Tablets and pharmaceutical preparations for the production of melanin. Sleeping pill melatonin Drug melanin

Melatonin is a synthetic analogue of the hormone of the brain structure of the pineal gland (epiphysis) melatonin.
The main mechanism of action is the ability to provide a biological change between wakefulness and sleep, circadian rhythms through the neurohumoral mechanisms of the central nervous system.
Increases mental and physical performance, reduces the manifestation of stress reactions. Has antioxidant and immunomodulatory effects; stabilizes cell membranes, normalizes the permeability of the vascular wall and increases its resistance, improves microcirculation.
Pharmacokinetics.
After administration, intravenous melatonin undergoes significant first-pass metabolism in the liver. The bioavailability of melatonin is 30 - 50%. When administered orally at a dose of 3 mg, maximum concentrations in serum and saliva are achieved within 20 and 60 minutes, respectively. Melatonin penetrates the blood-brain barrier and is detected in the placenta. The half-life is 45 minutes. Excreted from the body with urine.

Indications for use:
Melatonin intended for the prevention and treatment of sleep disorders, insomnia, negative consequences of stress reactions (especially in elderly patients), seasonal affective disorders (winter depression); to facilitate adaptation when changing time zones.

Mode of application:
The dosage regimen is set individually.
For insomnia in adults, take ½ to 2 tablets orally 30 to 40 minutes before bedtime, washed down with water. The duration of the course is determined by the doctor.
To adapt to time zone changes - 1 - 2 tablets once a day, at 6 pm, for one week, starting 3 days before the flight.
Melatonin should not be used in the first half of the day under bright daylight conditions.

Side effects:
When using the drug Melatonin morning drowsiness and moderate swelling are possible (in the first week of treatment).
In case of allergic reactions (skin rash), digestive disorders (nausea), dysphoria (in patients with depression), dizziness, the drug should be discontinued. May exhibit minor contraceptive effects and impaired sexual function.

Contraindications:
Contraindications to the use of the drug Melatonin are: individual drug, autoimmune diseases, lymphogranulomatosis, leukemia, lymphoma, myeloma, epilepsy, diabetes mellitus, pregnancy, lactation, simultaneous treatment with monoamine oxidase inhibitors, corticosteroids, cyclosporine; childhood and adolescence.

Interaction with other drugs:
β-adrenergic blockers, clonidine, dexamethasone, fluvoxamine and some other drugs can alter the secretion of endogenous melatonin.
Melatonin may affect the effectiveness of hormonal drugs (estrogens, androgens, etc.), increase the binding of benzodiazepines to specific receptors, so their simultaneous use requires medical supervision.
Melatonin may enhance the antitumor effect of tamoxifen.
The dopaminergic and serotonergic effects of methamphetamine may be enhanced when administered concomitantly with melatonin.
Melatonin may enhance the antibacterial effect of isoniazid.

Overdose:
Cases of melatonin overdose (24 - 30 mg) have been described.
In case of overdose Melatonin the most likely are disorientation, prolonged sleep, memory loss of previous events. In these conditions, it is necessary to rinse the stomach. Therapy is symptomatic.

Storage conditions:
Store out of reach of children, in a dry place, protected from light at a temperature not exceeding 25 ° C. Shelf life - 5 years.

Release form:
Film-coated tablets.

Compound:
1 film-coated tablet Melatonin contains melatonin 3 mg;
excipients: anhydrous disubstituted calcium phosphate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, magnesium, stearic acid.

Additionally:
Prescribe with caution to patients whose activities are associated with the need for increased concentration and high concentration of psychomotor reactions.
After taking the drug, it is not recommended to drive a car or any other complex equipment.
Prescribe with caution for hormonal disorders and/or hormonal therapy, as well as for patients with allergic diseases.
In patients with liver cirrhosis, the level of endogenous melatonin secretion is reduced.
When taking melatonin, you should avoid bright lighting.

