Norepinephrine dose mcg kg min. Formula for calculating the rate of infusion of solutions of inotropic and vasoactive drugs

Dopamine: instructions for use and reviews

Latin name: Dofamine

ATX code: C01CA04

Active substance: dopamine (dopamine)

Producer: Darnitsa (Ukraine), Armavir biofactory, EcoFarmPlus CJSC, Altair LLC, Bryntsalov-A CJSC (Russia)

Description and photo update: 16.08.2019

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The condition of a cardiac surgical patient in the early postoperative period is determined by the initial severity of the disease, the extent and degree of adequacy of the surgical intervention, as well as those changes in vital organs and systems that may occur as a result of the use of cardiopulmonary bypass. Therefore, postoperative management of patients should include, first of all, a correct assessment of not only the state of the cardiovascular, but also the functions of other vital organs and systems, careful care, as well as timely prevention and treatment of complications.

Observation of the patient should be extremely attentive and qualified, since any errors in the postoperative period can lead to an unexpected deterioration in the condition, up to death, even in a relatively mild patient.

Assessment and control of hemodynamics

To achieve optimal cardiac output, it is necessary to ensure an adequate value of the main parameters of blood circulation - the frequency and nature of heart contractions, preload (ventricular filling pressure), myocardial contractility and afterload.

Preload (ventricular filling pressure)

To control central venous pressure, as well as intravenous infusions, the internal jugular vein is used, since during puncture subclavian vein dramatically increases the risk of damage to the subclavian artery or lung tissue with the development of pneumothorax or hemothorax. For short-term infusion of solutions, the cubital vein is widely used.

In order to avoid an overdose of potent drugs (catecholamines, potassium preparations, vasodilators, etc.), their solutions are prepared in a standard way and injected into a separate line using microdroplets or perfusors. A patient with unstable hemodynamics should have a sufficient number of lines for intravenous administration. During these manipulations, it is necessary to carefully, completely prevent the entry of air bubbles into the catheters, because they can cause - in the presence of intracardiac shunts - embolization coronary arteries and cerebral vessels. Of course, the entry of air into the left atrial catheter is extremely strictly controlled.

To control blood pressure, one of the radial arteries is catheterized, sometimes the posterior tibial artery is used. Both arterial and venous catheters are preferably inserted by puncture; if this fails, then catheterization should be performed under direct observation (venesection), while the artery is not ligated. Blood from the arterial cannula should only be taken for the determination of blood gases. For other tests, venous blood is used.

Myocardial contractility

Digoxin. An effective remedy to enhance myocardial contractility for a long time is digoxin. Its action is manifested in 5-30 minutes, the maximum effect is 1.5-5 hours after intravenous administration; It is excreted from the body relatively quickly (half-life 34 hours, complete cessation of action after 2-6 days). Digoxin is indicated for patients with clinical signs heart failure, but does not cause a noticeable effect in hypotension. Patients who received digoxin before surgery (no later than 48 hours before surgery), after surgery, a maintenance dosage is prescribed with normal kidney function. The action of digoxin in children appears faster than in adults. Estimated doses of digoxin for children are shown in Table. 1. Before each administration of digoxin, an ECG is performed to the patient, the level of serum potassium in the plasma is checked.

Table 1 Calculation of digitalization and maintenance dose of digoxin in children with CHD

Table 2 Dopamine Dose Determination (mcg/kg/min)

Isoproterenol (izuprel). Isuprel has a positive inotropic and chronotropic effect. It reduces the resistance of peripheral and pulmonary vessels. Izuprel, to a greater extent than dopamine, causes tachycardia, increases myocardial oxygen demand. The decrease in venous pressure due to the expansion of peripheral vessels (vessels of the skin, muscles) may require the introduction of large volumes of blood and blood substitutes to maintain the filling pressure of the ventricles.

The dosage of the drug is selected depending on the frequency and nature of heart contractions, systemic arterial pressure (Table 3).

Table 3. Determination of the dose of isuprel (µg/kg/min)

Dobutrex is a direct-acting inotrope whose primary activity is due to stimulation of cardiac beta receptors. At the same time, the drug has a chronotropic and vasodilating effect, mainly on the vessels of the small circulation. In patients with reduced cardiac activity, dobutrex increases the cardiac output. Solution preparation: 250 mg in 250 ml of 5% glucose solution. Optimal doses are 2.5-10 µg/kg/min (Table 4).

