Lee rigevidon. Rigevidon - birth control pills

Tradename:

RIGEVIDON ®

International nonproprietary name or generic name:

Ethinyl estradiol + Levonorgestrel

Dosage form:

COMPOUND

Active substances:
Ethinyl estradiol: 0.03 mg
Levonorgestrel; 0.15 mg
Excipients:
- in the tablet core: colloidal silicon dioxide, magnesium stearate, talc, corn starch, lactose monohydrate;
- in the tablet shell: sucrose, talc, calcium carbonate, titanium dioxide, copovidone, macrogol 6000, colloidal silicon dioxide, povidone, carmellose sodium.

Description

White, round, biconvex, film-coated tablets.

Pharmacotherapeutic group:

ATX code: G03AA07.

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Rigevidon is an oral monophasic combined estrogen-progestogen contraceptive drug.
When taken orally, it inhibits the pituitary secretion of gonadotropic hormones.
The contraceptive effect is associated with several mechanisms. As a gestagenic component (progestin), it contains a derivative of 19-nortestosterone - levonorgestrel, which is more active than the corpus luteum hormone progesterone (and a synthetic analogue of the latter - pregnin), acts at the receptor level without preliminary metabolic transformations. The estrogenic component is ethinyl estradiol. Under the influence of levonorgestrel, there is a blockade of the release of releasing hormones (LH and FSH) of the hypothalamus, inhibition of the pituitary gland's secretion of gonadotropic hormones, which leads to inhibition of the maturation and release of an egg ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. Maintains high viscosity of cervical mucus (makes it difficult for sperm to enter the uterine cavity). Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, incl. tumor nature.

Pharmacokinetics

Levonorgestrel is rapidly absorbed (less than 4 hours). Levonorgestrel does not have a first-pass effect through the liver. When levonorgestrel is co-administered with ethinyl estradiol, there is a relationship between the dose and maximum plasma concentration. TC max (time to reach maximum concentration) of levonorgestrel is 2 hours, T 1/2 (half-life) - 8-30 hours. (on average 16 hours). Most of levonorgestrel binds in the blood to albumin and SHBG (sex hormone binding globulin).
Ethinyl estradiol quickly and almost completely absorbed from the intestines. Ethinyl estradiol has a first-pass effect through the liver, TC max is 1.5 hours, half-life is about 26 hours.
When taken orally, ethinyl estradiol is released from the blood plasma within 12 hours, the half-life is 5.8 hours.
Ethinyl estradiol is metabolized in the liver and intestines. Ethinyl estradiol metabolites are water-soluble products of sulfate or glucuronide conjugation and enter the intestine with bile, where they undergo disintegration with the help of intestinal bacteria.
Both components (levonorgestrel and ethinyl estradiol) are excreted in breast milk. Active substances are metabolized in the liver, T1/2 is 2-7 hours.
Levonorgestrel is excreted by the kidneys (60%) and through the intestines (40%); ethinyl estradiol - by the kidneys (40%) and through the intestines (60%).

INDICATIONS FOR USE

CONTRAINDICATIONS

CAREFULLY

Liver and gallbladder diseases, epilepsy, depression, ulcerative colitis, uterine fibroids, mastopathy, tuberculosis, kidney disease, adolescence (without regular ovulatory cycles).
In the presence of diabetes mellitus, diseases of the cardiovascular system, arterial hypertension, renal dysfunction, varicose veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy, minor chorea, intermittent porphyria, latent tetany, bronchial asthma, the use of the drug also requires caution.

PREGNANCY AND LACTATION

During pregnancy and lactation, taking the drug is contraindicated.

METHOD OF APPLICATION AND DOSES

Apply orally without chewing and with a small amount of liquid.
If hormonal contraception was not used during the previous menstrual cycle, contraception with Rigevidon is started from the first day of menstruation, taking 1 tablet daily for 21 days, at the same time of day.
This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day cycle of taking tablets from a new package containing 21 tablets must be started the next day after a 7-day break, i.e. on the eighth day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package occurs on the same day of the week.
When switching to taking Rigevidon from another oral contraceptive a similar scheme is used. The drug is taken as long as the need for contraception remains.
After an abortion, it is recommended to start taking the drug on the day of the abortion or the day after the operation.
After childbirth, the drug can be prescribed only to women who are not breastfeeding; You should start taking the contraceptive no earlier than the first day of menstruation. During lactation, the use of the drug is contraindicated.
Missed pills; The missed tablet should be taken within the next 12 hours. If 36 hours have passed since the last pill was taken, contraception is unreliable. To avoid intermenstrual bleeding, the drug must be continued from the package already started, with the exception of the missed tablet(s). In cases of missed pills, it is recommended to additionally use another, non-hormonal method of contraception (eg, barrier).
For medicinal purposes; The dose of Rigevidon and the regimen of use are selected by the doctor in each case individually.

SIDE EFFECT

The drug is usually well tolerated.
Possible side effects of a transient nature, spontaneously passing: nausea, vomiting, headache, engorgement of the mammary glands, changes in body weight and libido, mood changes, acyclic bleeding, in some cases - swelling of the eyelids, conjunctivitis, blurred vision, discomfort when wearing contact lenses (these phenomena are temporary and disappear after discontinuation without prescribing any therapy).
With long-term use, chloasma, hearing loss, generalized itching, jaundice, calf muscle cramps, and an increase in the frequency of epileptic seizures can very rarely occur. Hypertriglyceridemia, hyperglycemia, decreased glucose tolerance, increased blood pressure (BP), thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, vaginal candidiasis, increased fatigue, diarrhea are rarely observed.