A lack of melatonin leads to sleep disturbances, provokes insomnia, and reduces the body's adaptation to time zone changes. The deficiency of this pineal gland hormone can be compensated by taking special medications. They not only normalize sleep, but also have additional positive effects. In order for the product to bring maximum benefit, it is necessary to familiarize yourself in advance with the rules of administration, indications for use, and possible side effects.

Melatonin is a hormone responsible for regulating the circadian rhythm of living organisms, that is, wakefulness and sleep. The compound helps get rid of insomnia that occurs due to overwork, irritability from a sudden change in time zone. Due to these features, it is often called the “sleep hormone.” Melatonin is a derivative of serotonin produced by tryptophan.

The latter is an essential amino acid L-tryptophan. The highest concentration of the hormone in the blood occurs at night, namely from midnight to five in the morning. The highest peak is reached at 2 am. During the day, melatonin levels decrease. In other words, when a person is awake, melatonin decreases and increases during sleep.

Characteristic features of the hormone

The production of melatonin is directly determined by the circadian rhythm. In the light, that is, during the day, the production of the hormone decreases sharply. In the dark, its concentration, on the contrary, begins to increase. In summer, when the length of daylight hours increases, melatonin synthesis decreases significantly, and in winter, on the contrary, it increases. Age also plays an important role.

The older a person gets, the less melatonin is produced. This causes deterioration in falling asleep. A person is more often tormented by insomnia, which negatively affects the deep sleep phase. He becomes more irritable. His systems and organs cease to recover properly. Melatonin leads to a decrease in systolic blood pressure.

Why and when is it necessary to take a “sleep hormone”?

People need to take melatonin in the following situations:

1. The hormone is necessary for those who suffer from insomnia and have difficulty falling asleep due to severe fatigue and prolonged wakefulness. If you increase the concentration of melatonin, sleep problems will decrease to a large extent. This substance has a sedative effect and has a calming effect on the nervous system.
2. The connection is required for every person who experiences increased irritability either due to a change in time zone or work schedule. The hormone is also useful for those who engage in physical activity that leads to muscle fatigue. The substance helps you relax and recover better during sleep.

The substance helps cope with fatigue after training and overwork.

Effects and beneficial properties

The main function of the hormone is to improve sleep quality. The compound takes an active part in normalizing the processes of the endocrine system. Melatonin reduces emotional and physical activity, but only during the period when wakefulness becomes an obstacle to normal biorhythms.

The hormone also has positive side effects. It has anti-stress, antioxidant, immunostimulating, antitumor effects. In addition, it reduces the rate of aging processes. Along with general properties, the compound also has a specific effect, depending on the specific physical activity.

Athletes take melatonin primarily to improve sleep. This effect directly depends on the speed of the body’s recovery processes after sports. The higher the intensity of training, the more irritated the nervous system. This effect negatively affects the condition of the body.

The quality of sleep after strenuous physical activity becomes much worse, and recovery takes much longer. If a person experiences insomnia, it means that the athlete will not have enough strength to perform specific tasks. Sleep allows the muscles to relax and the internal organs and nervous system to recover. The better an athlete sleeps, the faster he recovers, and athletic performance improves significantly.

Effect on libido

A huge amount of research has been conducted on this topic. They showed that there is no direct relationship between melatonin concentration and libido. Taking medications that increase the level of this substance does not have a direct effect on the anabolic hormones that are responsible for male libido.

Effect on testosterone concentration

The level of the male hormone has a positive effect on anabolic processes, sexual desire, and sexual function. Melatonin, as research has shown, directly affects the production and does not suppress the synthesis of testosterone. The female hormone, called prolactin, has a negative effect on the male hormone. Such indirect effects are possible only at certain dosages.

Relationship with prolactin

There are no specific definitive results regarding the relationship between melatonin and prolactin. Some studies have demonstrated the absence of any effect on the female hormone, but no specifications have been made regarding the timing and period of exposure.

Young people who took five milligrams per day for thirty days showed an increase in prolactin levels. The increase in female hormone was recorded daily. An increase in prolactin concentration was observed not during the day, but at night, when the level of melatonin reached its highest concentration.