Table 4 Dobutrex Dosing (mcg/kg/min)

Epinephrine (adrenaline) has the ability to stimulate alpha and beta adrenoreceptors. In small doses, it contributes to the strengthening and acceleration of heart contractions, the use of higher doses is accompanied by a sharp increase in peripheral vascular resistance, which can dramatically increase the load on the myocardium and thereby reduce cardiac output. In addition, adrenaline reduces renal blood flow. Therefore, you should use this drug very carefully and, in order to avoid severe vasoconstriction, use it in combination with vasodilators (sodium nitroprusside, nitroglycerin). Adrenaline is given through a central vein to prevent skin necrosis. Dosages are shown in Table 5.

In conclusion, attention should be paid to the fact that before prescribing drugs that enhance myocardial contractility, it is necessary to assess the indicators of metabolism, respiration, water and electrolyte metabolism in order to correct the identified disorders (metabolic acidosis, respiratory acidosis, a decrease in calcium ions, hypo- or hyperkalemia, etc.), is carried out according to the following scheme:

General provisions for the correction of KShchR
1. Metabolic acidosis, base deficiency. Treatment: inject sodium bicarbonate according to the formula:

Table 5. Determination of the dose of adrenaline (µg/kg/min)

Afterload (vascular resistance)

There are several types of drugs used to reduce afterload: drugs that mainly cause vein dilatation (nitrates); drugs that cause a balanced expansion of arteries and veins (sodium nitroprusside, phentolamine).

Sodium nitroprusside has been widely used. It is ideal for low cardiac output, high arterial and left atrial pressure, but its use requires continuous monitoring of left atrial pressure and maintaining it at an optimal level. The combined use of sodium nitroprusside with dopamine or adrenaline gives the greatest hemodynamic effect. The initial dose of sodium nitroprusside is 0.5 µg/kg/min, the maintenance dose is 0.5-8 µg/kg/mi, but not more than 10 µg/kg/mi (Table 6).

Table 6. Determination of the dose of sodium nitroprusside (rate of administration of a solution with a concentration of 200 μg / ml)

Nitroglycerin basically dilates the veins, causing a decrease in filling pressure. In this case, the cardiac index changes slightly. Nitroglycerin significantly reduces the work of the ventricles and thereby reduces myocardial oxygen demand. The drug is administered intravenously drip: 20 mg of the drug is diluted in 200 ml of a 5% glucose solution or in physiological saline, the administration is started very slowly, with a few drops per minute, the maintenance dose is 0.2-0.8 mcg / kg / min, the maximum dose is 3.0 mcg / kg / min.

Low cardiac output

Hypovolemia is one of the most common causes development of low cardiac output after open heart surgery. Maintaining the proper filling pressure of the left ventricle is the first and main condition for increasing cardiac output.

The pressure in the left atrium, as mentioned above, must be maintained at 10-14 mm Hg. Art., however, for adequate cardiac output, its increase to 15 mm Hg is often required. Art.

The syndrome of low cardiac output as a consequence of left ventricular failure is characterized by: high left atrial pressure -> 15 mm Hg. Art. (moreover, the pressure in the left atrium is greater than in the right one), tachycardia, low saturation of mixed venous blood with oxygen (less than 40-50%), metabolic acidosis, decreased arterial P02, absence of peripheral pulse, oliguria or anuria.

With right ventricular failure, which is more often observed after operations on the right heart, especially after radical correction of the tetralogy of Fallot, double aortic discharge and pulmonary artery from the right ventricle, one should focus not only on the pressure in the left atrium, but also on the CVP or pressure in the right atrium. This is due to the fact that in patients with right ventricular failure, the pressure values ​​in the left atrium can be relatively low - 10-11 mm Hg. Art. along with high numbers of CVP. Therefore, the tactics of infusion therapy, which involves maintaining pressure in the left atrium at the level of 12-14 mm Hg. Art., as optimal, should be treated with caution, since this can lead to even greater overload of the right heart and a further decrease in cardiac output.

Cardiac tamponade. Cardiac tamponade is characterized by: paradoxical pulse and low voltage on the ECG, muffled heart sounds, the presence of a wide mediastinum on the radiograph, echocardiographically - expansion of the pericardial cavity. The diagnosis is made on the basis of Echocardiography, ECG, X-ray data. Puncture of the pericardial cavity is both a diagnostic and therapeutic measure. Other therapeutic measures that should be performed if cardiac tamponade is suspected include resternotomy, hemostasis, and blood volume replacement.

