, pyoderma, prolonged physical and psychological stress, during pregnancy and lactation, maintaining diets.

Vitamin B1:: Contraindications

Hypersensitivity. With caution. Wernicke's encephalopathy, premenopausal and menopause among women.

Vitamin B1:: Side effects

Allergic reactions (urticaria, pruritus, angioedema, rarely - anaphylactic shock), increased sweating, tachycardia. Soreness (due to the low pH of the solutions) with s / c, less often - with i / m administration.

Vitamin B1:: Dosage and Administration

Inside, in / m, in / in, s / c. Daily requirement for vitamin B1: for adult men - 1.2-2.1 mg; for the elderly - 1.2-1.4 mg; for women - 1.1-1.5 mg (in pregnant women it is more by 0.4 mg, in lactating women - by 0.6 mg); for children, depending on age - 0.3-1.5 mg. It is recommended to start parenteral administration with small doses (no more than 0.5 ml of a 5-6% solution) and only with good tolerance, higher doses are administered. In / m (deep into the muscle), in / in (slowly), less often - s / c. Adults are prescribed 20-50 mg of thiamine chloride (1 ml of 2.5-5% solution) or 30-60 mg of thiamine bromide (1 ml of 3-6% solution) 1 time per day, daily, switching to oral administration; children - 12.5 mg of thiamine chloride (0.5 ml of a 2.5% solution) or 15 mg of thiamine bromide (0.5 ml of a 3% solution). The course of treatment is 10-30 injections. Inside, after a meal, for adults for preventive purposes - 5-10 mg / day, in medicinal purposes- 10 mg per dose 1-5 times a day, the maximum dose is 50 mg / day. The course of treatment is 30-40 days. Children under the age of 3 years - 5 mg every other day; 3-8 years - 5 mg 3 times a day, every other day. The course of treatment is 20-30 days.

Vitamin B1:: Special instructions

When taking the recommended doses during pregnancy, lactation, as well as in the elderly, no adverse reactions other than the above were noted. When determining theophylline in blood serum by a spectrophotometric method, urobilinogen using the Ehrlich reagent can distort the results (when taking high doses). More often, an anaphylactic reaction develops after intravenous administration of large doses. Do not use instead of a balanced nutrition replacement, only in combination with diet therapy. Parenteral administration is recommended only if oral administration is not possible (nausea, vomiting, malabsorption syndrome, preoperative and / or postoperative conditions). In Wernicke's encephalopathy, the administration of dextrose should precede the administration of thiamine.

Vitamin B1:: Interaction

A solution of thiamine chloride should not be mixed with solutions containing sulfites, because. in them it completely disintegrates. Simultaneous parenteral administration of thiamine with pyridoxine or cyanocobalamin is not recommended: pyridoxine makes it difficult to convert thiamine into biologically active form, cyanocobalamin enhances the allergenic effect of thiamine. Do not mix thiamine with benzylpenicillin or streptomycin (destruction of antibiotics), thiamine and nicotinic acid(destruction of thiamine). Weakens the effect of depolarizing muscle relaxants (suxamethonium iodide, etc.). Thiamine is unstable in alkaline and neutral solutions; administration with carbonates, citrates, barbiturates with Cu2+ is not recommended. When administered intravenously simultaneously with solutions containing sodium hydrosulfite as an antioxidant or preservative, thiamine is unstable. Ethanol slows down the rate of absorption of thiamine after oral administration.

Content

Vitamin from group B at number 1 was called aneurin in the past. A completely water-soluble crystalline substance, which plays an important role in the body, is resistant to heating in acidic aqueous media, but is quickly destroyed by alkaline ones. Sometimes the vitamin is called thiamine.

Vitamin B1 - what is it for?

Some people claim that thiamine and vitamin B1 are different substances, but this is wrong. What is thiamine? It's just an alternative name. It contributes to the full absorption of proteins and fats, they are water-soluble substances. A person needs constant replenishment of substances of this group due to the effects of metabolism. Most healthy people get the required dose of the vitamin from food. A small amount of the substance is found in potatoes, lettuce, spinach, carrots.

Foods that are rich in thiamine are available to the general population:

• peas, soybeans, beans;
• nutritional yeast;
• liver;
• beef, pork;
• wheat bread;
• cabbage.

Daily requirement of thiamine for healthy person varies by age and gender. An adult male requires approximately 1.3 mg / day of the substance, for women this figure is 1.1 mg / day. In pregnant women, the need increases to 1.4 mg / day. For kids daily rate thiamine is highly dependent on the age of the child - from 0.2 mg to 0.9. What is vitamin B1 for?

• improves brain function;
• stimulates the concentration of memory, thought processes, attention;
• reduces the negative effects of alcohol, nicotine.

Vitamin deficiency leads to a complex of problems that can develop into diseases:

• Disorders of the cardiovascular system - acute cardiovascular failure, shortness of breath, tachycardia.
• Nervous system: irritability, insomnia, depression, numbness of the extremities, memory loss, Wernicke-Korsakoff syndrome (more common in alcoholism), neuritis, damage to the nervous system, development of paresis, intellectual impairment, etc.
• Disorders digestive system: loss of appetite, constipation, diarrhea, liver enlargement, nausea, kidney disease.

Vitamin B1 - indications for use

Clinical use of drugs involves two forms - thiamine and cocarboxylase. Phosphotiamine and benfotiamine belong to the first type of substance. Indications for the use of vitamin B1 can be very different, the drug is administered intramuscularly or intravenously. Independent use, even with a known diagnosis, is categorically not recommended. After being prescribed by a doctor, be sure to read the instructions.

Cocarboxylase is prescribed for the following diagnoses:

• metabolic acidosis;
• Ley's syndrome;
• respiratory failure;
• multiple sclerosis;
• alcohol poisoning;
• amyotrophy;
• development of paralysis
• Gaye-Wernicke syndrome;
• take-take disease.

Indications for the use of the thiamine form of the substance:

• heart failure;
• weight loss;
• general weakness;
• muscle weakness;
• leucinosis (hereditary disease);
• ischemic disease hearts;
• atherosclerosis;
• pyoderma (pustular skin lesions);
• chronic gastritis,
• Korsakoff-Wernicke syndrome.

Vitamin B1 - instruction

Before using the vitamin, you should carefully study the instructions for B1 and the rules for use:

1. The tablet form of the drug (pellets and capsules) is taken after meals 1-4 times a day. The drug should be taken with a small amount of water and not chewed. Taking it on an empty stomach (on an empty stomach) can be painful.
2. The therapeutic course for children under 14 years of age lasts 20-30 days.
3. Therapeutic course for adults - 30-40 days.

Vitamin B1 in ampoules

Vitamin B1 in ampoules is available for intramuscular, intravenous or subcutaneous administration. Cocarboxylase preparations are used to treat conditions not related to the lack of the vitamin itself. The conditions and methods of using solutions of thiamine and cocarboxylase are not the same: cocarboxylase is administered quickly, in a stream, and thiamine is administered drip or extremely slowly.

Vitamin B1 tablets

Vitamin B1 in tablets, capsules, dragees is available at any pharmacy. The composition of the drug includes thiamine diphosphate, thiamine monophosphate, thiamine triphosphate, non-phosphorylated thiamine. Phosphothiamine-based products have better absorption. Cocarboxylase is present on the market as rectal suppositories. Due to the way the substance enters the body, the drug is absorbed as quickly as with intramuscular injection.