OVERDOSE

Cases of toxic effects due to overdose are unknown.

INTERACTION WITH OTHER MEDICINES

Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can enhance the metabolism of the steroid hormones included in the drug.
A decrease in contraceptive effectiveness can also be observed when administered simultaneously with certain antimicrobial drugs (ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with changes in the microflora in the intestine.
When using anticoagulants, coumarin derivatives or indanedione, it may be necessary to additionally determine the prothrombin index and change the dose of the anticoagulant.
When using tricyclic antidepressants, maprotiline, beta-blockers, their bioavailability and toxicity may increase.
When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.
When combined with bromocriptine, the effectiveness of bromocriptine is reduced.
When combined with drugs with potential hepatotoxic effects, for example, with the drug dantrolene, increased hepatotoxicity is observed, especially in women over 35 years of age.

SPECIAL INSTRUCTIONS

Before starting contraception and subsequently every 6 months. A general medical and gynecological examination is recommended, including a cytological analysis of a cervical smear, assessment of the condition of the mammary glands, determination of blood glucose, cholesterol and other indicators of liver function, blood pressure monitoring, and urine analysis).
Prescribing Rigevidon to women with thromboembolic diseases at a young age and a family history of increased blood clotting is not recommended.
The use of oral contraception is allowed no earlier than 6 months after viral hepatitis, provided that liver functions are normalized.
If sharp pain appears in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding, a suspicion of a liver tumor may arise. If necessary, the drug should be discontinued.
If liver function deteriorates while taking Rigevidon, consultation with a physician is necessary.
If acyclic (intermenstrual) bleeding occurs, Rigevidon should be continued, since in most cases this bleeding stops spontaneously. If acyclic (intermenstrual) bleeding does not disappear or recurs, a medical examination should be performed to exclude organic pathology of the reproductive system.
In case of vomiting or diarrhea, the drug should be continued, additionally using another, non-hormonal method of contraception.
Women who smoke and take hormonal contraceptives have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and depending on the number of cigarettes smoked (especially in women over 35 years of age).
The drug should be stopped in the following cases:
- when a migraine-like headache appears for the first time or worsens, or when an unusually severe headache appears;
- when early signs of phlebitis or phlebothrombosis appear (unusual pain or swelling of the veins in the legs);
- if jaundice or hepatitis without jaundice occurs;
- for cerebrovascular disorders;
- when there is stabbing pain of unknown etiology when breathing or coughing, pain and a feeling of tightness in the chest;
- with acute deterioration of visual acuity;
- if thrombosis or heart attack is suspected;
- with a sharp increase in blood pressure;
- when generalized itching occurs;
- with increased frequency of epileptic seizures;
- 3 months before the planned pregnancy, approximately 6 weeks before the planned surgical intervention, with prolonged immobilization.
- if you are pregnant.

INFLUENCE OF THE DRUG ON THE ABILITY TO DRIVE A CAR AND OTHER MECHANISMS
Taking the drug does not affect the ability to drive a car or operate other machinery, the operation of which is associated with an increased risk of injury.

RELEASE FORM

Pills;
21 tablets in a blister made of PVC/PVDC film and aluminum foil;
1 or 3 blisters in a cardboard box with instructions for use.

STORAGE CONDITIONS

At a temperature of 15-30 °C.
The drug must be stored out of the reach of children!

BEST BEFORE DATE

CONDITIONS OF VACATION FROM PHARMACIES

MANUFACTURER

JSC "Gedeon Richter"
1103 Budapest, st. Demrei, 19-21, Hungary.
Consumer complaints should be sent to:
Moscow Representative Office of JSC Gedeon Richter

“Rigevidon” is a contraceptive pill containing hormones in low dosages, used both as a contraceptive and for the treatment of a number of gynecological pathologies.

The drug is produced in the form of white, film-coated, biconvex round tablets. One piece contains 30 mcg ethinyl estradiol, 150 mg levonorgestrel.

Auxiliary components: colloidal silicon dioxide, magnesium stearate, lactose monohydrate, corn starch, talc.

The shell includes: sucrose, calcium carbonate, talc, titanium dioxide, macrogol, copovidone, colloidal silicon dioxide, sodium carmellose, povidone.

Pharmacological influence

Birth control pills "Rigevidon" are a monophasic combined estrogen-progestogen drug. When taken orally, it suppresses the pituitary gland's secretion of gonadotropic hormones. The contraceptive effect is due to several mechanisms. The gestagenic element (progestin) is levonorgestrel, a derivative of 19-nortestosterone, which is more active than progesterone, the hormone of the corpus luteum (and its synthetic analogue, pregnin). It works at the receptor level. The estrogenic component is ethinyl estradiol.

Due to the effects of levonorgestrel, the release of FSH and LH - releasing hormones from the hypothalamus is blocked, the secretion of gonadotropic hormones by the pituitary gland is suppressed, which inhibits the maturation and then the release of the egg prepared for fertilization (ovulation). The protective effect is enhanced by ethinyl estradiol. The high viscosity of the cervical mucus remains, which makes it difficult for sperm to penetrate into the uterine cavity. Along with the contraceptive effect, when used regularly, it normalizes the menstrual cycle and prevents the appearance of many gynecological pathologies, including tumors.

Pharmacokinetics

Let's take a closer look at how the active components of the Rigevidon birth control pills work.

Ethinyl estradiol. This substance is almost completely and quickly eliminated from the intestines. It undergoes a kind of “first pass” effect through the liver. The half-life is approximately 26 hours.

When ethinyl estradiol is taken orally, it is cleared from the blood plasma within twelve hours. The half-life is 5.8 hours.