The main means of treating patients with low cardiac output are catecholamines.

Heart failure

The main principle in resuscitation is the immediate implementation of a set of measures: the use of artificial respiration with 100% oxygen, external cardiac massage, the establishment of a dropper (if it is not supplied) for intravenous administration of sodium bicarbonate in order to correct metabolic acidosis, as well as the introduction of other medicines, defibrillation.

If it is impossible to immediately take an ECG, defibrillation is carried out "blindly", since the probability of ventricular fibrillation is high, and the effectiveness of defibrillation decreases when time is lost, i.e. this procedure should be started as early as possible. At the same time, before defibrillation, it is necessary to correct metabolic acidosis, continue effective external cardiac massage to ensure good myocardial oxygenation. If cardiac arrest continues or recurs after defibrillation, inject 1 ml of adrenaline 1:10,000 (adult dose) via a central venous line or intracardiac.

It is not necessary to start artificial respiration only after intubation. Under certain conditions, this may require additional time, while the Ambu bag is very effective in ensuring adequate pulmonary gas exchange. It should be remembered that the first minutes of resuscitation can decide its success and should not be lost for intubation at the beginning of resuscitation, provided that an experienced specialist and the necessary tool are nearby.

After cardiac recovery intravenous administration adrenaline continues, this is necessary to enhance the systolic work of the heart, as well as maintain peripheral resistance, which falls with prolonged shock.

Indications for the introduction of calcium chloride are primary cardiac arrest, ventricular arrest after defibrillation, ineffective ventricular contractions, hypocalcemia, hyperkalemia. Blood gases and electrolytes should be monitored more frequently, as well as artery catheterization.

The effectiveness of heart massage is determined by the state of the pupils and peripheral pulse. If external cardiac massage is ineffective, open massage may be considered, especially when cardiac tamponade is suspected.

In all cases of cardiac arrest, it is necessary to very quickly begin to fight the developing acidosis with the introduction of a 4% sodium bicarbonate solution. Sometimes only after the reduction of acidosis is it possible to achieve effective electrical defibrillation or independent contraction of the ventricles. These basic measures, i.e. artificial ventilation with 100% oxygen, external massage, administration of adrenaline and correction of acidosis, should be carried out in all cases.

Assessment and control of the respiratory system

Disconnecting the patient from the ventilator

Criteria for extubation after a period of spontaneous breathing (3-5 hours):
- full consciousness of the patient;
- arterial P02 more than 120 mm Hg. Art. at 02 - 0.4-0.5 oxygen and the absence of intracardiac blood shunt from right to left;
- arterial PC02 below 45 mm Hg. Art.: tidal volume (exhalation) not less than 5 mm/kg;
- vital capacity of lungs (VC) not less than 15 mm/kg;
- the patient does not experience shortness of breath;
- auscultation and X-ray do not reveal pathology. Before extubation, be sure to:
- toilet of the nasopharynx and oral cavity;
- gastric lavage;
- toilet of the tracheobronchial tree.

After extubation, again hold the toilet of the oral cavity and nasopharynx.

Extubated patients are given oxygen through a nasal catheter at a rate of 6 L/min. If P02 is less than 80 mm Hg. Art., it is preferable to supply oxygen through the face mask. After extubation, blood gases are again determined.

Tracheostomy

The tracheal incision is best done on the 2nd or 3rd ring. Damage to the cricoid cartilage must be avoided. The edges of the trachea are moved apart with holders, the endotracheal tube is pulled back to free the entrance to the trachea and insert the tracheostomy tube. The wound is treated with iodine, the tube is fixed with special ribbons. It is necessary to have an Ambu bag ready for manual ventilation and a spare tube. After completion of the manipulation, auscultation and a control x-ray are performed.

Hydration. The temperature of the liquid in the humidifier should be around 55°C to prevent bacterial growth. In this mode, the temperature of the supplied air approximately corresponds to the temperature of the patient's body. Modern humidifiers regulate the temperature of the supplied gas.

Water-electrolyte balance

Factors affecting the water and electrolyte balance in patients after open heart surgery:
potassium metabolism. The optimal level of potassium in plasma is 4-4.5 mmol / l. Normal potassium metabolism in cardiac surgery patients is important for three reasons: potassium is essential for muscle function, including the heart; hypokalemia leads to a decrease in contractility and an increase in the excitability of the ventricles of the heart; against the background of hypokalemia, digitalis intoxication is possible; hyperkalemia is dangerous due to possible cardiac arrest.