Effect on growth hormone

Somatotropin (growth hormone) is dependent on melatonin. “Sleep hormone” has a positive effect on GH, the peak concentration of which occurs at night. Both compounds are produced during the rest period. Their concentration decreases with problems with sleep and insomnia, which leads to a decrease in the production of both melatonin and somatotropin.

GH has a positive effect on cell growth not only in children, but also in adults. It has catabolic and anabolic effects, participates in carbohydrate metabolism, and increases the absorption of calcium in bone tissue. Somatotropin is required not only in adolescence, but also for those who are actively involved in sports. The main property of melatonin is that it has a positive effect on sleep quality and recovery. This hormone has a good effect on the production of somatotropin.

Benefits for weight loss

A lot of research has been devoted to how melatonin affects a person’s weight. The hormone stimulates the absorption of glucose and the accumulation of glycogen in muscle tissue. The substance stimulates an increase in the production of creatine phosphate and energy, that is, ATP. This effect allows you to increase energy during physical activity. This helps to increase the duration of the training, which, in turn, promotes greater burning of subcutaneous fat. The fat-burning effect of insulin and glucose levels helps reduce weight.

Indications and contraindications

Those who suffer from diabetes, autoimmune diseases, myeloma, lymphoma, leukemia, and epileptic seizures should not take the drug with melatonin. The hormone is contraindicated for use by children under twelve years of age. For adolescents, medications should only be prescribed by a specialist.

The hormone is intended to be taken in the evening. It is best to take the drug thirty minutes before going to bed. The active substance begins to act after 45-60 minutes. When taking the hormone, you should avoid direct contact with bright light. It suppresses the effect after consuming the drug. Take the tablets with plenty of water.

The instructions and the optimal daily dosage of the drug completely depend on what dietary supplement or pharmaceutical drug is taken. It is necessary to carefully study how much melatonin is contained in one tablet. The daily optimal and safe dose of the active substance is up to three milligrams. In the first days, it is recommended to take one or two milligrams, and then increase the dosage. The maximum dosage is 6 mg. Deterioration in health is a signal that you need to stop taking the supplement.

Course duration

Melatonin is recommended to be taken for a month. A longer course (up to two months) is possible only as prescribed by a doctor. Next, be sure to take a break of a week. If the need arises, after a week's break the course is repeated again. From three months to six months, the drug can be prescribed to older people who are undergoing treatment to normalize blood pressure.

In what form is the drug available?

The supplement is sold in the form of white tablets, which are then washed down with water. Some manufacturers produce the drug in the form of chewable pills.

Preparations with melatonin

The hormone is contained in the following supplements:

1. Vita-melatonin, each tablet contains up to three milligrams of the active substance. Produced in the USA. One package contains 30 tablets.
2. Melarithm, containing a similar amount of melatonin as the American drug. The Russian supplement is produced in packages of 24 tablets.
3. Circadin, which is a Swiss drug. One pill contains two milligrams of the hormone.
4. Melaxen. Another American supplement. Each tablet contains three milligrams of the substance.

People who actively engage in sports are recommended to take dietary supplements rather than pharmaceutical drugs. Sports nutrition manufacturers develop and produce their own supplements that have a positive effect on recovery processes after training during the sleep phase. They have a positive anti-catabolic effect when a person experiences emotional and physical stress. This effect has made these drugs popular among people leading an active lifestyle.

It is recommended to take biologically active sports supplements with melatonin at night (half an hour before going to bed). In addition, they are recommended for use when flying when the time zone changes. You should take the supplement an hour before your flight. You should not take the drug before training. Suppression of physical activity with disorientation leads to a decrease in the effectiveness of the activity. It is not recommended to take the drug in the morning and during the day.

The best manufacturers and sports supplements

• Optimum Nutrition with 100 tablets of 3 mg.
• NOW Foods with 60 capsules of 3 mg.
• Ultimate Nutrition with 60 pills of 3 mg.
• Scitec Nutrition with 90 tablets of 1 mg.
• Universal Nutrition with 60 pills of 5 mg.

If we compare pharmaceutical drugs and sports supplements with the active substance, the latter are much more profitable. The melatonin content in each individual capsule is the same, but the number of tablets in dietary supplements is larger, but at the same time they have a lower cost.