Metabolism of ethinyl estradiol occurs in the intestines and liver. The metabolites of this substance are water-soluble glucuronide or sulfate conjugates, which enter the intestine with bile, where they are disintegrated by intestinal bacteria.

Metabolism occurs in the liver, the half-life ranges from 2 to 7 hours.

Ethinyl estradiol is excreted by the intestines and kidneys.

Levonorgestrel. This component is absorbed quickly (less than four hours). Not subject to the first pass effect through the liver. When levonorgestrel is coadministered with ethinyl estradiol, a relationship between maximum plasma levels and dosage is observed. The half-life of levonorgestrel from the body is from 8 to 30 hours (16 hours on average). A larger amount of levonorgestrel in the blood binds to SHBG (that is, globulin that binds sex hormones) and albumin. Metabolism occurs in the liver. This substance is excreted through the intestines and kidneys.

Indications

Contraceptive pills "Rigevidon" are used in the following cases:

• oral contraception;
• premenstrual syndrome;
• functional deviations of the menstrual cycle (including dysmenorrhea without an organic cause, as well as difunctional metrorrhagia).

Contraindications

According to the instructions for the Rigevidon birth control pills, the following are contraindications:

• severe liver pathologies;
• cholecystitis;
• hereditary hyperbilirubinemia (including Rotor, Dubin-Johnson and Gilbert syndrome);
• presence or history of serious cerebrovascular or cardiovascular diseases;
• thromboembolism, as well as predisposition to such;
• malignant tumors (primarily endometrial or breast cancer);
• liver tumors;
• severe forms of arterial hypertension;
• familial types of hyperlipidemia;
• sickle cell anemia;
• endocrine diseases (including severe types of diabetes);
• chronic hemolytic anemia;
• bleeding from the vagina of unknown origin;
• migraine;
• history of idiopathic jaundice during pregnancy;
• severe itching of the skin in pregnant women;
• age over 40 years;
• herpes during pregnancy;
• pregnancy itself;
• lactation period (breastfeeding);
• increased sensitivity of the body to the composition of the drug.

You should use the drug very carefully for diseases of the gallbladder and liver, depression, epilepsy, uterine fibroids, ulcerative colitis, tuberculosis, mastopathy, diabetes mellitus, kidney disease, pathologies of the cardiovascular system, impaired renal function, arterial hypertension, varicose veins, phlebitis , multiple sclerosis, chorea minor, latent tetany, intermittent porphyria, bronchial asthma, and also in adolescence (if there are no regular ovulation cycles).

How to take birth control pills "Rigevidon"?

Dosage

The drug is taken orally, the tablets do not need to be chewed, washed down with a small amount of water. In the absence of hormonal contraception during the previous menstrual cycle, for protection, Rigevidon is taken from the first day of menstruation, one tablet every day for 21 days, and at the same time.

After this, you need to take a break for a week, during which bleeding occurs, similar to menstrual bleeding. The next cycle is 21 days. You should take tablets from a new package, which also contains 21 tablets, and you should start the next day after a break for a week, that is, on the eighth day of the cycle, including when the bleeding has not stopped. The start of taking the drug from each new pack, therefore, falls on the same day of the week.

It is important to find out in advance how to take Rigevidon birth control pills. If you switch to this drug from any other oral contraceptive drug, the scheme is similar. The drug is taken as long as there is a need for protection.

After an abortion, use of the drug should begin on the day of the abortion or the day after it.

After childbirth, the drug can be prescribed only to women who are not breastfeeding. You should start using contraception no earlier than the first day of your period. During the lactation period, it is contraindicated to take the drug.

Many people are wondering whether it is possible to get pregnant while taking Rigevidon birth control pills? It is possible, but only if taken incorrectly.

The missed pill should be taken within the next twelve hours. If 36 hours have already passed since the last pill was taken, contraception is considered unreliable. To avoid bloody intermenstrual discharge, the use of the drug should be continued from the pack that has already been started, excluding only the missed tablet.

If a dose is missed, it is advisable to additionally use another method of contraception, non-hormonal (for example, barrier). The dosage of the drug and the regimen of use for medicinal purposes are determined by the doctor individually in each case.

According to reviews, the price of Rigevidon birth control pills is quite reasonable.

Side effects

Usually the drug is well tolerated.

Possible side effects of a transient nature that resolve spontaneously: vomiting, engorgement of the mammary glands, nausea, headache, changes in libido and weight, mood, bloody acyclic discharge; in some cases - conjunctivitis, swelling, blurred vision, discomfort when wearing contact lenses (these phenomena are temporary, they disappear after stopping use without prescribing any treatment).

With long-term use, very rarely the following may be observed: hearing loss, jaundice, itching, leg muscle cramps, increased frequency of epileptic seizures (in those suffering from this disease).

Rarely observed: hyperglycemia, hypertriglyceridemia, decreased glucose tolerance, thrombosis, increased blood pressure, venous thromboembolism, skin rashes, changes in the nature of vaginal secretion, diarrhea, vaginal candidiasis, fatigue.

The price of Rigevidon birth control pills will be given below.

special instructions

Before starting to use this drug, it is recommended to undergo a gynecological and general medical examination, which includes a cytological analysis of a smear from the uterine cervix, assessment of the condition of the breast glands, determination of blood glucose, cholesterol and other indicators of liver activity, urine analysis, and blood pressure monitoring.

Prescribing Rigevidon to patients with thromboembolic pathologies at a young age and a history of increased blood clotting is undesirable.

The use of an oral contraceptive is allowed no earlier than six months after the patient suffered viral hepatitis if the liver function has returned to normal.