Patients with normal renal function should be administered 50-100 mmol of potassium per day. The maximum safe intravenous dose of potassium is 1 mmol / kg / h, which corresponds to 4 ml / kg of a 2% potassium chloride solution. The daily maintenance dose of potassium is 23 mmol/kg of body weight. After operations, potassium is prescribed in the form of a 2% solution of potassium chloride, 4 ml of which contains 1 mmol of potassium (100 ml of the solution contains 25 mmol of potassium).

Potassium is a potentially dangerous drug that, if used incorrectly (overdose), can cause cardiac arrest. Therefore, potassium preparations should be administered slowly, into large veins. It is unacceptable to administer any other drugs through the same catheter through which the potassium solution is administered.

Hypokalemia - a decrease in plasma potassium concentration below 4.0 mmol / l. To correct severe hypokalemia (plasma potassium below 3.0 mmol / l), a 2% solution of potassium chloride is injected intravenously at a rate of 0.5 ml / kg of the patient's weight for 1.5 hours with an interval of 20 minutes until plasma potassium concentration will not reach 4 mmol / l. Then a maintenance dose is prescribed in the form of a cocktail (2% potassium chloride solution - 25 ml and 5% glucose solution - 100 ml). At a plasma potassium concentration of 3.0-3.5 mmol / l, hypokalemia can be corrected by infusion of a cocktail: 2% potassium chloride solution - 50 ml, 5% glucose solution - 100 ml.

In all cases of correction of hypokalemia by fractional administration of potassium, a control analysis should be performed 30 minutes after the administration of potassium preparations.

Hyperkalemia - the level of potassium in the plasma is more than 5.5 mmol / l. Correction of hyperkalemia requires urgent action: stop the introduction of potassium chloride solution; inject 100-200 ml of a 40% glucose solution with insulin, 10-40 mmol of sodium bicarbonate; inject 20-40 mg of lasix; inject 2-10 ml of a 10% calcium gluconate solution.

It should be remembered that the amount of potassium administered must be reduced if the patient develops oliguria, progressive acidosis, signs of increased tissue catabolism (sepsis).

Literature

Tskhovrebov S.V.

DILUTION AND DOSE CALCULATION OF DOBUTAMINE

Pharmachologic effect: Dobutamine Hexal is a predominantly beta-1 adrenoreceptor agonist and a mild alpha-1 and beta-2 adrenoreceptor agonist. Main pharmachologic effect: cardiostimulating. Inotropic agent with a direct effect. The drug directly stimulates beta-1-adrenergic receptors of the heart, thereby increasing myocardial contractility and stroke volume of the heart, which leads to an increase in cardiac output (MOV). Coronary blood flow and myocardial oxygen consumption also increase. Blood pressure and pulse pressure may increase due to an increase in MOS. Improves renal blood flow, diuresis, facilitates conduction in the atrioventricular node.

Pharmacokinetics: The effect develops 1-2 minutes after the start of the IV infusion. The duration of action is on average less than 5 minutes. Metabolized in the liver, excreted by the kidneys.

Indications:

1. Acute cardiac and pulmonary heart failure.

2. Chr. congestive heart failure.

3. Low MOS.

4. Syndrome of low cardiac output after heart surgery.

5. Acute hypotension (shock).

6. As a diagnostic tool for coronary artery disease.

7. If necessary, a full parenteral nutrition in patients with heart failure.

Dosing regimen: Individual, depending on the severity. Adults: injected into / in the cap. at a rate of 2.5-10 mcg / kg / min. Children: injected into / in the cap. at a rate of 5-20 mcg / kg / min. It is preferable to administer as a continuous infusion into the central vein using various dosing devices (infusator, perfusor, "dose-flow") (Table 18).

Table 18

It should be borne in mind that:

1. The concentration of the administered solution depends on the doses required by the patient and the volume of liquid, but should not exceed 5 mg of dobutamine in 1 ml.

2. Solutions must be used within 24 hours.

3. Freezing of the solution should be avoided.

4. The pink color of the solution indicates a slight oxidation of the drug without loss of activity, if the administration occurs within the recommended time.