Most of the substance is contained in rice. The amount of hormone that enters the body with food is quite small. This prevents you from obtaining a sufficient dosage to produce beneficial effects in terms of improving sleep quality. Much greater benefit comes from consuming foods with L-tryptophan, which promotes the production of melatonin. To enhance the results obtained, you need to supplement the hormone intake in the amount of 1-6 milligrams per day. It is simply impossible to obtain such dosages from regular food.

Melatonin during pregnancy

The supplement is contraindicated for women during pregnancy and breastfeeding. In addition, it is not recommended to use the drug for women who are planning to become pregnant, since the hormone has contraceptive properties.

Interaction with other drugs

Taking the drug with agents that block beta-adrenergic receptors leads to a decrease in the production of the hormone. Melatonin supplements work well with sleep aids, producing a synergistic effect. The hormone increases the effectiveness of tamoxifen, which has an antitumor effect. It enhances the antibacterial effect of isoniazid.

Side effects, risks and harm

Melatonin is generally considered safe to take. Some people may have individual intolerance, expressed in loss of coordination, severe dryness, vomiting, nausea. In the morning, some people may feel more tired and unwell. Some pharmaceutical drugs cause irritability, increased heart rate and excitability, headaches, dizziness, night sweats, loss of concentration, blurred vision, and migraines.

After taking the “sleep hormone” it is not recommended to drive a vehicle. This is due to the fact that melatonin has an effect on reducing attention and concentration. The drug should not be given to children, as there are no studies on how it affects them. It may slow down sexual development. An overdose also has a negative effect on the body if more than 30 milligrams are taken, when disorientation occurs, memory is lost, and sleep duration decreases.

Terms of sale and storage

The drugs are available without a prescription, even in pharmacies. Sports supplements are available for free sale. Products must be stored in purchased packaging, in a place where the temperature does not exceed 25 degrees, protected from direct sunlight. Typically, the shelf life of the drug is up to three years, but only under the correct storage conditions.

Melatonin analogue

Tryptophan is a dietary supplement, the intake of which in a daily dosage of 500 mg promotes the synthesis of serotonin. At night, this joy hormone is converted into melatonin. In addition, this preparation contains vitamins B5, B6.

There are few things worse than insomnia, the inability to get enough sleep, frequent awakenings in the middle of the night, and in the morning you have to go to work. Insomnia affects both the body and soul of a person, and to a large extent, the ability to function every day. In such cases, many people resort to sleeping pills to finally get some sleep. But not all sleeping pills are equally useful - and not all drugs have only positive effects on people.

When to look for a replacement

Melatonin is one of the most potent remedies for insomnia. The human body itself produces it to regulate sleep. Melatonin is produced by the pituitary gland, released at night in accordance with the rhythm of sleep, and then dissipates as soon as the morning light dawns and it is time to wake up.

Of the many functions of melatonin, the role best understood is the role it plays in maintaining circadian rhythms. In humans, circadian rhythms or "clocks" are regulated by an area called the suprachiasmatic nucleus.

• Using the daily cycle of light and dark, this area creates and maintains a daily cycle.
• Certain hormones are released at certain times of the day. Late evening and early evening release hormones that prepare the body for sleep. In the early hours of the morning, the body begins to prepare for wakefulness and activity.
• Information about light levels reaches the suprachiasmatic nucleus and is then transmitted to the pineal gland deep in the center of the brain.
• The pineal gland releases melatonin at night and suppresses its release during daylight.
• Even when a person is kept away from all external sources of light and time, the body maintains a natural rhythm of wakefulness and sleep.

Melatonin is also a powerful antioxidant, has an anti-inflammatory effect and plays an important role in the functioning of the immune system. Melatonin receptors are present in the brain, cardiovascular system, liver, intestines and kidneys. It is difficult to overestimate the role that melatonin plays for the body. Cheap analogues, although they allow a person to fall asleep, do not have the full range of beneficial properties that are inherent in melatonin.