If sharp pain, hepatomegaly and symptoms of intra-abdominal bleeding appear in the upper abdomen, the presence of a liver tumor may be suspected. If necessary, use of the product should be stopped. If liver activity is impaired, then while using the drug "Rigevidon" a consultation with a general practitioner is required.

If intermenstrual (acyclic) bleeding occurs, then taking Rigevidon must be continued, since in most cases these bleedings are not dangerous and stop on their own. If intermenstrual (acyclic) bleeding recurs or does not disappear, a medical examination should be performed to rule out diseases of the reproductive system.

In case of diarrhea or vomiting, the drug should be continued. This is confirmed by the instructions for use of the Rigevidon contraceptive pills.

Smoking patients who take hormonal contraceptives have a high risk of developing cardiovascular diseases with significant consequences (stroke, myocardial infarction). The risk increases with age and depends on the number of cigarettes smoked per day (especially in women over 35 years of age).

The use of the drug should be stopped in the following situations:

• if headache appears for the first time or worsens;
• if early symptoms of phlebothrombosis or phlebitis occur (swelling of the veins in the lower extremities or unusual pain);
• if hepatitis appears without jaundice or jaundice;
• in the presence of cerebrovascular disorders;
• if there are stabbing pains of unknown origin when coughing or breathing, a feeling of tightness and pain in the chest;
• if there is a suspicion of a heart attack or thrombosis;
• with acute decrease in visual acuity;
• if the pressure rises sharply;
• when itching occurs;
• if epileptic seizures become more frequent;
• approximately six weeks before the proposed surgery;
• three months before pregnancy is planned;
• upon pregnancy.

Taking a contraceptive does not in any way affect the ability to drive vehicles or operate machinery, which increases the risk of injury.

Rigevidon is a birth control pill that contains a low dose of hormones and can be used as a method of contraception and treatment of certain gynecological diseases.

ATTENTION: The drug has contraindications. Do not start using this drug without first consulting your doctor.

Composition of tablets and packaging

Rigevidon belongs to the group of monophasic birth control pills. This means that all tablets in the package contain the same dose of hormones. One tablet of Rigevidon contains 30 mcg of ethinyl estradiol and 150 mcg of levonorgestrel. One blister (plate) of Rigevidon contains 21 tablets, designed for 21 days of use.

Rigevidon 21+7 contains 28 tablets in one blister (plate). White tablets have the same dosage of hormones as regular Rigevidon (30 mcg ethinyl estradiol and 150 mcg levonorgestrel), and reddish-brown tablets do not contain hormones, being essentially placebo tablets, or dummies.

Benefits of Rigevidon

Rigevidon birth control pills have a reliable contraceptive effect and, if taken correctly, provide high protection against unwanted pregnancy. The contraceptive effect of Rigevidon is achieved by temporarily suppressing ovulation in the ovaries and increasing the viscosity of mucus in the cervical canal.

Taking Rigevidon for 3 consecutive months or more helps to normalize the menstrual cycle, reduce and reduce the volume of blood loss during menstruation. While taking the OK Rigevidon, the risk of developing mastopathy, ovarian cancer, uterine cancer and some other gynecological diseases is reduced.

The effect of the drug is reversible. Already in the first months after stopping taking Rigevidon, a woman becomes capable of conceiving again.

Rules for taking Rigevidon

Rigevidon is recommended to take one tablet per day, at any convenient time of the day, regardless of meals. If you are concerned about the side effects of the drug (nausea, headache), then it is recommended to change the time of taking the pills to the evening.

If you have not used any hormonal contraceptives in the past month

It is recommended to start taking Rigevidon on the first day of the menstrual cycle (on the first day of menstruation). After you start taking the pills, your periods may become more scanty or may stop altogether. This is normal. It is also possible that your periods will not stop, but on the contrary, will drag on for 7-10 days or more. This is also normal.

Take Rigevidon one tablet per day for 21 days in a row. After the tablets in the blister run out, take a 7-day break. During the 7-day break, your period may begin. Regardless of whether your period has ended, always start a new package of Rigevidon on the 8th day after a week's break.

If you are taking Rigevidon 21+7, then start taking the drug with white tablets and take one white tablet for 21 days. After the white tablets are gone, start taking the reddish-brown tablets. You may get your period while you take the last seven tablets. Despite your period, continue to take the pills every day. After finishing the blister pack (taking the last reddish-brown tablet), start a new pack the next day, without interruption.

When will the contraceptive effect occur?

The contraceptive effect of Rigevidon occurs immediately if you start taking the pills on the first day of your period. In this case, you may not need to use additional methods of protection against pregnancy.

If you took the first tablet of Rigevidon from the 2nd to the 5th day of menstruation, then you need to use it for another 7 days after starting to take the tablets. The contraceptive effect will occur after taking the eighth tablet.

Will the contraceptive effect continue after a week's break?

If in the previous month you took the pills correctly (without omissions and without factors that reduce the effect of OK), then the contraceptive effect of Rigevidon remains in the interval between packs, and you do not need to use additional methods of contraception.

If you had any omissions, or the effect of the tablets could be reduced for other reasons (diarrhea, vomiting, drinking large doses of alcohol, taking medications), see the instructions in the relevant paragraphs.

How to switch to Rigevidon from other birth control pills?