5. Dobutamine for injection must not be mixed in the same solution and administered in the same system with other drugs.

6. Dobutamine is incompatible with alkaline solutions and solvents containing sodium bisulfate or ethanol.

Contraindications:

1. idiopathic hypertrophic subaortic stenosis;

2. pheochromocytoma;

3. tachyarrhythmia;

4. ventricular fibrillation;

5. individual intolerance to the drug;

special instructions:

Hypovolaemia should be compensated before initiation of administration. It is not recommended to use as an aid in hypovolemic shock. In the presence of an obstruction to the filling of the ventricles or the outflow of blood from the ventricles, the administration of Dobutamine does not improve hemodynamics. With cardiac tamponade, valvular aortic stenosis, idiopathic hypertrophic subaortic stenosis, an inadequate response to administration is possible. The introduction should be carried out under constant monitoring of heart rate, blood pressure, ECG. During the introduction, regular determination of potassium ions in the blood serum is necessary.

It is also recommended to control the stroke volume of the heart, the filling pressure of the ventricles, the central venous pressure, the pressure in the pulmonary artery. During the introduction, it is necessary to monitor the body temperature and mental state of the patient.

It is prescribed with caution during pregnancy and children, although specific pediatric problems that would limit the use in children have not been identified.

It is prescribed with caution if the patient has: metabolic acidosis, hypoxia, atrial fibrillation, angle-closure glaucoma, pulmonary hypertension, myocardial infarction, history of occlusive vascular disease.

Vasopressors and cardiotonic drugs in anesthesiology are used in intensive care and prevention of perioperative complications associated with cardiovascular insufficiency. When working with this group of drugs, the anesthesiologist requires good knowledge of physiology and pharmacology, sufficient clinical experience and the ability to correctly assess the dynamics in the patient's condition. What is common and what are the differences between vasopressor and inotropic support? More about other drugs in anesthesiology and resuscitation

The concept, definition, classification of vasopressors and cardiotonic

Vasopressors (vasopressor, vasoconstrictor) - a group of drugs whose main task is to increase mean arterial pressure due to the vasoconstrictive effect . Examples: epinephrine, norepinephrine, mezaton. Luckily, vasopressors are not used as often planned anesthesialogsand so that they can be easily included in the applied during general or regional anesthesia . However, you should know and remember the indications for their appointment, especially emergency anesthesiology . On the other hand, vasopressors should and must be in the arsenal of drugs during any anesthesia (anesthetic benefit), since no one is immune from the occurrence, for example, of anaphylactic shock.

Cardiotonics (inotropes) - group of drugs with positive inotropic effect , i.e. capable of increasing the force of myocardial contraction and thereby increasing mean arterial pressure. Cardiotonics rarely used in planned anesthesiology, The exception is patients with chronic heart failure (eg, levosimendan used for preoperative preparation; dopamine - during induction anesthesia and maintenance stages). The main indications for the appointment cardiotonic - emergency anesthesiology and early postoperative period. Of the following drugs included in this group, the anesthesiologist should always have at hand dopamine .

Classification of cardiotonic drugs:

1. cardiac glycosides(digoxin, levosimendan);
2. preparations of non-glycoside structure- adrenomimetics ( dobutamine), dopaminomimetics ( dopamine), phosphodiesterase inhibitors ( milrinone), levosimendan.

Understanding physiology is the key to correct choice of inotropic or vasopressor support in clinical practice anesthesiologist-resuscitator . It is believed that catecholamines affect cardiovascular system through vasopressor activity, which adrenergic receptors α 1 , β 1 and β 2 and dopamine receptors have.

Alpha-adrenergic receptors. Activation of α 1 -adrenergic receptors located in vascular walls, causes significant vasoconstriction (increased systemic vascular resistance).

Beta-adrenergic receptors. Stimulation of β 1 -adrenergic receptors located in myocardiocytes leads to an increase in myocardial contractility. Stimulation of β 2 -adrenergic receptors in blood vessels leads to increased uptake of Ca 2+ by the sarcoplasmic reticulum and vasodilation.

dopaminergic receptors. Stimulation of D 1 and D 2 dopaminergic receptors leads to an increase in renal perfusion and expansion of mesenteric, coronary and cerebral vessels.

Vasopressin receptors V 1 and V 2
V 1 receptors - located in smooth muscles internal organs, in particular in vessels; V 2 receptors - located in the renal tubules.
Vasoconstriction occurs due to contraction of the smooth muscle wall of the vessels, and an increase in BCC occurs due to the reabsorption of water in the renal tubules.