The production of melatonin, the circadian rhythm hormone, is a completely natural process for the human body. However, certain events - such as stress, poor sleeping conditions, flying in a different time zone and other factors - can temporarily affect its production. If this happens, external melatonin can be added in medication form to help the body cope. However, if melatonin is consumed over a long period of time, the body's natural production of this substance decreases. As a result, addiction can form.

However, you can stop taking melatonin - cheap analogues in some cases can be no less effective for normalizing sleep. If you are already accustomed to using melatonin, you can gradually reduce the dose until the time comes to quit the drug completely.

It is also worth looking for an analogue of melatonin if there is an individual intolerance to the drug or its components, or the side effects when taking the drug are such that its further use is undesirable.

Side effects from taking melatonin may include:

• headache;
• dizziness;
• nausea;
• pressure surges;
• irritability;
• and, oddly enough, sleep disturbances.

Melatonin may interact negatively with other medications, such as immunosuppressants, blood thinners, diabetes medications, and birth control pills. In such cases, you should also think about possible alternatives to medications that contain melatonin. Substitutes may lack some or all of the side effects of melatonin, depending on how your body reacts to them.

Cheap replacement options

There are a huge number of simple measures for sleep that are more effective than medications.

• Mask for sleep. The simplest, but surprisingly effective solution. The mask protects the eyes from the slightest exposure to light, helping the body relax and increase the production of its own “sleep hormone” - melatonin - without any chemical additives.
• Herbal teas. For centuries, herbal infusions have been used to treat a wide range of physical and psychological conditions, including anxiety, depression and insomnia. Teas with valerian, lemon balm, motherwort tincture, and sedatives, which are sold over the counter at any pharmacy, are excellent for sleep disorders. It is important that these teas also taste good. They stimulate the body to produce its own melatonin.
• Magnesium-containing preparations. The body needs magnesium for muscle relaxation, proper alternation of sleep phases and stable functioning of the nervous system. A lack of magnesium balance can cause anxiety, irritability and insomnia.
• Glycine-containing drugs. Glycine is an amino acid that is produced by the body and plays an important role in various functions of the human body - from musculoskeletal and metabolic to cognitive. The human body uses glycine to prepare for sleep and relax. Studies have shown that taking glycine has a positive effect on the quality of sleep in people who tend to wake up in the middle of the night. Glycine also reduces brain hyperactivity, calms nerves, and relieves anxiety, which can impair sleep. In addition, the use of glycine does not cause drowsiness in the morning, as does melatonin.
• L-tryptophan. This is another amino acid necessary for the body to produce serotonin, a substance that is responsible for human mood. Serotonin also plays a crucial role in the production of melatonin. Based on these data, it is believed that taking l-tryptophan may help people suffering from insomnia get a good night's sleep. Although research on the effectiveness of l-tryptophan is limited, this supplement definitely has potential.
• L-theanine- a natural alternative to melatonin, which is devoid of side effects at all. This substance has a calming effect and is used to treat stress, both physical and mental, as well as insomnia. L-theanine in the body is also responsible for regulating and generating alpha waves in the brain, which occur when the human body is completely relaxed. L-theanine helps regulate sleep and suppress beta waves, which can cause a person to wake up in the middle of the night.

Popular

Some of the most popular melatonin analogues on the Russian market are the drug Melaxen, as well as Corvalol and glycine.

Both Melatonin and its analogues cannot be a complete replacement for sleeping pills. In a placebo-controlled study of overnight sleep in insomniacs, melatonin was not superior to placebo. However, melatonin has been shown to have a sedative effect. Simply put, it promotes sleep, but does not guarantee it.

Melaxen analogue, Russian and foreign options

Preparations that contain melatonin:

• Melaxen. The most advertised Russian synthetic melatonin-containing drug. Judging by the reviews, it is quite effective.
• Sonnovan. Melaxen's analogue is Russian, the main active ingredient of which is also melatonin. It is used in the same cases as melatonin - when sleep rhythm is disturbed, after flying between time zones, with poor sleep due to mental disorders, etc.
• Melarithm. Also a drug whose main active substance is melatonin. It costs a little more.
• Mälarena. Another drug is produced at a pharmaceutical plant in the Kaluga region. The manufacturer recommends its drug for the treatment of shift syndrome, weather sensitivity and increased fatigue.
• Circadin. The drug is produced in Germany or Switzerland under a license from an English company. Despite the same active substance, it costs much more.