If your previous birth control pills contained 21 tablets in a blister pack:

You can start taking Rigevidon the next day after the last tablet taken of the previous OCs, or

on the eighth day after the end of the previous OK

If your previous birth control pills contained 28 tablets per blister:

You can start taking Rigevidon the day after the last active tablet, or

the day after 28 tablets of the previous OK

If you did not manage to start taking Rigevidon within the specified time frame, then you should wait until your next menstruation and take the first tablet on the first day of your period. To avoid unwanted pregnancy, other methods of contraception should be used before starting to take the pills.

How to switch to Rigevidon from a vaginal ring or from a hormonal patch?

When switching to Rigevidon from a vaginal ring, the first tablet should be taken on the day the ring was removed, or on the day when a new ring needed to be installed.

When switching to Rigevidon, the first tablet of the drug should be taken on the day the patch is removed, or on the day when a new patch would need to be applied.

How to switch to Rigevidon from an intrauterine device (IUD)?

Take the first Rigevidon tablet on the day of removal of the intrauterine device. The contraceptive effect will occur only after 7 days of taking Rigevidon, so use condoms or other methods of contraception until the eighth tablet.

If you did not manage to start taking Rigevidon on time, then wait until your next menstruation and take the first tablet of the drug on the first day of menstruation. Before you start taking Rigevidon, use other methods of protection against pregnancy.

What should I do if I mixed up the order of taking Rigevidon?

If your package of Rigevidon contains 21 tablets, then nothing bad will happen. All tablets in the package have the same dose of hormones, so the body “will not notice” the difference. Continue to drink Rigevidon as usual: one tablet per day until the end of the package.

If you are taking the drug Rigevidon 21+7 (that is, the package of Rigevidon contains 28 tablets), then pay attention to which tablets you mixed up. If instead of one white pill you take another white pill, then nothing bad will happen, since all white pills contain the same dose of hormones. If instead of a white pill you accidentally took a reddish-brown one, the contraceptive effect of Rigevidon may be reduced. In this case, you need to do the same as if you missed a pill (depending on its number).

What to do if you miss a Rigevidon tablet?

If you forget to take another Rigevidon tablet, count how many hours have passed since the last tablet you took. If less than 36 hours have passed since taking the last pill, the contraceptive effect of the pills will not decrease. Take the missed tablet as soon as possible and continue taking the tablets as usual.

If more than 36 hours have passed since the last pill, the contraceptive effect of the pills may be reduced. In this case, your further actions depend on the number of the missed pill:

From 1 to 7 tablets (first week of use) : Take the missed tablet as soon as possible, even if you have to take two tablets at the same time. For another 7 days after skipping, the contraceptive effect of the pills will be reduced, so in case of sexual intercourse, use other methods of contraception.

From 8 to 14 tablets (second week of use) : Take the missed tablet as soon as possible, even if you have to take 2 tablets at once. The contraceptive effect of the pills will not decrease if you took the pills according to the rules in the previous 7 days before missing them. That is, if you have not missed a day in the last week, then you do not need to use condoms or other additional methods of contraception. If you missed a dose in the last week, you will need to use additional contraception for 7 days after the missed date.

From 15 to 21 tablets (third week of use) : Take the missed Rigevidon tablet as soon as you remember, even if you have to take two tablets at the same time. Then continue to take the tablets as usual until the package runs out. To ensure that the contraceptive effect of the pills does not decrease and you do not experience an unwanted pregnancy, you should skip the 7-day break. This means that after finishing the pack you need to start the next pack of Rigevidon the next day (without a break).

You do not need to use additional contraception if you have not had any other absences in the previous 7 days before your missed date. If you have already skipped in the last week, then you should use condoms for another 7 days after skipping.

If your package of Rigevidon contains 28 tablets, then the instructions remain the same for the first and second weeks of use (see above). Changes apply to the third week of taking the pills:

From 15 to 21 tablets: take the missed Rigevidon tablet as soon as you remember, even if you have to take two tablets at the same time. Then continue to take tablets as usual up to 21 tablets (until the last white tablet). Then throw away the package of remaining red-brown tablets and start taking a new package the day after taking the last 21 tablets. You do not need to use additional contraception if you have not had any other absences in the previous 7 days before your missed date. If you have already skipped in the last week, then you should use condoms for another 7 days after skipping.

From 22 to 28 tablets: These are inactive pills, so skipping them will not reduce the contraceptive effect. Throw away the missed tablet and continue taking the tablets as usual.

What should I do if I missed several Rigevidon tablets?

If you miss two Rigevidon tablets in a row the contraceptive effect may be reduced. To avoid unwanted pregnancy, you should follow the instructions.

Pay attention to the numbers of the missed tablets. If these are tablets of the first or second week of taking (from 1 to 14), then take 2 tablets immediately as you remember the omission and 2 more tablets the next day. Next, take one tablet of Rigevidon per day until the end of the package. Use another 7 days after skipping.

If the missed tablets are from the third week of dosing (from 15 to 21), then you should throw away the current pack of tablets and start a new pack with the first active (white) tablet. You should drink the new package to the end and only then take a 7-day break. If you have not had any other absences in the previous 7 days before your pass, you do not need to use condoms or other additional methods of contraception.

If you miss 3 Rigevidon tablets in a row, throw away the current pack of tablets and start a new pack with the first active (white) tablet. Use additional contraception for another 7 days. If you had unprotected sex during the absence or shortly before the absence, then the risk of pregnancy will be increased. In this case, you should take it 3.5 weeks after your last unprotected intercourse, or take it 11 days after your last unprotected intercourse.

If you are not sure what to do in your situation, use additional contraception (for example,) until you consult with your gynecologist.

What should you do if you experience spotting or menstruation while taking Rigevidon?

While taking the drug Rigevidon or Rigevidon 21+7, you may experience bleeding of varying degrees of abundance (scanty spotting or discharge similar to menstruation).