In this way, generalc spruce vasopressors and cardiotonics - intense increase in blood pressure, and difference between them is in solving the problem, i.e. at different pathophysiological levels. Therefore, it is more correct to talk about the advantage of one or another effect ( vasopressor or inotropic ) for a given drug in a specific clinical situation. It should not be forgotten that when choosing vasopressor and/or inotropic support, first of all, you need to find cause and effect occurrence cardiovascular insufficiency .

Pharmacological classification

• α andβ adrenomimetics(Adrenaline, Norepinephrine, Isoprenaline, Dobutamine, Dopamine, Dopexamine, Mezaton, Ephedrine)
• Vasopressin
• Phosphodiesterase inhibitors(Milrinon, Enoximon)
• Na + /K + ATPase blockers(Digoxin, Istaroxim)
• Ca 2+ synsetizers(Levosimendan)

Clinical classification

• Vasopressors(Mezaton, Norepinephrine, Vasopressin)
• Cardiotonics(Isoprenaline, Dopexamine, Milrinone, Levosimendan, PDE blockers, Dopamine, Dobutamine, Digoxin, Istaroxim)
• Vasopressors-cardiotonic(Ephedrine, Adrenaline)

Note! This classification is conditional!

The use of vasopressors and cardiotonic drugs in anesthesiology

Clinical Application vasopressors and cardiotonic drugs based on an understanding of pharmacology and pathophysiology.

Clinical situations

• Septic shock- norepinephrine (second line drugs: vasopressin, adrenaline)
• Heart failure(dopamine, dobutamine)
• Cardiogenic shock- norepinephrine, dobutamine (second-line drug - adrenaline)
• Anaphylactic shock- adrenaline (second-line drug - vasopressin)
• Hypotension:
  • anesthesia-induced- mezaton
  • after coronary bypass surgery- adrenaline

Below you will find indications, contraindications, doses and route of administration, as well as calculator for calculating the dose of vasopressors and cardiotonic drugs depending on the patient's body weight .

DOPAMINE

DOPAMINE (dopmin, dopamine, dopamine)

dopamine - vasopressor, cardiotonic. Catecholamine, identical to the natural neurotransmitter, which is the precursor of norepinephrine. Acts on α-adrenoreceptors and β-adrenergic receptors. Belongs to the group of dopaminomimetics.

• At low doses (0.5–2.5 µg/kg/min), dopamine causes vasodilatation of the renal, mesenteric, coronary, and cerebral vessels;
• At medium doses (2-10 mcg/kg/min) dopamine stimulates β1-adrenergic receptors, causing a positive inotropic effect;
• At high doses (10 mcg/kg/min or more), dopamine stimulates α1-adrenergic receptors, causing an increase in total peripheral vascular resistance and renal vasoconstriction.

Indications for the use of dopamine

Shock conditions of various origins (cardiogenic shock, hypovolemic shock, anaphylactic shock, infectious-toxic shock), acute cardiovascular failure in various pathological conditions.

Contraindications to the use of dopamine

Hypersensitivity to the components of the drug, idiopathic hypertrophic aortic stenosis, thyrotoxicosis, pheochromocytoma, angle-closure glaucoma, tachyarrhythmia, age up to 18 years.

How dopamine is used

Dilute 200 mg of dopamine to 50 ml with 0.9% sodium chloride solution.

DOPAMINE CALCULATOR

DOBUTAMIN

DOBUTAMIN (dobutrex, dobutamine)

Dobutmin - cardiotonic (inotrope) , β1-adrenomimetic. Has a positive inotropic effect on the myocardium; moderately increases heart rate, increases stroke and minute volumes of the heart, increases coronary blood flow, reduces total peripheral vascular resistance.

Indications for the use of dobutamine

Acute heart failure, acute decompensation of chronic heart failure.

Contraindications to the use of dobutamine

Hypersensitivity to the components of the drug, idiopathic hypertrophic aortic stenosis, thyrotoxicosis, pheochromocytoma, hypovolemia, ventricular arrhythmias, age up to 18 years.

How to take dobutamine

Intravenously, as a continuous infusion. The dose is selected individually.

Dilute 250 mg dobutmin to 50 ml with 0.9% sodium chloride solution.

DOBUTAMINE CALCULATOR

NORADRENALINE

NORADRENALINE (norepinephrine, noradrenaline)

Norepinephrine - vasopressor , an α1 and α2 adrenergic receptor agonist. Weakly excites β1- and practically does not affect β2-adrenergic receptors. It belongs to the group of adrenomimetics and sympathomimetics (α, β).