Prescription drugs

• Phenazepam. One of the oldest analogue drugs of Malaxen. A Russian drug (manufacturer: Valenta Pharmaceuticals OJSC), which has proven its effectiveness.
  Phenazepam belongs to the category of tranquilizers, therefore, it should be taken only as prescribed by a doctor and with great caution - the medicine can cause addiction. In addition, there are a number of side effects.
• So-called Z-group, consisting of three drugs - Zopiclone, Zaleplon and Zolpidem. Although they are produced in different countries and the duration of action and reasons for use of drugs are different, the basic properties of substances from this group are the same - they do not destroy the natural sleep cycle, do not inhibit thought processes and do not lead to addiction. A synonym for zaleplon is Andante, a synonym for zopiclone is Somnol. Zolpidem has not yet entered the Russian market.
• Donormil. A very effective remedy, although it can cause dizziness and drowsiness in the morning.

Drugs without a prescription

• Corvalol. A very popular product in the post-Soviet space, not least due to its low price. The main active ingredient is phenobarbital barbiturate.
• . This is a plant-based drug, the components of which are selected in such a way as to provide a person with the longest and healthiest sleep possible. The drug is available both in tablets and in the form of syrup.
• Glycine. Another popular remedy in Russia, it promotes relaxation and reduces the level of the remedy. For the best effect, it is recommended to dissolve the tablet under the tongue shortly before bedtime.

List of Russian and foreign substitutes

• Andante (Hungary) - from 130 rubles.
• Glycine (Russia) - from 60 rubles.
• Donormil (France) - from 160 rubles.
• Corvalol (Russia) - from 20 rubles.
• Melaxen (Russia) - 432 rubles.
• Melarena (Russia) — 280 rub.
• Melarithm (Russia) — 317 rub.
• Novo-passit (Czech Republic) - from 200 rubles.
• Somnol (Russia) - from 170 rubles.
• Sonnovan (Russia) — 277 rub.
• Phenazepam (Russia) - from 90 rubles.
• Circadin (Switzerland, Germany) - 676 ​​rubles.

• Latin name: Melatonin
• ATX code: H06A
• Active substance: Melatonin
• Manufacturer:"Healthway Production Inc.", USA

Compound

The drug contains the active ingredient, as well as a number of auxiliary components: microcrystalline cellulose, anhydrous disubstituted calcium phosphate, magnesium stearate, colloidal silicon dioxide, croscarmellose sodium, stearic acid.

Release form

Melatonin is produced in tablets, which are covered with a film shell. The blister contains 12 tablets.

pharmachologic effect

The sleep hormone melatonin is produced in the human body by the pineal gland, which is located at the base of the brain. Animal foods contain this substance; plant foods contain smaller amounts of this hormone. The secretion of melatonin also depends on the degree of illumination. In poor lighting, its production increases; in good lighting, it slows down.

In the human body, approximately 70% of the daily amount of this hormone is produced at night. Under the influence of melatonin, the amount of gamma-aminobutyric acid and serotonin in the hypothalamus and midbrain increases.

Melatonin is a solid substance, it can absorb or dissolve fat. It is very strong of natural origin. In the process of synthesis of this hormone, the body provides protection from the influence of free radicals, which provoke the acceleration of the aging process and the development of malignant diseases. This substance can penetrate all cells of the body and provide specific protection to the nucleus. As a result, damaged cells are restored.

Hormone melatonin also exists in a synthetic form, used as a supplement, which provides a hypnotic effect , and also acts as antioxidant . This hormone is a natural regulator of the circadian rhythm, ensuring healthy sleep, falling asleep and waking up quickly.