Bloody discharge appears especially often in the first 3 months of taking Rigevidon. As a rule, this is not dangerous, does not indicate pregnancy and does not require urgent medical attention.

Despite this discharge, continue taking the tablets as usual. Do not stop taking the tablets on your own without consulting your doctor, as this may increase bleeding.

If you have not missed pills, the contraceptive effect remains despite this discharge, so you can continue to be sexually active without fear of getting pregnant.

If spotting occurs as a result of missing one or more tablets, continue taking Rigevidon despite the spotting. Use additional contraceptives, since skipping pills may reduce the contraceptive effect of Rigevidon.

How to delay your periods with Rigevidon?

You can delay unwanted menstruation with Rigevidon tablets.

To postpone your period, finish your current pack of Rigevidon and then, without taking a break, start a new pack the next day. You need to finish the second package and only then take a break.

By missing the 7-day break, you may experience some spotting halfway through the second pack. This is not dangerous and does not require urgent medical attention. Despite this discharge, continue taking the tablets as usual until the end of the pack.

If your package contains 28 tablets, then in order to postpone unwanted menstruation, you should finish the active white tablets (up to 21 tablets inclusive) and then throw away the remaining red-brown (inactive) tablets. The day after taking your last active tablet, start a new pack. The second package must be completed to the end (including inactive tablets).

What to do if your period does not come during the Rigevidon break?

While taking Rigevidon tablets, your period may not come within a 7-day break. As a rule, this is not dangerous, but requires extra attention from you.

If you had any omissions in the past month, or there were other possible reasons for the decrease in the contraceptive effect (diarrhea, vomiting, taking alcohol or medications), then you should do so and consult a gynecologist. Until pregnancy has been ruled out, you should not start taking a new pack of Rigevidon.

What to do if pregnancy occurs while taking Rigevidon?

The drug Rigevidon provides a high degree of protection against unwanted pregnancy, but this protection cannot be considered one hundred percent. Within one year of taking Rigevidon tablets, one woman out of 2000 becomes pregnant.

As a rule, pregnancy is the result of missing pills or exposure to other factors that reduce the contraceptive effect (see next point). However, pregnancy can occur even if you take the pills perfectly.

If you become pregnant while taking Rigevidon, immediately stop taking the pills and contact your gynecologist. Since this drug does not cause malformations in the embryo, pregnancy can be continued despite the fact of taking birth control pills.

In what cases can the effect of Rigevidon decrease?

The effectiveness of contraception may be reduced in the following cases:

• If you miss one or more tablets
• As a result
• When consumed
• For (some antibiotics, phenobarbital, epilepsy medications, drugs, St. John's wort content, etc.)

What to do if the effect of Rigevidon could be reduced?

If you suspect that the contraceptive effect of Rigevidon may have been reduced, use additional contraception (such as condoms) for the next 7 days.

Do I need to take long breaks from taking Rigevidon?

Some women try to take long breaks from taking Rigevidon to give the body a break from the pills. You can read about whether this is really beneficial for the body by following the link:

How to properly stop taking Rigevidon?

If you no longer need contraception, or if you are planning a pregnancy, you should stop taking Rigevidon birth control pills.

In order to avoid the side effects of withdrawal and restore your own menstrual cycle as quickly as possible, listen to the following advice from gynecologists:

Never stop taking pills halfway through the pack. Even if you decide to get pregnant as soon as possible, finish the current package to the end and only then stop taking the pills.

After finishing your current pack of tablets, simply do not start a new pack.

Please note that after taking the last Rigevidon tablet, the contraceptive effect of the tablets disappears. That is, you can get pregnant within the first 7 days after stopping the pills. If you are not planning a pregnancy yet, start using other forms of contraception immediately after you stop taking the pills.

How to get pregnant after taking Rigevidon?

If you want to become pregnant, start taking it at least 1 month (or better yet, 3 months) before you plan to become pregnant.

Please note that pregnancy can occur in the first month after stopping Rigevidon tablets. However, gynecologists recommend starting attempts to conceive no earlier than 3 months after stopping the pills.

Women using contraceptives are increasingly choosing the pill. A convenient method that has a minimal set of contraindications and side effects. Many people prefer the contraceptive pills rigevidon, which have a low volume of hormones in their composition, used not only to avoid unwanted pregnancy, but also in the treatment of diseases of the woman’s reproductive organs.

The contraceptive is a type of monophasic means of protection against pregnancy. An identical dose of hormonal components is present in each tablet. Dragee consists of:

• Ethinyl estradiol – 30 mcg;
• Levonorgestrel – 150 mcg.

The blister contains 21 tablets, designed for a 3-week course of administration. The package contains 1-3 blisters.

Advantages of the drug

Rigevidon tablets, which have a contraceptive effect, reliably protect against unwanted pregnancy if the rules of administration are followed. The effectiveness of the drug is almost 100% reliable, temporarily suppressing the ovulation process, increasing the viscosity of the mucus located in the cervical canal.

By using the tablets for three or more months, following the instructions in the instructions, the menstrual cycle is normalized, pain during premenstrual syndrome and menstruation itself decreases or goes away, and the amount of blood released decreases.

The drug reduces the likelihood of uterine or ovarian cancer, endometriosis, and mastopathy. The effect of the drug is reversible; within a few months after stopping taking rigevidon, a girl can become pregnant.

Terms of use

The tablet is taken daily for three weeks, preferably at the same time, regardless of the time the food was taken. Most often, the drug is taken in the evening or before bed to avoid side effects such as nausea and headaches.