Indications for the use of norepinephrine

Norepinephrine is used in acute hypotension accompanying cardiovascular collapse and shock to restore and maintain blood pressure.

Contraindications to the use of norepinephrine

Arterial hypotension due to hypovolemia; thrombosis of mesenteric and peripheral vessels; hypoxia and hypercapnia; severe hypersensitivity to the drug.

How to use norepinephrine

Intravenously, as a continuous infusion. The dose is selected individually from 0.01 to 0.4 mcg / kg / min.

Dilute 16 mg of norepinephrine to 50 ml with 0.9% sodium chloride solution.

NORADRENALINE CALCULATOR

MEZATON

MEZATONE (phenylephrine)

Mezaton - vasopressor , belongs to the group of α-agonists. Stimulates α-adrenergic receptors, causing narrowing of arterioles, increased blood pressure and total peripheral vascular resistance.

Indications for the use of mezaton

Acute hypotension, shocks of various origins, vascular insufficiency.

Contraindications to the use of mezaton

hypersensitivity, arterial hypertension, decompensated heart failure, ventricular fibrillation, cerebral artery disease, pheochromocytoma.

Doses and route of administration of mezaton

For moderate hypotension 0.2 mg (0.1–0.5 mg) IV bolus on dilution, for severe hypotension and shock- continuous intravenous infusion of 0.18 mg / min.

ADRENALIN

ADRENALIN (epinephrine)

Adrenalin - vasopressor, adrenomimetic and sympathomimetic (α-, β).

Activates adenylate cyclase on the inner surface of the cell membrane, increases the intracellular concentration of cAMP and Ca 2+.

At an intravenous rate of less than 0.01 mcg/kg/min, epinephrine can lower blood pressure by relaxing skeletal muscles. At an injection rate of 0.04–0.1 µg/kg/min, it increases the force of heart contractions and stroke volume, and reduces the total peripheral vascular resistance. At a rate of administration above 0.2 μg / kg / min, it constricts blood vessels, lowers blood pressure and total peripheral vascular resistance. Doses above 0.3 μg / kg / min reduce renal blood flow, blood supply to internal organs, tone and motility of the gastrointestinal tract.

Indications for the use of adrenaline

Acute heart failure, cardiogenic shock, allergic reactions(urticaria, angioedema, anaphylactic shock), bronchial asthma(stopping an attack), bronchospasm during anesthesia, asystole, arterial hypotension (including shock, trauma, bacteremia, renal and heart failure, drug overdose).

Contraindications to the use of adrenaline

Hypersensitivity, hypertrophic obstructive cardiomyopathy, pheochromocytoma, arterial hypertension, tachyarrhythmias, ischemic heart disease, ventricular fibrillation, pregnancy.

Side effects of adrenaline

Tachycardia, bradycardia, increased blood pressure, arrhythmia, tremor, psychoneurotic disorders, nausea, vomiting, bronchospasm, hypokalemia, skin rash.

Doses and route of administration of adrenaline

The initial dose of adrenaline is 20–100 mcg intravenously slowly, if necessary, a continuous infusion of 0.01–0.3 mcg / kg / min. In cardiac arrest, 0.5-1 mg intravenously is administered as a bolus.

Preparation of a solution for intravenous infusion: dilute 4 mg of adrenaline to 50 ml of 0.9% NaCl. The table shows the rate in ml/h.

ADRENALINE CALCULATOR

LEVOSIMENDAN

Levosimendan (simdax)

Levosimendan - cardiotonic . It belongs to the group of cardiac glycosides and non-glycoside cardiotonic agents. Increases the sensitivity of contractile proteins to Ca 2+ by binding to troponin. Increases the strength of heart contractions, does not affect the relaxation of the ventricles. Opens ATP-sensitive K+ channels in vascular smooth muscle, causes relaxation of systemic and coronary arteries and veins.

Indications for the appointment of levosimendan

Short-term treatment of acute decompensation of severe chronic heart failure in case of failure of standard therapy.

Contraindications for levosimendan

Hypersensitivity, mechanical obstruction that prevents filling and / or ejection of blood from the ventricles, renal and hepatic insufficiency, severe arterial hypotension (systolic blood pressure less than 90 mm Hg), tachycardia more than 120 in 1 min, hypokalemia and hypovolemia, age up to 18 years.