If a person exposes the body to temporary adaptation disorders, the hormone ensures the correction of the body’s circadian rhythms, as well as the regulation of the wakefulness and sleep cycle. Melatonin tablets make it easier to fall asleep at unusual times, reduce the frequency of awakenings at night and normalize sleep in general.

The drug has a sedative, adaptogenic and hypnotic effect if taken in high doses; it also has antioxidant and immunostimulating effects. Also, under its influence, the frequency of attacks decreases, the intensity of stress reactions decreases, and neuroendocrine functions are regulated.

Pharmacokinetics and pharmacodynamics

Wikipedia indicates that the drug begins to act 1-2 hours after oral administration. Once inside, melatonin is converted during its initial passage through the liver. The bioavailability level is 30–50%. The substance is able to penetrate the blood-brain barrier. The average half-life is 45 minutes. It is excreted from the body through the kidneys.

Indications for use

It should be understood when taking Melatonin that it is a drug that promotes sleep.

Consequently, medications with melatonin are prescribed for the following diseases and conditions:

• conditions of the body in which sleep disturbances are observed;
• the need to regulate the biological cycle of awakening and sleep;
• the need to act as an antioxidant in order to protect against the effects of free radicals;
• to stimulate the immune system;
• in order to stabilize blood pressure and regulate cholesterol levels in the blood;
• for the purpose of preventing tumor diseases;
• mental adaptation disorders;
• anxiety and depression;
• to normalize sleep in older people.

Contraindications

The following contraindications are defined:

• to components;
• autoimmune diseases;
• lymphoma;
• lymphogranulomatosis;
• myeloma;
• pregnancy and lactation;
• childhood.

The drug should be taken with caution by those people who, due to their occupation, need to concentrate. It is also prescribed with caution for hormonal disorders, during hormonal replacement treatment, for people suffering.

Side effects

When taking it, you should remember that such treatment may cause side effects. In particular, the following side effects may occur: heaviness and discomfort in the stomach, headaches, heaviness in the head,. If these or other side effects occur during treatment, you should tell your doctor about it.

Instructions for use of Melatonin (Method and dosage)

The instructions for Melatonin stipulate that the tablets are taken orally and do not need to be crushed. The product should be taken with water. Adult patients should take 1-2 tablets before bedtime. Adolescents over 12 years of age are prescribed 1 tablet before bedtime. Instructions for use of Melatonin stipulate that tablets should be taken 30-40 minutes before bedtime. You can take no more than 6 mg of the substance per day.

The attending physician explains how to take the pills in each specific case.

Sports nutrition that includes Melatonin should be carried out strictly under the supervision of specialists.

Overdose

There is not enough data on an overdose of the drug. When taking more than 24 mg of the drug, patients experienced prolonged sleep, memory problems, and disorientation. For the purpose of treatment, it is necessary to perform gastric lavage and take. Symptomatic therapy is also practiced.

Interaction

With simultaneous treatment, it is possible to enhance the dopaminergic and serotonergic effects of methamphetamines.

During treatment Melatonin antibacterial effect is potentiated .

Terms of sale

The product is sold in pharmacies without a prescription.

Storage conditions

The product should be stored at room temperature; the tablets should be kept away from children. After the expiration date, the medicine should not be used.

Best before date

You can store the medicine for 3 years.

special instructions

It should be borne in mind that when taking tablets, there may be an adverse effect on concentration and the speed of physical and mental reactions. It is not recommended to drive vehicles or perform potentially dangerous activities that require special attention during therapy.

When treated with Melatonin, you should not smoke or drink alcohol.

Women who are trying to get pregnant should be aware that Melatonin can act as a weak hormone.

During the period of taking the medicine, you should avoid too bright lighting.

Analogs

Analogues of the drug Melatonin - medicines Melapur , Yukalin , Melaton . Despite the fact that these drugs have a similar effect, analogues should not be used without first consulting with a doctor.

For children

This medicine is not prescribed for children under 12 years of age. To normalize sleep, you can consume products containing this substance. This is, first of all, food of animal origin. Your doctor can tell you in detail which foods contain melatonin.

With alcohol

It is not advisable to drink alcohol during treatment with Melatonin.