Start of reception

The first day of the menstrual cycle is the best time to start taking the drug. Bloody discharge becomes less voluminous over time, and in rare cases disappears completely, do not be alarmed. It happens that menstruation, on the contrary, is extended to 7-10 days; when using a contraceptive, it is considered normal.

Rigevidon is taken one pill once a day for 21 days without breaks. When the blister is empty, take a break for seven days; it is during this time period that menstruation usually begins. Whether menstruation has ended or not, on the 8th day a new package is always opened and a new course of taking contraceptives begins.

Missing an appointment

Rigevidon has a contraceptive effect from the first day of administration; there is no need to use additional contraception. If the remedy is taken on days 2-5 from the beginning of menstruation, then there is a need for barrier protection throughout the week. The effect occurs on the 8th day of administration.

If during 21 days of admission there were no absences or failures with the intake schedule, then the protective effect is maintained and extends to the period of the 7-day break. There is no need for other contraceptives and condoms. If there are omissions or factors that reduce effectiveness, for example, a woman had vomiting, diarrhea, she was taking medications, or drinking alcoholic beverages in large doses, you should refer to the instructions:

• If a woman remembers the omission, less than 12 hours have passed since the moment when the pill needed to be taken, then it is taken as quickly as possible, and then proceed in accordance with the standard dose;
• If more than 36 hours have passed, then use additional contraceptives.

There is a more detailed description of what to do in such situations, when more than 36 hours have passed, based on the pill number:

• Initial week (1-7 tablets). Take the pill as quickly as possible. If you have to take two tablets at once, there is no need to be afraid. Use secondary contraceptives;
• Second week (8-14 tablets). Drink as soon as possible, even if you need to take two. The effect of protection is not reduced if the previous week was without passes or situations that reduced the level of protection. In case of at least one forgotten dose, use condoms for a week;
• Third week (15-21). Take the missed pill, two if necessary and when the time to take it comes. Until the blister runs out, continue to use the pills as usual. The woman does not take a break for a week, but opens a new blister and takes the pills. The situation with passes is repeated: if there were no passes in the previous week, then condoms are not needed, but if there were, then they use barrier protection.

Skipping 2 pills

A girl who has missed two pills in a row should remember the reduced protective effect. The next steps depend on the tablet number. If 1-14, then drink two pills at once, as well as two pills the next day, then drink 1 tablet per day, as usual, until the end of the pack. Use condoms for a week.

When it comes to 15-21 days, then get rid of the current blister, open a new one and start with 1 tablet. The packaging is used until completion; a break is taken for seven days. If there are no previous passes, secondary contraception is not required.

Skip 3 pills

The blister is thrown away and a new one is opened. Condoms are used throughout the week. If you have unprotected sexual intercourse during the period of time when the pills were not taken, the chance of conception increases. Doctors advise you to go to the gynecologist, get tested for pregnancy, or get an analysis.

Transition to Rigevidon

When previous OCs or COCs consisted of 21 tablets per package:

• The starting point is the next day after the final pill of the previous type was taken;
• You can start drinking pills from the 8th day after finishing the previous pills.

If a woman was unable to take the pill within the specified period of time, she must wait until the day the next menstruation begins, drink the pill and act according to the instructions, use other contraceptives for seven days.

Contraindications

• Presence of otosclerosis;
• Migraine;
• If the woman is over 40 years old;
• Presence of vesicular diarrhea;
• If you have chronic hemolytic or sickle cell anemia;
• If you have diseases related to the endocrine system, diabetes mellitus;
• In case of individual intolerance to the components in the composition of the drug;

• The use of tablets during pregnancy or lactation is strictly prohibited;
• Presence of arterial hypertension;
• Liver diseases;
• Cholecystitis;
• Congenital hyperbilirubinemia;
• Tumors;
• Idiopathic jaundice;
• Skin itching;
• Various bleedings.

Doctors prescribe the drug with great caution to those who have ulcerative colitis, multiple sclerosis, phlebitis, varicose veins, tuberculosis, kidney and liver diseases, gall bladder problems, epilepsy, depression, vascular and heart diseases, and others.

Side effects

Patients using the product rarely experience side effects.

The onset and resolution of symptoms occurs spontaneously. They manifest themselves in the appearance of nausea, vomiting, headaches, an increase or decrease in cravings for sex, an increase in body weight, sudden and frequent changes in mood, the appearance of spotting blood, and the formation of conjunctivitis.

It has been noted that in rare cases more serious side effects occur:

• In women, hearing deteriorates or disappears;
• Chloasma appears;
• Jaundice occurs;
• Epileptic seizures;
• Cramps and itching;
• Blood pressure increases;
• Thromboembolism or thrombosis occurs;
• A variety of rashes form on the skin;
• Secretion changes in the vagina;

• The woman gets tired quickly;
• Candidiasis appears;
• Hyperglycemia, etc.

Important Requirements

Before taking birth control pills, you need to consult a doctor every six months for as long as you are taking the pills. Gynecological and general medical examination consists of:

• From cytological analysis;
• The mammary glands are examined;
• The level of glucose in the blood is determined;
• Liver function is checked;
• Pressure;
• Composition of urine;
• Cholesterol levels.

Women who have recovered from viral hepatitis, with normal, restored liver function, can use the drug no earlier than six months after recovery.

If you experience sharp pain in the abdomen, hepatomegaly, or symptoms of intra-abdominal bleeding, you should be checked for the presence of a liver tumor, and the drug should be discontinued.

Rigevidon is produced in tablets, packaged in blisters of 21 pieces, 3 or 1 blister per package.

pharmachologic effect

Rigevidon tablets exhibit contraceptive action.