Side effects of levosimendan

Dizziness, headache, atrial flutter and fibrillation, ventricular extrasystole and tachycardia, decreased blood pressure, heart failure, myocardial ischemia. Often a decrease in hemoglobin, hypokalemia, nausea, vomiting.

Doses and route of administration of levosimendan

Loading dose 6–12 mcg/kg intravenous infusion over 10 minutes. The maintenance dose is 0.1 µg/kg/min, if well tolerated, the dose can be increased to 0.2 µg/kg/min. With severe hypotension and tachycardia, the dose is reduced to 0.05 mcg / kg / min. The recommended total duration of infusion is 24 hours.

DIGOXIN

DIGOXIN (digoxin)

Digoxin is a cardiotonic. It belongs to the group of cardiac glycosides and non-glycoside cardiotonic agents. It has a positive inotropic and bathmotropic effect, a negative chronotropic and dromotropic effect.

In anesthesiology, it is of limited use.

Indications for digoxin

Chronic heart failure, atrial fibrillation, supraventricular paroxysmal tachycardia, atrial flutter.

Contraindications to the appointment of digoxin

Hypersensitivity, glycoside intoxication, WPW syndrome, II-III degree AV block, intermittent complete block.

Side effects of digoxin

Headache and dizziness, delirium, hallucinations, decreased visual acuity, nausea and vomiting, ventricular extrasystole, AV block, thrombocytopenia, intestinal ischemia, rash.

Doses and route of administration of digoxin

During general anesthesia, it is not possible to carry out fast or slow digitalization. It is advisable to administer the maximum single dose of 0.25 mg intravenously as a slow bolus.

VAZOPRESSIN

VAZOPRESSIN

Vasopressin is a vasopressor. It is an endogenous antidiuretic hormone that, at high concentrations, causes direct peripheral vasoconstriction by activating V 1 MMC receptors. Constriction predominates in the vessels of the skin, skeletal muscle, intestine, and adipose tissue. Causes dilatation of cerebral vessels.

Benefits of Vasopressin

• The drug works independently of adrenergic receptors
• Decreased doses of norepinephrine, improved creatinine clearance and diuresis
• Vasopressin may be effective in severe acidosis and sepsis when norepinephrine and epinephrine are ineffective.
• Reducing heart rate without reducing cardiac output (prevention of myocardial dysfunction and cardiomyopathy).

Disadvantages of Vasopressin

Excessive systemic and/or regional vasoconstriction results in:

• decreased cardiac output and systemic oxygen delivery
• deterioration of intestinal microcirculation
• increase in pulmonary vascular resistance
• ischemic skin lesions

*This calculator allows you to calculate the rate of infusion of the drug through the lineomat (titration rate in ml / h) with a known amount of the drug in milligrams in a known volume of solution. It is also necessary to indicate the weight of the patient and the dosage, determined either in mcg * kg / min, or in ml / hour.

For example, A 4% solution of dopamine with a volume of 5 ml contains 200 mg of a pure substance (4% - 40 mg, 40*5=200). Ampoule of the drug (5 ml) diluted with physical. solution up to a volume of 20 ml. Accordingly, 200 mg is the amount of the drug, and 20 ml is the total volume of the solution. The patient's weight is 70 kg and the renal dosage of dopamine (2 µg*kg/hour) is used. Thus, the rate of administration will be 0.84 ml/hour.

The rate in ml/hour is automatically converted to the rate in drops per minute when specifying the dosage of the drug in micrograms per kilogram per minute. In this case, it is taken into account that 1 milliliter contains 20 drops.

If the rate in drops per minute is less than 1 drop per minute, the calculator suggests choosing a lower dilution and switching from drip to lineomat administration.

In order to use the calculator when calculating doses of drugs that do not depend on weight, enter a value equal to 1 in the "Patient weight" field.

Formula

Infusion rate = patient body weight (kg) * drug dose (mcg / kg * min) / (amount of drug in infusion solution (mg) * (1,000 / total volume of infusion solution)) * 60

additional information

Brief notes on the described preparations

Dopamine

If the infusion rate is > 20-30 mcg/kg/min, dopamine should be replaced with another vasoconstrictor (adrenaline, norepinephrine).

The effect on hemodynamics depends on the dose:

• Low dose: 1-5 mcg/kg/min, increases renal blood flow and diuresis.
• Average dose: 5-15 mcg / kg / min, increases renal blood flow, heart rate, myocardial contractility and cardiac output.
• High dose: > 15 mcg / kg / min, has a vasoconstrictive effect.

Phenylephrine