Pharmacodynamics and pharmacokinetics

This oral monophasic combined estrogen-progestogen contraceptive drug can have an inhibitory effect on the pituitary production of gonadotropins.

In this case, the contraceptive effect is associated with several mechanisms. Progestin component progestin includes a derivative of 19-nortestosterone known as levonorgestrel . This substance is more active than the corpus luteum hormone or its synthetic analogue pregnin , which has an effect at the receptor level without being affected.

The estrogenic component ethinyl estradiol leads to a blockade of the release of releasing hormones by the hypothalamus and inhibition of the production of gonadotropic hormones by the pituitary gland. At the same time, the maturation and release of the egg, ready for fertilization, is inhibited.

It has been established that ethinyl estradiol enhances the contraceptive effect of the drug. The increased viscosity of the cervical mucus remains, which makes it difficult for sperm to penetrate.

Also, regular use of the drug leads to normalization of the menstrual cycle and prevents the development of certain gynecological diseases, for example, tumors.

Inside the body, the drug undergoes rapid absorption. The concentration of Rigevidon depends on the dosage of the drug and the duration of use. In this case, the maximum concentration is usually detected after 2 hours, elimination occurs on average within 16 hours. The drug is excreted unchanged and unchanged through the intestines and kidneys.

Indications for use

• oral contraception;
• functional disorders of the menstrual cycle, for example, unidentified , dysfunctional metrorrhagia, .

Contraindications

Birth control pills Rigevidon are not prescribed for:

• sensitivity to the drug;
• , ;
• severe liver diseases;
• congenital hyperbilirubinemia;
• thromboembolism;
• tumor diseases;
• severe forms arterial hypertension;
• and other diseases of the endocrine glands;
• sickle cell anemia ;
• chronic hemolytic anemia;
• hydatidiform mole;
• over 40 years of age;
• otosclerosis.

Also, the drug is contraindicated for use in case of bleeding of various origins, idiopathic jaundice, and in pregnant women.

Rigevidon is prescribed with caution to patients with diseases of the liver, kidneys and gall bladder, , ulcerative, mastopathy, , diseases of the cardiovascular system, arterial hypertension, renal dysfunction, , phlebitis , otosclerosis and absent-minded . Caution is also required when prescribing tablets to adolescent patients.

Rigevidon during pregnancy and lactation

It has been established that the use of this drug is contraindicated during pregnancy and lactation.

Side effects of Rigevidon

Usually this drug is well tolerated by patients, but sometimes side effects of Rigevidon occur, which develop transiently and disappear spontaneously. For example, nausea, vomiting, weight gain And libido change , moods, manifestation of acyclic bleeding, conjunctivitis , vision problems and so on.

In rare cases, long-term use of the drug causes chloasma, hearing loss, jaundice, generalized seizures, convulsions, frequency of epileptic seizures, hypertriglyceridemia , hyperglycemia , increased blood pressure, thrombosis or venous thromboembolism, skin rashes, changes in vaginal secretion, high fatigue, etc.

Rigevidon tablets, instructions for use (Method and dosage)

When hormonal contraception was not used during the previous menstrual cycle, it should be started on the 1st day of menstruation. Then you need to take one tablet every day for 21 days, preferably at a certain time of day.

After this, a break of 7 days is taken, during which menstrual-like bleeding occurs. For the next 21 days, the tablets are taken from a new package, that is, already on the 8th day, regardless of whether the bleeding has stopped or not.

The transition to these contraceptive pills from another contraceptive is carried out according to the same scheme. You can take the drug as long as you need it.

The use of the drug for medicinal purposes requires individual selection of dosage and therapeutic regimen.

Overdose

There have been no cases of overdose with Rigevidon.

Interaction

Combination with barbiturates, antiepileptic drugs, for example, and, as well as sulfonamides, pyrazolone derivatives can lead to increased metabolism of the drugs contained in the drug.

The combined use of Rigevidon and certain antimicrobial drugs can reduce the contraceptive effect: , Polymyxin B , sulfonamides and, since they change the composition of the intestines.

This drug may increase the bioavailability and toxicity of tricyclic antidepressants, beta-blockers and A , reduce efficiency.

Combined use with hypoglycemic drugs and often requires changing their dosage. When taken with the drug Dantrolene it is possible that its hepatotoxicity may increase, mainly in women over 35 years of age.

special instructions

Before starting to take contraceptive pills, and every six months when using them, it is necessary to undergo a general medical and gynecological examination. It usually includes a cytological analysis, examination of the mammary glands, assessment of blood glucose, liver function, pressure and urine composition.

For patients who have undergone viral hepatitis and their liver functions have normalized, the drug is prescribed no earlier than 6 months from the moment of recovery.

If sharp pain appears in the abdominal cavity, and signs intra-abdominal bleeding , then this may indicate a liver tumor. If necessary, the drug is immediately discontinued.

Appearance intermenstrual bleeding does not require discontinuation of the contraceptive, since they usually stop on their own. When this does not happen, consultation with a gynecologist is necessary.

As is known, women who smoke when taking hormonal contraceptives can develop vascular diseases with serious consequences - myocardial infarction

There are many reviews of women taking one of these drugs for a long time. This did not lead to the development of undesirable effects, such as changes in libido or weight gain. Moreover, immediately after discontinuation of these contraceptives, pregnancy occurred almost immediately. Therefore, the selection of such drugs must be carried out taking into account individual characteristics after consultation with a gynecologist.

Alcohol and Rigevidon

There have been cases of decreased effectiveness of this drug when alcohol is consumed in large quantities.